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All Journal Denta: Jurnal Kedokteran Gigi
Yoifah Rizka
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Dentistry

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Chitosan Antibacterial Of Portunus Pelagicus Against Biofilm Porphyromonas Gingivalis Laurencia Isabella Loekito; Yoifah Rizka; Fani Pangabdian
Denta Journal Kedokteran Gigi Vol 12 No 2 (2018): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Background: Porphyromonas gingivalis bacteria are found in dental plaques and have the ability to form biofilms. Biofilms are collections of bacterial cells, which are tightly attached to a surface covered by an extracellular polymer matrix released by the bacteria. Periodontitis therapy generally uses tetracycline antibiotics which if used long-term can cause resistance. Chitosan Rajungan crab extract (Portunus pelagicus) has antimicrobial potential which can be used as an alternative therapy. Objective: To determine the antibacterial power of Rajungan crab chitosan extract (Portunus pelagicus) in various concentrations of Porphyromonas gingivalis bacterial biofilms. Method: This research was true experimental laboratorist. This study used Rajungan crab chitosan extract (Portunus pelagicus) to Porphyromonas gingivalis biofilm tested by the test method biofilm. Divided into 5 groups, where each group consisted of 4 samples. The control group consisted of: K- (negative control group), K + (positive control group / tetracycline group), and 3 treatment groups, namely P1 (0.25% Rajungan crab chitosan), P2 (0.5% Rajungan crab chitosan) , P3 (1% Rajungan crab chitosan). Antibacterial power was determined by the value of Optical density in the ELISA Reader. Data analysis using One Way ANOVA followed by LSD test. Result: There were significant differences (p <0.05) seen from the percentage of biofilm inhibition in the negative control group for all groups, the positive control group for the crab crab chitosan extract concentrations of 0.25% and 0.5%. Conclusion: The chitosan crab chitosan extract (Portunus pelagicus) with 1% concentration has the greatest antibacterial effect on the Porphyromonas gingivalis biofilm.
Effect of Hyperbaric Oxygen Therapy Combined with Golden Sea Cucumber (Stichopus hermanii Powder to the Level Of Blood Glucose Diabetic Wistar Rat Induced Porphyromonas gingivalis Rafika Rusydia Darojati; Yoifah Rizka; Syamsulina Revianti
Denta Journal Kedokteran Gigi Vol 11 No 2 (2017): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Background: Diabetes mellitus (DM) is a metabolic disorders characterized by hyperglycemia caused by oxidative stress. Porphyromonas gingivalis (P.g) is a periodontopathogen caused periodontitis exacerbate blood glucose levels (BGL). Hyperbaric oxygen therapy (HBOT) combined with stichopus hermanii (SH) has a role as an antioxidant and antibacterial agent. Purpopse: To analysis effect of HBOT, SH powder and combination of both to the level of blood glucose diabetic Wistar rat induced P.g. Materials and Methods: This study was pre-test-post-test control group design, using 20 male Wistar rat were divided into 5 groups, Group1 (STZ), Group2 (STZ+P.g), Group3 (STZ+P.g+HBOT), Group4 (STZ+P.g+SH powder), Group5 (STZ+P.g+HBO+SH). STZ induction intravenous for 4 days in a row. P.g. induction was exposure 3 times for 4 days. After therapy (7 days), sample blood tail vein of rat were taken for measure BGL by glucometer. Result: Level of blood glucose K1(280.25±88.786)mg/dl, K2(372.25±135.662)mg/dl, K3(249.50±96.652)mg/dl, K4(172.00±82.077)mg/dl, K5(104.75±38.257)mg/dl. Conclusion: Induction of STZ increased the BGL but induction of P.g. cannot exacerbate BGL . HBOT combined with SH powder can reduce BGL in STZ and P.g. induction group.
Bioviabilitas Ekstrak Gracilaria sp terhadap Stem Sel Mesenkimal sebagai Terapi Adjuvant Periodontitis Talsha Irzaputri A; Yoifah Rizka; Sarianoferni
Denta Journal Kedokteran Gigi Vol 10 No 1 (2016): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Background: Gracilaria Seaweed extracts are known to have an antibacterial content thatcan inhibit the growth of Porphyromonas gingivalis bacteria. P.Gingivalis are dominant inchronic periodontitis as a cause of periodontal tissue damage that can be inhibited by usingmaterials that contain antibacterial effect. Terms of materials to be applied in the oral cavitymust be biocompatible, through toxicity tests, one with bioviability test. In this studybioviability test performed on media mesenchymal stem cells. Purpose: To determinebioviability Gracilaria seaweed extract against mesenchymal stem cells as adjuvant therapyof periodontitis. Materials and Methods: study design was post test only control groupdesign. Mesenchymal stem cells in 96 wells were divided into a control group of cells (n=6),media controls (n=6), and treatment (n=6). The treatment group was given Gracilariaseaweed extract with a concentration of 2.5%, 5%, 10%, 20% and 40%. Stem cells wereincubated 24 hours before and after treatment. Once given MTT, optical density read with anELISA reader then calculated the percentage of living cells. Toxic material when living cells<50% and not toxic when living cells >50%. Living cell data were analyzed by statistical testKruskal Wallis and Man Whitney. Result: Viability cell at 2.5% concentration is 68.59%, 5%concentration = 29.67%, 10% concentration = 4.43%, 20% concentration = 2.5% and 40%concentration = 0.96 %. Conclusion: Extract of seaweed Gracilaria proven not toxic at 2.5%concentration and proved toxic at 5%, 10%, 20% and 40% concentration
Efektifitas Kombinasi Terapi Oksigen Hiperbarik dan Gel Teripang Emas (Stichopus hermanii) terhadap Peningkatan Jumlah Osteoblas pada Tikus Diabetes Melitus yang Diinduksi Bakteri Porphyromonas gingivalis Safina Majdina; Dian Mulawarmanti; Yoifah Rizka
Denta Journal Kedokteran Gigi Vol 10 No 1 (2016): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Background: The prevalence of diabetes mellitus (DM) is quite high in the world and Indonesia. Diabetes mellitus with poor glycemic control periodontitis as a complication the largest in the oral cavity which causes damage to the alveolar bone. Osteoblasts synthesize osteoid collagen to form bone as raw material. Oxygenation high pressure is able to increase the amount of alveolar bone osteoblasts in patients with DM. Sea cucumber contains growth factors that play a role in the differentiation of osteoblasts to bone formation. Purpose: To determine the effectiveness of combination hyperbaric oxygen therapy 2.4 ATA and sea cucumber gel 3% in the increasing of osteoblasts in rats with DM induced P.gingivalis. Materials and Methods: The study design was factorial design group. Rats are inducted with STZ single dose 65 mg/kg BB to make DM and are inducted with P.gingivalis 1x109 sel/ml to make them suffer periodontitis. Twenty male Wistar rats were divided into five groups. K-(without treatment); K1 (Streptozotocin + P.gingivalis); K2(Streptozotocin + P.gingivalis + sea cucumber gel); K3 (Streptozotocin+ P.gingivalis + HBO); K4 (Streptozotocin +P.gingivalis +HBO + sea cucumber gel). Result: One-way ANOVA here were significant differences (p<0.05) in K2 (24.97 ± 4.99), K3 (22.80 ± 6.45), K4 (28.47 ± 3.20) that compared with K1 (9.22 ± 4.95). Conclusion: Each hyperbaric oxygen therapy doses of 2.4 ATA 100% O2 3x30 minutes with 5 minute intervals for 7 days and sea cucumber gel (Stichopus hermanii) concentration of 3% and a combination of both therapies showed an increase of osteoblasts significantly in rats with diabetes mellitus induced P.gingivalis.
Daya Hambat Ekstrak Rumput Laut Spesies Eucheuma Cottonii Terhadap Pertumbuhan Bakteri Mixed Periodontopatogen Iqbal Fahmiliyan Asmoro; Yoifah Rizka; Paulus Budi Teguh
Denta Journal Kedokteran Gigi Vol 9 No 1 (2015): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Background: Bacterial mixed periodontopatogen dominated by gram negative. Eucheuma cottonii seaweed as one of the plant species have the antibacterial effect againts gram positive and gram negative bacteria.thus potentially developed as antibacterial agent in periodontal disease. Purpose: This study aimed to determine the inhibition effect of Eucheuma cottonii seaweed extract to the growth of mixed periodontopathogen bacteria concentration of 0,25%, 0,5%, 1% and 2%. Materials and Methods: Eucheuma cottonii seaweed extracted with 95% etanol by soxhlet method. Mixed periodontopathogen bacteria inoculated in BHI medium. Antibacterial effects of extracts of Eucheuma cottonii seaweed againts bacterial mixed periodontopathogen was tested by the diffusion method with the concentrations of 0,25%, 0,5%, 1%, 2%, aquadest and tetracycline, where each group consisted of 5 experiment unit. The effect of the inhibition observed by measuring the diameter of clear area on the disk using digital calipers stated in millimeters. Result: There were inhibition effect at each concentrations of treatment. The diameter zone were concentration of 0.25% (6.184), the concentration of 0.5% (6.356), the concentration of 1% (6.62), the concentration of 2% (7.148) and a positive control with tetracycline (39.336) Conclusion: Eucheuma cottonii seaweed extract has inhibition effect to the growth ofbacteria mixed periodontopatogen.
Co-Authors Dian Mulawarmanti Fani Pangabdian Iqbal Fahmiliyan Asmoro Laurencia Isabella Loekito Paulus Budi Teguh Rafika Rusydia Darojati Safina Majdina Sarianoferni Syamsulina Revianti Talsha Irzaputri A