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All Journal METHODIKA: Jurnal Teknik Informatika dan Sistem Informasi Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Pengabdian Farmasi Malahayati (JPFM) Jurnal Pembelajaran dan Biologi Nukleus MEDALION JOURNAL: Medical Research, Nursing, Health and Midwife Participation Radinka Journal of Health Science
Meita Mahardianti
Biomedical Engineering, Faculty of Industrial Technology, Institut Teknologi Sumatera
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Veterinary

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POTENSI HUBUNGAN BLASTOCYSTIS SPP. DENGAN SINDROM IRITASI USUS Meita Mahardianti; Ismalia Husna; Anisa Mulia Anasis
Jurnal Ilmu Kedokteran dan Kesehatan Vol 9, No 4 (2022): Volume 9 Nomor 4
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v9i4.7364

Abstract

Blastocystis spp. adalah parasit anaerobik usus dan salah satu protista usus yang paling umum pada manusia. Tiga belas subtipe (ST1-ST13), dengan sembilan subtipe pertama telah ditemukan pada manusia. Status patogen dari Blastocystis spp. secara luas diperdebatkan dalam literatur untuk menentukan apakah mikroorganisme ini adalah organisme yang benar-benar patogen atau komensal, meskipun saat ini studi baru telah melaporkan mengenai Blastocystis spp. sebagai patogen. IBS adalah gangguan usus fungsional yang ditandai dengan nyeri perut kronis atau berulang yang terkait dengan perubahan kebiasaan usus. Oleh karena itu, dilakukan sebuah studi pustaka di database elektronik, perpustakaan, portal jurnal, dll untuk laporan tentang hubungan antara parasit ini dan IBS. Pemilihan tidak dibatasi oleh tanggal, tetapi artikel yang diterbitkan dalam sepuluh tahun terakhir lebih diutamakan. Blastocystis spp. diketahui tidak menginvasi mukosa kolon tetapi menyebabkan gangguan pada fungsi barier dan permeabilitas. Protease dari Blastocystis sp. dapat memainkan peran kunci dalam patogenesis IBS. Gangguan ini dapat dikaitkan dengan modifikasi dari lumen mikrobiota pada pasien IBS dibandingkan dengan pasien yang sehat. Saat ini, penjelasan paling meyakinkan namun belum memuaskan untuk patogenisitas Blastocystis spp. adalah korelasi dari subtipe (ST) dengan virulensi. Namun demikian, Blastocystis spp. hanya dapat dianggap sebagai indikator disbiosis.
FEW-SHOT LEARNING FOR AML CELL CLASSIFICATION USING PROTOTYPICAL NETWORKS Dirgayussa, I Gde Eka; Herman, Kevin Elfancyus; Nugroho, Doni Bowo; Sekar Asri Tresnaningtyas; Meita Mahardianti; Nurul Maulidiyah; Rafli Filano; Rudi Setiawan; Muhammad Artha Jabatsudewa Maras; Yohanssen Pratama
METHODIKA: Jurnal Teknik Informatika dan Sistem Informasi Vol. 11 No. 2 (2025): Volume 11 Nomor 2 Tahun 2025
Publisher : Universitas Methodist Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46880/mtk.v11i2.4650

Abstract

Accurate blood cell classification is crucial for diagnosing Acute Myeloid Leukemia (AML) but limited medical data poses challenges for traditional machine learning models. This study presents a Few-Shot Learning (FSL) framework utilizing a Prototypical Network architecture with a ResNet-34 backbone to classify AML blood cell types from microscopic images. In this study, we utilize datasets consisting of 15 morphologically distinct cell classes. A 15-way, 5-shot, 5-query episodic setup was adopted to simulate data-scarce conditions. Evaluation via 5-fold cross-validation yielded strong performance, with an average accuracy of 97.76%, precision of 98.78%, recall of 96.55%, and F1-score of 97.76%. FSL training times were consistent (4.22–4.26 minutes per fold), and t-SNE along with confusion matrices confirmed the model’s ability to distinguish similar cell types. To validate the approach, its performance was compared with a conventional supervised CNN using the same ResNet-34 backbone. The FSL model outperformed the CNN across all metrics such as accuracy (98.32% vs. 77.25%), precision (98.55% vs. 76.87%), recall (98.31% vs. 78.66%), and F1-score (98.33% vs. 75.26%), while also requiring far less training time (~4.24 min/fold vs. ~420 min total). These results highlight the promise of FSL based methods for accurate, efficient, and scalable hematologic diagnostics in data limited settings.
Factors for Decreasing Cholinesterase Enzyme Activity in Farmers in Trimurdjo District, Central Lampung Regency Yusmutia, Annisa; Meita Mahardianti; Tiwi Lestari
RADINKA JOURNAL OF HEALTH SCIENCE Vol. 1 No. 2 (2023): Radinka Journal of Health Science (RJHS)
Publisher : RADINKA JAYA UTAMA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56778/rjhs.v1i2.157

Abstract

Blood cholinesterase level is the amount of active cholinesterase enzyme in blood plasma and red blood cells. Early detection of pesticide poisoning is by checking the cholinesterase enzyme in the blood. The purpose of this study was to determine the factors affecting cholinesterase enzyme activity in farmer groups in the Trimurdjo district and Central Lampung district. This study uses quantitative research that uses a cross-sectional approach, and the subject of this research is the farmers of Trimurjo District, Central Lampung, as many as 86 farmers. The results showed that there was a significant relationship between cholinesterase enzyme activity and nutritional status variables, pesticide doses, and the highest risk obtained was the variable use of personal protective equipment (PPE) (PR = 0.205, 95% CI = 0.048 - 0.866) in farmers in Trimurjo District, District of Trimurjo Regency. Central Lampung has been controlled by confounding variables. The results showed that the activity of the cholinesterase enzyme in farmer groups who used pesticide doses that were not under SOP (Standard Operating Procedures), did not use personal Protective Equipment (PPE) when spraying, and had poor nutritional status had a higher risk of experiencing pesticide poisoning or cholinesterase enzyme activity. low. Efforts that can be made to reduce the number of farmers experiencing pesticide poisoning or low cholinesterase enzyme activity are by conducting counseling by related sectors.
Phytochemical Profiling and Granule Formulation of Green Betel Leaf (Piper betle L.) Extract for Potential Bio-Larvicidal Application Meita Mahardianti; Puspa Rini Cahaya Nurani; Sekar Asri Tresnaningtyas; Suryadi Islami
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 11, No 4: Jurnal Pembelajaran Dan Biologi Nukleus December 2025
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v11i4.8448

Abstract

Background: The increasing spread of Aedes aegypti as a vector of dengue disease has encouraged the exploration of safer, plant-based larvicidal materials. This study aimed to identify the phytochemical constituents of green betel leaf (Piper betle L.) extract and to develop a bio-larvicidal granule formulation as a modified dosage form. Phytochemical screening was conducted to identify bioactive compounds potentially associated with larvicidal activity. Methodology: Granules were prepared using the wet granulation method, employing polyvinylpyrrolidone (PVP) as a binder and lactose as a filler. The formulated granules were further evaluated through physical characterization tests, including flow rate, angle of repose, and dispersion time, to assess their suitability as a granular dosage form. Findings: The results demonstrated that all formulations exhibited acceptable flow properties, appropriate angles of repose, and rapid dispersion in water, indicating favorable handling and application characteristics. The flow rate test results showed that granules with concentration variations of 25%, 50%, 75%, and 100% exhibited flow rates of 71.4 g/s, 62.5 g/s, 50 g/s, and 45.5 g/s, respectively. Physical evaluation demonstrated that the granules had acceptable angles of repose (31°–36°) and dispersion time (20–25 seconds). Contribution: This study was conducted as a step toward developing an environmentally safe, natural-material-based biolarvicide
SOSIALISASI POLA HIDUP BERSIH DAN SEHAT DI LINGKUNGAN STBA ANAS BIN MALIK LAMPUNG Rosita Wati; Meita Mahardianti; Endah Endah; I Gde Eka Dirgayussa; Yusuf Maulana; Muhammad Artha Jabatsudewa Maras; Marsudi Siburian; Dea Callista Argiyanti; Sabri Alfa Majid; Marulitua Lumban Siantar
Jurnal Pengabdian Farmasi Malahayati (JPFM) Vol 9, No 1 (2026)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jpfm.v9i1.26043

Abstract

Kegiatan Pengabdian kepada Masyarakat (PKM) bertema “Sosialisasi Pola Hidup Bersih dan Sehat di Lingkungan STBA Anas Al Malik Lampung” yang dilaksanakan berjalan dengan baik dan lancar. Kegiatan meliputi tahap persiapan, pelaksanaan, praktik, dan evaluasi. Pada tahap persiapan dilakukan koordinasi serta penyusunan materi dan sarana pendukung. Tahap pelaksanaan dilakukan secara interaktif dengan penyampaian materi tentang pola hidup sehat dan kebersihan diri. Selanjutnya, peserta mengikuti praktik mencuci tangan yang benar sesuai standar kesehatan. Hasil evaluasi menunjukkan adanya peningkatan pemahaman, keterampilan, serta kesadaran peserta terhadap pentingnya perilaku hidup bersih dan sehat. Kegiatan ini juga menghasilkan luaran berupa peningkatan pengetahuan, keterampilan praktis, serta terjalinnya kerja sama antara ITERA dan STBA Anas Al Malik Lampung.
COMPOSITE ORAL FILM BASED ON STARCH/POLY(VINYL ALCOHOL)/CHITOSAN CONTAINING Garcinia mangostana PEEL EXTRACT FOR RECURRENT APHTHOUS STOMATITIS Ramadhani Azzahra; Sekar Asri Tresnaningtyas; Muhammad Artha Jabatsudewa Maras; Endah; Meita Mahardianti; Asy Syifa Labibah
MEDALION Journal: Medical Research, Nursing, Health and Midwife Participation Vol. 7 No. 2 (2026): June
Publisher : PT. Radja Intercontinental Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.21671607

Abstract

Recurrent aphthous stomatitis affects approximately 5–25% of the global population, and the limited residence time of conventional topical formulations often reduces therapeutic efficacy at oral mucosal lesions. Polymeric films have emerged as promising localized oral drug delivery systems because they prolong mucosal retention and enable sustained release of bioactive compounds. Garcinia mangostana peel, an abundant agricultural by-product, is rich in xanthones, flavonoids, tannins, and phenolic compounds with antibacterial potential, although its application in oral films remains limited. This study aimed to fabricate and characterize a composite oral film based on starch/poly(vinyl alcohol)/chitosan containing Garcinia mangostana peel extract and evaluate its physicochemical properties and antibacterial activity against Streptococcus mutans. Mangosteen peel extract was prepared by maceration using 70% ethanol, cassava starch was isolated by wet extraction, and composite films containing 0%, 1%, and 2% extract were fabricated using the solvent-casting method. Mangosteen peel extraction and cassava starch isolation yielded 10% and 25%, respectively, while phytochemical screening confirmed the presence of flavonoids, saponins, tannins, and phenolic compounds. All formulations produced intact films with uniform thickness (0.260–0.268 mm), neutral pH (6.410–7.393), and folding endurance exceeding 300 cycles. Increasing extract concentration significantly enhanced antibacterial activity (p = 0.009), with inhibition zones increasing from 5.31 ± 0.19 mm (F1) to 6.66 ± 0.38 mm (F2). The 2% extract-loaded formulation exhibited the most balanced physicochemical properties and antibacterial performance, highlighting the potential of starch/poly(vinyl alcohol)/chitosan composite films as naturally derived platforms for localized oral drug delivery in recurrent aphthous stomatitis.
Co-Authors Anisa Mulia Anasis Asy Syifa Labibah Dea Callista Argiyanti Dirgayussa, I Gde Eka Doni Bowo Nugroho Endah Endah Endah Herman, Kevin Elfancyus I Gde Eka Dirgayussa Ismalia Husna Marsudi Siburian Marulitua Lumban Siantar Muhammad Artha Jabatsudewa Maras Muhammad Artha Jabatsudewa Maras Muhammad Artha Jabatsudewa Maras Nurul Maulidiyah Puspa Rini Cahaya Nurani Rafli Filano Ramadhani Azzahra Rosita Wati Rudi Setiawan Sabri Alfa Majid Sekar Asri Tresnaningtyas Sekar Asri Tresnaningtyas Sekar Asri Tresnaningtyas Suryadi Islami Tiwi Lestari Yohanssen Pratama Yusmutia, Annisa Yusuf Maulana