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All Journal African Journal of Biochemistry and Molecular Biology Research
Akafa Andes Tensaba
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Biochemistry, Genetics & Molecular Biology

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Exploring the Links between Genetics and Diseases: Review Isaac John Umaru; Chabunda Endashi Esseyi; Kerenhappuch Isaac Umaru; Akafa Andes Tensaba; Dafup Kadel Istifanus; David Umahi
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3482

Abstract

This review article delves into the intricate connections between genetics and diseases, exploring how genetic variations influence the development and progression of various health conditions. The paper provides a comprehensive overview of the latest research in the field of genomics, highlighting key discoveries that have advanced our understanding of the genetic underpinnings of diseases. We examine both monogenic and polygenic disorders, illustrating how mutations in single genes or complex interactions among multiple genes contribute to disease phenotypes. Furthermore, the review discusses the role of epigenetics and gene-environment interactions in modulating disease risk and expression. By synthesizing current findings, this article underscores the potential of genetic research in paving the way for personalized medicine and targeted therapies, offering new avenues for diagnosis, treatment, and prevention of genetic diseases. The review also addresses the ethical and societal implications of genetic research, emphasizing the importance of responsible scientific practices and equitable access to genetic advancements.
Ameliorative Effects of Stem bark Extract of Pterocarpus erinaceus on Indomethacin-induced Ulcer Isaac John Umaru; Otitoju Olawale; Emmanuel Chikodiri Okoli; Akafa Andes Tensaba; Kerenhappuch Isaac Umaru; Dafup Kadel Istifanus; David Umahi
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3487

Abstract

Pterocarpus erinaceus serve as a medicinal plant to many populations of Nigeria and West Africa. The stem bark, leaves, and root bark have been studied for their antioxidant, antimalaria, antiulcerogenic, and antibacterial properties. The study examined the anti-ulcerogenic properties of Pterocarpus erinaceus stem bark extracts in albino rats with indomethacin-induced ulcers and hepatic biochemical changes. The anti-ulcer effect was determined by histopathological examination of ulcerated rats treated with the stem bark extracts in a period of 14-days. The three extracts did not cause elevation of key liver biomarkers such as AST, ALT, and ALP. Hence are considered not non-toxic at the dose and duration given. The leaf extract exhibited anti-ulcer effect at 100, 200, and 300 mg/kg.
Co-Authors Chabunda Endashi Esseyi Dafup Kadel Istifanus David Umahi Emmanuel Chikodiri Okoli Isaac John Umaru Kerenhappuch Isaac Umaru Otitoju Olawale