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All Journal Majalah Kedokteran Bandung Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal of Urban Health Research
Jonny Setiawan
Departemen Ilmu Bedah Fakultas Kedokteran Universitas Atmajaya Jakarta
Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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Efektivitas Pemberian Metilprednisolon terhadap Pembentukan Seroma Pascaoperasi Mastektomi Modifikasi Radikal Setiawan, Jonny; Abdurahman, Maman; Rizki, Kiki A.
Majalah Kedokteran Bandung Vol 46, No 2 (2014)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1438.984 KB)

Abstract

Seroma adalah pengumpulan cairan serous di subkutis dan merupakan komplikasi pascaoperasi kanker payudara yang paling sering dijumpai. Insidensinya mencapai lebih dari 60%. Walaupun tidak mengancam jiwa, namun dapat menimbulkan morbiditas yang serius. Berbagai penelitian dilakukan untuk menentukan faktor risiko untuk mencegah timbulnya seroma. Saat ini, seroma terjadi karena proses inflamasi pascaoperasi. Teori inilah yang mendasari peranan antiinflamasi terhadap pembentukan seroma. Diketahui obat golongan glukokortikoid, memiliki peranan menghambat respons inflamasi. Tujuan penelitian ini untuk menilai efek profilaksis pemberian metilprednisolon perioperatif mastektomi terhadap pembentukan seroma. Penelitian ini merupakan uji klinis secara acak tersamar ganda terhadap 2 kelompok, yaitu antara kelompok karsinoma payudara stadium lokal lanjut yang diberikan metilprednisolon perioperatif mastektomi sebagai kelompok perlakuan dan kontrol. Penelitian ini dilakukan di Rumah Sakit Dr. Hasan Sadikin Bandung, periode April–Juli 2013. Subjek penelitian meliputi 30 wanita yang memenuhi kriteria inklusi dan dibagi menjadi dua kelompok, 15 pasien diberikan metilprednisolon dan 15 pasien sebagai kontrol. Penelitian ini menggunakan uji-t tidak berpasangan dan Mann Whitney. Didapatkan perbedaan rata-rata volume drainase hari ke-1, pada kelompok metilprednisolon sebanyak 104,7 mL dan pada kontrol sebanyak 158 mL, namun secara statistik tidak bermakna (p=0,053). Demikian pula dengan hari-hari selanjutnya dan total seroma, tidak didapatkan perbedaan yang bermakna. Simpulan, pemberian metilprednisolon tidak efektif menurunkan volume drainase seroma pascaoperasi mastektomi. [MKB. 2014;46(2):88–93]Kata kunci: Mastektomi, metilprednisolon, seromaEffectiveness of Methylprednisolone on Post-Operative Seroma Formation Following Radical Modified MastectomySeroma is a collection of serous fluid in the subcutaneous and is the most common complication of breast cancer surgery. The incidence is more than 60%. Although it is not life-threatening but it can cause serious morbidity. Various studies were conducted to determine the risk factors to prevent seroma formation. Currently, seroma occurrs due to postoperative inflammatory processes. This theory underlies the antiinflammatory role for seroma formation. Glucocorticoid drugs is known as playing a role in inhibiting the inflammatory response. The purpose of this study was to assess the prophylactic effect of perioperative administration of methylprednisolone on seroma formation. This study was a double-blind randomized control trial of 2 groups, i.e. a group of locally advanced breast carcinoma which were given methylprednisolone perioperatively as a treatment group and a control group. The research was conducted in Dr. Hasan Sadikin General Hospital Bandung from April to July 2013. Thirty women who met the inclusion criteria were included as subjects who were then divided into two groups: 15 women received methylprednisolone and 15 women serve as controls. This study used independent t and Mann-Whitney tests. There was a difference in the mean volume of drainage on day 1 between the methylprednisolone and control group as much as 104.7 mL and 158 mL, respectively, but not statistically significant (p=0.053). The same situation was also seen for the following days and total seroma, which was no significant difference was found. In conclusion, the use of methylprednisolone is not effective for reducing postoperative seroma drainage volume after mastectomy. [MKB. 2014;46(2):88–93]Key words: Mastectomy, methylprednisolone, seroma DOI:  10.15395/mkb.v46n2.279
Assessing the Correlation between Spicy Food Consumption and Dyspepsia Symptoms in Medical and Health Students at Atma Jaya Catholic University of Indonesia Lonah; Divara Ariesta Sekar Suryadi, Made; Arieselia, Zita; Vitria Kurniawan, Sandy; Hananta, Linawati; Setiawan, Jonny; Surjono, Edward; Santosa, Mariani; Ulina Margareta Situmorang, Evi; Fan, Tan Fei; Yuliana; Budiyanti, Ecie
Journal of Urban Health Research Vol. 2 No. 3 (2024): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v2i3.5463

Abstract

Introduction: The capsaicin (8-methyl-N-vanillyl-6-nonenamide) content in spicy foods can trigger irritation and increase gastric acid production, which potentially damages the stomach mucous layer by increasing chloric acid levels (HCl). It is known that dyspepsia has a variety of causes and one of them can be triggered by the consumption of irritating foods, such as spicy foods. Therefore, the research was conducted to determine whether there was a significant relationship between the consumption of spicy foods and the incidence of dyspepsia in students of the Faculty of Medicine and Health Sciences at the Atma Jaya Catholic University of Indonesia. Methods: This research method is an analytical observational study using cross-sectional methods. The main variables in this study were dyspepsia, measured using the Rome III questionnaire, and the frequency of spicy food consumption measured using the Food Frequency Questionnaire (FFQ). The sample consisted of 107 people randomly selected. The data was analyzed statistically using the Fischer Exact test. Results: This study showed that 56.1% of respondents frequently eat spicy foods, while the majority, as much as 95.3%, also have dyspepsia. There was a significant correlation between spicy eating habits and dyspepsia, with a p-value of 0.014 (p<0.05). Conclusion: The results showed a statistically significant relationship between spicy eating habits and dyspepsia, so it is recommended for students to reduce spicy food consumption as it can affect the onset of dyspepsia. Keywords: dyspepsia - spicy foods - stomach - Rome III questionnaire - food frequency questionnaire
Antioxidant, Antimicrobial, Anti-Inflammatory, and Gut Microbiota Modulation Effects of Kombucha: a Literature Review Hananta, Linawati; Kurniawan, Sandy Vitria; Lonah; Arieselia, Zita; Surjono, Edward; Setiawan, Jonny; Lieputra, Andrew Adhytia; Puspa Bunardi, Dewi; Prayoga Tjendratama, Jason; Vallerie Satyadi, Richelle; Dewi, Rita
Journal of Urban Health Research Vol. 3 No. 2 (2025): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v3i2.6445

Abstract

Introduction: The interest in probiotics has increased significantly in recent years. While most probiotic-containing foods are dairy-based, an increasing number of non-dairy probiotic products have emerged, including kombucha. Kombucha is a fermented tea beverage originating from China, known for its high polyphenol content and potential health benefits. Methods: This literature review aims to provide a comprehensive understanding of the health benefits of kombucha. A systematic search of published studies was conducted using the keywords "kombucha," "antioxidant," "anti-inflammatory," "antimicrobial," and "gut microbiota modulation." Only English-language articles were included, and there was no restriction on publication date to capture the full spectrum of research on kombucha. Results: Kombucha exhibits significant antioxidant capacity, with green tea kombucha demonstrating the highest Ferric Ion Reducing Antioxidant Power (FRAP) due to its high polyphenol content. Additionally, kombucha possesses antimicrobial properties attributed to organic acids, lactones, aldehydes, fatty acids, and alkaloids, which act synergistically. It also exhibits anti-inflammatory effects by inhibiting nitric oxide production and downregulating pro-inflammatory cytokines such as IL-1β and TNF-α. Furthermore, kombucha modulates gut microbiota composition by inhibiting the growth of Gram-negative bacteria, leading to reduced systemic inflammation and oxidative stress. Conclusion: Kombucha, a traditional fermented tea, has notable health benefits, including antioxidant, antimicrobial, anti-inflammatory, and gut microbiota-modulating properties. These findings highlight its potential as a functional beverage for health promotion. Keywords: kombucha – antioxidant - anti-inflammatory – antimicrobial - gut microbiota modulation
Is Radiofrequency Ablation Better than Venous Stripping for Management of Chronic Venous Insufficiency? Halomoan, Reynaldo; Singjie, Leonard Christianto; Setiawan, Jonny
Majalah Kedokteran Indonesia Vol 71 No 5 (2021): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.71.5-2021-519

Abstract

Chronic venous insufficiency (CVI) is a disease of the vein due to valve dysfunction, venous obstruction, or both. This results in increased vein pressure and related to disruption in the vein system.
Co-Authors Budiyanti, Ecie Divara Ariesta Sekar Suryadi, Made Edward Surjono, Edward Evi Ulina Margaretha Situmorang Fan, Tan Fei Halomoan, Reynaldo Kiki A. Rizki Kurniawan, Sandy Vitria Lieputra, Andrew Adhytia Linawati Hananta, Linawati Lonah, Lonah Maman Abdurahman Mariani Santosa, Mariani Prayoga Tjendratama, Jason Puspa Bunardi, Dewi Rita Dewi Singjie, Leonard Christianto Vallerie Satyadi, Richelle Yuliana Yuliana Zita Arieselia