Wiyono, Putri Dhiya Prameswari
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Vitamin K Supplementation for Reducing Cardiovascular Events in End-Stage Chronic Kidney Disease: A Systematic Review Liora, Kevin; Wiyono, Putri Dhiya Prameswari; Putra, Ananda; Alexander, Devin; Ramadhan, Afif; Oktavia, Anissya Rima; Larissa, Olivia; Nugroho, Fajar Prianto; Tjahyanto, Teddy
International Journal of Public Health Excellence (IJPHE) Vol. 4 No. 1 (2024): June-December
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v4i1.919

Abstract

This study was conducted to analyze the hSIL of Vitamin K Supplementation in Reducing Cardiovascular Events in End-Stage Chronic Kidney Disease: A Systematic Review. Cardiovascular disease (CVD) is the leading source of morbidity and mortality worldwide, and chronic kidney disease (CKD) is a major contributor to this matter. Kidney disease is estimated to affect over 850 million people worldwide. The present systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. We searched studies from electronic databases (PubMed Central, ScienceDirect, PLoS One, Google Scholar, Nature). Studies were considered eligible if they met the following criteria : (1) the study is a randomized controlled trial (RCT), (2) the study was published in the last 5 years (2018– 2022), (3) the study participants were adult patients with kidney disease from stage III to end-stage who were given vitamin K supplementation, (4) the study reported coronary artery calcium scores pre- and post- vitamin K supplementation, (5) the study was published in English. Risk of bias of each study was evaluated using Cochrane Risk of Bias (RoB) 2 tool. Data were descriptively examined and narratively reported. In conclusion, our results do not suggest that vitamin K supplementation may affect vascular calcification as measured by the CAC score. Up till now there is no treatment to reverse vascular calcification in ESKD patients. The current clinical practice should focus on prevention and retardation of its progression.
Vitamin K Supplementation for Reducing Cardiovascular Events in End-Stage Chronic Kidney Disease: A Systematic Review Liora, Kevin; Wiyono, Putri Dhiya Prameswari; Putra, Ananda; Alexander, Devin; Ramadhan, Afif; Oktavia, Anissya Rima; Larissa, Olivia; Nugroho, Fajar Prianto; Tjahyanto, Teddy
International Journal of Public Health Excellence (IJPHE) Vol. 4 No. 1 (2024): June-December
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v4i1.919

Abstract

This study was conducted to analyze the hSIL of Vitamin K Supplementation in Reducing Cardiovascular Events in End-Stage Chronic Kidney Disease: A Systematic Review. Cardiovascular disease (CVD) is the leading source of morbidity and mortality worldwide, and chronic kidney disease (CKD) is a major contributor to this matter. Kidney disease is estimated to affect over 850 million people worldwide. The present systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. We searched studies from electronic databases (PubMed Central, ScienceDirect, PLoS One, Google Scholar, Nature). Studies were considered eligible if they met the following criteria : (1) the study is a randomized controlled trial (RCT), (2) the study was published in the last 5 years (2018– 2022), (3) the study participants were adult patients with kidney disease from stage III to end-stage who were given vitamin K supplementation, (4) the study reported coronary artery calcium scores pre- and post- vitamin K supplementation, (5) the study was published in English. Risk of bias of each study was evaluated using Cochrane Risk of Bias (RoB) 2 tool. Data were descriptively examined and narratively reported. In conclusion, our results do not suggest that vitamin K supplementation may affect vascular calcification as measured by the CAC score. Up till now there is no treatment to reverse vascular calcification in ESKD patients. The current clinical practice should focus on prevention and retardation of its progression.
Prognostic Significance of Hypoalbuminemia in Transcatheter Aortic Valve Implantation Patients: A Systematic Review and Meta Analysis of Diagnostic Test Accuracy Huvi, Destino; Adrya, Jessica; Sofyan, Nihal; Fauzi, Daffa Rizqi; Dharmasaputra, Alan; Varsha, Srigita; Wiyono, Putri Dhiya Prameswari
Medicinus Vol. 15 No. 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i2.10973

Abstract

ckground: Calcific aortic stenosis is common in older adults, and TAVR has expanded treatment to patients with high comorbidity and frailty. Serum albumin is an inexpensive marker that reflects inflammation, nutrition, and physiologic reserve, but its prognostic performance in TAVR needs clearer quantification. Methods: We performed a PRISMA/PRISMA-DTA–guided systematic review and diagnostic test accuracy meta-analysis of studies evaluating pre-procedural hypoalbuminemia in adults undergoing TAVR/TAVI. PubMed, Embase, and Scopus were searched from inception to 18 January 2026. Hierarchical models were used to pool sensitivity and specificity for 30-day mortality, and a random-effects model pooled hazard ratios for time-to-event mortality. Risk of bias was assessed using PROBAST. Result: Ten studies met inclusion criteria. Definitions of hypoalbuminemia varied (most commonly <3.3–3.5 g/dL). For predicting 30-day mortality, pooled sensitivity was 47.7% (95% CI 35.5–59.9) and pooled specificity was 76.0% (95% CI 62.9–89.2), indicating better rule-in than rule-out performance. Across studies reporting time-to-event outcomes, hypoalbuminemia was associated with higher mortality (pooled HR 1.15, 95% CI 1.03–1.29). PROBAST ratings were generally low risk for participants, predictors, and outcomes, with some concerns in the analysis domain. Conclusions: Pre-procedural hypoalbuminemia is a practical risk marker in TAVR patients, showing moderate specificity for early mortality and a consistent association with worse survival, supporting its use in peri-procedural risk stratification.