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All Journal Jurnal Kedokteran Brawijaya Journal of Innovation and Applied Technology Research Journal of Life Science Majalah Kesehatan FKUB Indonesian Journal of Rheumatology Heart Science Journal CRJIM (Clinical and Research Journal in Internal Medicine) CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal
Pratama, Mirza Zaka
Universitas Brawijaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Exploring Knowledge Gaps in Systemic Lupus Erythematosus Among Pre-Clinical Students and Junior Doctors in Medical Faculty Pratama, Mirza Zaka; Rahman, Perdana Aditya; Wahono, Cesarius Singgih; Handono, Kusworini
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 6 No. 1 (2025): June
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

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Abstract

Understanding knowledge gaps is essential for developing more effective educational interventions that can bridge theory and practice. This study aimed to evaluate knowledge gaps in Systemic Lupus Erythematosus between pre-clinical students and junior doctors at a medical faculty. A cross-sectional study was conducted with 250 participants, divided equally between pre-clinical students and junior doctors (N=125 each). Variables such as gender, educational year, GPA, and study time were analyzed. Knowledge was assessed in five domains: pathophysiology, clinical manifestations, diagnosis, treatment, and complications. Linear regression analysis was used to identify factors associated with mean knowledge scores. No significant differences in gender distribution or study time (p = 0.899, p = 0.633, respectively). However, GPA scores were significantly higher among junior doctors (p < 0.001). Pre-clinical students scored higher than junior doctors in all SLE-related domains. GPA and study time were the strongest predictors of higher scores (Beta = 0.917, p < 0.001; Beta = 0.261, p < 0.001). GPA and study time significantly contributed to SLE knowledge scores, while gender and educational year did not. These findings suggest that academic performance and consistent study habits play critical roles in mastering SLE concepts among medical trainees.
Performance of Soluble CD28 and CTLA4 as a Potential Marker of Immunosenescence Pratama, Mirza Zaka; Handono, Kusworini; Poetri, Levrita Nindya; Maghfirah, Halimi Bidaimi
Clinical and Research Journal in Internal Medicine Vol. 6 No. 1 (2025): Volume 6 No 1, May 2025
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2025.006.01.05

Abstract

Background: Immunosenescence is a condition of decreased function of the immune system that is generally found in elderly individuals. Several costimulatory molecules, such as CD28 and CTLA-4 have been investigated for their essential role in the immune aging process. Aim: This study aimed to determine the role of the soluble costimulatory molecules in immunosenescence. Methods: This study was observational research with cross-sectional approach. Samples were tested using ELISA and flow cytometry examination. Statistical analysis was conducted using independent T-test or Kruskal-Wallis comparison test. Correlation between each biomarker was determined with Pearson or Spearman correlation test. Diagnostic performances of each biomarked were assessed using ROC curve. Results: This study involved 52 subjects, of which 20 were young individuals aged between 20 to 28 years and 32 were elderly individuals aged between 60 to 85 years. In this study we found that CD4CD28+ and CD8CD28+ T cells were lower in elderly group (p<0.001), while CD4CD57+ and CD8CD57+ T cells were higher in elderly group (p<0.001). sCD28 and sCTLA-4 were significantly higher (p 0.039 and p 0.025 respectively) in old individuals than in young individuals. CD8CD28+ and sCD28 exhibit a significant negative moderate correlation (p=0.007, r= -0.368) meanwhile sctla4 has no correlation with surface immunosenescence markers. Based on the results of roc analysis, sCTLA-4 was the best predictor to determine immunosenescence with area under curve of 0.7. The cut-off value for sCTLA-4 to determine immunosenescence is 26.5 ng/ml with sensitivity and specificity 58.6% and 63.2% respectively. Conclusion: sCTLA-4 as a soluble costimulatory molecule can be developed as promising predictive biomarkers of immunosenescence, which could be detected more quickly and efficiently using elisa as an alternative to flowcytometry.
Co-Authors Achmad Rifa'i Achmad Rifa'i Ade Wildan Rizky Fachry Ahmad Bayhaqi Nasir Aslam Anna Ariane Atma Gunawan Cesarius Singgih Wahono Cesarius Wahono Desfryda, Elynca Putri Duma Sianturi Dwinadella, Sephia Elvira Sari Dewi Erawati, Dini Rachma Faisal Parlindungan Firdaningrum, Nimas Eka Handono Halim Handono Kalim Handono Kalim Hani Susanti, Hani Hani Susianti Harry Isbagio Kalsumy, Umi Kusworini Handono Kusworini Handono Kusworini Handono Laniyati Hamijoyo, Laniyati Levrita Nindya Poetri Maghfirah, Halimi Bidaimi Megawanto, Nurhandi Nabila Mukti Nadina Mustamsir Nimas Eka Firdaningrum Norma Hanifah Sumarta Nurdiana Nurdiana Nurdiana Nurdiana Nursari Abdul Syukur Perdana Aditya Rahman Perdana Rahman Poetri, Levrita Nindya Putri, Choirinnisa Meilia Ayu Ra. Aminah Maya Radiyati Umi Partan Rahmawati Wahyuni Ria Famuji, Siti Roziah Rizky Fachry, Ade Wlidan RM Suryo Anggoro Rudy Hidayat Sari, Tita Luthfia Siti Roziah Ria Famuji Sumariyono Sumarta, Norma Hanifah Surya Darma Suryana, Bagus Suryana, Bagus Putu Putra Syahrul Chilmi Wahono, Caesarius Singgih Wahono, Cesarius Singgih Wisnu Barlianto Yulyani Werdiningsih Yuni Sari Zaenal Kusuma