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All Journal Medicinus : Jurnal Kedokteran
Putri, Syafira Ayudiah Syah
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Medicine & Pharmacology Public Health

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Investigating the Prognostic Value of Serum Albumin Levels in Patients Undergoing Hemodialysis: A Systematic Review and Meta-analysis Adrya, Jessica; Sasongko, Calvin; Andrean, Melvin; Kartadinata, Muhammad Faishal; Theis, Aveline Maisie; Putri, Syafira Ayudiah Syah; Mukti, A. Muh. Yasser; Moelyadi, Felly; Varsha, Srigita; Dhika, Veriantara Satya
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10770

Abstract

Background: Hypoalbuminemia, characterized by low serum albumin levels, is frequently observed in patients undergoing hemodialysis and has been identified as a potential predictor of increased mortality risk. This systematic review aims to evaluate the relationship between hypoalbuminemia and mortality in hemodialysis patients, assessing the prognostic value of serum albumin levels as an indicator for patient outcomes. Methods: A comprehensive search was conducted in databases including PubMed, Europe PMC, and Scopus to identify relevant studies. Studies were included if they investigated the association between serum albumin levels and mortality outcomes in adult patients undergoing hemodialysis. Data extraction was performed independently by two reviewers, focusing on study characteristics, patient demographics, albumin levels, and mortality outcomes. Quality assessment of studies was conducted using the Newcastle-Ottawa Scale (NOS). Result: A total of eight studies, encompassing 45,178 hemodialysis patients with a mean age in the 50s, met the inclusion criteria. The studies had a combined male cohort of 22,501 individuals. The definition of hypoalbuminemia varied across studies, with cutoff values ranging from 3.0 to 3.9 g/dL. Follow-up durations spanned from as early as 3 months to a maximum of 6.1 years. The meta-analysis revealed a pooled hazard ratio (HR) of 1.08 (95% CI: 0.94–1.25), suggesting a non-significant association between hypoalbuminemia and increased mortality risk (P = 0.28). However, substantial heterogeneity was present (I² = 79%), indicating variability across studies. Conclusions: Hypoalbuminemia showed a non-significant association with mortality in hemodialysis patients, though variability across studies suggests further research is needed for clarity.
The Role of Glycemic Load, Dairy, and Fatty Acids in Acne Disorders: A Systematic Review and Meta-Analysis Limanda, Claudia Felicia; Mathlubaa, Asya; Istikanto, Ferdian Harum; Sisca; Nabila, Yusra; Amalia, Shania Rizky; Putri, Syafira Ayudiah Syah; Ilmiani, Tasya Khalis; Hartanto, Ericko; Nurfadhila, Melinda
Medicinus Vol. 15 No. 1 (2025): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v15i1.10771

Abstract

Background: Modern dietary patterns characterized by high glycemic load, dairy consumption, and imbalanced fatty acid profiles may aggravate acne through insulin, IGF-1, and inflammatory pathways. However, findings across studies remain inconsistent. This systematic review and meta-analysis aimed to evaluate the associations between dietary glycemic load, glycemic index, dairy intake, and fatty acid composition with acne disorders. Methods: Following PRISMA 2020 guidelines, PubMed, EMBASE, and Scopus were systematically searched to September 2025. Eligible human studies assessing quantitative relationships between these dietary exposures and acne risk or severity were included. Random-effects meta-analyses were performed using the Hartung–Knapp–Sidik–Jonkman method, with effect sizes expressed as standardized mean differences (SMD) or risk ratios (RR). Result: Five studies encompassing 716 participants (426 acne, 290 controls) met the inclusion criteria. Pooled estimates indicated no significant associations for glycemic load (SMD = 0.09; 95% CI −0.30 to 0.49), glycemic index (SMD = 0.09; 95% CI −0.30 to 0.49), fatty acids/adiponectin (SMD = 0.11; 95% CI −0.74 to 0.97), or dairy consumption (RR = 1.04; 95% CI 0.25 to 4.25). Heterogeneity ranged from moderate to high (I² = 65–90%). Certainty of evidence was moderate for glycemic and dairy outcomes, and low for fatty acids. Conclusions: No significant pooled associations were observed between dietary glycemic load, dairy intake, or fatty acids and acne risk. Despite biological plausibility linking diet to acne via hormonal and inflammatory mechanisms, evidence remains inconsistent. Larger, controlled trials are warranted to define the role of nutritional interventions in acne management.
Co-Authors Adrya, Jessica Amalia, Shania Rizky Andrean, Melvin Dhika, Veriantara Satya Hartanto, Ericko Ilmiani, Tasya Khalis Istikanto, Ferdian Harum Kartadinata, Muhammad Faishal Limanda, Claudia Felicia Mathlubaa, Asya Moelyadi, Felly Mukti, A. Muh. Yasser Nabila, Yusra Nurfadhila, Melinda Sasongko, Calvin sisca Theis, Aveline Maisie Varsha, Srigita