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All Journal Jurnal Ilmiah Kesehatan Masyarakat Jurnal Sains dan Teknologi Journal of Pharmaceutical and Sciences.
Astriani Natalia Br Ginting
Universitas Prima Indonesia
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Uji Aktivitas Antijamur Nanopartikel Zink Oksida (ZnO) Ekstrak Kulit Jengkol terhadap Candida Albicans Ica Dwi Patricia; Vera Estefania Kaban; Astriani Natalia Br Ginting
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 1 (2026): Februari 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i1.7539

Abstract

Natural materials are increasingly being used as sources of bioactive chemicals due to increased concerns about safety, sustainability, and environmental effect. Jengkol peel is one such natural material with potential because it contains various secondary metabolites compounds that have biological activity. On the other hand, Candida albicans fungal infections remain a health problem, while conventional antifungal options are limited and have the potential to cause side effects. Zinc oxide (ZnO) nanoparticles are known to have broad antimicrobial activity, and their synthesis can be carried out in an environmentally friendly manner through a green synthesis approach using natural materials. This study aims to test the antifungal activity of ZnO nanoparticles synthesized using jengkol peel extract against Candida albicans. The study was conducted experimentally. Antifungal activity was tested using the well diffusion method with various concentrations of ZnO nanoparticles. The results showed the formation of an inhibition zone around the well, indicating the antifungal activity of ZnO nanoparticles. The increase in ZnO nanoparticle concentration is directly proportional to the increase in inhibition zone diameter, with the highest inhibition of 14 mm categorized as moderate activity. This study proves that jengkol-based ZnO nanoparticles have the potential to be developed as an environmentally friendly alternative antifungal agent.
Pengembangan Seedian Emulgel Kombinasi Fraksi Aktif Daun Kersen dan Kulit Kayu Manis Untuk Ulkus Diabetikum Brigita Julianti Manalu; Novitaria Br Sembiring; Astriani Natalia Br Ginting
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1361

Abstract

Introduction: Diabetic ulcer is a serious complication of diabetes mellitus that is often accompanied by bacterial infections, necessitating effective topical therapy. Kersen leaves (Muntingia calabura L.) and cinnamon bark (Cinnamomum sp.) are known to contain bioactive compounds with antibacterial potential. Aim: This study aims to develop and evaluate the antibacterial activity of an emulgel formulation containing a combination of active fractions from kersen leaves and cinnamon bark as a candidate for topical therapy for diabetic ulcers. Method: The active fractions were obtained through extraction and fractionation processes, then formulated into an emulgel at varying concentrations of 10%, 30%, 50%, 60%, and 70%. Antibacterial activity was tested against Staphylococcus aureus using the agar disk diffusion method, with clindamycin as a positive control and the emulgel base as a negative control. Result: The results showed that the emulgel began to exhibit antibacterial activity at a concentration of 50%, with an average inhibition zone diameter of 12.96 mm. Increasing the concentration to 60% and 70% enhanced the inhibition zones to 14.00 mm and 15.24 mm, respectively. Clindamycin produced an inhibition zone of 29.57 mm, while the negative control showed no inhibitory activity. Conclusion: The emulgel combination of active fractions from kersen leaves and cinnamon bark possesses concentration-dependent antibacterial activity and has the potential to be developed as a topical herbal preparation to support diabetic ulcer therapy.
Uji Total Flavonoid dan Aktivitas Antioksidan Fraksi Daun Brotowali sebagai Diabetes Ulkus Jhon Evan Iskandar Manullang; Novitaria Br Sembiring; Astriani Natalia Br Ginting
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 2 (2026): April 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i2.7866

Abstract

Diabetic ulcers are a chronic complication of diabetes mellitus characterized by impaired wound healing due to increased oxidative stress. One therapeutic approach that can be developed is the use of medicinal plants with antioxidant activity, such as Tinospora crispa leaves (Tinospora crispa), which contain flavonoids. This study aimed to determine the total flavonoid content and antioxidant activity of Tinospora crispa leaf fractions. Extraction was carried out using 96% ethanol, followed by fractionation using n-hexane, ethyl acetate, and water. Flavonoid content was determined using UV-Vis spectrophotometry using quercetin as a standard at a wavelength of 430.5 nm, while antioxidant activity was tested using the DPPH method. The results showed that the Tinospora crispa leaf aqueous fraction contained flavonoids of 0.2179 mg QE/g, with a linear calibration curve (R² = 0.997). Furthermore, the aqueous fraction demonstrated very strong antioxidant activity with an IC₅₀ value of ±16 µg/mL. Based on these results, the water fraction of brotowali leaves has the potential to be a source of natural antioxidants that can support the healing of diabetic ulcers by suppressing oxidative stress.
Formulasi dan Evaluasi Sediaan Topikal Nanogel Daun Kipahit (Tithonia diversifolia) dan aktivitas sebagai Antimikroba Faza Fauzan Azima; Vera Estefania Kaban; Astriani Natalia Br Ginting
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 3 (2026): Juni 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i3.8202

Abstract

Candida albicans is a fungal microorganism that can cause candidiasis and requires the development of alternative therapies derived from natural products. Bitter leaf (Tithonia diversifolia) contains bioactive compounds such as flavonoids, alkaloids, and tannins that have potential antifungal activity. This study aimed to formulate and evaluate a nanogel containing ethanol extract of Tithonia diversifolia leaves and to assess its antifungal activity against Candida albicans. The extract was obtained through maceration using 70% ethanol and formulated into nanogels using a modified emulsification-diffusion method at concentrations of 5%, 10%, and 15%. The formulations were evaluated for organoleptic properties, homogeneity, pH, spreadability, viscosity, particle size, and antifungal activity using the agar well diffusion method. The results showed that all nanogel formulations exhibited good physical characteristics and met the requirements for topical application. Particle size analysis revealed sizes ranging from 755.75 to 847.29 nm, indicating that all formulations met the criteria for nanoparticulate systems. All formulations demonstrated inhibitory activity against the growth of Candida albicans, with inhibition tending to increase as the extract concentration increased. The incorporation of bitter leaf extract into a nanogel system may improve the stability and delivery of bioactive compounds compared with conventional formulations. Therefore, the ethanol extract nanogel of Tithonia diversifolia leaves has the potential to be developed as a natural-based topical antifungal formulation.
Perbandingan Pelarut Etanol dan Gliserin pada Ekstrak Etanol Buah Bit (Beta vulgaris L.) terhadap Pertumbuhan Bakteri Staphylococcus aureus Tiani Nduru; Astriani Natalia Br Ginting; Roy Indrianto Bangar
SEHATMAS: Jurnal Ilmiah Kesehatan Masyarakat Vol. 5 No. 1 (2026): Januari 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/sehatmas.v5i1.7167

Abstract

Infectious diseases caused by Staphylococcus aureus remain a significant health concern globally, with increasing antibiotic resistance necessitating alternative antimicrobial agents. Beetroot (Beta vulgaris L.) contains bioactive compounds with potential antibacterial properties. This study investigated the antibacterial activity of beetroot ethanol extract against Staphylococcus aureus and compared the effects of ethanol and aqueous solvents in the extraction process. Beetroot simplicia was prepared and characterized according to standard protocols. Extraction was performed using 70% ethanol maceration method, yielding 20.29% extract. Phytochemical screening and thin-layer chromatography identified secondary metabolites. Antibacterial activity was evaluated using the Kirby-Bauer disc diffusion method at concentrations of 5%, 10%, and 15%, both with and without glycerin addition. Simplicia characterization met quality standards with moisture content of 0.25%. TLC analysis revealed alkaloids, flavonoids, terpenoids, steroids, saponins, and tannins. Beetroot ethanol extract demonstrated concentration-dependent antibacterial activity with inhibition zones of 8.1±0.87 mm (5%), 10.2±0.71 mm (10%), and 13.9±0.79 mm (15%). Glycerin-supplemented extracts showed comparable activity. Beetroot ethanol extract exhibits significant antibacterial activity against Staphylococcus aureus, supporting its potential as a natural antimicrobial agent for pharmaceutical applications.
Aktivitas Antijamur Nanopartikel Zinc Oxide (ZnO) yang Disintesis Menggunakan Ekstrak Kulit pinang Muda (Areca catechu L.) terhadap Candida albicans Arlimawati Pakpahan; Vera Estefania Kaban; Astriani Natalia Br Ginting
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1610

Abstract

Introduction: Infections caused by Candida albicans continue to pose serious clinical problems, largely due to increasing resistance to conventional antifungal drugs and the limited availability of therapeutic options. Therefore, the development of novel, effective, and safe antifungal agents using nature-based nanotechnology approaches is urgently needed. Objective: This study aimed to synthesize Zinc Oxide (ZnO) nanoparticles using a green synthesis method with aqueous extract of young areca nut peel (Areca catechu L.) and to evaluate their antifungal activity against Candida albicans. Methods: The research procedures included raw material and extract characterization, functional group identification using FTIR, ZnO nanoparticle synthesis, and antifungal activity testing using the well diffusion method at concentrations of 25, 50, 100, 125, 250, and 500 mg/mL. Data were analyzed using SPSS at a significance level of 0.05. Results: The biosynthesized ZnO nanoparticles exhibited inhibitory activity against Candida albicans at all tested concentrations. The inhibition zone diameter increased from 12.1 ± 0.65 mm at the lowest concentration to 20.2 ± 1.14 mm at the highest concentration. Statistical analysis revealed significant differences among concentrations (p < 0.05), indicating a clear dose-response relationship.Conclusion: ZnO nanoparticles biosynthesized using young areca nut peel extract possess significant antifungal activity against Candida albicans and have the potential to be developed as an environmentally friendly alternative agent for managing fungal infections. However, further characterization is required to confirm the physicochemical properties of the resulting nanoparticles
Co-Authors Arlimawati Pakpahan Brigita Julianti Manalu Faza Fauzan Azima Ica Dwi Patricia Jhon Evan Iskandar Manullang Novitaria Br Sembiring Novitaria Br Sembiring Roy Indrianto Bangar S Tiani Nduru Vera Estefania Kaban