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All Journal Medicinus : Jurnal Kedokteran Journal of Pharmaceutical and Sciences.
Dharmasaputra, Alan
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Hubungan human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) dengan kejadian penyakit kardiovaskular: konsistenkah bukti yang ada? Fitriani, Indah; Dharmasaputra, Alan; Marshella, Sally; Rosiana, Safira; Pramesuari, Florentina Dewi; Umar, Tungki Pratama
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.546

Abstract

Human Immunodeficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS) pose ongoing global health challenges. This literature review evaluates the relationship between HIV infection and increased cardiovascular diseases, outlining findings from sixteen observational studies. Key findings involve an elevated risk of hypertension, coronary artery disease, sudden cardiac death, and cardiovascular risk factors among HIV patients. Additionally, antiretroviral therapy (ART) side effects are highlighted, including specific impacts of certain drugs. The gender of HIV/AIDS patients also plays a role in cardiovascular risk profiles. The study details the pathophysiological mechanisms, such as immune activation and inflammation, involved in the heightened cardiovascular risk in individuals with HIV/AIDS. This study underscores the importance of a comprehensive understanding of cardiovascular health impacts on the HIV/AIDS population to guide informed therapeutic choices for preventing cardiovascular status deterioration.  
Prognostic Significance of Hypoalbuminemia in Transcatheter Aortic Valve Implantation Patients: A Systematic Review and Meta Analysis of Diagnostic Test Accuracy Huvi, Destino; Adrya, Jessica; Sofyan, Nihal; Fauzi, Daffa Rizqi; Dharmasaputra, Alan; Varsha, Srigita; Wiyono, Putri Dhiya Prameswari
Medicinus Vol. 15 No. 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i2.10973

Abstract

ckground: Calcific aortic stenosis is common in older adults, and TAVR has expanded treatment to patients with high comorbidity and frailty. Serum albumin is an inexpensive marker that reflects inflammation, nutrition, and physiologic reserve, but its prognostic performance in TAVR needs clearer quantification. Methods: We performed a PRISMA/PRISMA-DTA–guided systematic review and diagnostic test accuracy meta-analysis of studies evaluating pre-procedural hypoalbuminemia in adults undergoing TAVR/TAVI. PubMed, Embase, and Scopus were searched from inception to 18 January 2026. Hierarchical models were used to pool sensitivity and specificity for 30-day mortality, and a random-effects model pooled hazard ratios for time-to-event mortality. Risk of bias was assessed using PROBAST. Result: Ten studies met inclusion criteria. Definitions of hypoalbuminemia varied (most commonly <3.3–3.5 g/dL). For predicting 30-day mortality, pooled sensitivity was 47.7% (95% CI 35.5–59.9) and pooled specificity was 76.0% (95% CI 62.9–89.2), indicating better rule-in than rule-out performance. Across studies reporting time-to-event outcomes, hypoalbuminemia was associated with higher mortality (pooled HR 1.15, 95% CI 1.03–1.29). PROBAST ratings were generally low risk for participants, predictors, and outcomes, with some concerns in the analysis domain. Conclusions: Pre-procedural hypoalbuminemia is a practical risk marker in TAVR patients, showing moderate specificity for early mortality and a consistent association with worse survival, supporting its use in peri-procedural risk stratification.
Co-Authors Adrya, Jessica Fauzi, Daffa Rizqi Huvi, Destino Indah Fitriani Marshella, Sally Pramesuari, Florentina Dewi Rosiana, Safira Sofyan, Nihal Umar, Tungki Pratama Varsha, Srigita Wiyono, Putri Dhiya Prameswari