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Effect of the Feeding of Formula Milk Enriched with Pro-Antioxidants for the Prevention of Preeclampsia; Study of High Sensitivity C-Reactive Protein (hs-CRP) and Cell-Free mRNA of Plasminogen Activator Inhibitor-1 (PAI-1) in Plasma Wibowo, Noroyono
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 4, October 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (77.251 KB)

Objective: To evaluate the effect of the feeding of formula milk enriched with pro-antioxidants to high sensitivity C-reactive protein (hs-CRP) and cell-free mRNA of Plasminogen Activator Inhibitor-1 (PAI-1) in the first trimester, second trimester, and post labor for the prevention of preeclampsia. Method: This is double-blinded randomized clinical trial in 8-12 weeks pregnant woman with low (below 900 Î¼mol/l) Ferric Reducing Ability of Plasma (FRAP), as a marker of low systemic antioxidant. A total of 104 samples were collected from patients who had antenatal care in Bunda Hospital Jakarta, Budi Kemuliaan Hospital, and Dr.Cipto Mangunkusumo General Hospital from January 2007 until December 2009. From block randomization, 49 samples were allocated in the case group, and 55 samples to the control group. A formula milk enriched with pro-antioxidants was fed to the case group throughout their pregnancy, and a regular pregnancy formula milk was fed to the control group. Hs-CRP and cell-free mRNA PAI-1 test in the two groups at first trimester, second, and post labour was conducted. The incidence of preeclampsia was then compared in the two groups. Result: Significant difference (p

The Level of Zinc is Increasing, while the Serum Folat Level is Decreasing, after Multi-Micronutrient Supplementation in Pregnant Woman Wibowo, Noroyono
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 4, October 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (102.758 KB)

Objective: To measure the changes of serum iron, folic acid, zinc and selenium level on pregnant woman after multi-micronutrient supplementation. Method: First trimester pregnant woman whom attended Maternal- Fetal Policlinic at Dr. Cipto Mangunkusumo Hospital from July 2011 till October 2011 was considered into the study. The intervention was consumption of multi-micronutrient tablet once a day for three months period. The outcomes were the measurements of serum level of iron, folic acid, zinc and selenium before and after supplementation. We used paired T Test and Wilcoxon test for statistical analysis. Results: Twenty-eight pregnant women in their first trimester participated in the study. The micronutrient serum level was measured before and after supplementation during the time period. Before supplementation, serum iron and zinc level were below normal. Serum selenium level was normal with higher than normal serum folic acid level. After supplementation, serum zinc level was found to be below normal. Both level of serum iron and selenium increased to normal. Serum folic level was higher than normal. We found a decrease in serum zinc level with an increase in serum folic acid level that was statistically significant (p 0.009; p 0.003 respectively). We also found a slight decrease of serum iron level and an increase of serum selenium level that were not statistically significant (p 0.295; p 0.333). Conclusion: There is a decreased level of serum zinc with an increase in serum folic acid level after multi-micronutrient supplementation. [Indones J Obstet Gynecol 2012; 36-4: 171-5] Keywords: multi-micronutrient, supplementation

The Level of Zinc is Increasing, while the Serum Folat Level is Decreasing, after Multi-Micronutrient Supplementation in Pregnant Woman Wibowo, Noroyono
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 4, October 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To measure the changes of serum iron, folic acid, zinc and selenium level on pregnant woman after multi-micronutrient supplementation. Method: First trimester pregnant woman whom attended Maternal- Fetal Policlinic at Dr. Cipto Mangunkusumo Hospital from July 2011 till October 2011 was considered into the study. The intervention was consumption of multi-micronutrient tablet once a day for three months period. The outcomes were the measurements of serum level of iron, folic acid, zinc and selenium before and after supplementation. We used paired T Test and Wilcoxon test for statistical analysis. Results: Twenty-eight pregnant women in their first trimester participated in the study. The micronutrient serum level was measured before and after supplementation during the time period. Before supplementation, serum iron and zinc level were below normal. Serum selenium level was normal with higher than normal serum folic acid level. After supplementation, serum zinc level was found to be below normal. Both level of serum iron and selenium increased to normal. Serum folic level was higher than normal. We found a decrease in serum zinc level with an increase in serum folic acid level that was statistically significant (p 0.009; p 0.003 respectively). We also found a slight decrease of serum iron level and an increase of serum selenium level that were not statistically significant (p 0.295; p 0.333). Conclusion: There is a decreased level of serum zinc with an increase in serum folic acid level after multi-micronutrient supplementation. [Indones J Obstet Gynecol 2012; 36-4: 171-5] Keywords: multi-micronutrient, supplementation

The Levels of Zinc, Selenium, Iron and Copper in Preterm Pregnancy do not Differ with those of Healthy Pregnancy Wibowo, Noroyono; fitriana, Fitriana
Indonesian Journal of Obstetrics and Gynecology Volume 7 No. 2 April 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: to compare zinc, selenium, iron and copper levels in maternal serum of normal and preterm pregnancy. Methods: It is a cross sectional study with preterm and normal pregnant woman who will carry delivery in Dr. Cipto Mangunkusumo National Hospital and Budi Kemuliaan Hospital Jakarta from January to April 2017. This study was conducted by comparing the levels of each micronutrient in both groups of subjects. Result: From January until April 2017, there were 53 subjects divided into 30 normal pregnant women and 23 preterm pregnant women. The levels of zinc, selenium iron and copper in preterm pregnancy were 42 µg/dL, 72,39 µg/L, 74 µg/L, and 2144,52 µg/dL. Levels of zinc, selenium, iron and copper in normal pregnancy were 42 µg/dL, 67,27 µg/L, 70,5 µg/L, and 2221 µg/dL. There was no difference in micronutrients level in both groups. Conclusion: This study concluded that there was no difference in zinc, selenium, iron and copper levels in normal and preterm pregnancy. Keywords: pregnancy, zinc, selenium, iron, copper   LatarBelakang:Persalinan preterm adalahpersalinansebelumusiakehamilan 37 minggulengkap. Persalinan preterm inimasihmenjadimasalah di seluruhdunia.Padalaporan World Health Organization (WHO), Indonesia mendudukiperingkatkelimanegaradenganpersalinan preterm terbanyakyakni 675.700 persalinanpadatahun 2010.Berbagaifaktordihubungkandenganpenyebabterjadinyapersalinan preterm, termasuksalahsatunyaadalahgangguannutrisiselamakehamilan, terutamaseng, selenium, besidantembaga. Tujuan:Penelitianinimembandingkankadarseng, selenium, besidantembagapada serum maternal ibuhamil normal dan preterm. Metode:Penelitiandilakukandenganujipotong-lintangdengansubjekpenelitianibuhamilbaik preterm maupunaterm yang akanmelaksanakanpersalinan di RSUPN Dr. CiptoMangunkusumodan RS Budi Kemuliaan Jakarta padaJanuarihingga April 2017. Penelitiandilakukandenganmembandingkankadarmasing-masingmikronutrienpadakeduakelompoksubjek. Hasil:DalamjangkawaktuJanuarihingga April 2017 didapatkan 53 subjekpenelitianyakni 30 ibuhamil normal dan 23 ibudengankehamilan preterm. Seluruhsubjekdimasukkandalamanalisis data.Kadar seng, selenium, besidantembagapadaibudengankehamilan preterm secaraberurutanadalah 42 µg/dL, 72,39 µg/L, 74 µg/L, dan 2144,52 µg/dL.Sedangkankadarseng, selenium, besidantembagapadaibuhamil normal secaraberurutanadalah 42 µg/dL, 67,27 µg/L, 70,5 µg/L, dan 2221 µg/dL. Tidakadaperbedaanbermaknakadarmikronutrienpadakeduakelompoksubjek. Kesimpulan: Penelitianinimenyimpulkanbahwatidakadaperbedaankadarseng, selenium, besidantembagapadaibuhamil normal danibudengankehamilan preterm. Kata kunci:kehamilan, seng, selenium, besi, tembaga

Plasma Folate, Vitamin B6 and B12 in Their Relationship to the Presence of Probiotic Strain Bifidobacterium animalis subsp. Lactis HNO19 (DR10TM) Among Indonesian Pregnant Women in Their Third Semester Saptawati Bardosono; Noroyono Wibowo; Luciana Budiati Sutanto; Rima Irwinda; Rebecca Cannan; Angela Rowan; James Dekker
World Nutrition Journal Vol. 2 No. 2 (2019)
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V02.i2.0009

Introduction Vitamin B12 plays a role during pregnancy in maintaining folate metabolism. Together with folate and vitamin B6, B12 is involved as a coenzyme in DNA synthesis and various methylation reactions in developing embryos. This study aims to compare plasma folate, vitamin B6 and B12 blood levels with respect to the presence of probiotic strain Bifidobacterium animalis subsp. lactis HNO19 (DR10TM) among pregnant women in Indonesia. Methods: This study is part of a larger study entitled “Effects of Bifidobacterium animalis subsp. lactis HNO19 (DR10TM), inulin, and micronutrient fortified milk on fecal DR10TM, immune markers, and maternal micronutrients among Indonesian pregnant women.” Further analyses were performed using independent-t test or Mann Whitney test, GLM-repeated measures and chi-square test, to compare folate, vitamin B6 and B12 intake and blood concentration during pregnancy with presence (n=22) and absence (n=55) subjects of fecal DR10TM at third trimester. Results: At the first trimesters there was no difference in plasma vitamin B6 and vitamin B12 levels between the two groups, based on the presence or absence of fecal DR10TM. However, at the second and third trimester, vitamin B6 blood concentration (p=0.034 and p=0.001) and vitamin B12 blood concentrations at the third trimester (p=0.035) were significantly higher in the fecal DR10TM positive group, while having a similar vitamin B6 and B12 intake. Conclusion: Consumption of pre- and probiotics during the periconceptional period may be a useful strategy for improving maternal vitamin B’s vitamins, especially vitamin B6 and B12 status and therefore provide benefits for the offspring’s quality of life.

Effect of the Feeding of Formula Milk Enriched with Pro-Antioxidants for the Prevention of Preeclampsia; Study of High Sensitivity C-Reactive Protein (hs-CRP) and Cell-Free mRNA of Plasminogen Activator Inhibitor-1 (PAI-1) in Plasma Noroyono Wibowo
Indonesian Journal of Obstetrics and Gynecology Volume. 35, No. 4, October 2011
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (77.251 KB)

Objective: To evaluate the effect of the feeding of formula milk enriched with pro-antioxidants to high sensitivity C-reactive protein (hs-CRP) and cell-free mRNA of Plasminogen Activator Inhibitor-1 (PAI-1) in the first trimester, second trimester, and post labor for the prevention of preeclampsia. Method: This is double-blinded randomized clinical trial in 8-12 weeks pregnant woman with low (below 900 Î¼mol/l) Ferric Reducing Ability of Plasma (FRAP), as a marker of low systemic antioxidant. A total of 104 samples were collected from patients who had antenatal care in Bunda Hospital Jakarta, Budi Kemuliaan Hospital, and Dr.Cipto Mangunkusumo General Hospital from January 2007 until December 2009. From block randomization, 49 samples were allocated in the case group, and 55 samples to the control group. A formula milk enriched with pro-antioxidants was fed to the case group throughout their pregnancy, and a regular pregnancy formula milk was fed to the control group. Hs-CRP and cell-free mRNA PAI-1 test in the two groups at first trimester, second, and post labour was conducted. The incidence of preeclampsia was then compared in the two groups. Result: Significant difference (p

The Level of Zinc is Increasing, while the Serum Folat Level is Decreasing, after Multi-Micronutrient Supplementation in Pregnant Woman Noroyono Wibowo
Indonesian Journal of Obstetrics and Gynecology Volume. 36, No. 4, October 2012
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To measure the changes of serum iron, folic acid, zinc and selenium level on pregnant woman after multi-micronutrient supplementation. Method: First trimester pregnant woman whom attended Maternal- Fetal Policlinic at Dr. Cipto Mangunkusumo Hospital from July 2011 till October 2011 was considered into the study. The intervention was consumption of multi-micronutrient tablet once a day for three months period. The outcomes were the measurements of serum level of iron, folic acid, zinc and selenium before and after supplementation. We used paired T Test and Wilcoxon test for statistical analysis. Results: Twenty-eight pregnant women in their first trimester participated in the study. The micronutrient serum level was measured before and after supplementation during the time period. Before supplementation, serum iron and zinc level were below normal. Serum selenium level was normal with higher than normal serum folic acid level. After supplementation, serum zinc level was found to be below normal. Both level of serum iron and selenium increased to normal. Serum folic level was higher than normal. We found a decrease in serum zinc level with an increase in serum folic acid level that was statistically significant (p 0.009; p 0.003 respectively). We also found a slight decrease of serum iron level and an increase of serum selenium level that were not statistically significant (p 0.295; p 0.333). Conclusion: There is a decreased level of serum zinc with an increase in serum folic acid level after multi-micronutrient supplementation. [Indones J Obstet Gynecol 2012; 36-4: 171-5] Keywords: multi-micronutrient, supplementation

The Levels of Zinc, Selenium, Iron and Copper in Preterm Pregnancy do not Differ with those of Healthy Pregnancy: Kadar Seng, Selenium, Besi dan Tembaga pada Kehamilan Prematur tidak Berbeda dengan Kehamilan Sehat Noroyono Wibowo; Fitriana fitriana
Indonesian Journal of Obstetrics and Gynecology Volume 7 No. 2 April 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: to compare zinc, selenium, iron and copper levels in maternal serum of normal and preterm pregnancy. Methods: It is a cross sectional study with preterm and normal pregnant woman who will carry delivery in Dr. Cipto Mangunkusumo National Hospital and Budi Kemuliaan Hospital Jakarta from January to April 2017. This study was conducted by comparing the levels of each micronutrient in both groups of subjects. Result: From January until April 2017, there were 53 subjects divided into 30 normal pregnant women and 23 preterm pregnant women. The levels of zinc, selenium iron and copper in preterm pregnancy were 42 Âµg/dL, 72,39 Âµg/L, 74 Âµg/L, and 2144,52 Âµg/dL. Levels of zinc, selenium, iron and copper in normal pregnancy were 42 Âµg/dL, 67,27 Âµg/L, 70,5 Âµg/L, and 2221 Âµg/dL. There was no difference in micronutrients level in both groups. Conclusion: This study concluded that there was no difference in zinc, selenium, iron and copper levels in normal and preterm pregnancy. Keywords: pregnancy, zinc, selenium, iron, copper LatarBelakang:Persalinan preterm adalahpersalinansebelumusiakehamilan 37 minggulengkap. Persalinan preterm inimasihmenjadimasalah di seluruhdunia.Padalaporan World Health Organization (WHO), Indonesia mendudukiperingkatkelimanegaradenganpersalinan preterm terbanyakyakni 675.700 persalinanpadatahun 2010.Berbagaifaktordihubungkandenganpenyebabterjadinyapersalinan preterm, termasuksalahsatunyaadalahgangguannutrisiselamakehamilan, terutamaseng, selenium, besidantembaga. Tujuan:Penelitianinimembandingkankadarseng, selenium, besidantembagapada serum maternal ibuhamil normal dan preterm. Metode:Penelitiandilakukandenganujipotong-lintangdengansubjekpenelitianibuhamilbaik preterm maupunaterm yang akanmelaksanakanpersalinan di RSUPN Dr. CiptoMangunkusumodan RS Budi Kemuliaan Jakarta padaJanuarihingga April 2017. Penelitiandilakukandenganmembandingkankadarmasing-masingmikronutrienpadakeduakelompoksubjek. Hasil:DalamjangkawaktuJanuarihingga April 2017 didapatkan 53 subjekpenelitianyakni 30 ibuhamil normal dan 23 ibudengankehamilan preterm. Seluruhsubjekdimasukkandalamanalisis data.Kadar seng, selenium, besidantembagapadaibudengankehamilan preterm secaraberurutanadalah 42 Âµg/dL, 72,39 Âµg/L, 74 Âµg/L, dan 2144,52 Âµg/dL.Sedangkankadarseng, selenium, besidantembagapadaibuhamil normal secaraberurutanadalah 42 Âµg/dL, 67,27 Âµg/L, 70,5 Âµg/L, dan 2221 Âµg/dL. Tidakadaperbedaanbermaknakadarmikronutrienpadakeduakelompoksubjek. Kesimpulan: Penelitianinimenyimpulkanbahwatidakadaperbedaankadarseng, selenium, besidantembagapadaibuhamil normal danibudengankehamilan preterm. Kata kunci:kehamilan, seng, selenium, besi, tembaga

Low Vitamin D Levels Increase the Risk of Early Onset Neonatal Sepsis: Kadar vitamin D yang Rendah Meningkatkan Risiko Sepsis Neonatal Awitan Dini Lisnawati Yuyun; Ali Sungkar; Rinawati Rohsiswatno; Noroyono Wibowo; Denni Hermartin; Agustin Kindi
Indonesian Journal of Obstetrics and Gynecology Volume 8 No. 2 April 2020
Publisher : Indonesian Socety of Obstetrics and Gynecology

Abstract Objective: To identify the association between maternal and umbilical cord vitamin D levels with suspects of early-onset of neonatal sepsis (EONS) in newborns from mothers with preterm premature rupture of membranes (PPROM).Methods: This is a retrospective cohort study conducted from January 2017 to Augusts 2018. Data was taken consecutively from medical records and previous study data at Dr. Cipto Mangunkusumo and Persahabatan Hospital, Jakarta.Results: From total of 72 infants from mothers with PPROM, 22 infants (31%) were EONS-suspected and 50 infants (69%) were not EONS-suspected. There was a significant association between maternal and umbilical cord vitamin D levels with EONS.Conclusion: There was a significant association between maternal and umbilical cord vitamin D levels with EONS.Keywords: early-onset neonatal sepsis, preterm premature rupture of membrane, vitamin D, Abstrak Tujuan: Untuk mengetahui hubungan antara kadar vitamin D maternal dan tali pusat dengan risiko tejadinya Sepsis Neonatal Awitan Dini (SNAD) pada bayi dari ibu dengan Ketuban Pecah Dini (KPD).Metode: Desain penelitian kohort retrospektif secara consecutive sampling. Data diambil dari rekam medis dan data penelitian sebelumnya di Rumah Sakit Umum Pusat Nasional (RSUPN) Dr. Cipto Mangunkusumo dan Rumah Sakit Umum Pusat (RSUP) Persahabatan, Jakarta. Hasil: Dari 72 bayi yang dilahirkan dari ibu dengan KPD, 22 bayi (31%) diantaranya diduga mengalami SNAD, sedangkan 50 bayi lainnya tidak mengalami SNAD. Terdapat hubungan yang bermakna antara kadar vitamin D maternal dan tali pusat dengan kejadian SNAD. Kesimpulan:Terdapathubungan yang bermakna antara kadar vitamin D maternal dan tali pusat dengan kejadian SNAD.Kata kunci: ketuban pecah dini, sepsis neonatal awitan dini, vitamin D

Obstetrics and Gynecology in Indonesia and Its Challenges in the Near Future Noroyono Wibowo
Indonesian Journal of Obstetrics and Gynecology Volume 8 No. 2 April 2020
Publisher : Indonesian Socety of Obstetrics and Gynecology

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