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All Journal Jurnal Keperawatan Jiwa (JKJ): Persatuan Perawat Nasional Indonesia Public Health of Indonesia Jurnal Kepemimpinan dan Manajemen Keperawatan Jurnal Riset Kesehatan Nasional Jurnal Pijar MIPA JRKN Promotor: Jurnal Mahasiswa Kesehatan Masyarakat Jurnal Pengabdian Kepada Masyarakat Itekes Bali
I Gusti Agung Tresna Wicaksana
Institut Teknologi Dan Kesehatan Bali
Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Physics Public Health Veterinary Other

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Journal : Jurnal Pijar MIPA

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Hepatoprotective Effects of Balinese Grape Extract (Vitis vinifera L.) on Hepar Histology and Reducing Blood Sugar Levels Damayanti, Ida Ayu Manik; Wicaksana, I Gusti Agung Tresna; Sutrisna, I Putu Gede
Jurnal Pijar Mipa Vol. 19 No. 1 (2024): January 2024
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v19i1.6198

Abstract

This study aimed to determine the hepatoprotective activity of grape skin extract (Vitis vinifera L.) (BGE) on hepatic histology and blood sugar level reduction. This study was conducted in four stages: extraction of grape skin using 96% ethanol, phytochemical screening, antihyperglycemic activity test and hepatoprotective activity test. The experimental animals were divided into five groups consisting of negative control (Na CMC 0.5%), positive control (Curcuma), TI (100 mg BGE/kg BW), TII (300 mg BGE/kg BW), TIII (500 mg BGE/kg BW). Phytochemical screening showed that BGE positively contains terpenoids, flavonoids, tannins, saponins and carotenoids. The results of antioxidant analysis on BGE showed an IC50 value of 80.77 ppm, which included intense antioxidant activity. BGE and negative control can provide hepatoprotector effects on hepatic cells from hepatocyte cell damage due to paracetamol and can reduce blood sugar levels.
Co-Authors Ariani, Ni Komang Sri Darsana, Wayan Eko K, Rinik Garbhani, Anak Agung Istri Hiranya Gst Kade Adi Widyas Pranata I Gusti Ayu Rai Rahayuni I Gusti Bagus Panji Widiatmaja I Kadek Nuryanto I Ketut Alit Adianta I Ketut Setiabudi I Ketut Swarjana I Putu Gde Yudara Sandra Putra I Putu Gede Sutrisna . Ida Ayu Manik Damayanti Ida Ayu Putri Wulandari Kadek Buja Harditya Komang Rosa Tri Anggaraeni Lusiana Devi, Ni Luh Putu Ni Luh Putu Lusiana Devi Ni Luh Putu Lusiana Devi Ni Putu Ayu J Sastamidhyani Ni Wayan Kesari Dharmapatni Ni Wayan Sukaningsih Setiabudi, I Ketut Sukaningsih, Ni Wayan Sutrisna , I Putu Gede Wahju S, Teguh Wahyuningsih, Luh Gde Nita Sri Wayan Darsana Widiarta, Made Bayu Oka Yudara S, Putu