COMBINATION OF BASIL, TURMERIC AND BEAN SPROUTS TO HEMATOLOGY AND BIOCHEMISTRY OF FEMALE RAT BLOOD BEFORE PREGNANCY

Andriyanto Andriyanto (Division of Pharmacology and Toxicology, Department Anatomy, Physiology and Pharmacology, Faculty of Veterinary Medicine, IPB University, Bogor 16680, West Java, Indonesia)
Aulia Andi Mustika (Division of Pharmacology and Toxicology, Department Anatomy, Physiology and Pharmacology, Faculty of Veterinary Medicine, IPB University, Bogor 16680, West Java, Indonesia)
Wasmen Manalu (Division of Physiology, Department Anatomy, Physiology and Pharmacology, School of Veterinary Medicine and Biomedical Science, IPB University, Bogor, 16680, West Java, Indonesia)
Mawar Subangkit (Division of Pathology, Department Clinical, Reproduction and Pathology, School of Veterinary Medicine and Biomedical Science, IPB University, Bogor, 16680, West Java, Indonesia)
Sharon Aurelia (4Laboratory Animal Management, School of Veterinary Medicine and Biomedical Science, IPB University, Bogor 16680, West Java, Indonesia4Laboratory Animal Management, School of Veterinary Medicine and Biomedical Science, IPB University, Bogor 16680, We)
Leliana Nugrahaning Widi (4Laboratory Animal Management, School of Veterinary Medicine and Biomedical Science, IPB University, Bogor 16680, West Java, Indonesia4Laboratory Animal Management, School of Veterinary Medicine and Biomedical Science, IPB University, Bogor 16680, We)
Hamdika Yendri Putra (eLRosa Laboratory, Bogor 16680, West Java, Indonesia)
Elpita Tarigan (eLRosa Laboratory, Bogor 16680, West Java, Indonesia)
Yusa Irarang (eLRosa Laboratory, Bogor 16680, West Java, Indonesia)

Jurnal Kedokteran Hewan
Vol 17, No 4 (2023): December

The purpose of the study was to examine the safety of combination of basil, turmeric and bean sprouts extract solution on the hematological parameters and blood biochemistry profile of rats. The combined ingredients used in the study were obtained from different places. A total of 15 rats were divided into 3 groups based on the treatment dose. Each group consisted of 5 rats. The rats in control group (K) did not given extract combination, while the rats in group KKT 1 % and KKT 5% received combination of basil, turmeric and bean sprouts extract at dose of 1% and 5%, respectively. Effectiveness and safety tests were carried out by evaluating the hematological and blood biochemical profiles of female rats. The data were analyzed using one-way analysis of variance (ANOVA). The results showed that the rats given combination of basil, turmeric and bean sprouts extract at a dose of 1% and, dose of 5% did not had significant different compared to control (P0.05), but tend to have positive effects in increasing  several blood components that play an important role in maintaining immunity during pregnancy. It can be concluded that the combination of basil, turmeric and bean sprouts at dose of 1% and 5% do not adversely affect hematology profile and blood biochemistry of rats. This indicates that the extract combination does not cause any toxicity effects on the rats.