International Journal of Contemporary Sciences (IJCS)
Vol. 1 No. 1 (2023): November 2023

ADMET Prediction of the Dominant Compound from Mangosteen (Garcinia mangostana L.) using pkCSM: A Computational Approach

Muslikh, Faisal Akhmal (Unknown)
Kurniawati, Evi (Unknown)
Ma'arif, Burhan (Unknown)
Zenmas, Syendriva Zeptyan (Unknown)
Salmasfattah, Novyananda (Unknown)
Dhafin, Anis Akhwan (Unknown)
Prasetyawan, Fendy (Unknown)



Article Info

Publish Date
30 Dec 2023

Abstract

Mangosteen (Garcinia mangostana L.) is a plant belonging to the Guttiferae family with origins in Southeast Asia. The primary components in mangosteen peel consist of xanthones, particularly α-mangostin, which displays diverse pharmacological effects such as anti-diabetic properties, antioxidant activity, and anti-inflammatory effects. However, due to the insufficient information regarding studies on pharmacokinetics (administration, distribution, metabolism, excretion, and toxicity), the objective of this investigation is to explore pharmacokinetic predictions utilizing the pkCSM web tool. The α-mangostin compound, acquired from PubChem accessible at https://pubchem.ncbi.nlm.nih.gov/, underwent pharmacokinetic analysis using the web tool available at https://biosig.lab.uq.edu.au/pkcsm/prediction. The study findings revealed that the α-mangostin compound, subjected to pharmacokinetic analysis with pkCSM, exhibited limited distribution capability.

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Journal Info

Abbrev

ijcs

Publisher

Subject

Religion Humanities Decision Sciences, Operations Research & Management Education

Description

International Journal of Contemporary Sciences (IJCS) is an online, peer-reviewed international research journal that addresses both applied and theoretical issues. The scope of the journal encompasses research articles, case studies, original research reports, reviews, and scientific commentaries ...