<![CDATA[The tamarind peel (Tamarindus indica L.) extract contains flavonoids that have the ability to provide photoprotection. An optimal cream formulation is required to achieve a high-quality dosage form. This study aimed to determine the total flavonoid content (TFC), to obtain the optimal cream formula, and to measure its photoprotective activity. This research was conducted experimentally and optimized using the Simplex Lattice Design (SLD) method using factors (stearic acid and triethanolamine) and responses (pH, viscosity, spreadability, and adhesiveness). In vitro photoprotective activity determination test using sun protection factor (SPF), erythema transmission percentage (%Te), and pigmentation transmission percentage (%Tp) parameters. The TFC is 47.7018±1.68 mg QE/g. The optimization results showed that variations in stearic acid and trietanolamine concentrations affected pH, viscosity, spreadability, and adhesiveness. The optimization produced a desirability value of 0.967 with predicted factors of 16.078% stearic acid and 3.922% triethanolamine. The predicted responses included pH (4.933), viscosity (247.32 dPas), spreadability (7.07 cm), and adhesiveness (7.37 seconds). A one-sample t-test showed no significant difference between the predictions and the actual results, as indicated by the calculated t-value (pH 0.002, viscosity 0.049, spreadability 0.000, and adhesion 0.000) < t-table (4.303). The cream containing tamarind peel extract exhibits photoprotective activity, with an SPF value of 13.63 ± 1.01, a %Te of 4.64 ± 1.19, and a %Tp of 12.37 ± 1.89. Photoprotective parameters show that the cream is quite good and has the potential for further development. In conclusion, this study shows that the optimized tamarind peel extract cream has photoprotective activity.]]>
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