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All Journal Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Syntax Literate: Jurnal Ilmiah Indonesia Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Respirasi (JR) MEDICINUS
Saroyo, Yudianto Budi
Department Of Obstetrics And Gynecology, Universitas Indonesia, Jakarta, Indonesia.
Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Maternal outcome in accreta cases. Conservative surgery and hysterectomy in Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, from January 2017 to January 2018 Fita Maulina; Mohammad Adya Firmansha Dilmy; Yudianto Budi Saroyo; Yuditiya Purwosunu
Majalah Obstetri dan Ginekologi Vol. 29 No. 3 (2021): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V29I32021.129-135

Abstract

HIGHLIGHT1. As the incidence of placenta accreta is increasing which seems to parallel the increasing cesarean delivery rate, advance planning should be made for the management of delivery. 2. Maternal outcome of placenta accreta cases in a national hospital was reported based on the surgical technique performed.3. No significant results of maternal outcome undergoing conservative surgery and conventional hysterectomy in managing accreta cases in the national hospital.ABSTRACTObjectives: To report maternal outcome based on surgical technique on the management of accreta. The study was conducted in Cipto Mangunkusumo Hospital, Jakarta, Indonesia from January 2017 to January 2018.Case Report: There were 1609 cases of pregnant women delivered during the study period. From these, the prevalence of previous caesarean section was 73 cases, including 20 cases of accreta. Total maternal mortality for 1 year in Cipto Mangunkusumo Hospital, Jakarta, Indonesia, was 11, and accreta contributed 3 cases. We reported 20 cases of accreta in pregnancy The maternal outcomes, including bladder injury, duration of operation, intraoperative bleeding, length of hospitalization, and mortality, were evaluated. From 20 cases, 8 patients had one previous caesarean history, 11 had second previous caesarean section, while 2 patient had third previous caesarean section history. Of women with placenta accreta, about 7 patients (35%) had delivery in fullterm pregnancies, while 13 (65%) had delivery in preterm pregnancy. Surgical technique in accreta management mostly was hysterectomy to override bleeding complication along the delivery. From 20 cases, 16 caesarean sections were followed-up with hysterectomy. Four cases were with conservative management. From all the hysterectomy performed, four were complicated with bladder injury. The mean intraoperative bleeding was 600 - 5500 cc of blood, while the mean of post-operative transfusion was 1000 -3000 cc. There were 2 maternal deaths in this study. Thirteen patients were admitted to the ICU after the procedure.Conclusion: Accreta increases morbidity due to massive bleeding. It is important to have algorithm for managing abnormal implantation of the placenta. Our cases revealed no significant results of maternal outcome between conservative surgery and conventional hysterectomy in managing accreta cases in Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Complicated vivax malaria in pregnancy: A case report in rural area of Indonesia Surya, Raymond; Manurung, Edward Sugito; Saroyo, Yudianto Budi
Majalah Obstetri & Ginekologi Vol. 31 No. 3 (2023): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V31I32023.162-166

Abstract

HIGHLIGHTS In malaria endemic area, pregnant women are highly prone to suffer from malaria infection. Vivax malaria in pregnancy can contribute to anemia and preterm delivery.   ABSTRACT Objective: This study aimed to report a preterm delivery and anemia as part of P. vivax malaria infection complications in a pregnant woman in Timor Tengah Selatan regency, East Nusa Tenggara, Indonesia. Case report: A 42-year-old pregnant woman, gravida 6 para 5,36-week of gestational age pregnant woman came with complaints of water breaking since one day before admission. She had fever with chills for three days, especially at night along with muscle, headache, joint soreness, dizziness, and palpitations. Rapid diagnostic test for malaria showed positive result. Peripheral blood smear examination revealed microcytic hypochromic due to iron deficiency or chronic infection and presence of trophozoites-ring form of P. vivax with 4,235 parasitemia. A baby boy was born with weight of 2,470 grams (percentile 28%), fetal head 31 cm (percentile 13%), birth length 43 cm (percentile 4%), and Apgar Score (AS) 8 and 9 at 1 and 5 minutes, respectively. The treatment was provided according to anti-malarial guideline in Indonesia using dihydroartemisin 120 mg and piperaquine phosphate 960 mg fixed dose as DHP for 3 days and primaquine 15 mg for 14 days. Conclusion: Anemia as part of vivax malaria complication in pregnancy contributes to preterm delivery.
Secondary Syphilis with Giant Condyloma Acuminatum in Pregnant Women: A Report from a Limited Resource Area Surya, Raymond; Chelsea, Edelyne; Manurung, Edward Sugito; Banunaek, Diana; Nilasari, Hanny; Saroyo, Yudianto Budi
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 3 November 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v6i3.536

Abstract

Introduction: This report shows a case of secondary syphilis in pregnancy with Giant Condyloma Acuminatum (GCA) co-infection DD/condyloma lata which was resolved with alternative treatment of syphilis.Case illustration: A 21-year-old, primigravid woman came to obstetrics outpatient clinic in rural SoE Hospital, East Nusa Tenggara, with a complaint of mass enlargement around vulva (minor and major labia) since 2 months before. Based on Last Menstrual Period (LMP), she was in 34 + 6 weeks of gestation. There were coin lesions in the palms. On genital examination, there was protruded mass sized around 15 x 10 cm, erythematous, and it easily bled on the center part which was suspected to be GCA. Treponema Pallidum rapid (TP-rapid) test using AIM© syphilis rapid test revealed positive results. The patient was diagnosed with secondary syphilis in pregnancy mixed with GCA with dd/condyloma lata and administered Ceftriaxone 1 g intramuscularly once daily for 14 days. She delivered at 41-42 weeks of gestation and a baby girl with 1,980 grams of body weight according to symmetric Intrauterine Growth Restriction (IUGR) was born. No clinical signs of congenital syphilis found.Discussion: Vertical transmission which occurs in each stage of syphilis is related to the presence of spirochetes in the blood circulation. Infants born from syphilis pregnant women consist of 56% of jaundice, 14% of hearing impairment, 8% of renal disease, 8% of mental retardation, and 6% of IUGR or Small for Gestational Age (SGA).Conclusion: Secondary syphilis coinfection with GCA in pregnancy is a rare case report. Syphilis is a significant public health problem globally, especially in Indonesia.Sifilis Sekunder dengan Kondiloma Akuminata Besar pada Wanita Hamil: Sebuah Laporan dari Daerah dengan Keterbatasan Sumber DayaAbstrakPendahuluan: Kasus ini melaporkan sifilis sekunder pada kehamilan dengan kondiloma akuminatum besar dengan koinfeksi dd/kondiloma lata yang beresolusi setelah pemberian tatalaksana alternatif sifilis.Ilustrasi Kasus: Seorang wanita primigravida berusia 21 tahun datang ke poliklinik obstetrik di RSUD SoE, Nusa Tenggara Timur dengan pembesaran massa sekitar vulva (labia minor dan mayor) sejak 2 bulan sebelumnya. Berdasarkan Hari Pertama Haid Terakhir (HPHT), usia kehamilan 34 + 6 minggu. Terdapat lesi pada telapak tangan. Pada pemeriksaan genital, terdapat massa ukuran 15 x 10 cm, eritema, mudah berdarah pada bagian tengah dengan kecurigaan kondiloma akuminatum besar. Hasil tes rapid Treponema Pallidum menggunakan tes rapid sifilis (AIM©) menunjukkan hasil positif. Pasien didiagnosis mengidap sifilis sekunder pada kehamilan dengan kondiloma akuminatum besar dengan koinfeksi dd/ kondiloma lata dan diberikan terapi seftriakson 1 gram intramuscular setiap hari selama 14 hari. Pasien melahirkan saat usia kehamilan 41-42 minggu dan lahir bayi 1.980 gram sesuai dengan Pertumbuhan Janin Terhambat (PJT) simetrik. Tidak ada tanda klinis sifilis kongenital yang ditemukan. Diskusi: Transmisi vertikal dapat terjadi pada setiap tahap sifilis berkaitan dengan keberadaan spiroseta di sirkulasi darah. Bayi lahir dari wanita hamil sifilis biasanya menunjukkan tanda 56% kuning, 14% gangguan pendengaran, 8% gangguan ginjal, 8% retardasi mental, dan 6% PJT atau Kecil Masa Kehamilan (KMK).Kesimpulan: Sifilis sekunder koinfeksi kondiloma akuminatum besar merupakan kasus jarang. Sifilis masih menjadi perhatian kesehatan global, khususnya di Indonesia.Kata kunci: sifilis, koinfeksi, kondiloma akuminatum besar, pertumbuhan janin terhambat
Feasibility Study For Birth Defect’s and Congenital Abnormalities’s Integrated Service In A Low-Middle Income Country Saroyo, Yudianto Budi; Firmansha Dilmy, Mohammad Adya; Salsabila Putri, Cut Tisya; Islamah, Rachelya Nurfirdausi; Budiman, Jenica Xaviera; Rumondang, Amanda; Purwosunu, Yuditiya; Irwinda, Rima; Rohsiswatmo, Rinawati
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 3 July 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i3.2783

Abstract

Background: Congenital abnormalities are anatomical and physiological abnormalities that are present in babies from birth. One of the main causes of high infant mortality and neonatal mortality in Indonesia is congenital abnormalities in babies. This study describes the prevalence of congenital abnormalities in Dr. Cipto Mangunkusumo Hospital, as a tertiary referral hospital in Indonesia, which requires integrated healthcare service to be treated well. Methods: Data obtained from 323 patients at Dr. Cipto Mangunkusumo General Hospital are collected in a year, to be further analyzed in retrospective cohort study. Collected data includes the patients’ age, birth date, reproductive history, gestational age, and congenital abnormalities of the baby. Results: The data shows that patients with the age group of 30-39 years old dominated the cases of pregnancy with congenital abnormalities. Cases are also more dominant in the gestational age of 13 – 28 weeks (second-trimester). Most cases of abnormalities are from the central nervous system with 159 cases and followed by cardiovascular system with 130 cases. Overall prevalence of congenital abnormalities are detected within patients during prenatal screening in Dr. Cipto Mangunkusumo General Hospital. Conclusion: This study highlights the importance in managing congenital abnormalities and birth defects by developing an integrated service in the healthcare system to lower infant and neonatal mortality. Keywords: birth defect, congenital abnormalities, prenatal screening
Higher Trace Elements and Lower Fatty Acids Levels in Erythrocytes as Predictors of Preeclampsia Putri, Ruth Widhiati Raharjo; Prasmusinto, Damar; Wibowo, Noroyono; Irwinda, Rima; Purwosunu, Yuditiya; Saroyo, Yudianto Budi
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3256

Abstract

BACKGROUND: Preeclampsia is one of the common causes of maternal death in Indonesia. Many studies only focus on the diagnosis and pharmacological treatment of preeclampsia. However, predictors of preeclampsia need to be observed to add more focus on the etiology and prevention of preeclampsia. The imbalances of trace elements and fatty acids play an important role in preeclampsia. Therefore, this study was conducted to evaluate the status of trace elements and fatty acids in preeclampsia patients as predictors of preeclampsia.METHODS: A cross-sectional study was conducted in 3 hospitals, and involving 40 pregnant women classified into severe preeclampsia and normotensive groups. Trace elements and fatty acids were measured in serum and erythrocytes using Inductively Coupled Plasma and Gas Chromatography-Mass Spectrometry. Serum and erythrocytes fatty acid levels' cut-off value, sensitivity, and specificity were analyzed using Receiver Operating Characteristic (ROC) curve and Area Under the Curve (AUC) value.RESULTS: Serum selenium, manganese, and iron levels were significantly different in the preeclampsia group than in the controls (p<0.05). Of all the heavy metals, higher concentrations of cadmium, arsenic, lead, and mercury were found in preeclampsia groups compared to control. Linoleic acid showed the highest predictive value to increase severe preeclampsia with AUC of 0.8. The ratio of high omega-6/omega-3 increases the risk of preeclampsia.CONCLUSION: Selenium, manganese, iron, cadmium, arsenic, lead, and mercury levels are higher in the serum of preeclampsia patients. Almost all erythrocyte fatty acids were significantly higher in the control group compared to preeclampsia. Measurement of trace elements and fatty acids is needed as a predictor of preeclampsia. Erythrocyte fatty acids measurement is considered better than serum.KEYWORDS: trace elements, fatty acids, preeclampsia
Pregnancy-Related Disorders and Intrauterine Impaired Lung Development Zulhadji, Harry Agustio; Yunus, Faisal; Rasmin, Menaldi; Saroyo, Yudianto Budi; Amien, Bagus Radityo
Jurnal Respirasi Vol. 10 No. 2 (2024): May 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.2.2024.178-185

Abstract

Various pregnancy-related disorders are known to affect fetal lung development negatively. During pregnancy, chronic nutrition and/or oxygen limitation is known to impede lung maturation and induce airway and lung abnormalities. Structural abnormalities and reduced lung function may be evident immediately after birth, persist, or develop with age. The expansion of the fetal lung, fetal breath movements, fetal lung growth, alveolarization, blood-air barrier, extracellular matrix (ECM), airways, surfactant system, and lung immune function are all affected by nutritional limitations during pregnancy. Gestational hypoxia disrupts fetal lung development, which manifests as morphological and functional pulmonary abnormalities. Additionally, intrauterine growth restriction (IUGR), preeclampsia (PE), exposure to air pollution, and smoking are known to interfere with embryonic lung development. Birth defects, such as bronchopulmonary dysplasia, as well as chronic obstructive pulmonary disease (COPD), can be caused by abnormalities in pregnancy. Adequate nutrition, avoidance of smoking, and watchful monitoring and intervention during pregnancy should be promoted to prevent chronic lung disease of the newborn, child, and adult.
Studi Ekspresi Glukosa Transporter pada Preeklampsia dan Hubungannya dengan Gangguan Metabolik pada Ibu Hamil Fairuz, Vycka Fikriyani; Saroyo, Yudianto Budi; Purwosunu, Yuditiya
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i2.55163

Abstract

Gangguan metabolik merupakan masalah kesehatan global yang ditandai dengan obesitas, resistensi insulin, hipertensi, dan hiperglikemia. Patogenesis sindrom metabolik bersifat multifaktorial, dipengaruhi oleh faktor nutrisi, genetik, dan lingkungan. Pada ibu hamil, gangguan metabolisme akibat obesitas dan hipertensi meningkatkan risiko diabetes melitus gestasional dan preeklamsia. Preeklamsia terjadi akibat gangguan plasenta yang disebabkan oleh defisiensi invasi trofoblas pada arteri spiral miometrium, mengakibatkan iskemia janin. Metabolisme karbohidrat, terutama glukosa, berperan penting dalam patofisiologi preeklamsia. Glukosa merupakan sumber utama energi yang dimetabolisme oleh sel trofoblas plasenta melalui ekspresi glukosa transporter (GLUT) pada jaringan fetomaternal. Tiga jenis GLUT utama yang berperan dalam transport glukosa antara ibu dan janin adalah GLUT1, GLUT3, dan GLUT4. Dalam kondisi preeklamsia, berkurangnya perfusi plasenta dan hipoksia menyebabkan gangguan ekspresi GLUT, sehingga transport glukosa ke janin menurun. Akibatnya, terjadi keterbatasan pertumbuhan janin serta peningkatan risiko komplikasi lainnya. Studi ini bertujuan untuk memahami hubungan antara ekspresi GLUT dan preeklamsia guna mengidentifikasi potensi intervensi terapeutik yang dapat meningkatkan transport glukosa ke janin. Hasil penelitian menunjukkan bahwa gangguan regulasi GLUT pada preeklamsia berkontribusi terhadap restriksi pertumbuhan janin. Kesimpulannya, pemahaman lebih lanjut mengenai ekspresi GLUT dalam preeklamsia dapat berkontribusi pada pengembangan strategi pengobatan yang lebih efektif untuk meningkatkan kesehatan ibu dan janin.
Triple-Threat Pregnancy: Navigating PPCM, Preeclampsia, and Thalassemia Major – A Holistic Reproductive Risk Assessment Post-Cesarean Delivery Arya Ady Nugroho; Yudianto Budi Saroyo; Dwiana Ocviyanti
MEDICINUS Vol. 39 No. 1 (2026): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/qdxs3625

Abstract

Background: Pregnancies complicated by multiple severe maternal conditions such as peripartum cardiomyopathy (PPCM), preeclampsia, and β-thalassemia major, pose significant risks to both mother and fetus. This case explores the challenges of managing a high-risk pregnancy, involving these conditions and highlights the importance of a multidisciplinary approach in high-risk pregnancy management.Case presentation: A 33-year-old pregnant woman with β-thalassemia major presented at 32+4 weeks of gestation with acute dyspnea, severe preeclampsia, and signs of PPCM. She was carrying dichorionic diamniotic twins and required emergency cesarean section after stabilization. Echocardiography revealed severe left ventricular systolic dysfunction with an ejection fraction of 35%. The patient underwent immediate postoperative management and received a trans-cesarean intrauterine device (IUD) insertion for long-term contraception. Both neonates were admitted to the neonatal intensive care unit (NICU) for prematurity care.Conclusion: This case underscores the critical need for a holistic, multidisciplinary approach in managing complex highrisk pregnancies, focusing on immediate maternal stabilization, neonatal care, and long-term reproductive planning.
Lower Ferrum, Selenium, and Cadmium; Higher Chromium and Lead Levels in Preeclampsia Patients’ Erythrocyte: A Cross-Sectional Study Sandhy Prayudhana; Damar Prasmusinto; Noroyono Wibowo; Rima Irwinda; Yuditiya Purwosunu; Yudianto Budi Saroyo
The Indonesian Biomedical Journal Vol 17, No 1 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i1.3257

Abstract

BACKGROUND: Oxidative stress and trace elements in erythrocytes are linked to impaired nitric oxide that can lead to endothelial dysfunction in preeclampsia patients. The morphology of erythrocytes could also be affected by oxidative stress and trace elements. While the relationships between erythrocyte index, superoxide dismutase (SOD) activity, and oxidative stress in preeclampsia have been well established, less attention has been given to the erythrocyte trace elements and their role in disease progression. This study was performed to examine the erythrocyte trace element profile in women with preeclampsia, comparing it with controls. Additionally, it will explore the correlations between erythrocyte trace element levels, the erythrocyte index, and SOD activity.METHODS: A cross-sectional study was conducted involving 40 pregnant women consisting of those with severe preeclampsia and normotensive. Erythrocytes was isolated from blood samples, and analysis of erythrocyte SOD activity and trace elements were performed using the enzyme linked immunosorbent assay (ELISA) and inductively coupled plasma mass spectrometry (ICP-MS), respectively.RESULTS: Among 15 examined erythrocyte trace elements, the levels of ferrum (Fe), selenium (Se), and cadmium (Cd) were significantly lower, meanwhile, the levels of chromium (Cr) and lead (Pb) were significantly higher in preeclampsia subjects. Additionally, preeclampsia subjects exhibited smaller erythrocyte sizes compared to the normotensive subjects. The erythrocyte SOD activity was significantly elevated in the preeclampsia subjects than the normotensive subjects.CONCLUSION: Erythrocyte trace element levels of Fe, Se, Cd, Cr, and Pb were significantly altered in preeclampsia compared to normotensive controls. These findings suggest that these trace elements may serve as potential predictors for preeclampsia.KEYWORDS: preeclampsia, trace elements, antioxidant, oxidative stress, superoxide dismutase, erythrocyte index
Preeclampsia in the Modern Era: New Insights from Global Research and Implications for Practice in Indonesia Arya Ady Nugroho; Yudianto Budi Saroyo; Allan Taufiq Rivai
MEDICINUS Vol. 39 No. 2: MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/v8ne8639

Abstract

Preeclampsia (PE) remains a leading cause of maternal and neonatal morbidity and mortality worldwide, affecting 2–15% of pregnancies. This review synthesizes recent advancements in the understanding of PE pathophysiology, includingplacental dysfunction, endothelial impairment, and novel biomarkers such as angiogenic factors. Drawing on global studies published up to 2025, we explore predictive models for early detection before 11 weeks of gestation, innovativemanagement strategies including aspirin prophylaxis, and disparities in maternal and neonatal outcomes. In Indonesia, where PE contributes to 26–30% of maternal deaths, we highlight local epidemiology, risk factors such as anemia and obesity, and tailored interventions to improve screening and care in resource-limited settings. By emphasizing evidencebasedpractices, this article underscores the need for integrated approaches to reduce the burden of PE and provides actionable insights for clinicians in both global and Indonesian contexts.
Co-Authors Allan Taufiq Rivai Amien, Bagus Radityo Arya Ady Nugroho Banunaek, Diana Budiman, Jenica Xaviera Chelsea, Edelyne Damar Prasmusinto Damar Prasmusinto Dilmy, Mohammad Adya Firmansha Dwiana Ocviyanti Fairuz, Vycka Fikriyani Faisal Yunus Firmansha Dilmy, Mohammad Adya Fita Maulina Hanny Nilasari Islamah, Rachelya Nurfirdausi Mahendra, Arya Ivan Manurung, Edward Sugito Menaldi Rasmin Mohammad Adya Firmansha Dilmy Noroyono Wibowo Noroyono Wibowo Purwosunu, Yuditiya Putri, Atikah Sayogo Putri, Lysandra Olivia Prasanti Putri, Ruth Widhiati Raharjo Raymond Surya Rima Irwinda Rima Irwinda, Rima Rinawati Rohsiswatmo Rumondang, Amanda Salsabila Putri, Cut Tisya Sandhy Prayudhana Yuditiya Purwosunu Yuditiya Purwosunu Zulhadji, Harry Agustio