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All Journal Journal of Tecnologia Quantica Journal of Biomedical and Techno Nanomaterials
Al-Khouri, Bassam
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Biochemistry, Genetics & Molecular Biology Physics

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Quantum Field Theory in Curved Spacetime Judijanto, Loso; Al-Khouri, Bassam; Khatib, Rania
Journal of Tecnologia Quantica Vol. 2 No. 1 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/quantica.v2i1.1964

Abstract

Quantum field theory and general relativity are the two main pillars of modern physics. However, the two still cannot be combined consistently to explain cosmic phenomena at the microscopic level, especially in the context of curved spacetime. This research aims to explore the interaction between quantum fields and the curvature of spacetime, with a focus on the implications of quantum gravity. This research aims to understand how quantum fields interact with curved spacetime, as well as to develop a more comprehensive model of physics that combines these two concepts. The methods used include the development of mathematical models and numerical simulations to integrate quantum field theory with general relativity. The analysis was carried out by examining the impact of space-time curvature on quantum field fluctuations around massive objects such as black holes. The findings show that the curvature of spacetime has a major influence on the behavior of the quantum field, leading to modifications in energy distribution and field fluctuations. This discovery opens up new possibilities in the development of a more complete theory of quantum gravity. This study provides new insights into understanding the relationship between quantum fields and curved spacetime, as well as opening the way for further research in the field of quantum gravity and extreme cosmic phenomena.  
Immunomodulation Mechanism by Gold Nanoparticles for Cancer Therapy Hamdan, Salma; Al-Khouri, Bassam; Hariri, Rami
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 2 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i2.2024

Abstract

Conventional cancer treatment is often limited by side effects and resistance to therapy. Therefore, immunotherapy research, especially those involving gold nanoparticles (AuNPs), is growing as a more effective and specific therapeutic alternative. AuNPs have the potential to modulate the body's immune response, improving the recognition and destruction of cancer cells by the immune system. This study aims to investigate the immunomodulation mechanisms triggered by AuNPs and evaluate their potential as cancer therapeutic agents by increasing immune cell activity and cytokine production. This study used cell culture to test the effects of AuNPs on the activity of T cells, macrophages, and dendritic cells as well as the production of cytokines IL-2, TNF-?, and IL-12. Gold nanoparticles were applied at various concentrations (5, 10, 20 ?g/ml) and treatment times (24, 48, 72 hours), then measured using flow cytometry and ELISA. The results showed that AuNPs increased the activity of immune cells, especially dendritic cells, macrophages, and T cells, as well as the production of cytokines IL-2, TNF-?, and IL-12. This increase in immune cell and cytokine activity is directly related to the concentration and duration of AuNPs treatment. This study shows that AuNPs can modulate the body's immune system and increase the immune response to cancer. Gold nanoparticles have the potential as immunomodulatory agents in more effective and safe cancer therapy. More research is needed to confirm these findings in animal and human models.
Co-Authors Hamdan, Salma Hariri, Rami Judijanto, Loso Khatib, Rania