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Lonah, Lonah
Department Of Pharmacology, School Of Medicine And Health Sciences, Universitas Katolik Indonesia Atma Jaya, Jl. Pluit Raya No 2, Jakarta 14440
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Pharmacogenomic Role in Cytochrome P450 Enzymes-Mediated Metabolism for Drug Therapy Lonah; Zita Arieselia; Jonny Setiawan; Rita Dewi; Maria Dara Novi Handayani; Linawati Hananta
Journal of Urban Health Research Vol. 1 No. 3 (2023): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v1i3.4629

Abstract

The rapid development of genetic science in recent decades has provided opportunities for clinical implementation. In the field of pharmacology, this opens up hope for the use of more targeted drugs with fewer side effects.Genetic variation's influence on pharmacological response has been well-established in practice. Patients' responses to pharmacological therapies can be varied, ranging from positive effects to serious adverse drug reactions (ADRs). Numerous genetic variations have been found to have a major impact on how people react to routinely prescribed medications over time, according to experts. In order to use this genetic information to inform treatment choices, a pharmacogenomic (PGx) profile can be used. PGx works on identifying and validating genomic variations that affect drug response. The generic approach to healthcare has given way to a more individualized and precise treatment paradigm as it has developed. Keywords: Adverse Drug Reactions - Genetic Variants – Pharmacogenomics - Cytochrome P450
Prevalence of E-cigarette Users Students and Determinant Factors Affecting Their Use Behavior Zita Arieselia; Lonah Lonah; Linawati Hananta; Margareta Amelia; Fenny Mariska; Via Dolorosa Halilintar; Mariani Santosa; Meiliyana Wijaya; Rita Dewi; Jonny Setiawan; Monalisa Heryani
Bahasa Indonesia Vol 22 No 2 (2023): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v22i2.3820

Abstract

Pendahuluan: Prevalensi pengguna rokok tembakau pada remaja di Indonesia terus meningkat dari 7,2% pada tahun 2013 menjadi 9,1% pada tahun 2018, tingkat penggunaannya dianggap dapat dikurangi dengan menggunakan rokok elektrik. Namun sebenarnya rokok elektrik belum dapat disebut sebagai terapi berhenti merokok konvensional karena belum terdapat bukti yang cukup kuat dan dampak penggunaannya pada kesehatan yang tidak dapat dikesampingkan. Sementara itu, beberapa studi menunjukkan bahwa penggunaan rokok elektrik juga berdampak buruk bagi kesehatan. Tujuan penelitian ini adalah untuk mengetahui prevalensi pengguna dan faktor determinan yang memengaruhi perilaku penggunaan rokok elektrik pada mahasiswa. Metode: Studi ini merupakan penelitian kuantitatif dengan desain studi potong lintang atau cross sectional. Sampel yang digunakan sebanyak 410 orang dengan kriteria inklusi berupa mahasiswa aktif Unika Atma Jaya serta orang yang telah setuju untuk menjadi responden penelitian setelah membaca informed consent, dan kriteria eksklusi yaitu responden yang mengisi kuesioner dengan tidak lengkap. Perhitungan sampel dilakukan dengan metode proportional stratified random sampling. Pengambilan data responden menggunakan kuesioner secara daring melalui Google Forms. Analisis data menggunakan uji Chi Square dan Mann-Whitney.   Hasil: Prevalensi pengguna rokok elektrik pada mahasiswa sebesar 21,7%. Pada penelitian ini faktor yang berpengaruh pada keputusan penggunaan rokok elektrik adalah jenis kelamin (p<0,001), persepsi (p<0,001), tersedianya suplai (p<0,001), dukungan keluarga (p=0,002), dan dukungan teman (p<0,001). Simpulan: Tingginya tingkat penggunaan rokok elektrik pada mahasiswa menunjukkan perlunya informasi dan edukasi serta promosi kesehatan mengenai dampak merugikan dari penggunaan rokok elektrik.
Faktor Determinan yang Memengaruhi Perilaku Swadiagnosis dan Swamedikasi pada Mahasiswa Kedokteran dan Non-Kedokteran Lonah, Lonah; Halilintar, Via Dolorosa; Lauwly, Edlyn Edrea
Jurnal Kesehatan Vol 14 No 1 (2023): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v14i1.3328

Abstract

Self-diagnosis and self-medication are some of the global health phenomena. Inappropriate behavior may lead to harmful effects such as misdiagnosis, antibiotic resistance, etc. Determinant factors such as age, gender, ownership of health insurance, and others are influencing self-medication. This study aims to find the prevalence of self-diagnosis and self-medication and the determinant factors influencing self-medication in university students. This study used a cross-sectional method conducted in April 2021 online. Using consecutive non-probability sampling, the research sample successfully obtained was 184 medical and non-medical faculty students. The research data were analyzed in univariate and bivariate. The prevalence of self-diagnosis and self-medication was 64.1% and 46.7% in the medical faculty-student group, then 63.0% and 43.5% in the non-medical faculty-student group. Duration of illness in the medical faculty-student group, self-diagnosis, and support from other persons in both groups of respondents significantly correlated with self-medication (p-value
Assessing the Correlation between Spicy Food Consumption and Dyspepsia Symptoms in Medical and Health Students at Atma Jaya Catholic University of Indonesia Lonah; Divara Ariesta Sekar Suryadi, Made; Arieselia, Zita; Vitria Kurniawan, Sandy; Hananta, Linawati; Setiawan, Jonny; Surjono, Edward; Santosa, Mariani; Ulina Margareta Situmorang, Evi; Fan, Tan Fei; Yuliana; Budiyanti, Ecie
Journal of Urban Health Research Vol. 2 No. 3 (2024): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v2i3.5463

Abstract

Introduction: The capsaicin (8-methyl-N-vanillyl-6-nonenamide) content in spicy foods can trigger irritation and increase gastric acid production, which potentially damages the stomach mucous layer by increasing chloric acid levels (HCl). It is known that dyspepsia has a variety of causes and one of them can be triggered by the consumption of irritating foods, such as spicy foods. Therefore, the research was conducted to determine whether there was a significant relationship between the consumption of spicy foods and the incidence of dyspepsia in students of the Faculty of Medicine and Health Sciences at the Atma Jaya Catholic University of Indonesia. Methods: This research method is an analytical observational study using cross-sectional methods. The main variables in this study were dyspepsia, measured using the Rome III questionnaire, and the frequency of spicy food consumption measured using the Food Frequency Questionnaire (FFQ). The sample consisted of 107 people randomly selected. The data was analyzed statistically using the Fischer Exact test. Results: This study showed that 56.1% of respondents frequently eat spicy foods, while the majority, as much as 95.3%, also have dyspepsia. There was a significant correlation between spicy eating habits and dyspepsia, with a p-value of 0.014 (p<0.05). Conclusion: The results showed a statistically significant relationship between spicy eating habits and dyspepsia, so it is recommended for students to reduce spicy food consumption as it can affect the onset of dyspepsia. Keywords: dyspepsia - spicy foods - stomach - Rome III questionnaire - food frequency questionnaire
Hubungan Pengetahuan, Sikap, dan Perilaku Mengakses Situs Pornografi terhadap Nilai Akademis Pelajar SMA Kota Bogor Situmorang, Evi Ulina Margareta; Muhaji, J. Antonio; Pramono, Laurentius Aswin; Santosa, Mariani; Lonah; Nathaniel, Bryan
Jurnal Kedokteran Meditek Vol 30 No 2 (2024): MEI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v30i2.2545

Abstract

Mayoritas siswa SMP dan SMA di kota Jakarta dan Banten telah terpapar konten pornografi dan ditemukan peningkatan akses internet, terutama situs pornografi dan game online, di masa pandemi COVID-19. Penelitian ini bertujuan untuk mengetahui hubungan antara pengetahuan, sikap, dan perilaku mengakses situs pornografi serta bermain game online terhadap nilai akademis pada pelajar SMA di kota Bogor di masa pandemi COVID-19. Penelitian ini menggunakan desain potong-lintang dengan menggunakan data kuesioner yang diambil menggunakan aplikasi Zoom. Penelitian dilakukan di SMA X di Bogor dan melibatkan 107 responden dan metode analisis dalam penelitian ini adalah uji Chi-Square. Variabel bebas penelitian ini adalah pengetahuan, sikap, dan perilaku pelajar SMA. Adapun variabel terikat dalam penelitian ini adalah nilai akademis. Hasil analisis menunjukkan bahwa tidak ada hubungan yang signifikan antara pengetahuan, sikap, dan perilaku pelajar SMA dalam mengakses situs pornografi dan bermain game online dengan nilai akademis dengan nilai p = 0,109; 0,869; 0,258 secara berurutan. Disimpulkan dalam penelitian ini bahwa tidak ada hubungan antara pengetahuan, sikap, dan perilaku mengakses situs pornografi serta bermain game online terhadap nilai akademis pada pelajar SMA di kota Bogor di masa pandemi COVID-19.
ECONOMIC EVALUATION OF PHARMACOGENETIC-GUIDED PRESCRIBING IN PRECISION MEDICINE FOR CARDIOVASCULAR DISEASES: AN EVIDENCE SYNTHESIS FROM ASIAN COUNTRIES Halilintar, Via Dolorosa; Lonah, Lonah; Pujiyanto, Pujiyanto
Jurnal Manajemen Kesehatan Indonesia Vol 12, No 3 (2024): Desember 2024
Publisher : Magister Kesehatan Masyarakat, Fakultas Kesehatan Masyarakat, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jmki.12.3.2024.252-265

Abstract

Precision medicine, particularly pharmacogenetic-guided approaches, has emerged as a promising tool to optimize treatment strategies for cardiovascular disease. However, the economic evaluation of these approaches in Asian populations remains underexplored. This review study aimed to synthesize evidence on the implementation, methodology, research gaps, and limitations of pharmacogenetic-guided precision medicine in cardiovascular disease among the Asian population. A comprehensive search of electronic databases (Pubmed, Embase, Google Scholar and Cochrane Library) was conducted to identify relevant studies. The data were extracted and synthesized to address the study objectives A total of 12 studies were included in the analysis. Economic evaluation studies of pharmacogenetic-guided precision medicine in cardiovascular disease management in Asian countries are still limited, with precision medicine interventions often requiring high resources. The sampling process remains a challenge in conducting economic evaluation studies, and there are limitations in obtaining clinical outcome descriptions from real-world evidence, as most studies rely on literature reviews or modeling-based approaches. Furthermore, most studies use a provider or healthcare cost perspective, limiting the comprehensiveness of cost information. This evidence synthesis highlights the potential for pharmacogenetic-guided precision medicine in cardiovascular disease management among the Asian population, as well as the current challenges and limitations in conducting economic evaluations. Further research is needed to address these issues, develop more robust sampling strategies, obtain real-world clinical outcome data, and provide comprehensive cost information to inform clinical practice and healthcare policy in the region.
Transcriptional Regulation of CYP2D6 by Nrf2 and Its Implications in Breast Cancer Therapy: Bioinformatics and Experimental Evidence Ferbian Milas Siswanto; Maria Dara Novi Handayani; Lonah Lonah; Rita Dewi; Zita Arieselia; Linawati Hananta; Putu Suwarastra Andarisuta
The Indonesian Biomedical Journal Vol 17, No 1 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i1.3194

Abstract

BACKGROUND: Tamoxifen (TAM) resistance in patient with breast cancer is the leading cause of mortality among women globally. Cytochrome P450 2D6 (CYP2D6) is involved in the metabolism of TAM, and recently NF-E2-related factor 2 (Nrf2) has recently been found as its regulator. However, the impact of Nrf2-mediated CYP2D6 regulation in the context of breast cancer and TAM resistance are currently unknown. Therefore, this study was conducted to examine the role of CYP2D6 and Nrf2 in breast cancer prognosis. MEDTHODS: The roles of CYP2D6 and Nrf2 were investigated in the T47D breast cancer cell line and T47D-derived TAM-resistant cells by examining the gene expression, cell viability, and transcriptional regulation by quantitative reverse transcription polymerase chain reaction (qRT-PCR), MTT, and reporter gene assay, respectively. Additionally, comprehensive in silico analysis of the transcriptomic and clinical data from The Cancer Genome Atlas database were performed to uncover the prognostic role of CYP2D6 and its regulator in breast cancer patients. RESULTS: CYP2D6 mRNA was low and Nrf2 protein was high in TAM-resistant T47D cells compared to parental cells. Nrf2 knockdown upregulated CYP2D6 mRNA levels and enhanced the cytotoxicity of TAM. Similarly, in silico analysis revealed that low CYP2D6 mRNA and high Nrf2 protein were related to a lower probability of survival. The rs1238662089 within the identified Nrf2-binding site was found to greatly affect CYP2D6 expression levels, indicating its role as predictor for better prognosis. CONCLUSION: This study revealed for the first time that Nrf2 regulates CYP2D6expression in breast cancer and is involved in TAM sensitivity; thus, plays a role in breast cancer patient prognosis.KEYWORDS: breast cancer, CYP2D6, Nrf2, pharmacoepigenetics, SNPs
Antioxidant, Antimicrobial, Anti-Inflammatory, and Gut Microbiota Modulation Effects of Kombucha: a Literature Review Hananta, Linawati; Kurniawan, Sandy Vitria; Lonah; Arieselia, Zita; Surjono, Edward; Setiawan, Jonny; Lieputra, Andrew Adhytia; Puspa Bunardi, Dewi; Prayoga Tjendratama, Jason; Vallerie Satyadi, Richelle; Dewi, Rita
Journal of Urban Health Research Vol. 3 No. 2 (2025): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v3i2.6445

Abstract

Introduction: The interest in probiotics has increased significantly in recent years. While most probiotic-containing foods are dairy-based, an increasing number of non-dairy probiotic products have emerged, including kombucha. Kombucha is a fermented tea beverage originating from China, known for its high polyphenol content and potential health benefits. Methods: This literature review aims to provide a comprehensive understanding of the health benefits of kombucha. A systematic search of published studies was conducted using the keywords "kombucha," "antioxidant," "anti-inflammatory," "antimicrobial," and "gut microbiota modulation." Only English-language articles were included, and there was no restriction on publication date to capture the full spectrum of research on kombucha. Results: Kombucha exhibits significant antioxidant capacity, with green tea kombucha demonstrating the highest Ferric Ion Reducing Antioxidant Power (FRAP) due to its high polyphenol content. Additionally, kombucha possesses antimicrobial properties attributed to organic acids, lactones, aldehydes, fatty acids, and alkaloids, which act synergistically. It also exhibits anti-inflammatory effects by inhibiting nitric oxide production and downregulating pro-inflammatory cytokines such as IL-1β and TNF-α. Furthermore, kombucha modulates gut microbiota composition by inhibiting the growth of Gram-negative bacteria, leading to reduced systemic inflammation and oxidative stress. Conclusion: Kombucha, a traditional fermented tea, has notable health benefits, including antioxidant, antimicrobial, anti-inflammatory, and gut microbiota-modulating properties. These findings highlight its potential as a functional beverage for health promotion. Keywords: kombucha – antioxidant - anti-inflammatory – antimicrobial - gut microbiota modulation
The Relationship Between Halitosis and Anxiety in Medical Students Faculty of Medicine at Universitas Katolik Atma Jaya Latumahina, Cleo Michaela; Oktaria, Indriani; Lonah
Interdental Jurnal Kedokteran Gigi (IJKG) Vol. 21 No. 2 (2025): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Fakultas Kedokteran Gigi, Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v21i2.12197

Abstract

Introduction: Halitosis is a common occurrence among people. Halitosis can be classified as genuine halitosis, where the sufferer genuinely has bad breath that can be smelled by people around them, or as delusional halitosis, where the sufferer believes that they have bad breath but it cannot be smelled by people around them. Halitosis can become a significant problem, especially when the sufferer is socializing with others, due to the anxiety that their bad breath might disturb their conversation partners. This condition can lead to poor communication skills and actions of isolation or withdrawal from others. Material & methods: This study seeks to explore the perceptions and knowledge of medical students at Universitas Katolik Atma Jaya about halitosis, as well as its impact on their anxiety levels. Utilizing a cross-sectional design, the research involved 150 students from the Faculty of Medicine and Health Sciences, class of 2020–2022. Halitosis, as the independent variable, was assessed using the Halitosis Consequences Inventory (ICH), while anxiety, the dependent variable, was measured through the Depression Anxiety Stress Scale (DASS-42). Data analysis was conducted using the Spearman Rank Correlation Coefficient test. Results: Results of the research are 34.7% of Faculty of Medicine at Universitas Katolik Atma Jaya’s students from the class 2020-2022 experience halitosis, while 65.3% experience anxiety. 76.9% of students with halitosis also experience anxiety. The results of the Spearman Rank Correlation Coefficient test indicate a weak positive correlation (rs = 0.321) that is statistically significant (p = 0.000) between halitosis and anxiety. In other words, there is a tendency that an increase in halitosis will affect the increase in anxiety levels. Conclusion Relation between halitosis and anxiety is a synergy (positive correlation).   Halitosis has a moderate positive influence on anxiety among the students of the Faculty of Medicine at Universitas Katolik Atma Jaya, class of 2020. This indicates that students experiencing halitosis are concerned about their bad breath, which affects their social communication. Therefore, the approach to treating halitosis should include both physical treatment (halitosis) and mental health care.
Relationship between Knowledge and Attitude toward BSE Behavior for Early Breast Cancer Detection among Atma Jaya Hospital Nurses Zita Arieselia; Kurniawan, Sandy Vitria; Lonah; Linawati Hananta; Freggy Spicano Joprang; Edward Surjono; Jonny Setiawan; Andrew Liputra; Jennifer
Journal of Urban Health Research Vol. 3 No. 3 (2025): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v3i3.7114

Abstract

Introduction : Breast cancer is a frequently occurring type of cancer in Indonesia, with symptoms of rapid and invasive growth of abnormal cells. Deaths due to this cancer can be reduced by avoiding risk factors and early detection, such as through breast self-examination (BSE). Assessing knowledge, attitudes, and behavior regarding BSE is important for early detection, especially for nurses as health workers. This study assessed the relationship between knowledge and attitudes towards BSE behavior among Atma Jaya Hospital nurses.  Methods: This is an analytical observational study employing a cross-sectional design, involving 105 samples selected through purposive sampling according to established inclusion and exclusion criteria. The variables in this study include knowledge, attitude, and behavior regarding breast self-examination (BSE). Data were collected through the distribution of questionnaires to respondents and will be statistically analyzed using the Chi-Square test (x2) with a significance level (a) = 5%, and the analysis will be conducted using STATA software. Results: Based on the data analysis, there is no correlation between knowledge and attitude toward the practice of breast self-examination (BSE), with p-values of 0.623 and 0.994. Conclusion: There is no significant relationship between Knowledge and Attitude towards BSE Behavior. Keywords:  BSE Attitude - BSE Behavior - BSE Knowledge
Co-Authors Andrew Liputra Budiyanti, Ecie Divara Ariesta Sekar Suryadi, Made Edward Surjono Edward Surjono, Edward Evi Ulina Margaretha Situmorang Fan, Tan Fei Fenny Mariska Ferbian Milas Siswanto Freggy Spicano Joprang Halilintar, Via Dolorosa Irawan, Robi Jennifer Jhonvini, Lessya Jonny Setiawan Jonny Setiawan Jonny Setiawan Jonny Setiawan Kurniawan, Sandy Vitria Latumahina, Cleo Michaela Laurentius Aswin Pramono Lauwly, Edlyn Edrea Lieputra, Andrew Adhytia Linawati Hananta Linawati Hananta, Linawati Margareta Amelia Maria Dara Novi Handayani, Maria Dara Novi Mariani Santosa, Mariani Meiliyana Wijaya Monalisa Heryani Muhaji, J. Antonio Nathaniel, Bryan Oktaria, Indriani Prayoga Tjendratama, Jason Pujiyanto Pujiyanto Puspa Bunardi, Dewi Putu Suwarastra Andarisuta Rita Dewi Rita Dewi Rita Dewi Rita Dewi Dewi Vallerie Satyadi, Richelle Via Dolorosa Halilintar Wijaya, Meiliyana Yuliana Yuliana Zita Arieselia