Indonesian Journal of Pharmaceutical and Clinical Research
Vol. 7 No. 1 (2024): Indonesian Journal of Pharmaceutical and Clinical Research

Antibacterial Activity Test of Malacca Leaf Extract (Phyllanthus emblica) Against Staphylococcus aureus and Staphylococcus epidermidis Bacteria

Ridwanto, Ridwanto (Unknown)
Aprilia, Hijjatun (Unknown)
Rani, Zulmai (Unknown)
Putri Aisyia Fauzi, Ziza (Unknown)
Kaban, Vera Estefania (Unknown)
Nasri, Nasri (Unknown)



Article Info

Publish Date
16 Nov 2024

Abstract

Antibacterials are substances that can interfere with the growth or even kill bacteria and have the side effect of antibacterial resistance. One effort to reduce resistance is choosing to use natural bacterial ingredients. One plant that can potentially contain antibacterial activity is malacca leaves (Phyllanthus emblica). The contents of this plant include flavonoids, alkaloids, tannins, saponins, and steroids/triterpenoids. This research aimed to prove the antibacterial activity test of malacca leaf extract. The stages in this research included phytochemical screening and testing the antibacterial activity of ethanol extract from Malacca leaves for Staphylococcus aureus and Staphylococcus epidermidis bacteria using the diffusion method using paper discs. The characteristics of malacca leaf simplicia obtained were water content of 4.6%, water-soluble content of 28%, ethanol-soluble essence content of 23.33%, total ash content of 2.00%, and insoluble ash content of 0.5%. The results of phytochemical screening showed the presence of flavonoids, saponins, tannins, glycosides, and steroids/triterpenoids. The antibacterial test results of malacca leaf extract at concentrations of 500 mg/ml, 400 mg/ml, 300 mg/ml, and 200 mg/ml have an antibacterial effect against Staphylococcus aureus and Staphylococcus epidermidis, and there is no difference in the effectiveness of the inhibitor against gram-positive and negative grams.

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Journal Info

Abbrev

idjpcr

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Description

Indonesian Journal of Pharmaceutical and Clinical Research (IDJPCR) is a-peer-reviewed publication of original research works. The mission of the journal is to offer a medium to exchange ideas and information about the advancement of knowledge and research in disciplines of pharmaceutical ...