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All Journal Majalah Kedokteran Bandung Jurnal Ilmu Peternakan dan Veteriner Tropis (Journal of Tropical Animal and Veterinary Sciences) Jurnal Kedokteran Hewan Jurnal Penelitian Sains dan Kesehatan Avicenna
Elpita Tarigan
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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COMBINATION OF BASIL, TURMERIC AND BEAN SPROUTS TO HEMATOLOGY AND BIOCHEMISTRY OF FEMALE RAT BLOOD BEFORE PREGNANCY Andriyanto, Andriyanto; Mustika, Aulia Andi; Manalu, Wasmen; Subangkit, Mawar; Aurelia, Sharon; Widi, Leliana Nugrahaning; Putra, Hamdika Yendri; Tarigan, Elpita; Irarang, Yusa
Jurnal Kedokteran Hewan Vol 17, No 4 (2023): December
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v17i4.33189

Abstract

The purpose of the study was to examine the safety of combination of basil, turmeric and bean sprouts extract solution on the hematological parameters and blood biochemistry profile of rats. The combined ingredients used in the study were obtained from different places. A total of 15 rats were divided into 3 groups based on the treatment dose. Each group consisted of 5 rats. The rats in control group (K) did not given extract combination, while the rats in group KKT 1 % and KKT 5% received combination of basil, turmeric and bean sprouts extract at dose of 1% and 5%, respectively. Effectiveness and safety tests were carried out by evaluating the hematological and blood biochemical profiles of female rats. The data were analyzed using one-way analysis of variance (ANOVA). The results showed that the rats given combination of basil, turmeric and bean sprouts extract at a dose of 1% and, dose of 5% did not had significant different compared to control (P0.05), but tend to have positive effects in increasing several blood components that play an important role in maintaining immunity during pregnancy. It can be concluded that the combination of basil, turmeric and bean sprouts at dose of 1% and 5% do not adversely affect hematology profile and blood biochemistry of rats. This indicates that the extract combination does not cause any toxicity effects on the rats.
Analisis potensi hepatoprotektif minyak jintan hitam (Nigella sativa) pada kerusakan hati akibat paracetamol: Potential analysis of black cumin oil hepatoprotective (Nigella sativa) on liver damage due to paracetamol Yendri, Hamdika; Andriyanto, Andriyanto; Mustika, Aulia A.; Manalu, Wasmen; Subangkit, Mawar; Tarigan, Elpita
Jurnal Ilmu Peternakan dan Veteriner Tropis (Journal of Tropical Animal and Veterinary Science) Vol. 14 No. 1 (2024): Jurnal Ilmu Peternakan dan Veteriner Tropis (Journal of Tropical Animal and Ve
Publisher : Fakultas Peternakan Universitas Papua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46549/jipvet.v14i1.353

Abstract

Abstract  A decrease in liver function can cause some clinical impact on the body. The loss of the body's ability to metabolize toxins makes metabolic remains accumulate in the blood.  This study aims to determine the potential of black cumin oil hepatoprotective. This study used 25 ddY mice. Mice were given black cumin oil for 20 days and inducted liver cell damage using paracetamol dose 300mg/KgBB. Results showed the potential of black cumin oil hepatoprotective in the group given 60μL of black cumin oil. These results were obtained from the measurement of SGPT, SGOT values and histopathological observations of the liver organs of mice. These results show that black cumin preparations are able to suppress liver damage due to paracetamol. Keywords: Black cumin; Liver; Paracetamol   Abstrak  Penurunan fungsi hati dapat menyebabkan beberapa dampak klinis pada tubuh. Kehilangan kemampuan tubuh untuk memetabolisme racun menjadikan sisa-sisa metabolisme menumpuk di dalam darah. Penelitian ini bertujuan untuk mengetahui potensi hepatoprotektif minyak jintan hitam. Penelitian ini menggunakan mencit ddY berjumlah 25 ekor. Mencit diberikan minyak jintan hitam selama 20 hari dan dilakukan induksi kerusakan sel hati menggunakan paracetamol dosis 300mg/KgBB. Hasil penelitian menunjukan adanya potensi hepatoprotektor minyak jintan hitam pada kelompok yang diberikan 60µL minyak jintan hitam. Hasil ini didapatkan dari pengukuran nilai SGPT, SGOT dan pengamatan histopatologi organ hati mencit. Hasil ini menunjukan sediaan jintan hitam mampu menekan kerusakan hati akibat paracetamol. Kata kunci: Hati; Jintan hitam; Paracetamol
Hepatoprotective Potentials of Dates Extract (Phoenix dactylifera) in Acetaminophen-Induced Mice Andriyanto, Andriyanto; Putra, Hamdika Yendri; Aurelia, Sharon; Mustika, Aulia Andi; Manalu, Wasmen; Subangkit, Mawar; Tarigan, Elpita; Irarang, Yusa
Majalah Kedokteran Bandung Vol 55, No 3 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n3.3155

Abstract

Dates (Phoenix dactylifera) are considered as a well-known fruit consumed by many people in various countries. This study aimed to examine potential effects of dates as a hepatoprotective agent in mice. This study was conducted at the Iratco Group’s eLRosa Laboratory Research Facility, Indonesia, starting from June 2022 to July 2022. Mice from ddY strain were randomly divided into 5 groups (n=5 per group) of positive and negative control groups, and treatment groups 1, 2, and 3. The negative control group as the normal baseline did not receive acetaminophen and date extract. In treatment groups, 30 µL/30 gr BW, 60 µL/30 gr BW,  and 100 µL/30 gr BW extract was given per oral to Treatment Group 1, Group 2, and Group 3, respectively for 20 days. On day 21, all  treatment groups were induced with 300mg/KgBW acetaminophen for 3 days via the intraperitoneal route. Blood tests were performed on day 24 to measure the serum transaminase level as the parameter of liver damage. The lowest level of transaminase serum was found in group 3 with the highest volume of dates extract, which was 100 µL, followed by group 2 (60 µL), and group 1 (30 µL). There was a significant difference between the positive control group and treatment groups with  no significant difference was seen between negative and the treatment groups. This study concludes that dates extract has the potential of being a hepatoprotective agent.
Paparan Stresor Tidak Terprediksi Secara Kronis Meningkatkan Perilaku Depresi dan Rasio Neutrofil Limfosit Tikus Sitanggang, Fajar Islam; Elpita Tarigan; Sindi Farhana
Jurnal Penelitian Sains dan Kesehatan Avicenna Vol 5 No 1 (2026): Jurnal Penelitian Sains dan Kesehatan Avicenna
Publisher : Lembaga Penelitian Dan Pengabdian Kepada Masyarakat (LPPM), Institut Teknologi Dan Kesehatan (ITK) Avicenna

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69677/avicenna.v5i1.284

Abstract

Latar Belakang: Stres kronis telah diakui sebagai faktor penting pada gangguan depresi, Dampaknya tidak hanya pada aspek perilaku tetapi juga pada fungsi fisiologis. Paparan stres yang berlangsung lama dapat mengganggu regulasi emosi dan motivasi, memicu perubahan pada sistem imun memebentuk kondisi inflamasi sistemik. Dalam konteks tersebut, penggunaan model hewan eksperimental menjadi pendekatan penting untuk memahami perilaku depresi serta keterkaitannya dengan respons biologis yang menyertainya. Penelitian ini bertujuan untuk mengevaluasi efek paparan stres kronis tidak terprediksi terhadap perilaku menyerupai depresi dan status inflamasi sistemik pada tikus. Metode: Penelitian ini menggunakan tikus jantan Sprague Dawley, yang dibagi ke dalam dua kelompok, yaitu kelompok kontrol normal dan kelompok tikus terpapar stres kronis. Metode paparan stress merupakan metode stress kronis yang dimodifikasi dari beberapa penelitia sebelumnya. Kelompok stres dipaparkan empat jenis stresor secara acak satu kali setiap hari selama 28 hari untuk mencegah adaptasi terhadap stres. Perilaku menyerupai depresi dievaluasi melalui uji nest building dan uji spontaneous grooming, yang merefleksikan tingkat motivasi, perilaku perawatan diri, serta kondisi afektif hewan. Status inflamasi sistemik dinilai melalui pengukuran rasio neutrofil terhadap limfosit dari darah perifer. Analisis statistik dilakukan untuk membandingkan antara kelompok kontrol dan kelompok stres. Hasil: Paparan stres kronis tidak terprediksi menyebabkan gangguan perilaku yang nyata pada tikus. Tikus kelompok stres menunjukkan penurunan signifikan skor nest building, mengindikasikan berkurangnya motivasi dan perilaku berorientasi tujuan. Tikus stress menunjukkan peningkatan waktu latensi grooming disertai penurunan durasi grooming, mengindikasikan gangguan perilaku perawatan diri. Kelompok stres juga menunjukkan peningkatan rasio neutrofil terhadap limfosit, menunjukkan aktivasi respons inflamasi sistemik akibat stres berkepanjangan. Kesimpulan: Temuan ini menunjukkan bahwa paparan stres kronis tidak terprediksi mampu menginduksi perubahan perilaku menyerupai depresi yang disertai dengan peningkatan marker inflamasi perifer pada tikus. Hasil ini memperkuat validitas model stres kronis sebagai pendekatan eksperimental untuk merepresentasikan keterkaitan antara disfungsi perilaku dan disregulasi imun yang berasosiasi dengan kondisi depresi
Co-Authors Agus Setiyono Akterono D. Budiyati Andriyanto Andriyanto Aulia Andi Mustika Aurelia, Sharon I Ketut Suada Irarang, Yusa Mustika, Aulia A. Putra, Hamdika Yendri Sindi Farhana Sitanggang, Fajar Islam Subangkit, Mawar Wasmen Manalu Widi, Leliana Nugrahaning Yendri, Hamdika