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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Wan Tisya Muhaira
Institut Kesehatan Helvetia
Health Professions Medicine & Pharmacology Nursing Public Health

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Formulation and anti-aging efficacy of Ambon banana peel (Musa paradisiaca L.) extracts in a stick mask Adek Chan; Rufina; Wan Tisya Muhaira; Rasyidah Azzahra; Seri Rezeki; Muhammad Amin Nasution; Muhammad Andry
Pharmaciana Vol. 16 No. 1 (2026): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v16i1.31367

Abstract

Premature aging is often induced by oxidative stress resulting from ultraviolet (UV) radiation, which produces free radicals that harm lipids, proteins, and nucleic acids. The Ambon banana peel (Musa paradisiaca L.), often considered waste, is abundant in bioactive compounds such as flavonoids and phenolics, which demonstrate considerable antioxidant properties, thereby establishing it as a promising natural resource for anti-aging cosmetics. This study aimed to formulate and evaluate the efficacy of ethanol extract from Ambon banana peel (Musa paradisiaca L.) as a prospective anti-aging agent in stick mask formulations. The extract was obtained through maceration with 96% ethanol and subsequently analyzed for phytochemical constituents, antioxidant activity using DPPH and ABTS assays, and formulated into mask sticks with extract concentrations of 1% (F1), 3% (F2), and 5% (F3). Physical attributes such as organoleptic properties, uniformity, drying duration, and stability were assessed, while in vivo efficacy was examined in mice subjected to UV radiation, followed by histopathological analysis of epidermal thickness and melanocyte quantity. The extract demonstrated high levels of flavonoids (224.184 ± 0.252 mg QE/g) and phenolics (197.279 ± 0.250 mg GAE/g), with IC50 values of (12.88 ± 0.12) µg/mL and (17.15 ± 0.11) µg/mL in DPPH and ABTS assays, respectively. The stick mask formulations demonstrated adequate physical properties and stability, while in vivo evaluations indicated protective effects against UV-induced skin damage, particularly in the 5% formulation. The results indicate that Ambon banana peel (Musa paradisiaca L.) extract can be developed into an effective anti-aging mask stick with notable antioxidant and photoprotective properties.
Uji Ekstrak N-Heksan Daun Kirinyuh (Chromolaena Odorata L.) Terhadap Model Hewan Luka Bakar Derajat IIA Wan Tisya Muhaira; Luthvia Luthvia; Ningrum Wahyuni; Indah Afriwanty Simatupang; Bayu Ariatama
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 2 No. 4 (2024): Oktober: Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v2i4.514

Abstract

Chromolaena odorata referred to as Kirinyuh leaves, contains tannins, phenols, flavonoids, saponins, and steroids, which possess antibacterial properties against several pathogenic bacteria in humans, including Staphylococcus aureus, Escherichia coli, and Candida albicans. This investigation aimed to assess the moderate efficacy of the N-Hexan cream derived from Chromolaena odorata L. against Grade IIA burns in male Wistar rats. The research employed a laboratory experimental approach, encompassing the creation of an N-hexane extract from Chromolaena odorata L. and the formulation of various burn cream preparations of 20%, 25%, and 30% concentrations. Multiple tests are conducted: organoleptic assessment, homogeneity evaluation, and testing of pH, spreadability, adhesion, and burn. The research analysis employed a one-way ANOVA followed by the LSD test. The most effective dose for hastening burn wound healing is a 30% concentration of n-Hexan extract, resulting an average healing rate of 79%. The ANOVA test outcomes revealed a significant value of 0.000 (≤ 0.05) indicating a statistically significant difference in burn wound healing by day 21. The findings indicate that the N-Hexan extract from Chromolaena odorata L, exhibits a capacity to expedite the healing of burn wounds in male Wistar rats, as evidenced in both the 25% and the 30% concentration group.  
Profil Tingkat Pengetahuan Siswa SMA/SMK Yapim Kota Medan Tentang Pernikahan Dini Fahmi Irsan Nasution; Muhammad Yoga Dwi Anggara Sopiyan; Wan Tisya Muhaira; Ita Purnama; Nimas Ayu Retno Natasya
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 3 (2026): Mei : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i3.2525

Abstract

Early marriage remains an important adolescent health and social issue because it may be associated with early pregnancy, reproductive health complications, interrupted education, and psychosocial consequences. Adequate knowledge among school-age adolescents is therefore important for informed decision-making and prevention efforts. This study aimed to describe the level of knowledge regarding early marriage among students of YAPIM senior high/vocational high schools in Medan. A descriptive quantitative design was used. Data were collected on 11 April 2026 at YAPIM, Jalan Air Bersih, Medan, using a structured questionnaire. The questionnaire contained 10 multiple-choice knowledge items covering the definition of early marriage, contributing factors, health risks, social and psychological consequences, prevention, and the role of schools. Each correct answer was scored 1 and each incorrect answer 0. Knowledge was categorized as good (76–100%), moderate (56–75%), or poor (<56%). The study involved 30 students, consisting of 12 males (40.0%) and 18 females (60.0%). The knowledge distribution showed that 10 respondents (33.3%) had good knowledge, 12 (40.0%) had moderate knowledge, and 8 (26.7%) had poor knowledge. Thus, 73.3% of respondents were in the good or moderate categories, while more than one-quarter still had poor knowledge. The findings indicate that knowledge about early marriage among students was heterogeneous and that a meaningful proportion of students still requires strengthening of information, particularly concerning long-term reproductive, educational, psychological, and socioeconomic consequences. School-based reproductive health education involving teachers and health professionals may be used as a preventive strategy. Further studies with larger samples and analytical designs are recommended to examine factors associated with knowledge and to evaluate the effectiveness of educational interventions.
Co-Authors Adek Chan Bayu Ariatama Fahmi Irsan Nasution Indah Afriwanty Simatupang Ita Purnama Luthvia Luthvia Muhammad Amin Nasution Muhammad Andry Muhammad Yoga Dwi Anggara Sopiyan Nimas Ayu Retno Natasya Ningrum Wahyuni Rasyidah Azzahra Rufina Seri Rezeki