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All Journal Multidiciplinary Output Research for Actual and International Issue (Morfai Journal) Cermin Dunia Kedokteran Jurnal Kedokteran Methodist
Endy Juli Anto
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A Case of Complete Recovery From Recurrent Bell’s Palsy After Peripheral Blood Stem Cell Transplantation : A Case of Complete Recovery From Recurrent Bell’s Palsy After Peripheral Blood Stem Cell Transplantation lim, hadyanto; Hutasoit, Eka Samuel P; Endy Juli Anto
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

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Abstract

Background Recurrent Bell’s palsy is a rare condition that can affect the ipsilateral or contralateral to the affected side of the primary attack. There is still no consensus on treatment guidelines for recurrent Bell’s palsy. Therefore, we report a case of idiopathic recurrent contralateral facial palsy treated with autologous peripheral blood stem cell (PBSC) transplantation. Case Presentation A 72-year-old man presented with the sudden onset of right facial weakness, which was contralateral to the affected side of the first episode of facial palsy. The weakness had progressed with difficulty in closing the right eye, drooling the water from the right side of the mouth, and chewing impairment which was consistent with House Brackmann grade IV or moderately severe facial nerve grading system. He had exposure to cold stimulation, and a history of hypertension. He was given G-CSF 10 ug/kg/day for 5 days to mobilize stem cells, followed by apheresis on the 5th day. He did not receive acupuncture treatment. He had a complete recovery in 3 weeks with House Brackmann grade I or normal function of facial nerve. Conclusion Peripheral blood stem cell transplantation had a beneficial effect on the complete recovery of this recurrent Bell’s palsy and provides a treatment strategy in patients with unilateral facial palsy.
A Case of Complete Recovery From Recurrent Bell’s Palsy After Peripheral Blood Stem Cell Transplantation : A Case of Complete Recovery From Recurrent Bell’s Palsy After Peripheral Blood Stem Cell Transplantation lim, hadyanto; Hutasoit, Eka Samuel P; Endy Juli Anto
Jurnal Kedokteran Methodist Vol. 17 No. 1 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i1.2812

Abstract

Background Recurrent Bell’s palsy is a rare condition that can affect the ipsilateral or contralateral to the affected side of the primary attack. There is still no consensus on treatment guidelines for recurrent Bell’s palsy. Therefore, we report a case of idiopathic recurrent contralateral facial palsy treated with autologous peripheral blood stem cell (PBSC) transplantation. Case Presentation A 72-year-old man presented with the sudden onset of right facial weakness, which was contralateral to the affected side of the first episode of facial palsy. The weakness had progressed with difficulty in closing the right eye, drooling the water from the right side of the mouth, and chewing impairment which was consistent with House Brackmann grade IV or moderately severe facial nerve grading system. He had exposure to cold stimulation, and a history of hypertension. He was given G-CSF 10 ug/kg/day for 5 days to mobilize stem cells, followed by apheresis on the 5th day. He did not receive acupuncture treatment. He had a complete recovery in 3 weeks with House Brackmann grade I or normal function of facial nerve. Conclusion Peripheral blood stem cell transplantation had a beneficial effect on the complete recovery of this recurrent Bell’s palsy and provides a treatment strategy in patients with unilateral facial palsy.
THE EFFECT OF CELERY LEAF EXTRACT (APIUM GRAVEOLENS L.) ON TNF-Α, IL-6 AND MDA LEVELS IN HYPERPIGMENTED WISTAR RATS (RATTUS NOVERGIUS SP.) Dina R. Purba; Jekson M. Siahaan; Endy Juli Anto; Syafruddin Ilyas
Multidiciplinary Output Research For Actual and International Issue (MORFAI) Vol. 6 No. 3 (2026): Multidiciplinary Output Research For Actual and International Issue
Publisher : RADJA PUBLIKA

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The objective of this study was to evaluate the anti-inflammatory effects of Celery leaf extract (Apium graveolens L.) on hyperpigmented Wistar rats (Rattus norvegicus sp.) induced by Azidothymidine (AZT). Celery leaves are known to contain bioactive compounds which may serve as potent anti-inflammatory and antioxidant agents. About 30 male Wistar rats were divided into five groups, including a positive control, a negative control, and groups treated with various doses (1%, 3% and 5%) of celery leaf extract. The study examined inflammation indicators such as MDA, TNF-α, and IL-6. Celery leaf extract significantly (P<0.001) reduced MDA, TNF-α, and IL-6 levels in rats, demonstrating its capacity to attenuate inflammation and oxidative stress produced by AZT. With the increase in celery leaf extract concentration from 1% to 5%, MDA, IL-6 and TNF-α levels decreased from 42.083 ± 3.49 to 28.277 ± 10.27 nmol/ml, 14.588 ± 3.38 to 4.539 ± 1.40 nmol/ml and 667.614 ± 143.41 to 326.920 ± 62.72 nmol/ml respectively. Histopathological examinations demonstrated improvements in skin tissues damaged by inflammation. The results indicate that an ethanol extract of celery leaves has the potential to be an efficient anti-inflammatory drug, notably in lowering AZT-induced inflammation and hyperpigmentation. Further research is required to explore its clinical applicability in controlling inflammatory diseases in human.
ANTI-MELANOGENIC PROPERTIES OF CELERY LEAF EXTRACT IN HYPERPIGMENTATION INDUCED BY AZIDOTHYMIDINE Dearni Damanik; Jekson M. Siahaan; Endy Juli Anto; Syafruddin Ilyas; Hadyanto L
Multidiciplinary Output Research For Actual and International Issue (MORFAI) Vol. 6 No. 3 (2026): Multidiciplinary Output Research For Actual and International Issue
Publisher : RADJA PUBLIKA

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Abstract

The purpose of this study is to examine the impact of ethanolic extract form Celery leaves (Apium graveolens L.) on hyperpigmented Wistar rats (Rattus norvegicus sp.) induced by Azidothymidine (AZT). Celery leaves are known to contain bioactive compounds which may serve as potent anti-inflammatory and antioxidant agents. About 30 male Wistar rats were divided into five groups, including a positive control, a negative control, and groups treated with various doses (1%, 3% and 5%) of celery leaf extract. The study examined inflammation indicators such as MDA, TNF-α, and IL-6. Celery leaf extract significantly (P<0.001) reduced MDA, TNF-α, and IL-6 levels in rats, demonstrating its capacity to attenuate inflammation and oxidative stress produced by AZT. With the increase in celery leaf extract concentration from 1% to 5%, MDA, IL-6 and TNF-α levels decreased from 42.083 ± 3.49 to 28.277 ± 10.27 nmol/ml, 14.588 ± 3.38 to 4.539 ± 1.40 nmol/ml and 667.614 ± 143.41 to 326.920 ± 62.72 nmol/ml respectively. Histopathological examinations demonstrated improvements in skin tissues damaged by inflammation. The results indicate that an ethanol extract of celery leaves has the potential to be an efficient anti-inflammatory drug, notably in lowering AZT-induced inflammation and hyperpigmentation. Further research is required to explore its clinical applicability in controlling inflammatory diseases in human.
The Impact of a High-Fat Diet on Blood Glucose Levels Atta Celine Nouli Saruksuk; Jekson Martiar Siahaan; Irene Ruminta Tua Damanik; Endy Juli Anto; Jadeny Sinarta
Jurnal Kedokteran Methodist Vol. 17 No. 2 (2024): Jurnal Kedokteran Methodist
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/jkm.v17i2.5374

Abstract

Background: Diabetes mellitus (DM) sufferers in the world and even inIndonesia are expected to continue to increase, especially type 2 DM(DMT2). DMT2 often occurs in people who are obese, the cause of obesityis often consuming foods that contain a lot of fat. Hyperlipidemia plays arole in the pathogenesis of pancreatic β-cell dysfunction.Research method: This study is an experimental laboratory study with apretest-posttest only controlled group design, using male white rats(Rattus norvegicus) with a sample size of 30 divided into 6 groups, namelythe normal group, the negative control group, the positive control group,the group given a high fatty diet (HFD). The independent variable is HFD,while the dependent variable is blood sugar levels. Data were analyzedusing the Anova test.Results: Giving HFD of 4 ml/day for 4 weeks has not been able to increaseKGD to hyperglycemic, this is thought to be because the HFD was notgiven for long enough so that insulin resistance had not occurred in thetest animals.Conclusion: Based on the results of the study, it was concluded that givingHFD for 4 weeks still could not increase KGD in male white mice tobecome hyperglycemic
Peran Lutein dan Zeaxanthin dalam Formulasi AREDS 2: Mekanisme Protektif dan Implementasi Klinis pada Age-Related Macular Degeneration: Tinjauan Pustaka Endy Juli Anto; Rusli, Kenvin
Cermin Dunia Kedokteran Vol 53 No 04 (2026): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i04.2134

Abstract

Lutein and zeaxanthin are carotenoids that serve as key components in the Age-Related Eye Disease Study 2 (AREDS 2) formulation, replacing beta-carotene from the original formulation due to safety concerns. These carotenoids exhibit dual protective mechanisms as blue light filters and antioxidants within the macula. This literature review aims to analyze the specific roles of lutein and zeaxanthin in AREDS 2, their molecular protective mechanisms, and their optimal clinical implementation in age-related macular degeneration (AMD). Literature searches were conducted through PubMed, Cochrane Library, and Google Scholar using the keywords "lutein", "zeaxanthin", "AREDS 2","macular pigment", and "photoprotection". Lutein and zeaxanthin selectively accumulate in the macula, forming macular pigment optical density (MPOD), which functions as blue light filter (400–500 nm) and free radical scavenger. Supplementation with lutein 10 mg and zeaxanthin 2 mg in AREDS 2 has been proven to increase MPOD and reduce the risk of age-related macular degeneration (AMD) progression by 10%–26%. Clinical implementation requires baseline MPOD evaluation, individualized response monitoring, and dose optimization based on nutritional status and patient-specific risk factors.
Co-Authors Atta Celine Nouli Saruksuk Dearni Damanik Dina R. Purba Hadyanto L Hadyanto Lim Hutasoit, Eka Samuel P Irene Ruminta Tua Damanik Jadeny Sinarta Jekson M. Siahaan Rusli, Kenvin Siahaan, Jekson Martiar Syafruddin Ilyas