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All Journal MNJ (Malang Neurology Journal) BAKIRA: Jurnal Pengabdian Kepada Masyarakat
Akas, Ignasius Dede Setyo
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Agriculture, Biological Sciences & Forestry Neuroscience Other

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PELATIHAN BANTUAN HIDUP DASAR DAN RESUSITASI JANTUNG PARU, SERTA BAKTI SOSIAL KESEHATAN BERSAMA PAPDI MALUKU DI DESA WAHAI, SERAM UTARA Kusadhiani, Indrawanti; Rahawarin, Halidah; Irwan, Irwan; Hataul, Is Asmaul Haq; Qisthi, Dian; Pattinasarany, Joane Christy Agavera; Ridy, Rizal Kurniawan; Marahena, Dhea Ananda; Akas, Ignasius Dede Setyo
BAKIRA: Jurnal Pengabdian Kepada Masyarakat Vol 6 No 2 (2025): BAKIRA : Jurnal Pengabdian Kepada Masyarakat
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/bakira.2025.6.2.175-185

Abstract

This community engagement program was designed to strengthen the knowledge and skills of residents in Wahai Village, North Seram, in responding to medical emergencies such as sudden cardiac arrest, choking, and loss of consciousness. The primary focus was on Basic Life Support (BLS) and Cardiopulmonary Resuscitation (CPR), as timely intervention is widely recognized to improve survival outcomes before professional medical assistance becomes available. The program was implemented through structured health education, demonstrations, guided hands-on practice, and case-based simulations to ensure comprehensibility and applicability for the general community. In addition to the training, a social service initiative was conducted, providing free medical care including general health examinations, specialist consultations, and distribution of essential medications. The activity was delivered by a multidisciplinary health team comprising general practitioners, specialists, and medical students, in collaboration with the Indonesian Society of Internal Medicine (PAPDI) Maluku. The outcomes demonstrated strong community participation, enhanced first aid competence, and improved communication between healthcare providers and the community. This program is expected to foster greater community preparedness in emergencies and reinforce their role in preventive and promotive health efforts.
DIAGNOSTIC AND PROGNOSTIC VALUE OF CIRCULATING miRNAs AS NON-INVASIVE BIOMARKERS IN GLIOBLASTOMA MULTIFORME: A SYSTEMATIC REVIEW AND META-ANALYSIS Akas, Ignasius Dede Setyo; Seleky, Cherlyn; Febriani, Reka; Titaley, Christiana Rialine; Huwae, Laura Bianca Sylvia
MNJ (Malang Neurology Journal) Vol. 12 No. 2 (2026): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2026.012.02.14

Abstract

Background: Glioblastoma multiforme (GBM) is most prevalent and aggressive form of glioma, characterized by a high mortality rate and significant effect on patient's quality of life. The challenges in diagnosing, treating, and predicting prognosis of GBM highlight the need for more reliable biomarkers.  Promising characteristics as noninvasive biomarkers have been identified in microRNA (miRNAs) to their critical role in glioblastoma pathogenesis. Objective: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 standards guided implementation of this systematic review and meta-analysis examining diagnostic and prognostic relevance of microRNAs in GBM as non-invasive biomarkers. A total of 9 studies on diagnostic accuracy and 6 studies on prognostic analysis were included. Articles were identified through comprehensive searches in PubMed, EBSCO, and Wiley databases. Availability of diagnostic indicators such as area under curve (AUC), sensitivity, and specificity for miRNA-based diagnosis, along with survival measurements reported as hazard ratios (HRs) or mean survival outcomes, constituted main inclusion requirements for original studies. Results: In meta-analysis, circulating miRNAs achieved notable diagnostic performance, supported by sensitivity and specificity values of 0.86 and 0.92, respectively, along with AUC of 0.93. Subgroup analysis was then performed to assess consistency of accuracy based on ethnicity, sample source, dysregulation category, and miRNA profile mapping. Certain miRNAs also showed promise as prognosis markers as they are involved in glioblastoma progressivity. Conclusion: Circulating miRNAs demonstrate high accuracy as non-invasive biomarkers for GBM diagnosis and prognosis. Their role in glioblastoma progression suggests potential applications in more precise therapeutic approaches.
Co-Authors Dian Qisthi, Dian Febriani, Reka Hataul, Is Asmaul Haq Huwae, Laura Bianca Sylvia Irwan Irwan Kusadhiani, Indrawanti Marahena, Dhea Ananda Pattinasarany, Joane Christy Agavera Rahawarin, Halidah Ridy, Rizal Kurniawan Seleky, Cherlyn Titaley, Christiana Rialine