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All Journal Jurnal Veteriner Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Masyarakat Althea Medical Journal Damianus Journal of Medicine The Indonesian Biomedical Journal Universa Medicina Journal of Urban Health Research Media Penelitian dan Pengembangan Kesehatan Mitramas Jurnal Pengabdian dan Pemberdayaan Masyarakat Mitramas Jurnal Pengabdian dan Pemberdayaan Masyarakat
Maria Dara Novi Handayani, Maria Dara Novi
Departemen Biokimia Dan Kimia, Fakultas Kedokteran Dan Ilmu Kesehatan, Universitas Katolik Indonesia Atma Jaya, Indonesia
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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Anthropometric Prediction Equations for Estimating Muscle Mass of Elderly Women Handayani, Maria Dara Novi; Sadewa, Ahmad Hamim; Farmawati, Arta; Rochmah, Wasilah
KEMAS: Jurnal Kesehatan Masyarakat Vol 14, No 2 (2018)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v14i2.14073

Abstract

Muscle Mass (MM) has an important role in health and physical performance. There are many MM prediction equations, but none is formulated in Indonesia. This study aimed to develop Anthropometric Equations (AE) prediction for MM. A cross sectional study was used to formulate AE prediction through multiple regression analysis.  The significance of observed differences between predicted and actual MM was tested by t test while level of agreement was assessed by Bland Altman plot. A significant correlation was found between MM and height, body mass index, calf/arm/waist circumferences, and waist hip ratio (p<0.05).  Regression anal¬ysis indicated that age, height, and Mid Arm Circumference (MAC) contributed significantly to MM. The resulting equation was MM (kg) = -10.22+(-.097x age)+(0.16xheight)+(0.30xMAC). There was no significant difference between actual and predicted MM results, and both had significant correlation. These results suggest that age, AP related to MM and AE provide valid prediction of MM for healthy elderly women in Jakarta.
HUBUNGAN KADAR HEMOGLOBIN TERHADAP KETAHANAN AEROBIK DAN KEKUATAN OTOT PADA LANJUT USIA Sandy Theresia; Nelly Tina Widjaja; Maria Dara Novi Handayani
Bahasa Indonesia Vol 18 No 1 (2019): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v18i1.2195

Abstract

Introduction: The increase in the elderly population causes many health problems. One of them is the decline in physical function, making the elderly have difficulty performing daily activities. Some studies suggest the relation between decreased hemoglobin level with aerobic endurance and muscle strength. This study aims to determine the relation between hemoglobin and aerobic endurance, muscle strength in the elderly. Methods: This research is an analytic-correlative research conducted cross-sectionally on 84 respondents in Kelurahan Cideng, Central Jakarta. The data is collected from questionnaires, hemoglobin level (sodium lauryl sulfate-hemoglobin method), and physical performance tests (2-minutes test, arm curl test, and chair stand test). Results: The mean hemoglobin level is 14.37 g/dL. There was a significant relation between hemoglobin with aerobic endurance (p<0.05), whereas no significant relation between hemoglobin with upper and lower limb muscle strength (p>0.05). Conclusion: There was a relation between hemoglobin level with aerobic endurance in the elderly.
Indeks Massa Tubuh Paling Berpengaruh Terhadap Rasio Extracellular Mass/Body Cell Mass Myra Antonia; Maria Dara Novi Handayani; Agnes Rensa; Vetinly Vetinly
Bahasa Indonesia Vol 20 No 2 (2021): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v20i2.2638

Abstract

ABSTRACT Background: Extracellular mass/body cell mass (ECM/BCM) ratio is a independent predictor mortality in nutritional status and certain chronic disease. ECM/BCM ratio is influenced by various factors such as muscle mass, blood cells, bone mass, tendons, total body water, and certain chronic diseases. Objective: Determine factors associated with elderly ECM/BCM ratio in Jakarta nursing home. Methods: This observational cross-sectional study was conducted in four nursing home in Jakarta. Nutritional status measured with Mini Nutritional Assessment (MNA) score, Body Mass Index (BMI), Waist Circumference (WC), Mid-Arm Circumference (MAC), and calf circumference (CC) using measurement. ECM/BCM ratio is measured using Maltron Bioscan 916, Pearson correlation and Kendall's Tau B were used for bivariate analysis. Simple linear regression was used for multivariate analysis. Results: A total of 74 subjects were recruited (mean age 72.12 years, 71.6% women). Body mass index (p<0.05), WC (p<0.05), and CC (p<0.05) were negatively associated with ECM/BCM ratio, while MNA score (p<0.05) and age (p<0.05) were positively associated with ECM/BCM ratio. There wasn't any significant difference in TBW between male and female elderly. In the multivariate linear regression analysis, BMI was negatively associated with ECM/BCM ratio (p<0.05). Conclusions: Significant relationship were found independently between MNA score, BMI, WC,MAC, and age with ECM/BCM ratio. Body mass index is the main factor associated with ECM/BCM ratio in the elderly in Jakarta nursing homes. Our findings suggest that elderly with lower BMI have higher ECM/BCM ratio.
Hubungan Fungsi Kognitif Dengan Keseimbangan Pada Lansia Di Jakarta Ireina Karyn; Maria Dara Novi Handayani; Octavianus Darmawan
Bahasa Indonesia Vol 20 No 2 (2021): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v20i2.2639

Abstract

Introduction: The world is entering an aging population. With aging comes many challenges due to changes of the brain structure that affect both cognitive function and balance. The amount of cognitive function and balance impairment cases in the elderly are rising. If left unattended, it can cause numerous adverse effects in the elderly, eventually leading to the loss of the ability to perform activities of daily living. Studies have observed the relationship between cognitive impairment and balance in Indonesia, but only a few were conducted in Jakarta, specifically among elders in the nursing home. This study is aimed to observe the association between cognitive function and balance in the elderly.Methods: This is a secondary analysis using a previous study conducted in PSTW Budi Mulia Jakarta in 2016. Demographic data, cognitive function, and balance were assessed using the demographic questionnaire, Mini-Mental State Examination (MMSE), and Berg Balance Scale (BBS). Statistical analysis is conducted using IBM SPSS Ver 22.Results: Most respondents were female, aged 60-69 years old, had low education level, good MMSE score (53,3%), and a normal BBS (90,7%) score. We found a significant relationship between cognitive functions and balance (p=0,045).Conclusion: Cognitive function is related to balance impairment in the elderly. Key Words: balance, cognitive function, elderly
Red fruit oil supplementation fails to prevent oxidative stress in rats Maria Dara Novi Handayani; Parwati Abadi Soekarno; Septelia Inawati Wanandi
Universa Medicina Vol. 32 No. 2 (2013)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2013.v32.86-91

Abstract

BACKGROUNDRed fruit oil (RFO) is popular in Indonesia especially in Papua. It is consumed by people for maintaining health and to treat diseases. Red fruit (Pandanus conoideus Lam) oil is reported to contain the antioxidants á-tocoferol and âcarotene.The aim of this study was to confirm the protective effect of RFOagainst decreased glutathione levels in the plasma and liver of rats induced by 2N-(2-fluorenyl) acetamide (2-FAA).METHODSWistar male rats weighing 200 ± 20 g were randomly assigned into a control group (receiving distilled water only) and three intervention groups, designated RFO, FAA, and RFO-FAA (n=6 rats per group). RFO was given RFO 10 ì l/g/BW/day, FAA received fluoroenylacetamide (FAA) at 40ìg/day, while RFOFAA received both RFO and FAA. At 4 weeks blood samples were taken from the tail. At 8 weeks the rats were sacrified for collection of blood and liver tissues. Ellman’s method was employed to determine the parameters of antioxidantglutathione (glutahione sulfhydryl/GSH). One-way ANOVA and Tukey post hoc test were used to compare glutathione levels between groups.RESULTSThis study showed that liver and plasma glutathione levels were not significantly lower in the RFO-FAA group than in the FAA group. Glutathione levels were significantly lower in plasma and liver homogenates of the RFO group compared with the control group and were not significantly different from those in theFAA group.CONCLUSIONAdministration of RFO in rats does not protect against decreased glutathione but is a potential source of oxidative stress.
A Comparative Study on Different Effects and Exposure Duration Between Conventional Cigarette Smoke and Electronic Cigarette Vapor on Serum Interleukin-1? Level: An In Vivo Study Vienna Christantia; Iskandar Rahardjo Budianto; Tena Djuartina; Maria Dara Novi Handayani
Jurnal Veteriner Vol 23 No 2 (2022)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (98.053 KB) | DOI: 10.19087/jveteriner.2022.23.2.252

Abstract

Smoking is known to have bad effects on health. People start using e-cigarettes with the assumption that e-cigarettes are safer, but the safety of e-cigarettes is still in doubt. Harmful substances from cigarettes can trigger an increase in free radicals and induce inflammatory process. The aim of this study was to evaluate and compare the increase of serum Interleukin-1? due to exposure to conventional cigarette smoke and e-cigarette vapor based on exposure time. This study was conducted experimentally on 30 male white rats Sprague Dawley strain. The rats were divided into five treatment groups (control group, two and four weeks of exposure to conventional cigarette smoke, and two and four weeks of exposure to electronic cigarette vapor). Smoking session was given once a day. The rats were sacrificed then necropsied and Interleukin-? levels were calculated using the enzyme linked immunosorbent assay (ELISA) Kit. The data obtained were analyzed using one-way analysis of variance (ANOVA) statistical test. Exposure to conventional cigarette smoke and e-cigarette vapor did not give any significant changes to Interleukin-1? level in rats, both at two weeks and four weeks of exposure. However, there was a tendency of increased Interleukin-1? levels with increasing time. This tendency is more obvious in groups with exposure to conventional cigarette.
Effect of Avocado Seed Extract through Milling on Reducing Triglyceride in Hyperlipidemic Rats Rita Dewi Firmansyah; Jojor Lamsihar Manalu; Yulia Tanti Narwati; Maria Dara Novi Handayani; Alexander Yose Ardin Bagas Sulistyo
Journal of Urban Health Research Vol. 1 No. 3 (2023): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v1i3.4617

Abstract

Background : Hypertriglyceridemia is a condition in which there is an increase in triglycerides in the blood. This increase is influenced by foods that contain extra calories. Hypertriglyceridemia can cause disturbances in the body in the form of cardiovascular disease. Methods : The study used experimental methods on male Sprague Dawley rats. The research sample used fourteen rats which were divided into a control group and a treatment group. All experimental mice were induced to become hyperlipidemic by PTU14 gram/kg for 14 day. The control group was not given any treatment. The treatment group was given avocado seed extract 250 mg/kg for 14 day. Avocado seed extract is obtained through crushing and extraction processes. The statistic we used in this study is paired T-test. Results : In the control group, there was no decrease in triglyceride levels with an average of 134.78 mg / dL. In the treatment group there was a decrease in the average triglyceride levels both after seven days of giving avocado seed extract on (day 28) 127.92 md / dL and after fourteen days of giving avocado seed extract on (day 35) 124.21 mg / dL. Conclusion: Giving of avocado seed extract by grinding method for 30 minutes selama sekian hari had an effect in reducing triglyceride levels in hyperlipidemic rats. Keywords: Avocado Seed Extract - Sprague Dawley Rats - Triglyceride Level.
Pharmacogenomic Role in Cytochrome P450 Enzymes-Mediated Metabolism for Drug Therapy Lonah; Zita Arieselia; Jonny Setiawan; Rita Dewi; Maria Dara Novi Handayani; Linawati Hananta
Journal of Urban Health Research Vol. 1 No. 3 (2023): Journal of Urban Health Research
Publisher : School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/juhr.v1i3.4629

Abstract

The rapid development of genetic science in recent decades has provided opportunities for clinical implementation. In the field of pharmacology, this opens up hope for the use of more targeted drugs with fewer side effects.Genetic variation's influence on pharmacological response has been well-established in practice. Patients' responses to pharmacological therapies can be varied, ranging from positive effects to serious adverse drug reactions (ADRs). Numerous genetic variations have been found to have a major impact on how people react to routinely prescribed medications over time, according to experts. In order to use this genetic information to inform treatment choices, a pharmacogenomic (PGx) profile can be used. PGx works on identifying and validating genomic variations that affect drug response. The generic approach to healthcare has given way to a more individualized and precise treatment paradigm as it has developed. Keywords: Adverse Drug Reactions - Genetic Variants – Pharmacogenomics - Cytochrome P450
Effect of Surya Namaskar yoga practice on flexibility in the pre-elderly and elderly Karasugi, Ni Made Ayu Regina; Lilis, Lilis; Amita, Angela Shinta Dewi; Novi Handayani, Maria Dara; Prastowo, Nawanto Agung
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 4 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005504202304

Abstract

Anatomical and physiological changes occur along with the aging process. One of the changes is decreased flexibility due to changes in the musculoskeletal system. Upper and lower limb flexibility is closely related to the ability to carry out daily activities, which affects the quality of life of the elderly. Surya  Namaskar yoga is known to help increase flexibility because it integrates stretching components within its movement. This study aimed to investigate the effect of Surya  Namaskar on flexibility in the pre-elderly and elderly. It was is quasi-experimental study with a pre-experimental one-group pretest-posttest research design. A total of 20 participants were selected using consecutive sampling according to the inclusion criteria. Flexibility measurements of the upper and lower limbs were carried out before and after the intervention using the back scratch test and chair sit and reach test methods. Surya  Namaskar intervention was carried out for 8 wk. Data were analyzed using the Shapiro-Wilk normality test, paired t-test, and Wilcoxon test. The results showed that there was a highly significant difference between the mean value of the back-scratch test (for upper limb flexibility) before and after the intervention (p<0.001). Significant differences were also found in the mean values of chair-sit-and-reach test measurements (for lower extremity flexibility) before and after the intervention (p<0.001). In conclusion, Surya  Namaskar exercises can improve the flexibility of the upper and lower extremities in the pre-elderly and elderly. 
History of Falls and The Use of Walking Aids on The Incidence of Depression in The Elderly in Indonesia Rahmadanty, Nadiya Kamila; Novi Handayani, Maria Dara; Turana, Yuda; Hardi, Nicholas; William, William
Jurnal Kesehatan Masyarakat Vol 20, No 1 (2024)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v20i1.46202

Abstract

Depression is a prevalent concern, especially among the elderly who are at risk of falling and rely on walking aids. This study examines the relationship between falls, walking aid usage, and depression in the elderly using data from the Indonesian Family Life Survey 5 (IFLS-5). Conducted as a cross-sectional study, it included respondents aged ≥ 60 years. Among the 2909 respondents, the majority of respondents were aged below 75 years (13.4%), women (51.6%), and lower level of education (84.1%) with a prevalence of depression of 24,1%. The research revealed that age, education, and a history of falls were significantly associated with the occurrence of depression (p0.05). Age above 75 years old (OR: 0,653; 95% CI: 0,495-0,862) and higher education level (OR: 0,626; 95% CI: 0,483-0,811) was found to be a protective factor, while a history of falls was found to be a predictive factor to depression in elderly (OR: 1,996; 95%CI: 1,393-2,332). However, the use of walking aids showed no correlation with depression. These findings suggest that while age and education act as protective factors, a history of falls serves as a predictive factor for depression in the elderly.
Co-Authors Adisuhanto, Marcella Adrianto, Nicholas Ahmad Hamim Sadewa Alexander Yose Ardin Bagas Sulistyo Amita, Angela Shinta Dewi Ana Lucia Ekowati Arta Farmawati Dewi, Angela Shinta Evi Ulina Margaretha Situmorang Ferbian Milas Siswanto Finnegan, Meisy Gratia, Isadora Hardi, Nicholas Indayang, Willyanto Kurniawan Ireina Karyn Iskandar Rahardjo Budianto Jojor Lamsihar Manalu Jonny Setiawan Karasugi, Ni Made Ayu Regina Lians, Airine Stefanie Lilis Lilis, Lilis Linawati Hananta, Linawati Lonah, Lonah Mora Octavia Myra Antonia Narwati, Yulia Tanti Nawanto Agung Prastowo Nelly Tina Widjaja Novelya , Novelya Octavianus Darmawan Pakpahan, Hotmaria Agustina Parwati Abadi Soekarno Putu Suwarastra Andarisuta Rahmadanty, Nadiya Kamila Rensa, Rensa Rita Dewi Rita Dewi Rita Dewi Dewi Rita Dewi Firmansyah Sandy Theresia Santi, Bryany Titi Septelia Inawati Wanandi Shinta, Angela Tena Djuartina, Tena Vetinly Vetinly Vienna Christantia Wasilah Rochmah Wijaya, Ferdian Manuel William William Yuda Turana Zita Arieselia