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All Journal African Multidisciplinary Journal of Sciences and Artificial Intelligence African Journal of Sciences and Traditional Medicine
Emmanuel Kinsley Chinedu
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Nursing Public Health

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Organocatalysis: A Revolutionary Approach in Organic Synthesis Kabiru Bashir Ahmad; Emmanuel Kinsley Chinedu; Reuben Pambani; Ansar Bilyaminu Adam; Musa Yahaya Abubakar; Ruslan Shamsuddeen
African Multidisciplinary Journal of Sciences and Artificial Intelligence Vol 1 No 1 (2024): African Multidisciplinary Journal of Sciences and Artificial Intelligence
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/amjsai.v1i1.3518

Abstract

Organocatalysis has emerged as a powerful tool in organic synthesis, enabling the efficient and selective formation of complex molecules. This review highlights the recent advances in organocatalysis, including the development of new catalysts, reactions, and applications. The advantages and limitations of organocatalysis are discussed, and its potential for scalability and sustainability is evaluated. The review also explores the mechanistic insights and future directions in this field, demonstrating the versatility and impact of organocatalysis in modern organic synthesis. This paradigm shift not only addresses the pressing environmental challenges but also paves the way for more innovative and economically viable synthetic strategies. As a result, organic synthesis is poised to play a crucial role in advancing pharmaceuticals, materials science, and agrochemicals, driving forward a more sustainable and resilient chemical industry.
Natural Products as Leads for Neglected Trophical Diseases (NTDs) Treatment; A Chemical and Biological - Review Twan Sale Mathew; Emmanuel Kinsley Chinedu; Muhammed Haladu; Musa Yahaya Abubakar; Ansar Bilayamin Adam; Ruslan Shamsuddeen
African Multidisciplinary Journal of Sciences and Artificial Intelligence Vol 1 No 1 (2024): African Multidisciplinary Journal of Sciences and Artificial Intelligence
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/amjsai.v1i1.3735

Abstract

Natural compounds are mostly found in medicinal plants that are used to treat various ailments. They are distinguished by their structural complexity and diversity, which span a wide chemical universe and present both benefits and shortcomings to the process of discovering novel drugs. Neglected tropical diseases (NTDs) are common tropical diseases that impact over one billion people globally. Numerous pathogens, such as bacteria, fungi, viruses, parasites, and poisons, are responsible for them. Natural products have always been important in the search for new drugs to treat differents diseases including NTDs. The purpose of this chapter is to provide an update on the evaluation of both the chemical and biological properties of natural compounds that have been extracted and identified from plant sources, and may be utilized as viable candidates for the development of new drugs treat NTDs with lower incidence such as: Buruli ulcer, dracunculiasis, echinococcosis, food-borne trematodiases, leprosy, lymphatic filariasis, parasitics, schistosomiasis, soil-transmitted helminthiases, taeniasis/cysticercosis, trachoma and yaws. This chapter also intends to make a critical review on the chemical analysis of natural products’ structure and classification, biological evaluation of natural products’ antiparasitic, anti-inflammatory and immunomodulatory activities. In conclusion, Natural products continue to be a key source of fresh ideas for treating NTDs. Their distinct methods of action and variety of chemicals offer potential for the development of new treatments.
Challenges and Opportunities in Repurposing Natural Products for the Treatment of Neglected Trophical Diseases: A Review of Scaffold Optimization Strategies Musa Yahaya Abubakar; Twan Sale Mathew; Ruslan Shamsuddeen; Saeed Abdullahi; Ansar Bilyamin; Emmanuel Kinsley Chinedu
African Journal of Sciences and Traditional Medicine Vol 1 No 1 (2024): African Journal of Sciences and Traditional Medicine
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajstm.v1i1.3725

Abstract

Neglected Tropical Diseases (NTDs) are serious health issues that affect the entire world, especially in low-income tropical and subtropical areas, yet they do not get enough facilities. Natural items have great potential for treating NTD because of their varied chemical scaffolds. Nevertheless, there are a number of difficulties in optimizing these scaffolds for drug development. Attempts at synthesis and modification are complicated by the structural complexity of natural compounds. Economic and regulatory hurdles also obstruct advancement. Despite these difficulties, there are plenty of chances. Natural products are a significant source of structural variety that makes them ideal for drug discovery. developments in biotechnology and synthetic biology. Sustainable production is improved via biotechnology. Targeted optimization is made easier by advances in computer power and molecular understanding. Research collaborations can expedite the process of discovery and development. Finding efficient scaffolds can be done quickly by looking for NTD activity in already-existing natural product libraries. By tackling these issues scientifically and cooperatively, we can develop novel, practical, and affordable treatments for non-traumatic disabilities (NTDs), which will eventually improve the health of impacted communities.
Co-Authors Ansar Bilayamin Adam Ansar Bilyamin Ansar Bilyaminu Adam Kabiru Bashir Ahmad Muhammed Haladu Musa Yahaya Abubakar Reuben Pambani Ruslan Shamsuddeen Saeed Abdullahi Twan Sale Mathew