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All Journal Majalah Kedokteran Bandung Damianus Journal of Medicine SRIWIJAYA JOURNAL OF MEDICINE Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal of Urban Health Research Mitramas Jurnal Pengabdian dan Pemberdayaan Masyarakat Mitramas Jurnal Pengabdian dan Pemberdayaan Masyarakat
Jonny Setiawan
Departemen Ilmu Bedah, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Katolik Indonesia Atma Jaya
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Efektivitas Pemberian Metilprednisolon terhadap Pembentukan Seroma Pascaoperasi Mastektomi Modifikasi Radikal Setiawan, Jonny; Abdurahman, Maman; Rizki, Kiki A.
Majalah Kedokteran Bandung Vol 46, No 2 (2014)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1438.984 KB)

Abstract

Seroma adalah pengumpulan cairan serous di subkutis dan merupakan komplikasi pascaoperasi kanker payudara yang paling sering dijumpai. Insidensinya mencapai lebih dari 60%. Walaupun tidak mengancam jiwa, namun dapat menimbulkan morbiditas yang serius. Berbagai penelitian dilakukan untuk menentukan faktor risiko untuk mencegah timbulnya seroma. Saat ini, seroma terjadi karena proses inflamasi pascaoperasi. Teori inilah yang mendasari peranan antiinflamasi terhadap pembentukan seroma. Diketahui obat golongan glukokortikoid, memiliki peranan menghambat respons inflamasi. Tujuan penelitian ini untuk menilai efek profilaksis pemberian metilprednisolon perioperatif mastektomi terhadap pembentukan seroma. Penelitian ini merupakan uji klinis secara acak tersamar ganda terhadap 2 kelompok, yaitu antara kelompok karsinoma payudara stadium lokal lanjut yang diberikan metilprednisolon perioperatif mastektomi sebagai kelompok perlakuan dan kontrol. Penelitian ini dilakukan di Rumah Sakit Dr. Hasan Sadikin Bandung, periode April–Juli 2013. Subjek penelitian meliputi 30 wanita yang memenuhi kriteria inklusi dan dibagi menjadi dua kelompok, 15 pasien diberikan metilprednisolon dan 15 pasien sebagai kontrol. Penelitian ini menggunakan uji-t tidak berpasangan dan Mann Whitney. Didapatkan perbedaan rata-rata volume drainase hari ke-1, pada kelompok metilprednisolon sebanyak 104,7 mL dan pada kontrol sebanyak 158 mL, namun secara statistik tidak bermakna (p=0,053). Demikian pula dengan hari-hari selanjutnya dan total seroma, tidak didapatkan perbedaan yang bermakna. Simpulan, pemberian metilprednisolon tidak efektif menurunkan volume drainase seroma pascaoperasi mastektomi. [MKB. 2014;46(2):88–93]Kata kunci: Mastektomi, metilprednisolon, seromaEffectiveness of Methylprednisolone on Post-Operative Seroma Formation Following Radical Modified MastectomySeroma is a collection of serous fluid in the subcutaneous and is the most common complication of breast cancer surgery. The incidence is more than 60%. Although it is not life-threatening but it can cause serious morbidity. Various studies were conducted to determine the risk factors to prevent seroma formation. Currently, seroma occurrs due to postoperative inflammatory processes. This theory underlies the antiinflammatory role for seroma formation. Glucocorticoid drugs is known as playing a role in inhibiting the inflammatory response. The purpose of this study was to assess the prophylactic effect of perioperative administration of methylprednisolone on seroma formation. This study was a double-blind randomized control trial of 2 groups, i.e. a group of locally advanced breast carcinoma which were given methylprednisolone perioperatively as a treatment group and a control group. The research was conducted in Dr. Hasan Sadikin General Hospital Bandung from April to July 2013. Thirty women who met the inclusion criteria were included as subjects who were then divided into two groups: 15 women received methylprednisolone and 15 women serve as controls. This study used independent t and Mann-Whitney tests. There was a difference in the mean volume of drainage on day 1 between the methylprednisolone and control group as much as 104.7 mL and 158 mL, respectively, but not statistically significant (p=0.053). The same situation was also seen for the following days and total seroma, which was no significant difference was found. In conclusion, the use of methylprednisolone is not effective for reducing postoperative seroma drainage volume after mastectomy. [MKB. 2014;46(2):88–93]Key words: Mastectomy, methylprednisolone, seroma DOI:  10.15395/mkb.v46n2.279
The Relationship Between Smoking Status And Diabetic Foot Severity Surya, Nadhea Debrinita; Jonny Setiawan; Rensa
Sriwijaya Journal of Medicine Vol. 3 No. 3 (2020): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v3i3.98

Abstract

Diabetes mellitus is a chronic metabolic disease which happens to be the 7th leading cause of death worldwide. In Indonesia, 6.9% of population aged ³ 15 years old suffers from this disease. Diabetic foot is one of the complication of diabetes mellitus which has high mortality and morbidity level. Smoking is an addictive behavior that is really common in Indonesia. Components inside a cigarette, such as nicotine, can contribute in determining the prognosis of diabetic foot through various mechanism. This study aims to investigate the association between smoking status and the severity degree of diabetic foot. This study is an observational analytic study using a cross-sectional approach. Data collection was conducted on January 2019 until July 2019 in RSUK Pesanggrahan and Atma Jaya Hospital Jakarta. The research data was obtained through interviews with diabetic foot patients and medical record reading. Data was analyzed using the chi-square method. There were 40 patients eligible to be the subject of this study. The smoker status with the most distribution was moderate smoker (27.5%) and severity degree of diabetic foot with most distribution was Wagner 3 (25%). Bivariate analysis showed that there was a significant association between smoking status and severity degree of diabetic foot (p < 0.001). In conclusion, there is a significant association between smoking status and the severity degree of diabetic foot. Therefore, education regarding the importance of smoking cessation to diabetic foot patients should be done in order to improve the prognosis of diabetic foot patients.
The Relationship Between Smoking Status And Diabetic Foot Severity Nadhea Debrinita Surya; Jonny Setiawan; Rensa
Sriwijaya Journal of Medicine Vol. 3 No. 3 (2020): Vol 3, No 3, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v3i3.79

Abstract

The Association Between Smoking Status and Severity Degree of Diabetic Foot. Diabetes mellitus is a chronic metabolic disease which happens to be the 7th leading cause of death worldwide. In Indonesia, 6.9% of population aged  15 years old suffers from this disease. Diabetic foot is one of the complication of diabetes mellitus which has high mortality and morbidity level. Smoking is an addictive behavior that is really common in Indonesia. Components inside a cigarette, such as nicotine, can contribute in determining the prognosis of diabetic foot through various mechanism. This study aims to investigate the association between smoking status and the severity degree of diabetic foot. This study is an observational analytic study using a cross-sectional approach. Data collection was conducted on January 2019 until July 2019 in RSUK Pesanggrahan and Atma Jaya Hospital Jakarta. The research data was obtained through interviews with diabetic foot patients and medical record reading. Data was analyzed using the chi-square method. There were 40 patients eligible to be the subject of this study. The smoker status with the most distribution was moderate smoker (27.5%) and severity degree of diabetic foot with most distribution was Wagner 3 (25%). Bivariate analysis showed that there was a significant association between smoking status and severity degree of diabetic foot (p < 0.001). In conclusion, there is a significant association between smoking status and the severity degree of diabetic foot. Therefore, education regarding the importance of smoking cessation to diabetic foot patients should be done in order to improve the prognosis of diabetic foot patients.
Pharmacogenomic Role in Cytochrome P450 Enzymes-Mediated Metabolism for Drug Therapy Lonah; Zita Arieselia; Jonny Setiawan; Rita Dewi; Maria Dara Novi Handayani; Linawati Hananta
Journal of Urban Health Research Vol. 1 No. 3 (2023): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v1i3.4629

Abstract

The rapid development of genetic science in recent decades has provided opportunities for clinical implementation. In the field of pharmacology, this opens up hope for the use of more targeted drugs with fewer side effects.Genetic variation's influence on pharmacological response has been well-established in practice. Patients' responses to pharmacological therapies can be varied, ranging from positive effects to serious adverse drug reactions (ADRs). Numerous genetic variations have been found to have a major impact on how people react to routinely prescribed medications over time, according to experts. In order to use this genetic information to inform treatment choices, a pharmacogenomic (PGx) profile can be used. PGx works on identifying and validating genomic variations that affect drug response. The generic approach to healthcare has given way to a more individualized and precise treatment paradigm as it has developed. Keywords: Adverse Drug Reactions - Genetic Variants – Pharmacogenomics - Cytochrome P450
Prevalence of E-cigarette Users Students and Determinant Factors Affecting Their Use Behavior Zita Arieselia; Lonah Lonah; Linawati Hananta; Margareta Amelia; Fenny Mariska; Via Dolorosa Halilintar; Mariani Santosa; Meiliyana Wijaya; Rita Dewi; Jonny Setiawan; Monalisa Heryani
Bahasa Indonesia Vol 22 No 2 (2023): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v22i2.3820

Abstract

Pendahuluan: Prevalensi pengguna rokok tembakau pada remaja di Indonesia terus meningkat dari 7,2% pada tahun 2013 menjadi 9,1% pada tahun 2018, tingkat penggunaannya dianggap dapat dikurangi dengan menggunakan rokok elektrik. Namun sebenarnya rokok elektrik belum dapat disebut sebagai terapi berhenti merokok konvensional karena belum terdapat bukti yang cukup kuat dan dampak penggunaannya pada kesehatan yang tidak dapat dikesampingkan. Sementara itu, beberapa studi menunjukkan bahwa penggunaan rokok elektrik juga berdampak buruk bagi kesehatan. Tujuan penelitian ini adalah untuk mengetahui prevalensi pengguna dan faktor determinan yang memengaruhi perilaku penggunaan rokok elektrik pada mahasiswa. Metode: Studi ini merupakan penelitian kuantitatif dengan desain studi potong lintang atau cross sectional. Sampel yang digunakan sebanyak 410 orang dengan kriteria inklusi berupa mahasiswa aktif Unika Atma Jaya serta orang yang telah setuju untuk menjadi responden penelitian setelah membaca informed consent, dan kriteria eksklusi yaitu responden yang mengisi kuesioner dengan tidak lengkap. Perhitungan sampel dilakukan dengan metode proportional stratified random sampling. Pengambilan data responden menggunakan kuesioner secara daring melalui Google Forms. Analisis data menggunakan uji Chi Square dan Mann-Whitney.   Hasil: Prevalensi pengguna rokok elektrik pada mahasiswa sebesar 21,7%. Pada penelitian ini faktor yang berpengaruh pada keputusan penggunaan rokok elektrik adalah jenis kelamin (p<0,001), persepsi (p<0,001), tersedianya suplai (p<0,001), dukungan keluarga (p=0,002), dan dukungan teman (p<0,001). Simpulan: Tingginya tingkat penggunaan rokok elektrik pada mahasiswa menunjukkan perlunya informasi dan edukasi serta promosi kesehatan mengenai dampak merugikan dari penggunaan rokok elektrik.
Assessing the Correlation between Spicy Food Consumption and Dyspepsia Symptoms in Medical and Health Students at Atma Jaya Catholic University of Indonesia Lonah; Divara Ariesta Sekar Suryadi, Made; Arieselia, Zita; Vitria Kurniawan, Sandy; Hananta, Linawati; Setiawan, Jonny; Surjono, Edward; Santosa, Mariani; Ulina Margareta Situmorang, Evi; Fan, Tan Fei; Yuliana; Budiyanti, Ecie
Journal of Urban Health Research Vol. 2 No. 3 (2024): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v2i3.5463

Abstract

Introduction: The capsaicin (8-methyl-N-vanillyl-6-nonenamide) content in spicy foods can trigger irritation and increase gastric acid production, which potentially damages the stomach mucous layer by increasing chloric acid levels (HCl). It is known that dyspepsia has a variety of causes and one of them can be triggered by the consumption of irritating foods, such as spicy foods. Therefore, the research was conducted to determine whether there was a significant relationship between the consumption of spicy foods and the incidence of dyspepsia in students of the Faculty of Medicine and Health Sciences at the Atma Jaya Catholic University of Indonesia. Methods: This research method is an analytical observational study using cross-sectional methods. The main variables in this study were dyspepsia, measured using the Rome III questionnaire, and the frequency of spicy food consumption measured using the Food Frequency Questionnaire (FFQ). The sample consisted of 107 people randomly selected. The data was analyzed statistically using the Fischer Exact test. Results: This study showed that 56.1% of respondents frequently eat spicy foods, while the majority, as much as 95.3%, also have dyspepsia. There was a significant correlation between spicy eating habits and dyspepsia, with a p-value of 0.014 (p<0.05). Conclusion: The results showed a statistically significant relationship between spicy eating habits and dyspepsia, so it is recommended for students to reduce spicy food consumption as it can affect the onset of dyspepsia. Keywords: dyspepsia - spicy foods - stomach - Rome III questionnaire - food frequency questionnaire
Antioxidant, Antimicrobial, Anti-Inflammatory, and Gut Microbiota Modulation Effects of Kombucha: a Literature Review Hananta, Linawati; Kurniawan, Sandy Vitria; Lonah; Arieselia, Zita; Surjono, Edward; Setiawan, Jonny; Lieputra, Andrew Adhytia; Puspa Bunardi, Dewi; Prayoga Tjendratama, Jason; Vallerie Satyadi, Richelle; Dewi, Rita
Journal of Urban Health Research Vol. 3 No. 2 (2025): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v3i2.6445

Abstract

Introduction: The interest in probiotics has increased significantly in recent years. While most probiotic-containing foods are dairy-based, an increasing number of non-dairy probiotic products have emerged, including kombucha. Kombucha is a fermented tea beverage originating from China, known for its high polyphenol content and potential health benefits. Methods: This literature review aims to provide a comprehensive understanding of the health benefits of kombucha. A systematic search of published studies was conducted using the keywords "kombucha," "antioxidant," "anti-inflammatory," "antimicrobial," and "gut microbiota modulation." Only English-language articles were included, and there was no restriction on publication date to capture the full spectrum of research on kombucha. Results: Kombucha exhibits significant antioxidant capacity, with green tea kombucha demonstrating the highest Ferric Ion Reducing Antioxidant Power (FRAP) due to its high polyphenol content. Additionally, kombucha possesses antimicrobial properties attributed to organic acids, lactones, aldehydes, fatty acids, and alkaloids, which act synergistically. It also exhibits anti-inflammatory effects by inhibiting nitric oxide production and downregulating pro-inflammatory cytokines such as IL-1β and TNF-α. Furthermore, kombucha modulates gut microbiota composition by inhibiting the growth of Gram-negative bacteria, leading to reduced systemic inflammation and oxidative stress. Conclusion: Kombucha, a traditional fermented tea, has notable health benefits, including antioxidant, antimicrobial, anti-inflammatory, and gut microbiota-modulating properties. These findings highlight its potential as a functional beverage for health promotion. Keywords: kombucha – antioxidant - anti-inflammatory – antimicrobial - gut microbiota modulation
Relationship between Knowledge and Attitude toward BSE Behavior for Early Breast Cancer Detection among Atma Jaya Hospital Nurses Zita Arieselia; Kurniawan, Sandy Vitria; Lonah; Linawati Hananta; Freggy Spicano Joprang; Edward Surjono; Jonny Setiawan; Andrew Liputra; Jennifer
Journal of Urban Health Research Vol. 3 No. 3 (2025): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v3i3.7114

Abstract

Introduction : Breast cancer is a frequently occurring type of cancer in Indonesia, with symptoms of rapid and invasive growth of abnormal cells. Deaths due to this cancer can be reduced by avoiding risk factors and early detection, such as through breast self-examination (BSE). Assessing knowledge, attitudes, and behavior regarding BSE is important for early detection, especially for nurses as health workers. This study assessed the relationship between knowledge and attitudes towards BSE behavior among Atma Jaya Hospital nurses.  Methods: This is an analytical observational study employing a cross-sectional design, involving 105 samples selected through purposive sampling according to established inclusion and exclusion criteria. The variables in this study include knowledge, attitude, and behavior regarding breast self-examination (BSE). Data were collected through the distribution of questionnaires to respondents and will be statistically analyzed using the Chi-Square test (x2) with a significance level (a) = 5%, and the analysis will be conducted using STATA software. Results: Based on the data analysis, there is no correlation between knowledge and attitude toward the practice of breast self-examination (BSE), with p-values of 0.623 and 0.994. Conclusion: There is no significant relationship between Knowledge and Attitude towards BSE Behavior. Keywords:  BSE Attitude - BSE Behavior - BSE Knowledge
Is Radiofrequency Ablation Better than Venous Stripping for Management of Chronic Venous Insufficiency? Reynaldo Halomoan; Leonard Christianto Singjie; Jonny Setiawan
Majalah Kedokteran Indonesia Vol 71 No 5 (2021): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.71.5-2021-519

Abstract

Chronic venous insufficiency (CVI) is a disease of the vein due to valve dysfunction, venous obstruction, or both. This results in increased vein pressure and related to disruption in the vein system.
KENALI LEBIH AWAL, SELAMATKAN LEBIH BANYAK: SEMINAR DETEKSI DINI KANKER PAYUDARA UNTUK MAHASISWA ATMA JAYA Daniel Ardian Soeselo; Bryan Pan Durdin; Hansen Hansen; Carolyn Grace Donlon; Jesslyn Alvina; Angelica Yaputri; Natashya Chresentia Wibowo; Aerika Bellatrix Heriyanto; Jonny Setiawan
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 4 No. 02 (2026): Mitramas, Jurnal Pengabdian dan Pemberdayaan Masyarakat
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v4i02.7390

Abstract

Kanker payudara merupakan masalah kesehatan global utama dan menjadi penyebab kematian tertinggi akibat kanker pada perempuan. GLOBOCAN 2020 mencatat sebanyak 68.858 kasus baru dan lebih dari 22.000 kematian di Indonesia, dengan tingginya angka mortalitas terutama disebabkan oleh keterlambatan diagnosis karena sebagian besar pasien datang pada stadium lanjut. Rendahnya literasi kesehatan dan kesadaran masyarakat terhadap deteksi dini, termasuk praktik SADARI, menjadi faktor penting yang perlu diatasi. Sebagai bentuk intervensi promotif dan preventif, dilakukan kegiatan pengabdian masyarakat berupa seminar kesehatan yang ditujukan kepada mahasiswa, berfokus pada peningkatan pemahaman mengenai faktor risiko, tanda dan gejala, serta pentingnya deteksi dini dan pemeriksaan payudara mandiri. Seminar juga dilengkapi dengan sesi diskusi interaktif untuk memperkuat pemahaman peserta dan mendorong perubahan perilaku. Evaluasi pretest dan posttest dilakukan untuk mengetahui tingkat pengetahuan dan perilaku deteksi dini. Kegiatan ini diharapkan dapat meningkatkan kesadaran, memperkuat sikap proaktif terhadap kesehatan reproduksi, serta mendorong praktik deteksi dini di kalangan generasi muda, sehingga angka kesakitan dan kematian akibat kanker payudara di Indonesia dapat ditekan secara signifikan.
Co-Authors Aerika Bellatrix Heriyanto Andrew Adhytia Lieputra Andrew Liputra Angelica Yaputri Bryan Pan Durdin Carolyn Grace Donlon Daniel Ardian Soeselo Divara Ariesta Sekar Suryadi, Made Ecie Budiyanti Edward Surjono Evi Ulina Margareta Situmorang Fan, Tan Fei Fenny Mariska Freggy Spicano Joprang Hansen Hansen Jennifer Jesslyn Alvina Kiki A. Rizki Leonard Christianto Singjie Linawati Hananta, Linawati Lonah Maman Abdurahman Margareta Amelia Maria Dara Novi Handayani, Maria Dara Novi Mariani Santosa, Mariani Meiliyana Wijaya Monalisa Heryani Nadhea Debrinita Surya Natashya Chresentia Wibowo Prayoga Tjendratama, Jason Puspa Bunardi, Dewi Rensa Reynaldo Halomoan Rita Dewi Sandy Vitria Kurniawan Surya, Nadhea Debrinita Vallerie Satyadi, Richelle Via Dolorosa Halilintar Yuliana Yuliana Zita Arieselia