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All Journal Interdental Jurnal Kedokteran Gigi (IJKG) Journal of Community Development
Rosdah, Ayeshah
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Medicine & Pharmacology Nursing Public Health Social Sciences

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Rat Models of Periodontitis: A Focused Review on Ligature, Bacterial Inoculation, and LPS-Induced Approaches Astarini, Afifah; Harahap, Debby Handayati; Rosdah, Ayeshah
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 21 No. 3 (2025): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v21i3.12391

Abstract

Introduction: Periodontitis is a common chronic inflammatory disease that leads to progressive destruction of the gingiva, periodontal ligament, and alveolar bone. This is due to a dysbiotic oral microbiome that triggers an exaggerated host immune response. Preclinical rat models are indispensable in periodontal research, allowing for controlled investigations of disease mechanisms and therapeutic interventions. Review: This review examines three widely used rat models of experimental periodontitis, including ligature-induced, oral bacterial inoculation, and lipopolysaccharide (LPS) injection. The ligature-induced model is favored for its rapid and reproducible induction of localized inflammation and bone loss, although mechanical trauma may confound the microbial effects. Oral inoculation with pathogens such as Porphyromonas gingivalis simulates natural infections and chronic progression, offering greater biological relevance. The LPS model provides a controlled inflammatory stimulus that facilitates the study of host immune pathways and cytokine expression; however, it lacks microbial complexity. Recent studies have explored the combination of ligature and LPS methods to synergistically intensify inflammation and bone loss, thereby improving model robustness for therapeutic evaluation. Conclusion: Each animal model offers specific benefits for studying periodontitis development and treatment. Although these models have certain limitations, ongoing improvements in research methods will increase their relevance to human health. Advances in technology, imaging, and microbiological techniques are expected to improve the accuracy and usefulness of these models. These developments will enhance our understanding of the disease and contribute to the discovery of more effective and targeted treatment options for periodontitis.
Deteksi Dini Penyakit Asam Urat dan Inovasi Pembuatan Teh Dari Tanaman Obat Keluarga untuk Mengatasi Penyakit Asam Urat Pada Guru dan Tendik SDN 149 Palembang Adenina, Syarinta; Adnindya, Msy.; Harahap, Debby; Sutandar, Vivi; Parisa, Nita; Rosdah, Ayeshah; Hasbi, Alfian; Hanifah, Masayu; Nurhaura, Nailah; Putri , Marsyadilla
Journal of Community Development Vol. 6 No. 2 (2025): Desember
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/comdev.v6i2.1809

Abstract

Kadar asam urat yang tinggi merupakan salah satu masalah kesehatan yang sering terjadi pada usia produktif, termasuk guru dan tenaga kependidikan (tendik) dengan beban kerja tinggi dan aktivitas fisik rendah. Deteksi dini diperlukan untuk mencegah komplikasi metabolik. Selain itu, edukasi mengenai pemanfaatan Tanaman Obat Keluarga (TOGA) melalui inovasi teh herbal, dapat menjadi alternatif pengelolaan mandiri asam urat. Kegiatan pengabdian masyarakat ini bertujuan untuk melakukan skrining kadar asam urat dan tekanan darah pada guru dan tendik SDN 149 Palembang, serta memperkenalkan teh herbal dari TOGA. Metode pelaksanaan program dilakukan dengan pendekatan partisipatif yang mengedepankan keterlibatan aktif warga sekolah sejak perencanaan, pelaksanaan, hingga evaluasi kegiatan sebagai subjek utama dalam proses pembelajaran. Program meliputi penyuluhan, demonstrasi pembuatan teh herbal, pemeriksaan kesehatan, dan penyerahan bibit TOGA. Hasil menunjukkan rerata usia peserta 47,9 tahun. Hasil evaluasi pre dan posttest penyuluhan menunjukkan pengetahuan peserta meningkat signifikan setelah edukasi. Hasil skrining menunjukkan sebanyak 68,7% memiliki kadar asam urat tinggi, sedangkan tekanan darah terbagi menjadi 15,6% normal, 31,3% prahipertensi, 31,3% hipertensi derajat 1, dan 21,8% hipertensi derajat 2. Kegiatan ini terbukti efektif dalam meningkatkan pemahaman mengenai pencegahan hiperurisemia berbasis TOGA. Pembagian bibit TOGA diharapkan menjadi langkah berkelanjutan untuk mendukung gaya hidup di lingkungan sekolah.
Co-Authors Adnindya, Msy. Astarini, Afifah Debby Handayati Harahap Hanifah, Masayu Harahap, Debby Hasbi, Alfian Nita Parisa Nurhaura, Nailah Putri , Marsyadilla Sutandar, Vivi Syarinta Adenina