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All Journal African Journal of Biochemistry and Molecular Biology Research
Emmanuel Chikodiri Okoli
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology

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Ameliorative Effects of Stem bark Extract of Pterocarpus erinaceus on Indomethacin-induced Ulcer Isaac John Umaru; Otitoju Olawale; Emmanuel Chikodiri Okoli; Akafa Andes Tensaba; Kerenhappuch Isaac Umaru; Dafup Kadel Istifanus; David Umahi
African Journal of Biochemistry and Molecular Biology Research Vol 1 No 1 (2024): African Journal of Biochemistry and Molecular Biology Research
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/ajbmbr.v1i1.3487

Abstract

Pterocarpus erinaceus serve as a medicinal plant to many populations of Nigeria and West Africa. The stem bark, leaves, and root bark have been studied for their antioxidant, antimalaria, antiulcerogenic, and antibacterial properties. The study examined the anti-ulcerogenic properties of Pterocarpus erinaceus stem bark extracts in albino rats with indomethacin-induced ulcers and hepatic biochemical changes. The anti-ulcer effect was determined by histopathological examination of ulcerated rats treated with the stem bark extracts in a period of 14-days. The three extracts did not cause elevation of key liver biomarkers such as AST, ALT, and ALP. Hence are considered not non-toxic at the dose and duration given. The leaf extract exhibited anti-ulcer effect at 100, 200, and 300 mg/kg.
Co-Authors Akafa Andes Tensaba Dafup Kadel Istifanus David Umahi Isaac John Umaru Kerenhappuch Isaac Umaru Otitoju Olawale