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All Journal Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan The Hip and Knee Journal
Ludwig A. Pontoh
Department Of Orthopaedic And Traumatology Fatmawati General Hospital Jakarta
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Education Health Professions Medicine & Pharmacology Neuroscience

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Measurements of Patellofemoral Morphology Characteristics in Indonesian Population: an MRI Based Study Ludwig Andre Pontoh; Ismail Hadisoebroto Dilogo; Achmad Fauzi Kamal; Wahyu Widodo; Sholahuddin Rhatomy; Jessica Fiolin
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 15, No 2 (2021): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v15i2.3043

Abstract

Patellar malalignment is the imbalance relationship between patella and trochlea, in which clinical findings most of the time are obscured; hence diagnosis is often challenging. Magnetic resonance imaging (MRI) is the most sensitive tool to detect subtle patellar malalignment features, so diagnosis can be made early. However, there has been no clear consensus on the normal value of patella morphology until today. This study aims to determine patellofemoral morphology values in Indonesian using MRI. This was a retrospective study of 202 patients aged 18-40 years old with knee problems without patellar instability. Patellar morphology parameters including Insal Savati ratio (IS ratio), patellar tilt angle (PTA), sulcus angle (SA) and tibial tubercle-trochlear groove distance    (TT-TG) were evaluated and recorded for statistical analysis. There was no significant correlation between anthropometric values and patellar morphology values. There were significantly higher PTA, SA and TT-TG values in females compared to males. The mean value of the IS ratio in the Asian population using MRI was 0.99 ± 0.14, PTA was 9.09 ± 6.88, SA was 139.20 ± 6.38, and TT-TG distance was 8.00 ± 5.25. Further studies with larger samples and multi-center results are required.
Isolation and Characterization of Adipose-Derived Mesenchymal Stem Cell Exosomes: an In-Vitro Study Jessica Fiolin; Ismail Hadisoebroto Dilogo; Radiana Dhewayani Antarianto; Ludwig Andre Pontoh
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 16 No 2 (2022): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v16i2.4867

Abstract

Exosomes from Mesenchymal Stem Cells (MSC) is currently one of the highlighted research due to its more specific action on the target tissue. Exosome is one of the MSC Extracellular Vesicle (EVs) that acts as a mediator in the cellular communication. However, not so many literatures have succeed in elaborating its isolation and characterization process. This study aimed to explain the method used in exosomes isolation from Adipose-Derived MSC (ASC) and elaborate its characteristics. This is an in-vitro study performed in the Stem Cell and Tissue Engineering (SCTE) Indonesia Medical Education and Research Institute (IMERI) laboratory. Ultracentrifugation method was performed to isolate exosome from ASC. The exosome were characterized based on its particle size, morphology, and CD63 and CD81 expression for its purity. We were able to isolate sterile exosome from ASC by performing differential ultracentrifugation. The mean size of exosome was 88.7 nm ± 40 nm SD and showed expression of CD63 and CD81. Exosome was successfully isolated from ASC using ultracentrifugation method and characterization following the MISEV standard should be implemented in order to meet the therapeutic efficacy and safety issues as a regenerative agent.
Prosthetic Joint Infection Microorganism Pattern and Risk Factor Profile: A Single Center Study Fahreza Hilmy; Yoshi Pratama Djaja; Anggaditya Putra; Jamot Silitonga; Ludwig Andribert Pontoh
The Hip and Knee Journal Vol 1, No 1 (2020): August
Publisher : Indonesian Hip and Knee Society (IHKS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (805.612 KB) | DOI: 10.46355/hipknee.v1i1.24

Abstract

Introduction: Prosthetic joint infection (PJI) is a serious complication especially following arthroplasty surgeries. The outcome of these cases is affected by the pattern of infection, causative microorganism, and antibiotic resistance. This study was aimed to evaluate the prevalence of PJI, distribution of causative microorganism, antibiotic resistance, and risk factor profiling.Methods: A retrospective review was performed by arthroplasty registry evaluation from 2008-2018, followed by a medical record review and patient interview. Distribution of causative microorganisms, antibiotic resistance patterns, and the onset of infection was extracted. Risk factor evaluation was performed by assessing preoperative (age, body mass index (BMI), frailty index) and perioperative parameters (duration of surgery, number of previous surgeries, the interval between those surgeries). Results: Seventeen patients were diagnosed with PJI (13 hip and 4 knees), with a prevalence of 1.56% and 1.77% respectively. The most common causative organism was Staphylococcus aureus and Escherichia coli with multiple antibiotic resistance patterns. These infections mostly occurred in patients with the age of 40-60 years, BMI 30kg/m2, and pre-operative frailty index of 4. The perioperative risk factor was the duration of surgery for more than 3 hours, have undergone more than 3 surgeries with an average surgical interval of 2 months.Conclusions: The prevalence of PJI in this series was 1.56% in hip and 1.77% in the knee. The risk factor profile showed that most cases have high BMI, prolonged duration of surgery, and a high number of previous surgeries within a short interval. 
Adhesive Plastic Drapes Did Not Prove to Prevent Surgical Site Infection in Total Knee Arthroplasty: A Randomized Controlled Trial Pontoh, Ludwig Andretia Powantia; Dilogo, Ismail Hadisoebroto; Putra, Anggaditya; Widodo, Wahyu; Oesman, Ihsan; Fiolin, Jessica; Herdiman, Joshua Alward
The Hip and Knee Journal Vol 5, No 2 (2024): August
Publisher : Indonesian Hip and Knee Society (IHKS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46355/hipknee.v5i2.159

Abstract

Surgical site infection (SSI) prevention is crucial in total knee arthroplasty (TKA) procedures. One controllable factor is preventing foreign substances from contaminating the surgical field, for which adhesive draping over surgical drapes is commonly used. To determine whether using adhesive transparent film dressing has any effect on the occurrence of SSI in TKA. We conducted a study comparing 100 TKA, divided into two groups (each with 50 participants). The first group received adhesive plastic draping during TKA, while the second group was the control. Bacterial aerobic culture swabs were taken before applying the plastic draping and after surgery following skin closure. Follow-up evaluations were conducted within one month to detect signs of SSI. The results none of the 100 TKAs included in the study yielded positive bacterial culture results. One-month post-operative evaluations revealed no signs of SSI in any of the groups.The conclusion use of adhesive plastic drapes does not provide any benefit in preventing SSI in TKA. Skin preparation, prophylaxis, and surgeon preparation protocols are more crucial for SSI prevention than adhesive plastic drapes.
Co-Authors Achmad Fauzi Kamal Andri M.T. Lubis Anggaditya Putra Edu Tehupeory Fahreza Hilmy Fiolin, Jessica Harahap, Alida R. Herdiman, Joshua Alward Hori Hariyanto Ismail Hadisoebroto Dilogo Jamot Silitonga Jessica Fiolin Jessica Fiolin John Butarbutar Mohammad Hidayat Oesman Ihsan Pandelaki, Jacub Putra, Anggaditya Radiana Dhewayani Antarianto Saptawati Bardosono Sholahuddin Rhatomy Wahyu Widodo Wahyu Widodo Yeremia Tatang Yoshi Pratama Djaja