Journal of Urban Health Research
Vol. 1 No. 3 (2023): Journal of Urban Health Research

Pharmacogenomic Role in Cytochrome P450 Enzymes-Mediated Metabolism for Drug Therapy

Lonah (Department of Pharmacology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia)
Zita Arieselia (Department of Pharmacology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia)
Jonny Setiawan (Department of Surgery, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia)
Rita Dewi (Department of Chemistry and Biochemistry, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia)
Maria Dara Novi Handayani (Department of Chemistry and Biochemistry, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia)
Linawati Hananta (Department of Pharmacology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia)



Article Info

Publish Date
20 Aug 2023

Abstract

The rapid development of genetic science in recent decades has provided opportunities for clinical implementation. In the field of pharmacology, this opens up hope for the use of more targeted drugs with fewer side effects.Genetic variation's influence on pharmacological response has been well-established in practice. Patients' responses to pharmacological therapies can be varied, ranging from positive effects to serious adverse drug reactions (ADRs). Numerous genetic variations have been found to have a major impact on how people react to routinely prescribed medications over time, according to experts. In order to use this genetic information to inform treatment choices, a pharmacogenomic (PGx) profile can be used. PGx works on identifying and validating genomic variations that affect drug response. The generic approach to healthcare has given way to a more individualized and precise treatment paradigm as it has developed. Keywords: Adverse Drug Reactions - Genetic Variants – Pharmacogenomics - Cytochrome P450

Copyrights © 2023






Journal Info

Abbrev

juhr

Publisher

Subject

Medicine & Pharmacology

Description

The journal open-access electronic journal. JUHR is a peer-reviewed journal. The journal aims to improve discussion and dissemination of knowledge in the fields of medicine, health, and pharmacy in order to improve the health outcomes of urban populations. JUHR accepts manuscripts written in English ...