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All Journal MDJ (Makassar Dental Journal) Journal of Dental and Biosciences
Multri, Violentri
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Dentistry Health Professions Medicine & Pharmacology Public Health

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UJI Aktifitas Antifungi Ekstrak Etanol Daun Pepaya (Carica papaya Linn) terhadap Candida albicans Multri, Violentri; Peramiarti, IDSAP; Rochmawati, Mutia; Ichsyani, Meylida; Satrio, Rinawati
Journal of Dental and Biosciences Vol 1 No 01 (2024): Journal of Dental and Biosciences
Publisher : Jurusan Kedokteran Gigi Fakultas Kedoketaran Universitas Jenderal Soedirman

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Abstract

Candida albicans merupakan patogen oportunistik pada membran mukosa rongga mulut. C. albicans dalam jumlah berlebihan pada mukosa rongga mulut dapat menimbulkan infeksi kandidiasis oral. Pengobatan kandidiasis menggunakan obat sintetik memiliki efek samping pada pasien dengan kondisi khusus seperti mual, muntah dan diare, sehingga diperlukan alternatif pengobatan yang lebih aman, salah satunya dengan memanfaatkan daun pepaya. Daun pepaya memiliki kandungan senyawa metabolit sekunder yang berkhasiat sebagai antifungi. Tujuan penelitian ini untuk mengetahui aktivitas antifungi dan KHM ekstrak etanol daun pepaya California pada konsentrasi 2,5%, 5%, 7,5%, 10 %, 12,5%, 15%. Jenis penelitian ini adalah eksperimental laboratoris secara in vitro dengan rancangan penelitian berupa post-test only control group design. Penelitian ini menggunakan metode dilusi dengan pengukuran menggunakan spektrofotometer. Uji fitokimia ekstrak etanol daun pepaya California mengandung senyawa aktif berupa flavonoid, saponin, tannin, dan alkaloid. Ekstrak etanol daun pepaya dapat menghambat pertumbuhan C. albicans pada konsentrasi 7,5%, 10%, 12,5% dan 15% dengan nilai absorbansi -0,0250, -0.0125, -0.0368 dan -0.0397. Ekstrak etanol daun pepaya California mempunyai aktivitas antifungi terhadap jamur C. albicans dengan nilai KHM sebesar 7,5%.
Oral manifestation in patient with systemic lupus erythematosus: Manifestasi oral pada pasien sistemik lupus eritematosus Djati, Fanni Kusuma; Hutajulu, Reynaldo Binsar; Anissa, Ayu Intan Nur; Kuncoro, Bestaria Sani; Multri, Violentri
Makassar Dental Journal Vol. 15 No. 1 (2026): Volume 15 Issue 1 April 2026
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35856/mdj.v15i1.934

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect various organs, including the oral cavity. Oral manifestations such as ulcers, candidiasis, cheilitis, and lichen planus-like lesions often reflect the activity of certain systemic diseases. A 26-year-old woman with a history of SLE, lu-pus nephritis, severe anaemia, and suspected neuropsychiatric lupus presented with complaints of fatigue, dizziness, leg swelling, pain when swallowing, re-current seizures, and oral discomfort. Intraoral examination revealed lichen planus-like lesions on the anterior buccal mucosa, ulcers on the posterior buccal mucosa, traumatic ulcers on the lateral tongue due to seizures, candidiasis on the dorsum of the tongue, and exfoliative cheilitis on the lips. Laboratory results showed severe anaemia, leukocytosis with lymphopenia, hypocalcaemia, and renal dysfunction. Treatment included oral hygiene education, use of a soft-bristled toothbrush, tongue cleaning with sterile gauze, nutritional counselling, and coordination with the Department of Internal Medicine for systemic monito-ring. Invasive procedures were avoided due to the risk of bleeding and infection. It was concluded that oral manifestations in SLE vary and can be indicators of systemic conditions. Dentists play an important role in early detection, supportive therapy, and multidisciplinary collaboration to improve patients' quality of life.
Co-Authors Anissa, Ayu Intan Nur Fanni Kusuma Djati Hutajulu, Reynaldo Binsar Kuncoro, Bestaria Sani Meylida Ichsyani Mutia Rochmawati Peramiarti, IDSAP Satrio, Rinawati