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All Journal AloHA International Journal of Health Advancement (AIJHA) Pharmacia Jurnal Kesehatan Tujuh Belas (Jurkes TB)
Novi Ayuwardani
STIKes Bhakti Husada Mulia Madiun
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Antibacterial Activity of Salmonella Typhi in Combination of Earth-Worms Extract (Lumbricus rubellus) and Turmeric Rhizoma Extract (Curcuma Longa L.) In Vitro Novi Ayuwardani; Arikha Ayu Susilowati
Aloha International Journal of Health Advancement (AIJHA) Vol 2, No 7 (2019): July
Publisher : Alliance oh Health Activists (AloHA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/aijha20703

Abstract

Salmonella typhi s a gram-negative bacteria in the form of coccus, is motile and pathogenic, which can cause a salmonellosis (typhoid fever). Treatment of thiophid fever generally uses paracetamol and chloramphenicol. The development of traditional medicine, such as earthworms and turmeric, which is believed to cure typhoid fever. This study aims to determine the activity of a combination of extracts of earthworm and turmeric on the growth of Salmonella typhi. This study applied an experimental laboratory method. The treatment group consisted of a combination of earthworm extract and turmeric rhizome extract at various concentrations (40%: 60%; 50%: 50%; 60%: 40%), solely earthworm extract, solely turmeric rhizome extract and chloramphenicol 30 µg as a control positive. Earthworm extract and turmeric rhizome extract were prepared using maceration method with 96% ethanol solvent. Antibacterial activity test was performed in vitro using disk diffusion method against Salmonella typhi for 24 hours incubated at 37˚C and then the inhibitory zone (mm) was measured. The inhibitory zone was further analyzed using One Way ANOVA statistical analysis. The results showed that turmeric rhizome single extract better combination of earthworm extract and turmeric rhizome extract could inhibit Salmonella typhi growth optimally at a concentration of 50%: 50% with inhibitory value of 11.1 mm which was closer to the value of inhibition positive control ( 21.93 mm) compared with the other groups (p = 0.000). Keywords: antibacterial activity; earthworm extract; turmeric rhizome extract; concentration; Salmonella typhi; inhibitory power
Manfaat Kefir Dan Yoghurt Sebagai Prospek Masa Depan Bahan Baku Kosmetik Antiaging Dan Ramah Lingkungan Firman Rezaldi; Jihan Nabilla; Rina Nurmaulawati; Novi Ayuwardani; Erni Suminar; Mohammad Zulkarnain; Chairul Anam Afgani; Roni Gumilar; Heny Sasmita; Ucu Wandi Somantri
Jurnal Kesehatan Tujuh Belas (Jurkes TB) Vol. 6 No. 1 (2025): November
Publisher : Sekolah Tinggi Ilmu Kesehatan Tujuh Belas, Karanganyar, JAwa, Indonesia

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Abstract

Penuaan kulit merupakan proses biologis kompleks yang melibatkan stres oksidatif, penurunan kolagen, peradangan kronis, dan peningkatan aktivitas enzim pemecah matriks seperti MMPs. Dalam upaya mencari bahan aktif alami yang efektif dan berkelanjutan untuk kosmetik anti-aging, produk fermentasi susu seperti kefir dan yoghurt mulai mendapat perhatian. Keduanya mengandung berbagai komponen bioaktif seperti probiotik, peptida, eksopolisakarida, asam organik, dan senyawa antioksidan yang dapat menurunkan stres oksidatif, meningkatkan sintesis kolagen, serta memperbaiki fungsi barrier kulit. Kajian literatur ini bertujuan menelaah mekanisme biologis kefir dan yoghurt dalam memperlambat penuaan kulit, mencakup aktivitas antioksidan, antiinflamasi, modulasi mikrobioma, dan stimulasi matriks dermis. Berdasarkan hasil telaah pustaka terbaru, kefir dan yoghurt terbukti berpotensi besar sebagai bahan aktif kosmetik anti-aging yang ramah lingkungan dengan keunggulan pada keberlanjutan proses fermentasi dan pemanfaatan limbah biomassa. Namun, dibutuhkan penelitian lanjut mengenai formulasi topikal terstandar dan uji klinis untuk memastikan efektivitas serta keamanan penggunaannya.
FORMULASI SEDIAAN ODOL KOMBUCHA BUNGA TELANG SEBAGAI PRODUK BIOTEKNOLOGI FARMASI DAN ANTIMIKROBA (Staphylococcus aureus, Streptococcus mutan, Candida albicans).Telang flower kombucha has been widely studied as a probiotic drink that can boost the immune s Firman Rezaldi; Yuliana Kolo; Ratna Fitry Yenny; Vevi Maritha; Novi Ayuwardani; Andri Tri Cahyono; Fitria Eka Resti Wijayanti; Rifkarosita Putri Ginaris; Reni Purbanova
PHARMACIA Vol. 2 No. 2 (2024): Pharmacy
Publisher : Program Studi Farmasi Universitas Mulia

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Abstract

Telang flower kombucha has been widely studied as a probiotic drink that can boost the immune system which in recent research has various pharmacological activities as a source of antimicrobials, especially in health problems related to dental disease. Previous studies and this is still a renewable research has found that mouthwash formulations and preparations made from an active ingredient of seagrass kombucha fermented solution have been shown to be able to inhibit the growth of Staphylococcus aureus, Candida albicans, and Streptococcus mutans. This study aims to make toothpaste formulations and preparations with an active ingredient of telang flower kombucha fermented solution as a pharmaceutical biotechnology product designed to inhibit the growth of Staphylococcus aureus and mutant Streptococcus bacteria as well as pathogenic fungi in the form of Candida albicans species. This type of research is a laboratory experiment in which we make a toothpaste base without the active substance as a negative control. Provide toothpaste that is sold in the market as a positive control. Make formulations and preparations of toothpaste with active ingredients from the fermented butterfly pea flower kombucha solution which includes concentrations of 20%, 30% and 40%. Data analysis was used through one way ANOVA where in the results of the study each preparation had a P value <0.05, so that further tests could be carried out through post hoc analysis. eggplant at a concentration of 40% was significantly different from 20% and 30% as a pharmaceutical biotechnology product in inhibiting the growth of the three test microbes and the results of this study it can be concluded that the formulation and preparation of toothpaste made from the active ingredient of butterfly pea flower kombucha fermentation solution is the best treatment as an antimicrobial and pharmaceutical biotechnology products.
Co-Authors Afgani, Chairul Anam Andri Tri Cahyono Arikha Ayu Susilowati Erni Suminar Fitria Eka Resti Wijayanti Jihan Nabilla Mohammad Zulkarnain Ratna Fitry Yenny Reni Purbanova Rifkarosita Putri Ginaris Rina Nurmaulawati Roni Gumilar Sasmita, Heny Ucu Wandi Somantri Vevi Maritha Yuliana Kolo