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Jurnal Farmasi Sains dan Komunitas

JFSK
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Published by Universitas Sanata Dharma

ISSN : 16935683 EISSN : 25277146 DOI : https://doi.org/10.24071/

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 8 Documents

Search results for , issue "Vol 11, No 2 (2014)" : 8 Documents clear

FORMULASI MATRIKS TRANSDERMAL PENTAGAMAVUNON-0 DENGAN KOMBINASI POLIMER PVP K30 DAN HIDROKSIPROPIL METILSELULOSA Beti Pudyastuti; Akhmad Kharis Nugroho; Sudibyo Martono
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 2 (2014)
Publisher : Sanata Dharma University

Abstract: Transdermal delivery system is one of the delivery system for Pentagamavunon-0 (PGV-0) toavoid the high intensity of first pass metabolism of PGV-0 in peroral route. The purpose of this researchwas to optimize the formula of PGV-0 transdermal matrix with a combination of PVP K30 and HPMCpolymers.The simplex lattice optimization approach of the transdermal matrix formulas was performed byusing Design Expert 7.1.5 software. The visual appearance, weight, thickness, moisture content, moistureuptake, folding endurance, drug content, and dissolution efficiency of the release profil of PGV-0 from thematrix for 6 hours were evaluated as responses to determine optimum formula of matrix. The resultshowed that a combination of PVP K30 and HPMC polymers had a significant influence on the visualappearance, moisture content, and dissolution efficiency of PGV-0. Combination of 1.98% of PVP K30and 4.52% of HPMC as the optimum formula could produce homogeneous and flexible matrix withmoisture content of 3.21%. The dissolution efficiency was 9.11%, indicating that 101.93 g of PGV-0 wasreleased from the optimum formula during 6 hours.Keywords : Pentagamavunon-0, Transdermal matrix, PVP K30, HPMC

UJI TOKSISITAS SUBKRONIS INFUSA DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) PADA TIKUS: STUDI TERHADAP GAMBARAN MIKROSKOPIS JANTUNG DAN KADAR SGOT DARAH Ignasius Kuncarli; Ipang Djunarko
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 2 (2014)
Publisher : Sanata Dharma University

Abstract: Red betel (Piper crocatum Ruiz Pav) is one of the plants used as traditional medicinecommunity. To determine the level of safety of long-term consumption, then tested subchronic toxicity. Thestudy aimed to determine the relationship spectrum of toxic effects of infusion with changes in levels ofserum glutamic oxaloacetic transaminase (SGOT) and cardiac histopathology. The study was purelyexperimental, randomized study design complete unidirectional pattern. A total of 40 Wistar rats (20 malesand 20 females), 2-3 months were divided randomly into 4 groups: control group distilled water and 1.38;2.07; 3.105 g/KgBW of red betel leaf infusion with administration once daily for 28 days. Observationswere made before treatment and on day 28 by orbital sinus sampling through to measurement of bloodlevels of SGOT be analyzed by one way ANOVA and partially dissected mouse to see the damage to theheart. The results showed there was no significant change (p 0.05) in SGOT levels compared the controlgroup. Histology showed no specific changes were observed after administrating 28 days of red betel leafinfusion. The red betel leaf infusion did not cause significant change in SGOT level and histology of heart.Keywords : red betel, subchronic toxicity tests, SGOT, cardiac histology.

UJI DAYA ANTIBAKTERI DAN IDENTIFIKASI ISOLAT SENYAWA KATEKIN DARI DAUN TEH (Camellia sinensisL. var Assamica) Christina Astutiningsih; Wahyuning Setyani; Himawan Hindratna
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 2 (2014)
Publisher : Sanata Dharma University

Abstract: Antibacterial is a substance that can interfere with the growth and metabolism of bacteria, sothat these substances can inhibit growth or even kill bacteria. This research aimed to utilize naturalmaterials as a natural antibacterial. This study investigated the ability of isolates catechins of tea leaves toinhibit Staphylococcus aureus and spectral identification of these catechins. Catechin compounds wasextracted by water, and then fractionated with CHCl3 and ethyl acetate. Ethyl acetate phase wasconcentrated fractionation results using a rotary evaporator for further separation using thin layerchromatography with various mobile. The results of the study showed that the concentration of isolates ofdemonstrated to be effective as antibacterial, with MIC 12.5%. UV spectrum measurement showed that theisolates had a maximum absorption at a wavelength of 279 nm while the FTIR spectrophotometer showedthat isolates catechin-containing functional groups C = C aromatic absorption 1500-1600 nm^-1 and OHgroups, a broad band between 2000 and 3600 nm^-1.Key words: isolates catechins, Staphylococcus aureus, tea leaves, antibacterial

EVALUASI DRUG RELATED PROBLEMS PADA PASIEN GERIATRI DENGAN HIPERTENSI DISERTAI VERTIGO DI RS PANTI RINI YOGYAKARTA AGUSTUS 2013 Kresensiana Yosriani; Maria Wisnu Donowati; Aris Widayati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 2 (2014)
Publisher : Sanata Dharma University

Abstract : This study aimed to evaluate Drug Related Problems (DRPs) among hypertensive geriatricpatients with vertigo co morbid at Panti Rini Hospital Yogyakarta. This is a non-experimental researchdescriptive evaluative design using a retrospective medical record data. Collected data including patient'sidentity; initial, final, and complication diagnosis; cardiovascular system drugs and antivertigo,laboratory data. The inclusion criteria were ? 60 years with an initial diagnosis of hypertension withvertigo co morbid, used a diuretic drug, and had creatinine test result. Data were analyzed case by caseusing selected literatur. There were 20 cases found. Result of the study showed that 100% of patients usedantihypertensive as the cardiovascular system drugs and 80% patients used antivertigo as nervous systemdrugs. There were 18 cases of DRPs found related to the use of antihypertensive and antivertigo. 1 case ofdosage too low, 8 cases of adverse drug reaction, and 9 cases of dosege too high.Keywords : hypertension with vertigo co morbid, geriatrics, Drug Related Problems

KORELASI RASIO LINGKAR PINGGANG PANGGUL (RLPP) TERHADAP PROFIL LIPID PADA PRA-GERIATRI DAN GERIATRI Linawati Yunita; Dita Maria Virginia
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 2 (2014)
Publisher : Sanata Dharma University

Abstract: Abnormality of lipid profile is one of cardiovascular risk factors which increases with aging.Anthropometric measurement is one of the predictors of abnormal lipid profile without invasive methodsand affordable cost. One of the anthropometric measurements that could be used as a predictor is waist tohip ratio (WHR). The aim of this study was to determine the correlation between WHR with abnormality oflipid profile which were related to total cholesterol, Low Density Lipoprotein (LDL), High DensityLipoprotein (HDL), and triglyceride (TG) in pre-geriatrics and geriatrics group. This study was analyticalobservational with cross sectional design. Statistical analysis used Kolmogorov-Smirnov followedbivariable analysis with confidence interval (CI) 95%. The correlation statistical test used Pearson andSpearman. The results showed no statistically significant correlation between WHR with total cholesterol(r=-0.054, p 0.05), LDL (r=-0.047, p 0.05), TG (r=0.018, p 0.05), and HDL (r=0.016, p 0.05).Keywords: lipid profile, waist-to-hip ratio (WHR), pre-geriatric, geriatri

POTENSI ANTIMIKROBIA KRIM EKSTRAK RANTING PATAH TULANG (Euphorbia tirucalli Linn.) TERHADAP Propionibacterium acnes ATCC 11827 DAN Candida albicans ATCC 24433 Melina Scandinovita Setiorini; C.J. Soegihardjo; Kianto Atmodjo
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 2 (2014)
Publisher : Sanata Dharma University

Abstract: Euphorbia tirucalli L. (Euphorbiaceae) or patah tulang has been used traditionally in Java fortreatment of fungal infections (Propionibacterium acnes causing acne and Candida albicans causingcandidasis). Information on their use is available, but scientific data on their bioactivity and safety ofactions still scanty. A study was conducted on the effect of organic extracts of this plant on fungal strains.Aceton extract were evaluated through the disc diffusion assay. Aceton extract was prepared by Soxhletapparatus for eight hours. Bacteria and yeast test strains were cultured on TSA (Trypthone Soya Agar)and on PDA (Potato Dextrose Agar) for Candida albicans. A 0.5 McFarland standard suspension wasprepared. Sterile paper discs 6 mm in diameter impregnated with 10 ml of the test extract (100 mg/ml)were aseptically placed onto the surface of the inoculated media. Thymol 0,5% and ketokonazol 2% wereused as standards. Discs impregnated with dissolution medium were used as controls. Activity of theextracts was expressed according to zone of inhibition diameter. Dimethylsulfoxide (DMSO) was used forpreparing test extracts (10, 20, 40, 60, 80, 100%) and were tested for Minimum Inhibitory Concentration(MIC) to Propionibacterium acnes and Candida albicans. MIC were obtained that 100% test extract wasgreatest and 10% test extract was weakest. Then, test extracts were prepared by concentrations 10, 9, 8, 7,6, 5%, and the result were the best were 10% test extract to Propionibacterium acnes and 6% test extractto Candida albicans. Antimicrobial test for pharmaceutical preparation, i.e. cream (o/w) were preparedusing 9 and 10% test extracts mixed with cream for testing to Propionibacterium acnes and 5 and 6% testextracts with cream for testing Candida albicans.The final results were 10% test extract had MIC toPropionibacterium acnes and 6% test extract had MIC in cream to Candida albicans.Keywords: Euphorbia tirucalli L., DMSO, Thymol, antimicrobial potency, cream (o/w), Propionibacteriumacnes, Candida albicans

AKTIVITAS ANTIBAKTERI LOTION MINYAK KAYU MANIS TERHADAP Staphylococcus epidermidis PENYEBAB BAU KAKI Fitri Apriliyani Tiran; Christofori M.R.R. Nastiti
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 2 (2014)
Publisher : Sanata Dharma University

Abstract: Trans-cinnamaldehyde is the major chemical compound of cinnamon oil which is potential as anantibacterial agent. Due to this activity, Cinnamon oil can be formulated into a lotion for practical use.This study aimed to determine the antibacterial activity of cinnamon oil and cinnamon oil lotion againstStaphylococcus epidermidis, which causes unacceptable foot odor. This study was a pure experimentalstudy. Stages of this study were starting from the obsevation of antibacterial activity of Cinnamon oilagainst Staphylococcus epidermidis which was done by using diffusion method to determine theconcentrations used in the formulation. Cinnamon oil was then formulated into lotions with variation ofconcentrations of 12; 18; and 24% (w/w) respectively. Furthermore, the quality of lotion based on itsphysical properties such as viscosity and spread-ability, and the antibacterial activity of lotion weredetermined. The inhibition zones then were statistically analyzed by using the Kruskal-Wallis test withassistance of R 2.14.1software. The result showed that cinnamon oil lotion had good physical properties ata concentration of 12% (w/w). Cinnamon oil itself and the formulations had significant activity againstStaphylococcus epidermidis. Moreover, cinnamon oil and its formulation showed similar antibacterialactivity against Staphylococcus epidermidis.Keywords : antibacterial activity, cinnamon oil, lotion, Staphylococcus epidermidis

HUBUNGAN PROCALSITONIN DAN GAMBARAN MORFOLOGI LEUKOSIT PADA INFEKSI BAKTERIAL Fenty Fenty; Dita Maria Virginia
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 11, No 2 (2014)
Publisher : Sanata Dharma University

Abstract: Bacterial sepsis increases morbidity and mortality in all ages. Early detection has been shownto be crucial for the improved outcome of patients with sepsis. Till now there is no routine test forscreening. Procalcitonin and morphology of leukocytes are biomarkers of bacterial sepsis. The aim of thisstudy was to determine the relationship between procalcitonin and morphology of leukocytes as marker inbacterial infection. This study was analytical observational with cross sectional design and data collectedprospectively.This study measured simultaneously the value of procalcitonin and morphology of leukocytesexamination in patients with suspected bacterial infection in hospital X of Yogyakarta. Data were analysedby statistics. The results showed immature granulocytes and vacuolization of neutrophils in the leucocytesmorphology has a significant correlation with level of procalcitonin.Keywords: bacterial infection, procalcitonin, morphology of leukocytes

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Florentinus Dika Octa Riswanto

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Daerah istimewa yogyakarta

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Abstract

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Florentinus Dika Octa Riswanto

Contact Email editorial.jpsc@usd.ac.id

Phone -

Journal Mail Official editorial.jpsc@usd.ac.id

Editorial Address Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location Kab. sleman, Daerah istimewa yogyakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Florentinus Dika Octa Riswanto

Contact Email
editorial.jpsc@usd.ac.id

Phone
-

Journal Mail Official
editorial.jpsc@usd.ac.id

Editorial Address
Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA