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All Journal Buletin Veteriner Udayana
I Wayan Wirata
Laboratorium Ilmu Bedah dan Radiologi Veteriner, Fakultas Kedokteran Hewan Universitas Udayana, Jl. PB. Sudirman, Denpasar, Bali, Indonesia, 80234
Immunology & microbiology Public Health Veterinary

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HISTOPATHOLOGICAL ANALYSIS OF INCISION WOUND HEALING IN RATS TREATED WITH PIG BLOOD-DERIVED PLATELET-RICH PLASMA GEL Stevanny Lastra; I Wayan Wirata; Ni Luh Eka Setiasih; I Gusti Ngurah Sudisma; I Wayan Gorda; I Made Kardena
Buletin Veteriner Udayana Bul. Vet. Udayana. February 2025 Vol. 17 No. 1
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2025.v17.i01.p23

Abstract

Platelet Rich Plasma (PRP) can be used as a regenerative treatment to enhance the activity of growth factors in the blood with the aim of wound healing. PRP can enhance neovascularization, fibroblast formation, and tissue epithelialization more quickly and efficiently. This study aims to determine the histopathological observation of incision wound healing on the skin of white rats given PRP gel. This study used male white rats of the Wistar strain, aged 2-2.5 months and weighing 200-300 grams. The 27 rats used were divided into three treatment groups: P0 (negative control, given 0.9% NaCl solution), P1 (positive control, given Bioplacenton), and P2 (given PRP Gel). The treatment was administered once after the skin had been incised and was given only once. On days 1, 5, and 11, a biopsy of the skin organ was performed for histopathological examination. Histopathological examination includes four indicators: inflammatory cell infiltration, angiogenesis, fibroblasts, and collagen density. Data were analyzed using the Kruskal-Wallis test followed by the Mann-Whitney test, and then described descriptively. The research results show that the infiltration of inflammatory cells and collagen density indicate a difference (P≤0,05) in the group of receiving PRP gel compared to the negative and positive control groups. However, there was no difference in angiogenesis and fibroblasts (P>0.05). In the wound healing process, the histopathological picture of incisional wound healing in the skin of white rats (Rattus norvegicus) given pig blood PRP gel shows an increase and development. Therefore, further research can be conducted to create a more optimal PRP gel formulation, and histopathological examinations can be carried out over a longer observation period to obtain significant results.
HISTOPATHOLOGICAL ANALYSIS OF INCISION WOUND HEALING IN RATS GIVEN PLATELET RICH PLASMA DROPS FROM PIG BLOOD Anak Agung Ngurah Hery Brian Priantara; I Wayan Wirata; I Ketut Berata; I Gusti Ngurah Sudisma; I Wayan Gorda Sudisma; Ni Luh Eka Setiasih
Buletin Veteriner Udayana Bul. Vet. Udayana. April 2025 Vol. 17 No. 2
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2025.v17.i02.p09

Abstract

Platelet Rich Plasma (PRP) is platelet-rich plasma derived from whole blood. Platelet Rich Plasma (PRP) contains growth factors such as transforming growth factor-beta (TGF-β), insulin like growth factor (IGF-I), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) and epidermal growth factor (EGF) which play a role in accelerating wound healing. This study aims to determine the histopathological analysis of incision wound healing of white rats given pig blood PRP drops. This study used white rats of male sex with the age of 2 - 2.5 months with a body weight of 200 - 300 g. The rats used in this study were 27 rats divided into two groups. The 27 rats used were divided into 3 treatment groups, namely P0 (negative control, given 0.9% NaCl solution), P1 (positive control, given Bioplacenton), P2 (given PRP drops). On days 1, 5, and 11, biopsies were taken for histopathological examination. Histopathological examination was performed including four indicators: inflammatory cell infiltration, angiogenesis, fibroblasts, and collagen density. Data were then analyzed using Kruskal-Wallis and if there was a significant difference (P<0.05), it would be followed by the Mann Whitney test. From the results of the study on the histopathology of white rat incision wounds given pig blood PRP drops showed an increase in development. On the first day, inflammatory cell infiltration and angiogenesis increased, but decreased on days 5 and 11. Fibroblasts were seen on the first day then decreased until day 11. Collagen on day 1 began to be seen until on day 11 the density of collagen was very tight. It is necessary to make observations in a more detailed period of time to find out more clearly about the effect of PRP drops on angiogenesis.
CASE STUDY: MANAGEMENT OF VENTRAL HERNIA IN A 2-YEAR-OLD MIXED BREED FEMALE CAT WITH LAPAROTOMY Gusti Putu Arni Safitri; I Gusti Agung Gde Putra Pemayun; I Wayan Wirata
Buletin Veteriner Udayana Bul. Vet. Udayana. August 2025 Vol. 17 No. 4
Publisher : Fakultas Kedokteran Hewan Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/bulvet.2025.v17.i04.p29

Abstract

Ventral hernia is an abnormality in the median abdomen in the form of a lump caused by incomplete closure of the abdominal wall so that the visceral organs or omentum come out of the abdominal cavity. This case study aims to determine how to diagnose and treat cases of ventral hernia in female cats. A 2-year-old female tortie mix cat weighing 3.58 kg with clinical signs of a lump in the ventral abdomen after an ovariohysterectomy. Supporting examinations were carried out in the form of radiography (x-ray) to support the diagnosis and the results showed a radiolucent image in the area of ​​the lump containing fatty tissue (omentum). The cat was diagnosed with ventral hernia with a fausta prognosis. Treatment was carried out by laparotomy surgery to reposition the contents of the hernia into the abdominal cavity with general anesthesia using a combination of xylazine and ketamine. The closure of the abdominal wall and peritoneum was sutured with a simple interrupted pattern and the subcutaneous part with a simple continuous pattern and combined with subcuticular pattern sutures using Polyglycolic acid 3-0 thread. Postoperatively, the cat was given antibiotiks cefotaxime sodium (20 mg/kg BW, IV, q12h) for 3 consecutive days and continued with Cefixime (10 mg/kg BW, PO, q12h) for 5 consecutive days. On the 11th day, the cat was declared cured with the surgical wound that had healed and dried perfectly with normal appetite and drinking, smooth defecation and urination. It is recommended for owners not to take this condition lightly and a veterinary examination is required to prevent complications that could endanger the animal's health.
Co-Authors Anak Agung Ngurah Hery Brian Priantara Gusti Putu Arni Safitri I Gusti Agung Gde Putra Pemayun I Gusti Ngurah Sudisma I Ketut Berata I Made Kardena I Wayan Gorda I Wayan Gorda Sudisma Ni Luh Eka Setiasih Ni Luh Eka Setiasih Stevanny Lastra