The case of drug discontinuation in West Papua Province in 2024 was 20.2%. The general objective of the study was to examine the factors causing drug discontinuation in tuberculosis (TB) patients at the Sanggeng Health Center in 2024. The type of research is qualitative research with a phenomenological approach.at Sanggeng Health Center, Manokwari Regency, West Papua Province. The results showed that the main causes of patients discontinuing medication were drug side effects, suboptimal service quality, wrong perceptions in completing treatment, accessibility barriers, and low economic factors of informants. The factors causing discontinuing medication related to patients were low knowledge, drug side effects, wrong perceptions about treatment, and low socio-economic status. The factors causing medication related to health services were lack of education about TB disease and suboptimal support from officers to informants. The availability of medication was not a problem at Sanggeng Health Center. Environmental factors found that there was still stigma against informants although not dominant, access to health services was far away, and the culture of the community still using herbal remedies as a companion and substitute for medical drugs. Family support existed but was not optimal.
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