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Riskfactors of scabies in students of Aulia Cendikia Islamic BoardingSchool, Palembang Fifa Argentina; Debby Handayati Harahap; Evi Lusiana
JURNAL KEDOKTERAN DAN KESEHATAN Vol 6, No 3 (2019)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Abstract.Scabies is a skin disease caused by infestation and sensitization of Sarcoptesscabiei var. hominis. Scabies can infect everyone at all ages, races, genders and social economic levels. This disease is usually found in places such as dormitories, orphanages, prisons, islamic boarding schools that lack personal hygiene. Observational analytic research with cross sectional design has been carried out at boarding school Aulia Cendikia in Palembang from June to December 2017. There were 199 samples of students of Aulia Cendikia boarding school in Palembang city that met the inclusion criteria. In this study, there were no age differences between students with or without scabies (p = 0.374; p> 0.05). This study showed that the number of people per room was the factor that most contributed to the incidence of scabies (PR = 2.746, p = 0.002) followed by personal hygiene (PR = 2.333, p = 0.007) and gender (PR = 2.068, p = 0.019). Number of people in the room, personal hygiene and gender are risk factors for scabies at the Aulia Cendikiaislamic boarding school in Palembang.

Efficacy of Topical Coffee Paste to Collagen Density in Wistar Rats Incision Wound Debby Handayati Harahap; Fifa Argentina; Yuli Kurniawati; Citra Tresna Murti; Yudha Dwi Satrio
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 1 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i1.14

Background :Collagen plays a very important role in humans at every stage of wound healing. Coffee contains many antioxidants that stimulate the formation of collagen dermis by increasing the production of Tissue Inhibitor of Matrix Metalloproteinas-1 in the dermis that serves to inhibit the breakdown of collagen. This study aims to determine the efficacy of topical pasta coffee to collagen density. Methods: Experimental Laboratories Study with pre and post test controlled group design research was undertaken from September to November 2017 at Animal House and Dyatnitalis Laboratory, Palembang. 30 male white rats of wistar strain were divided into 5 groups then performed 2 cm dermal incision and giving various concentration of coffee paste. On the day 0 and 5th after coffee paste, the percentage of collagen density is checked. The efficacy of coffee paste was analyzed by Paired T Test/Wilcoxon while the comparison of efficacy was analyzed by Independent T Test / Mann Whitney then continued with One Way ANOVA Test and Tukey test. Data analysis using SPSS version 18.0. Results: There was an average difference of percentage level of collagen density before and after vitamin C (p = 0,003), coffee paste 20% (p = 0,043), coffee paste 40% (p = 0,045) and coffee paste 80% (p = 0,011) . In addition, there was an average difference of percentage of collagen density between negative control group with positive control group and 40% coffee paste. From the results of Post Hoc test results showed that there was a difference of percentage of collagen density of negative control group with coffee paste group 40%. Conclusion: There is efficacy of topical coffee paste on collagen density in various concentrations where the highest increase of collagen density is 246,96% after coffee paste 40%. Keyword: Coffee Pasta, Collagen, Injured Incision, Vitamin C

Efficacy of Topical Coffee Paste to Collagen Density in Wistar Rats Incision Wound Debby Handayati Harahap; Fifa Argentina; Yuli Kurniawati; Citra Tresna Murti; Yudha Dwi Satrio
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 1 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i1.14

Background :Collagen plays a very important role in humans at every stage of wound healing. Coffee contains many antioxidants that stimulate the formation of collagen dermis by increasing the production of Tissue Inhibitor of Matrix Metalloproteinas-1 in the dermis that serves to inhibit the breakdown of collagen. This study aims to determine the efficacy of topical pasta coffee to collagen density. Methods: Experimental Laboratories Study with pre and post test controlled group design research was undertaken from September to November 2017 at Animal House and Dyatnitalis Laboratory, Palembang. 30 male white rats of wistar strain were divided into 5 groups then performed 2 cm dermal incision and giving various concentration of coffee paste. On the day 0 and 5th after coffee paste, the percentage of collagen density is checked. The efficacy of coffee paste was analyzed by Paired T Test/Wilcoxon while the comparison of efficacy was analyzed by Independent T Test / Mann Whitney then continued with One Way ANOVA Test and Tukey test. Data analysis using SPSS version 18.0. Results: There was an average difference of percentage level of collagen density before and after vitamin C (p = 0,003), coffee paste 20% (p = 0,043), coffee paste 40% (p = 0,045) and coffee paste 80% (p = 0,011) . In addition, there was an average difference of percentage of collagen density between negative control group with positive control group and 40% coffee paste. From the results of Post Hoc test results showed that there was a difference of percentage of collagen density of negative control group with coffee paste group 40%. Conclusion: There is efficacy of topical coffee paste on collagen density in various concentrations where the highest increase of collagen density is 246,96% after coffee paste 40%. Keyword: Coffee Pasta, Collagen, Injured Incision, Vitamin C

Pendampingan pemanfaatan tanaman herbal pada pasien hipertensi dan diabetes melitus sebagai upaya pencegahan penyakit gagal ginjal di Puskesmas Gandus Palembang Lusiana, Evi; Kurniati, Ardesy Melizah; Harahap, Debby Handayati; Tamzil, Nia Savitri; Parisa, Nita; Adenina, Masayu Syarinta; Rosdah, Ayesha Augusta; Oktariana, Desi; Pariyana, Pariyana; Azizah, Aida Nur; Islami, Arya Putera
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 5 No 1 (2024): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V5I1.138

Hypertension and diabetes mellitus are risk factors for chronic kidney disease. A person diagnosed with hypertension and diabetes mellitus is required to regularly take medication for life, which can lead to side effects of drugs (ESO). This triggers the search for more effective and safer drugs, so many people start to turn to traditional medicine. The main objective of this community service is to increase community knowledge and skills through assistance in cultivating herbal plants such as Sambiloto, Celery, and Ginger. The method of service carried out in this activity is by giving questionnaires before and after the delivery of material with the community in the working area of the Gandus Palembang Health Center. The targets of community service activities are hypertension and diabetes mellitus patients and the community registered in the working area of the Gandus Palembang Health Center as many as 30 participants. The results of the counseling showed that there was an increase in the results of participants who fell into the good category, according to the variables of knowledge, attitude and action respectively 56.7%, 23.3% and 40%.

Pemberdayaan Ibu-Ibu Majelis Taklim Al Kahfi: Deteksi Asam Urat dan Edukasi Sindrom Terowongan Karpal Adnindya, Msy Rulan; Adenina, Syarinta; Harahap, Debby Handayati; Tamzil, Nia Savitri; Kurniati, Ardesy Melizah; Islamia, Medina Putri; Rafli, Muhammad
Science and Technology: Jurnal Pengabdian Masyarakat Vol. 1 No. 3 (2024): September
Publisher : CV. Science Tech Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69930/scitech.v1i3.53

Masalah kesehatan sendi, khususnya sindrom terowongan karpal (CTS), sering dialami oleh ibu-ibu rumah tangga yang melakukan gerakan repetitif. Berdasarkan wawancara dengan ketua pengajian Majelis Taklim Al Kahfi, nyeri pada persendian tangan merupakan salah satu keluhan utama yang dirasakan oleh anggota ibu pengajian. Selain itu, tingkat pengetahuan mereka mengenai CTS masih rendah. Fokus pengabdian ini adalah memberdayakan ibu-ibu pengajian dalam pengelolaan kesehatan melalui deteksi dini kadar asam urat dan edukasi pencegahan CTS. Tujuan dari pengabdian ini adalah meningkatkan pengetahuan ibu-ibu tentang CTS, melakukan deteksi dini kesehatan melalui pemeriksaan kadar asam urat, dan memberikan informasi terkait CTS. Metode yang digunakan meliputi penyuluhan dengan alat bantu presentasi dan flyer, diskusi, skrining kesehatan menggunakan alat strip asam urat, serta evaluasi melalui pretest dan posttest. Hasil pengabdian diharapkan dapat meningkatkan pemahaman ibu-ibu pengajian tentang CTS, serta kemampuan mereka dalam mencegah dan menangani masalah kesehatan sendi. Evaluasi menunjukkan peningkatan pengetahuan dan kesadaran kesehatan di kalangan peserta. Program ini juga memfasilitasi pembentukan kelompok pendukung di media sosial untuk pendampingan berkelanjutan.

EFFECTIVENESS OF ANTHOCYANIN AS A HEPATOPROTECTOR: A SYSTEMATIC LITERATURE REVIEW Amanda Putri, Khairunnisa Rizqika; Lusiana, Evi; Theodorus; Rosdah, Ayeshah Augusta; Harahap, Debby Handayati; Larasati, Veny
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 1 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i1.453

Exposure to free radicals can cause hepatotoxicity in liver cells. Hepatoprotectors are needed to prevent free radicals. The flavonoid group anthocyanin compounds, which give many plants purple, blue, and red colors, have antioxidant activity as hepatoprotectors. This study uses a systematic literature review to review the effectiveness of various plants containing anthocyanins as hepatoprotectors. Articles were searched using Google Scholar, PubMed, and NCBI with keywords such as "Anthocyanin compounds and Hepatoprotective effects" that met the inclusion and exclusion criteria. The results obtained from 7 review articles show that several plants contain anthocyanins, such as bilberry and blackberry, Rosella, purple cabbage, butterfly pea flower, Aronia melanocarpa Elliot (AMA), red cabbage, and radish. The mechanisms in plants containing anthocyanins as hepatoprotective include antioxidant activity, inhibition of cytochrome enzymes, inhibition of inflammation, protein expression, and modulation of the apoptotic signal pathway. This review concludes that plants containing anthocyanins are effective as natural hepatoprotectors with various mechanisms.

Anti-Inflammatory and Anti-Hyperuricemic Effects of Chrysin in a Rat Model of High Fructose Corn Syrup Induced Hyperuricemia Tahany, Hanifah; Parisa, Nita; Nugraha, M Daffa; Harahap, Debby Handayati; Theodorus, Theodorus
Biomedical Journal of Indonesia Vol. 11 No. 1 (2025): Vol 11, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i1.200

An increase in the blood level of uric acid, or hyperuricemia, is a disorder that can cause damage to the kidneys and gout among other health problems. Worldwide, the incidence of hyperuricemia has been rising, in part because of dietary factors such the use of HFCS, a prevalent sweetener found in processed foods. Thus, research into natural substances with anti-inflammatory and anti-hyperuricemia attributes, such as chrysin, is critical to the fields of therapeutic and preventive medicine. This study investigates the anti-inflammatory and anti-hyperuricemic effects of chrysin in a rat model of hyperuricemia induced by high-fructose corn syrup. The research reveals that chrysin exerts its therapeutic effects through antioxidant activity and the inhibition of inflammatory signaling pathways, resulting in a decrease in oxidative stress and the expression of the pro-inflammatory cytokine IL-1β. Treatment with chrysin leads to a significant increase in tissue weight, tissue index, and kidney histology, indicating its potential in mitigating kidney damage associated with hyperuricemia. The study demonstrates a dose-dependent reduction in IL-1β levels and inflammation activation with chrysin treatment, surpassing the anti-inflammatory effects of the comparison group. Furthermore, chrysin treatment reduces malondialdehyde concentration and mitigates the activation of inflammasome-related protein induced by high-fructose corn syrup. These findings highlight the promising therapeutic potential of chrysin in managing hyperuricemia and related metabolic disorders.

The use of cetirizine in allergic contact dermatitis patients at Sekip Palembang Health Center Rukmana, Cici Chintya Aulia; Harahap, Debby Handayati; Theodorus
Indonesian Journal of Pharmacology and Therapy Vol 6 No 1 (2025)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.12729

World Allergy Organization (WAO) reported that 22% of the global population experiences allergies, and this prevalence continues to increase each year. The prevalence of dermatitis in Indonesia is quite high, at 6.78%, with the highest rate in South Kalimantan (11.3%) and the lowest in West Sulawesi (2.57%). In South Sumatra, approximately 2,584,000 people suffer from dermatitis. Therapy for allergic contact dermatitis patients includes medicamentous treatments, such as systemic antihistamines, with cetirizine being one of the options. This study aimed to determine the pattern of cetirizine use, including the frequency, duration of administration, and the characteristics of allergic contact dermatitis patients such as gender and age who received cetirizine therapy. The drug utilization study of cetirizine was conducted in December 2021 at the Sekip Palembang Community Health Center, involving 34 out of 49 patients who met the inclusion criteria. The sampling method used was total sampling. The majority of allergic contact dermatitis patients were late elderly individuals, aged 56-65 yr (32.4%), and women (58.8%). Rationality assessment showed good results in terms of diagnosis (100%), indication (100%), duration of drug administration (97.1%), frequency of drug administration (100%), and drug interactions (93.7%). This study hopefully can enhance the effectiveness of cetirizine usage, enabling healthcare providers to prescribe the medication more rationally according to the patients' allergic symptoms.

POTENSI KOLAGEN IKAN TERHADAP PENYEMBUHAN SOKET PASCA PENCABUTAN GIGI Ricardo, Angelina Natalia; Harahap, Debby Handayati; Rosdah, Ayeshah A.
Jurnal Kesehatan Gigi dan Mulut (JKGM) Vol 6 No 2 (2024): Jurnal Kesehatan Gigi dan Mulut (JKGM)
Publisher : Jurusan Kesehatan Gigi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkgm.v6i2.2577

ABSTRAK Latar Belakang: Pencabutan gigi merupakan prosedur perawatan invasif yang merangsang proses penyembuhan luka yang terdiri dari fase hemostasis, inflamasi, proliferasi, dan remodelling. Dalam berbagai fase penyembuhan, kolagen berperan mempercepat penyembuhan luka dengan cara menghentikan perdarahan, mencegah inflamasi yang berkepanjangan, mendukung angiogenesis, pembentukan jaringan granulasi, dan kontraksi luka. Kolagen umumnya diekstraksi dari kulit atau tulang sapi atau babi, namun kontroversi agama dan risiko penularan penyakit memicu pencarian sumber kolagen alternatif, yaitu ikan. Pemanfaatan kolagen yang diekstraksi dari produk limbah ikan membantu menambah nilai ekonomi dan mengurangi masalah lingkungan. Kolagen ikan bersifat biokompatibel dan memiliki komposisi asam amino yang setara dengan kolagen sapi atau babi. Kesimpulan: Kolagen ikan berpotensi sebagai bahan terapi tambahan untuk mempercepat penyembuhan luka pasca pencabutan gigi karena bersifat biokompatibel, tidak berisiko menularkan penyakit, dan mengandung asam amino yang berperan dalam mendukung proliferasi makrofag, fibroblas, dan epitel, sintesis kolagen, angiogenesis, dan kontraksi luka. Kata kunci : Kolagen ikan, pencabutan gigi, penyembuhan luka, soket gigi ABSTRACT Background : Tooth extraction is an invasive treatment procedure that stimulates the wound healing process, consisting of the hemostasis, inflammation, proliferation, and remodelling phases. In the wound healing phases, collagen plays a role in accelerating wound healing by stopping bleeding, preventing prolonged inflammation, promoting angiogenesis, the formation of granulation tissue, and wound contraction. Generally, collagen is extracted from the skin or bone of bovine or porcine, but religious controversies and the risk of disease transmission have triggered the search for alternative sources of collagen, namely fish. Extracting collagen from fish waste products helps to increase economic value and reduce environmental problems. Fish collagen is biocompatible and have similar amino acid composition to bovine and porcine collagen. Conclusion : Fish collagen has the potential to be an additional therapeutic material to accelerate after tooth extraction healing because that collagen is biocompatible, low risk of disease transmission, and contains amino acids that play role in promoting the proliferation of macrophage, fibroblast, and epithelial cells, collagen sintesis, angiogenesis, and wound contraction. Keywords : Fish collagen, tooth extraction, tooth socket, wound healing

Edukasi swamedikasi obat herbal yang rasional pada kelompok ibu rumah tangga di Kelurahan Karya Baru Rosdah, Ayeshah Augusta; Adenina, Masayu Syarinta; Parisa, Nita; Harahap, Debby Handayati; Lusiana, Evi; Fatmawati, Fatmawati
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 6 No 1 (2025): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V6I1.169

Indonesian Health Survey reported that more than half of the population in South Sumatera utilizes herbal medicine to alleviate disease symptoms. The survey also indicated that factors such as lower-middle income levels and the female gender are relatively more likely to utilize medicinal plants compared to higher-income levels and the male gender. The findings from this health survey strongly support the characteristics of the target audience for this community service, specifically the residents of Karya Baru Village represented by the women in Majelis Taklim Al-Kahfi. Initial interviews with several members of this group revealed a tendency to self-treat sick family members, particularly using herbal remedies, as they are perceived to have no side effects compared to modern medications (synthetic drugs). These findings indicate a potential irrational use of herbal medicine in self-medication practices. Self-medication refers to the efforts made by individuals to determine treatments for their disease symptoms. For self-medication practices to be safe and effective, it is essential for the community to be equipped with adequate knowledge about the rational use of herbal medicines. Therefore, a community service initiative is necessary to enhance public knowledge regarding the types of herbal medicines and promote rational behaviors on self-medication practice of herbal medicines within the community.

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