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All Journal Griya Widya: Journal of Sexual and Reproductive Health Journal of Applied Holistic Nursing Science
Arifa, Vira Nur
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Health Professions Nursing Public Health Other

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Recurrence Factors in Cervical Precancerous Lesions: A Narrative Exploration Kusuma, Fitriyadi; Gung Binathara, Geraldus Sigap; Suryoadji, Kemal Akbar; Tahsya Hermawan, Tsaniya Meidini; Arifa, Vira Nur; Masrie, Marshaly Safira
Griya Widya: Journal of Sexual and Reproductive Health Vol. 5 No. 2 (2026): Griya Widya: Journal of Sexual and Reproductive Health
Publisher : Nur Science Institute and Perkumpulan Keluarga Berencana Indonesia (PKBI) Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53088/griyawidya.v5i2.2287

Abstract

Background: Recurrent cervical pre-cancerous lesions remain a major clinical challenge in preventing progression to invasive cancer and achieving long-term remission. Persistent infection with high-risk human papillomavirus (HPV), particularly subtype 16, is strongly associated with recurrence, especially in women under 40 years of age. Method: This narrative review analyzed recent literature focusing on the main determinants of recurrence after treatment of cervical pre-cancerous lesions, including viral, surgical, and immunological factors. Result: The findings showed that incomplete surgical excision significantly increased the risk of recurrence. The type of surgical procedure also influenced outcomes, with cold knife and laser conization associated with lower recurrence rates than LLETZ. Post-treatment HPV vaccination was found to reduce recurrence by enhancing immunity against re-infection. Implication: These findings highlight the importance of individualized treatment selection, complete lesion excision, and the use of HPV vaccination as part of a comprehensive strategy to minimize recurrence and improve long-term outcomes.Novelty: This review provides an integrated overview of viral, surgical, and immunological factors influencing cervical lesion recurrence, emphasizing the importance of combining optimal surgical technique with preventive immunization.
Determinants of Mortality in Epithelial Ovarian Cancer: Systematic Review and Meta-analysis (Last 5 Years) Kusuma, Fitriyadi; Suryoadji, Kemal Akbar; Mulansari, Nadia Ayu; Soloan, Garry; Sini, Kieran Pasha Ivan; Wulandari, Anisa Saphira; Arifa, Vira Nur; Masrie, Marshaly Safira; Faqih, Fahrayhansyah Muhammad; Wirawan, Bintang
Journal of Applied Holistic Nursing Science Vol. 2 No. 2 (2026): February 2026
Publisher : CV. CENDIKIA JENIUS INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70920/jahns.v2i2.375

Abstract

ABSTRACT Background: Ovarian cancer, ranking third among gynecologic cancers, poses a significant global health challenge. Despite affecting over 239,000 annually and causing 150,000 deaths, the overall survival rate is 45.6%. Variability in survival rates across different stages necessitates a detailed understanding of contributing factors. This systematic review and meta-analysis explores recent research to illuminate crucial aspects influencing epithelial ovarian cancer (EOC) patient outcomes. Methods: A protocol registered in PROSPERO (ID: CRD42024502616) guided this systematic review, focusing on cohort studies examining prognostic factors for EOC mortality. Eligibility criteria included relevance to mortality risk, clear extraction methods, and English language. A PRISMA-guided search with the keywords “((Ovarian Cancer) AND (Mortality) AND (Risk)” across Scopus, PubMed, and Cochrane. Evaluation of 66,191 samples from 16 cohort studies identified several key prognostic factors for mortality in epithelial ovarian cancer (EOC). Results: Advanced FIGO stage (III-IV) and high-grade serous histology were significant predictors of higher mortality, with stage III-IV showing a risk ratio of 3.62 (95% CI 3.35–3.91). Older age, greater inflammation (higher BMI, smoking), and bilateral tumors also increased mortality risk. Additionally, lifestyle factors like reduced physical activity and rural living, as well as treatment-related factors such as perioperative red blood cell transfusion, were associated with poorer survival outcomes. This systematic review provides comprehensive insights into the complex landscape of EOC survival. Key prognostic factors for mortality in EOC patients include advanced cancer stage, high-grade serous histology, older age, inflammation, and bilateral tumors. Treatment factors such as perioperative transfusion and neoadjuvant chemotherapy intensity also play a critical role. Conclusion: These findings highlight the need for personalized treatment strategies based on these factors to improve survival outcomes for EOC patients.
Co-Authors Bintang Wirawan Faqih, Fahrayhansyah Muhammad Fitriyadi Kusuma Gung Binathara, Geraldus Sigap Masrie, Marshaly Safira Nadia Ayu Mulansari, Nadia Ayu Sini, Kieran Pasha Ivan Soloan, Garry Suryoadji, Kemal Akbar Tahsya Hermawan, Tsaniya Meidini Wulandari, Anisa Saphira