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All Journal Pharmacia Jurnal Kesehatan Tujuh Belas (Jurkes TB)
Vevi Maritha
Universitas PGRI Madiun Jawa Timur
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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FORMULASI SEDIAAN HAND BODY LOTION ANTIPENUAAN DARI KOMBINASI TANAMAN KOMODITAS HORTIKULTURA EKSTRAK BUAH PEPAYA DAN STROBERI DALAM MENGHAMBAT ENZIM TIROSINASE Firman Rezaldi; Vevi Maritha; Muhammad Faizal Fathurrohim; Andri Tri Cahyono; Dyah Rohmawati; Sukardi Sugeng Rahmad; Roni Gumilar; Ratna Fitry Yenny
Jurnal Kesehatan Tujuh Belas (Jurkes TB) Vol. 4 No. 1 (2022): November 2022
Publisher : Sekolah Tinggi Ilmu Kesehatan Tujuh Belas, Karanganyar, JAwa, Indonesia

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Abstract

One of the long-term losses in homeostatic balance in every living creature is a sign of aging skin. Hyperpigmentation conditions caused by the activity of the tyrosinase enzyme are an indicator of aging. One of the solutions that can be applied to prevent premature signs of aging is skin care using the most affordable pharmaceutical preparation, namely Hand Body Lotion. Hand Body Lotion which has anti-aging properties can be produced from bioactive compounds from horticultural commodity plants because it has been proven and is quite popular. Apart from being able to be used as an active ingredient in functional food, it can also be recommended as a pharmaceutical, namely the preparation of active cosmetic ingredients. This is because the content of vitamins, antioxidants, essential oils, proteins, even phenolic compounds and other active ingredients which are quite environmentally friendly can be produced from horticultural commodity plants, especially in the fruit group used in this research. Strawberry fruit has been reported to contain organic compounds such as gallic acid, elagic acid, and ferulic acid which can inhibit the melanogenesis process both in vitro and in vivo from previous findings. Papaya fruit contains saponins, flavonoids, alkaloids and tannins so it can be designed to inhibit the tyrosinase enzyme. This research aims to determine the inhibitory power of the tyrosinase enzyme from horticultural commodity plant extracts, both strawberries and papaya, in the form of formulations and hand body lotion preparations. The results of this research have proven that based on the IC50 value of horticultural commodity plant extracts, papaya has better inhibitory power for the tyrosinase enzyme compared to strawberries, namely 8,875 µg/mL. The conclusion in this research is that horticultural commodity plants in the form of papaya fruit extract are more recommended as an active ingredient in inhibiting the tyrosinase enzyme when compared with strawberry fruit extract based on the IC50 value even though in the form of hand body lotion it has the potential to inhibit the tyrosinase enzyme.
FORMULASI SEDIAAN ODOL KOMBUCHA BUNGA TELANG SEBAGAI PRODUK BIOTEKNOLOGI FARMASI DAN ANTIMIKROBA (Staphylococcus aureus, Streptococcus mutan, Candida albicans).Telang flower kombucha has been widely studied as a probiotic drink that can boost the immune s Firman Rezaldi; Yuliana Kolo; Ratna Fitry Yenny; Vevi Maritha; Novi Ayuwardani; Andri Tri Cahyono; Fitria Eka Resti Wijayanti; Rifkarosita Putri Ginaris; Reni Purbanova
PHARMACIA Vol. 2 No. 2 (2024): Pharmacy
Publisher : Program Studi Farmasi Universitas Mulia

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Abstract

Telang flower kombucha has been widely studied as a probiotic drink that can boost the immune system which in recent research has various pharmacological activities as a source of antimicrobials, especially in health problems related to dental disease. Previous studies and this is still a renewable research has found that mouthwash formulations and preparations made from an active ingredient of seagrass kombucha fermented solution have been shown to be able to inhibit the growth of Staphylococcus aureus, Candida albicans, and Streptococcus mutans. This study aims to make toothpaste formulations and preparations with an active ingredient of telang flower kombucha fermented solution as a pharmaceutical biotechnology product designed to inhibit the growth of Staphylococcus aureus and mutant Streptococcus bacteria as well as pathogenic fungi in the form of Candida albicans species. This type of research is a laboratory experiment in which we make a toothpaste base without the active substance as a negative control. Provide toothpaste that is sold in the market as a positive control. Make formulations and preparations of toothpaste with active ingredients from the fermented butterfly pea flower kombucha solution which includes concentrations of 20%, 30% and 40%. Data analysis was used through one way ANOVA where in the results of the study each preparation had a P value <0.05, so that further tests could be carried out through post hoc analysis. eggplant at a concentration of 40% was significantly different from 20% and 30% as a pharmaceutical biotechnology product in inhibiting the growth of the three test microbes and the results of this study it can be concluded that the formulation and preparation of toothpaste made from the active ingredient of butterfly pea flower kombucha fermentation solution is the best treatment as an antimicrobial and pharmaceutical biotechnology products.
Co-Authors Andri Tri Cahyono Andri Tri Cahyono Dyah Rohmawati Fitria Eka Resti Wijayanti Muhammad Faizal Fathurrohim Novi Ayuwardani Ratna Fitry Yenny Reni Purbanova Rifkarosita Putri Ginaris Roni Gumilar Sukardi Sugeng Rahmad Yuliana Kolo