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All Journal Berkala Ilmiah Kedokteran Duta Wacana MEDICINUS
Probowati, Wiwiek
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Berkala Ilmiah Kedokteran Duta Wacana

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ASSOCIATION BETWEEN ACUTE RESPIRATORY DISTRESS SYNDROME (ARDS) INCIDENCE AND INCREASED D-DIMER IN COVID-19 PATIENTS AT BETHESDA HOSPITAL YOGYAKARTA Hutagaol, Frans Iqlessias; Probowati, Wiwiek; Manus, Widya Christine
Berkala Ilmiah Kedokteran Duta Wacana Vol. 9 No. 1 (2024): BERKALA ILMIAH KEDOKTERAN DUTA WACANA
Publisher : Faculty of Medicine Universitas Kristen Duta Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21460/bikdw.v9i1.930

Abstract

Background: Acute Respiratory Distress Syndrome (ARDS) is one of the most common complications of COVID-19 infection and is closely related with patient mortality. Increased D-dimer levels are considered one of the most consistent clinical indicators of coagulopathy. Theoretically, this event is based on the emergence of a cytokine storm triggering lung tissue damage, pulmonary microvascular endothelial damage and alveolar edema, leading to hypoxia in the body. Objective: To determine the association between ARDS incidence and the increase in D-dimer levels in COVID-19 patients at Bethesda Hospital Yogyakarta. Method: This research was conducted in retrospective cohort design. The data utilized in this study came from the medical records of male and female COVID-19 patients between 19 and 60 years old, who were diagnosed with ARDS by doctors at Bethesda Yogyakarta Hospital. The medical records were collected between June 1, 2021, and September 30, 2021. The data analysis included univariate (descriptive statistics) and bivariate (Chi-Square, Mann-Whitney, Spearman Rank) analyses. Result: There was a significant relationship between COVID-19 ARDS patients and the increased levels of D-dimer in patients undergoing hospitalization at Bethesda Hospital Yogyakarta (p<0,001, OR=4,589, 95%CI=2,104-10,007). Additionally, there was a significant difference in D-dimer levels between ARDS and non-ARDS patients. The severity of ARDS, duration of hospitalization, gender, and age did not have a significant association with the increase in D-dimer levels (p>0,05). Conclusion: There was a significant relationship between the incidence of ARDS and elevation of D-dimer levels in COVID-19 patients at Bethesda Hospital Yogyakarta.
THE CORRELATION OF ABO BLOOD TYPES AND COVID-19 SEVERITY IN BETHESDA HOSPITAL YOGYAKARTA Pranata, Korin Bagas; Probowati, Wiwiek; Wuryaningsih, Nining Sri
Berkala Ilmiah Kedokteran Duta Wacana Vol. 8 No. 2 (2023): BERKALA ILMIAH KEDOKTERAN DUTA WACANA
Publisher : Faculty of Medicine Universitas Kristen Duta Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21460/bikdw.v8i2.588

Abstract

Background COVID-19 is caused by the SARS-CoV-2 virus. The most recent study showed that there was a possible correlation between ABO blood types and COVID-19 risk. However, some studies disproved the correlation. The contradiction indicated that the correlation between the two variables has not been established. Objective To find the correlation between ABO blood types and the severity of COVID-19.  Methods It applied an observational-analytic method with a retrospective cohort approach. It used secondary data from 2020-2021 in Bethesda Hospital Yogyakarta. Samples were taken using a consecutive sampling technique. The collected data were analyzed using SPSS 26. Univariate analysis was made using descriptive statistics. Sequentially, bivariate and multivariate analyses were made using chi-square, odds-ratio, relative-risk, and ordinal logistic regression analysis. Results There were 212 data. Blood type O got the biggest percentage (38.2%) with a sample of 81 individuals. There were 88 patients with severe symptoms (41.5%), 86 patients with moderate symptoms (40.6%), and 38 patients with mild symptoms (17.9%). The Chi-square analysis of ABO blood types and the severity of COVID-19 was 0.05 (?0.05). The blood type B had a 2.8 times higher probability of severe incidence (95% CI 0.618–12.16) than the non-B blood type. Meanwhile, blood type O had a 0.33 times lower probability of severe incidence (95% CI 0.618–12.16) than non-O blood type. Conclusion The ABO blood types correlated with COVID-19 severity. Blood type O became a protective factor, and blood type B is the risk factor for severe COVID-19. TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian     TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back
Co-Authors Amumpuni, Antonia Namelia Wahyu Christiane Marlene Sooai, Christiane Marlene Hendi Wicaksono Hutagaol, Frans Iqlessias Manus, Widya Christine Neneng Ratnasari Nining Sri Wuryaningsih, Nining Sri Pranata, Korin Bagas Priskila, Loury Putut Bayupurnama