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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Riset Ilmu Kesehatan Umum dan Farmasi
Wan Tisya Muhaira
Institut Kesehatan Helvetia
Health Professions Medicine & Pharmacology Public Health

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Formulation and anti-aging efficacy of Ambon banana peel (Musa paradisiaca L.) extracts in a stick mask Adek Chan; Rufina; Wan Tisya Muhaira; Rasyidah Azzahra; Seri Rezeki; Muhammad Amin Nasution; Muhammad Andry
Pharmaciana Vol. 16 No. 1 (2026): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v16i1.31367

Abstract

Premature aging is often induced by oxidative stress resulting from ultraviolet (UV) radiation, which produces free radicals that harm lipids, proteins, and nucleic acids. The Ambon banana peel (Musa paradisiaca L.), often considered waste, is abundant in bioactive compounds such as flavonoids and phenolics, which demonstrate considerable antioxidant properties, thereby establishing it as a promising natural resource for anti-aging cosmetics. This study aimed to formulate and evaluate the efficacy of ethanol extract from Ambon banana peel (Musa paradisiaca L.) as a prospective anti-aging agent in stick mask formulations. The extract was obtained through maceration with 96% ethanol and subsequently analyzed for phytochemical constituents, antioxidant activity using DPPH and ABTS assays, and formulated into mask sticks with extract concentrations of 1% (F1), 3% (F2), and 5% (F3). Physical attributes such as organoleptic properties, uniformity, drying duration, and stability were assessed, while in vivo efficacy was examined in mice subjected to UV radiation, followed by histopathological analysis of epidermal thickness and melanocyte quantity. The extract demonstrated high levels of flavonoids (224.184 ± 0.252 mg QE/g) and phenolics (197.279 ± 0.250 mg GAE/g), with IC50 values of (12.88 ± 0.12) µg/mL and (17.15 ± 0.11) µg/mL in DPPH and ABTS assays, respectively. The stick mask formulations demonstrated adequate physical properties and stability, while in vivo evaluations indicated protective effects against UV-induced skin damage, particularly in the 5% formulation. The results indicate that Ambon banana peel (Musa paradisiaca L.) extract can be developed into an effective anti-aging mask stick with notable antioxidant and photoprotective properties.
Uji Ekstrak N-Heksan Daun Kirinyuh (Chromolaena Odorata L.) Terhadap Model Hewan Luka Bakar Derajat IIA Wan Tisya Muhaira; Luthvia Luthvia; Ningrum Wahyuni; Indah Afriwanty Simatupang; Bayu Ariatama
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 2 No. 4 (2024): Oktober: Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v2i4.514

Abstract

Chromolaena odorata referred to as Kirinyuh leaves, contains tannins, phenols, flavonoids, saponins, and steroids, which possess antibacterial properties against several pathogenic bacteria in humans, including Staphylococcus aureus, Escherichia coli, and Candida albicans. This investigation aimed to assess the moderate efficacy of the N-Hexan cream derived from Chromolaena odorata L. against Grade IIA burns in male Wistar rats. The research employed a laboratory experimental approach, encompassing the creation of an N-hexane extract from Chromolaena odorata L. and the formulation of various burn cream preparations of 20%, 25%, and 30% concentrations. Multiple tests are conducted: organoleptic assessment, homogeneity evaluation, and testing of pH, spreadability, adhesion, and burn. The research analysis employed a one-way ANOVA followed by the LSD test. The most effective dose for hastening burn wound healing is a 30% concentration of n-Hexan extract, resulting an average healing rate of 79%. The ANOVA test outcomes revealed a significant value of 0.000 (≤ 0.05) indicating a statistically significant difference in burn wound healing by day 21. The findings indicate that the N-Hexan extract from Chromolaena odorata L, exhibits a capacity to expedite the healing of burn wounds in male Wistar rats, as evidenced in both the 25% and the 30% concentration group.  
Co-Authors Adek Chan Bayu Ariatama Indah Afriwanty Simatupang Luthvia Luthvia Muhammad Amin Nasution Muhammad Andry Ningrum Wahyuni Rasyidah Azzahra Rufina Seri Rezeki