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All Journal PREPOTIF : Jurnal Kesehatan Masyarakat Malang Respiratory Journal
Arfan, Ahmad
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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Chronic Obstructive Pulmonary Disease Exacerbation Complicated with Pneumonia and Lung Cancer: An Evidence-based Case Report of Erdosteine Role in the Management of Complex COPD Ilham, Ahmad Fadhil; Rakasiwi, Muhammad Ilham Dhiya; Felim, Ris Raihan; Arfan, Ahmad; Burhan, Erlina
Malang Respiratory Journal Vol. 6 No. 2 (2024): September 2024
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2024.006.02.05

Abstract

Background: Acute exacerbations of chronic obstructive pulmonary disease (COPD) are strongly associated with poor health status and morbidity. Erdosteine is a mucolytic agent that also has anti-inflammatory, antioxidant and antibacterial effects. This case report aims to evaluate the role of erdosteine in the prevention and treatment of acute exacerbations of complex COPD case. Case: A 73-year-old male arrived at the emergency department with an increased difficulty in breathing that had deteriorated over the previous 5 days, and had a history of heavy smoking for more than 40 years. Following a thorough examination, he was diagnosed with acute exacerbation of COPD (Anthonisen criteria type 2) in clinical group E, pneumonia, along with stage IIIA right lung tumor (T4N1Mx), and received erdosteine inhalation as part of his treatment. Discussion: A comprehensive search of journal databases (PubMed, EMBASE, CENTRAL, EBSCO Medline, Scopus, and ProQuest) was conducted using specific keywords, critical appraisal based on the Oxford Center for Evidence-Based Medicine. Article selection resulted in 1 systematic review article for the prevention of acute exacerbations and 1 systematic review article for the management of acute exacerbations of COPD. In patients with stable COPD, administration of erdosteine in the standard COPD regimen significantly reduced the risk of exacerbations (RR=0.65; p=0.01), while in patients with acute exacerbations of COPD, erdosteine increased treatment success (OR=3.2; p<0.0001). Conclusion: Erdosteine may serve as a therapeutic choice for COPD patients in preventing or managing acute exacerbations.
PEMERIKSAAN MIKROBIOLOGI PADA ASPERGILOSIS PULMONAL Sari, Rifta; Arfan, Ahmad; Karuniawati, Anis; Haryanto, Budi
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 10 No. 1 (2026): APRIL 2026
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v10i1.54309

Abstract

Aspergilosis pulmonal merupakan infeksi jamur oportunistik yang disebabkan oleh Aspergillus spp. dan memiliki spektrum klinis luas, mulai dari bentuk alergi, kronik, hingga invasif yang mengancam jiwa. Peningkatan jumlah pasien imunokompromais, penyakit paru kronis, serta penggunaan kortikosteroid jangka panjang berkontribusi terhadap meningkatnya insidensi aspergilosis paru. Diagnosis penyakit ini masih menjadi tantangan karena gejala klinis dan temuan radiologis sering tidak spesifik serta menyerupai penyakit paru lain, seperti tuberkulosis dan keganasan paru. Artikel ini bertujuan untuk mengkaji secara komprehensif pemeriksaan mikrobiologi pada aspergilosis pulmonal, meliputi pemeriksaan mikroskopis langsung, kultur jamur, identifikasi spesies, uji kepekaan antijamur, pemeriksaan serologi, serta deteksi molekuler. Metode yang digunakan adalah studi kepustakaan dengan pendekatan deskriptif naratif terhadap literatur ilmiah nasional dan internasional sepuluh tahun terakhir. Hasil kajian menunjukkan bahwa pemeriksaan mikrobiologi memegang peranan penting dalam menunjang diagnosis aspergilosis pulmonal, namun harus diinterpretasikan bersama data klinis dan radiologis untuk membedakan kolonisasi, kontaminasi, dan infeksi aktif. Cairan bronchoalveolar lavage (BAL) merupakan spesimen terbaik untuk berbagai metode diagnostik. Kombinasi pemeriksaan kultur, serologi, dan biomarker jamur seperti galaktomanan dapat meningkatkan akurasi diagnosis dan membantu penatalaksanaan yang tepat.
Co-Authors Anis Karuniawati Budi Haryanto Erlina Burhan Felim, Ris Raihan Ilham, Ahmad Fadhil Rakasiwi, Muhammad Ilham Dhiya Sari, Rifta