Effect of Purple Leaf (Graptophyllum pictum (L.) Griff) Emulsion on the Histological Parameters of Streptozotocin-Induced Diabetic Rats

Niluh Puspita Dewi (STIFA Pelita Mas Palu)
Komang Dewik (STIFA Pelita Mas Palu)
Syafika Alaydrus (STIFA Pelita Mas Palu)
Athia Kurnia Kasim (Academy of Pharmacy Bina Farmasi)
Nani Astria Polontalo (Akademi Farmasi Bina Farmasi)
Wayan Wirawan (STIFA Pelita Mas Palu)
Dian Andini (STIFA Pelita Mas Palu)
Irma Irma (STIFA Pelita Mas Palu)
Imelda Synthia Fatu (STIFA Pelita Mas Palu)

Jurnal Penelitian Pendidikan IPA (JPPIPA)
Vol 12 No 1 (2026)

Damage to vital organs such as the liver, kidneys, and pancreas is a common complication of diabetes mellitus, characterized by chronic hyperglycemia due to pancreatic cell dysfunction. Graptophyllum pictum (purple leaf) is a potential herbal therapy containing bioactive compounds with antioxidant and organ-protective effects. This study aimed to evaluate the effect of purple leaf emulsion on blood glucose levels and the histopathological features of diabetic rats induced by streptozotocin. Rats were divided into six groups: normal control, negative control, positive control (glibenclamide), and three doses of purple leaf emulsion (100, 200, and 300 mg/kg BW). After 28 days of treatment, the emulsion significantly reduced blood glucose levels and improved the histological structures of the liver, kidneys, and pancreas. The 200 mg/kg BW dose was most effective for pancreatic protection, while 300 mg/kg BW provided optimal hepatoprotective and renoprotective effects. These findings highlight the potential of purple leaf as a natural antidiabetic and organ-protective agent.