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Jurnal Farmasi Sains dan Komunitas

JFSK
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Published by Universitas Sanata Dharma

ISSN : 16935683 EISSN : 25277146 DOI : https://doi.org/10.24071/

Core Subject : Health,

Medicine & Pharmacology

Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community / J Pharm Sci Community) firstly published in 2003, is a peer-reviewed, open access scientific journal that publishes research articles, review articles, as well as short communication in various pharmaceutical fields, including Pharmaceutical Technology and Pharmaceutics, Pharmaceutical Analysis, Medicinal Chemistry, Pharmacology and Toxicology, Pharmaceutical Biology, Community Pharmacy, and Clinical Pharmacy.

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 7 Documents

Search results for , issue "Vol 17, No 2 (2020)" : 7 Documents clear

ANTIBACTERIAL ACTIVITY AND TLC-BIOAUTOGRAPHY ANALYSIS OF THE ACTIVE FRACTIONS OF Muntingia calabura L. LEAVES AGAINST Staphylococcus aureus Rizky H. Mawardi; Nanik Sulistyani; Nurkhasanah Nurkhasanah; Ricke Desyratnaputri
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 2 (2020)
Publisher : Sanata Dharma University

This study aims to determine the antibacterial activity and TLC-bioautography profile of the active fractions of Muntingia calabura L. leaves against Staphylococcus aureus. Muntingia calabura L. leaves were macerated with ethanol 96% then fractionated with n-hexane, ethyl acetate, and methanol solvent, respectively. The antibacterial activity was tested by the Kirby-Bauer method to determine the most active fraction and the lowest concentration that inhibited the growth of Staphylococcus aureus. TLC-bioautography was tested using chloroform: ethyl acetate (2:8) as the mobile phase and silica gel F254 as the stationary phase. Antibacterial activity test of n-hexane and ethyl acetate fractions at a concentration of 10% w/v showed activities with inhibition zone diameter of 0.330.288 and 9.665.77 mm, respectively. At the same time, the methanol fraction showed no activity. The lowest concentration of ethyl acetate fraction which still showed the inhibition zone was 0.312% w/v. The TLC-bioautography profile showed active spots with an Rf value of 0.82 and had an inhibitory zone diameter of 4.0130.864 mm. It can be concluded that the ethyl acetate fraction was the most active fraction that inhibited the growth of Staphylococcus aureus and had one active spot on the bioautography test.

CORRELATION AMONG SLEEP DURATION, BLOOD PRESSURE, AND BLOOD GLUCOSE LEVEL OF MORANGAN PEOPLE, SINDUMARTANI, NGEMPLAK, SLEMAN Gregorius Bhaskara Wikanendra; Rita Suhadi; Christianus Heru Setiawan; Dita Maria Virginia; Phebe Hendra; Fenty Fenty
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 2 (2020)
Publisher : Sanata Dharma University

Sleep deprivation is a risk factor for cardiovascular and metabolic diseases. There was a high prevalence of high blood pressure and type 2 diabetes in Morangan, Yogyakarta Province. This study aims at studying the correlation between sleep duration, systolic blood pressure and fasting blood glucose levels of people in Morangan. This study was a cross-sectional study conducted in cooperation with a public health care program for people in Morangan. Data collection was done using a questionnaire and health screening procedure during the public health care program. Collected data were covering aspects of systolic blood pressure, fasting blood glucose, sleep duration, and sleep habit. There was a high prevalence of high systolic blood pressure (130mmHg; 66.04%) and high fasting blood glucose level (100mg/dL; 39.62%) in Morangan people. There was a significantly positive correlation between sleep duration and systolic blood pressure (p:0.024; r:0.31) but no significant correlation between sleep duration and fasting blood glucose level. The major contributing habits towards sleep deprivation were caffeine consumption and medium pre-sleep routine. The result of this research will provide help in designing an education program for people of Morangan in preventing and treating high blood pressure and type 2 diabetes.

OPTIMIZATION OF OLIVE OIL, TWEEN 80, AND PROPYLENE GLYCOL OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM OF ZINC OXIDE BY D-OPTIMAL METHOD Dian Eka Ermawati; Adi Yugatama; Wening Wulandari
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 2 (2020)
Publisher : Sanata Dharma University

The incidence of skin cancer in Indonesia reaches 6-8%, so the skin needs effective protection. Zinc Oxide (ZnO) is a sunscreen with Sun Protecting Factor (SPF) 50 which is able to reduce exposure to Ultraviolet rays. ZnO is difficult to dissolve in water making an obstacle if dispersed in a hydro gel matrix, so it is formulated into a Self-Nanoemulsifying Drug Delivery System (SNEDDS) preparation. SNEDDS formula was made using tween 80 as surfactant, propylene glycol as a co-surfactant, and olive oil. The optimum proportion of the three components was optimized with the D-Optimal method using Design Expert Stat-Ease 9 Trial software. Software obtained 16 formulas which were tested for physical stability response: transmittance value (%) and pH value. SNEDDS optimum formula was compared with the D-Optimal prediction formula using the student's t-test statistical analysis (p0.05), the loading dose of ZnO, Particle Size Analysis, and Zeta Potential. The optimum proportion of propylene glycol, tween 80, and olive oil making up SNEDDS were 9.9%: 81%: 9.1% respectively. The result of the percent transmittance response was 92.30% and the pH value was 7.20. Software prediction results: transmittance value was 92.59% and pH value was 7.37. Statistical analysis of one sample t-test showed no difference between observations and D-Optimal predictions. SNEDDS was able to load 2.0 mg ZnO/gram SNEDDS with a particle size of 150.2 nm; polydispersity index of 0.54 and zeta potential of -28.50 mV. The SPF value of SNEDDS ZnO was 16.

ASSOCIATION BETWEEN SMOKING BEHAVIOUR AND GLYCOHEMOGLOBINE LEVELS AMONG ADULT JAVANESE INDONESIAN SMOKERS Christine Patramurti; Fenty Fenty
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 2 (2020)
Publisher : Sanata Dharma University

Nicotine, the active compound in cigarettes, can cause impaired glucose metabolism byincreasing insulin resistance as well as decreasing insulin secretion in ? cell pancreas. Thiscondition can increase the risk of type 2 diabetes in human. This study aims to evaluate the effectof smoking behaviour, determined by Cigarette per Day (CPD) and smoking duration, onglychohemoglobine (HbA1c) levels of Javanese Indonesian smokers. 30 smokers were studiedconsisting of 7 smokers with 10 CPD, 19 smokers with 11-20 CPD and 4 smokers with 21-30CPD. They had been smoking for more than 10 years. The whole blood sample was used toexamine the HbA1c levels. The HbA1c levels were tested at Bethesda Hospital's cliniclaboratories using Architect 600 instrument. The results showed that CPD and smoking durationsignificantly influenced HbA1c, in which F count was F table (370.541 3.354) withsignificance 0.05 (2.35. 10-20 0.05) and multiple correlation coefficient (R) of 0.982.Therefore, based on this research finding, it was concluded that longer smoking duration andhigher CPD caused higher smokers HbA1c level.

CHOLESTEROL LOWERING EFFECT OF CHITOSAN NANOPARTICLES USING PARIJOTO FRUITS EXTRACT Fania Putri Luhurningtyas; Rissa Laila Vifta; Nur Syarohmawati; Mahardika Adhi Candra
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 2 (2020)
Publisher : Sanata Dharma University

Parijoto (Medinilla speciosa Reinw. ex Blum) fruit is known to have pharmacological activity as cholesterol lowering levels. Its activity needs to be increased with nanoparticle system so that the active substance can bind 100% to the action target. This study aims to determine the formation of nanoparticles from parijoto fruit (NEBP) and activity test as a decrease in cholesterol levels. The formation of nanoparticles used variations of concentration and volume of chitosan and NaTPP. Anti-cholesterol testing is based on the amount of free cholesterol in the sample that reacted with Lieberman-Burchard into complex green compounds. The best formation of NEBP was 0.2% chitosan, 0.1% NaTPP and volume ratio 5:1. The particle size showed an average size of 269.3 nm (10-1000 nm). The result of the percent transmittance and polydispersity index were 99,379 (close to 100%) and 0.378 (PDI 0.5). The functional group-specific of NEBP was OH, N-H, PO3. The morphology was round and non-uniform particles. NEBP can decrease 50% cholesterol levels with a smaller EC50 value was 89.08 compared to the extract (EC50 259.98 ppm). Nanoparticles of parijoto fruit is a potential candidate for anti-cholesterol drug.

EFFECTS OF INTERPROFESSIONAL COLLABORATION PROGRAM IN COMMUNITY ON THE PERCEPTION OF PHARMACY AND MEDICAL STUDENTS Christianus Heru Setiawan; Rita Suhadi; Phebe Hendra; Fenty Fenty; Dita Maria Virginia; Gregorius Bhaskara Wikanendra
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 2 (2020)
Publisher : Sanata Dharma University

Cardiovascular disease is the highest cause of mortality in Indonesia. One of the factors that causes the disease is low level of health awareness, including healthy lifestyle and health control. Improving public health awareness can be done by providing health education in collaboration with interprofessional health services. A collaboration involving students from various health-related disciplines aims to build good collaboration in the future after the corresponding students become health workers. This study is quasi-experimental. Students from health-related disciplines, especially pharmacy and medical students, were authorized to work directly in health screening and to provide education to the community. Students perceptions on the Interprofessional Collaboration (IPC) program were explored through Student Perceptions of Physician-Pharmacist Interprofessional Clinical Education (SPICE) questionnaire, which were given before and after the community project. Among 87 SPICE questionnaires, 78 questionnaires filled in completely were collected from pharmacy and medical students. The results of the questionnaire showed good perceptions before and after activities in the community with mean scores of 4.46 (0.35) and 4.5 (0.37) respectively. Wilcoxon test results found no significant difference on the total SPICE scores before and after the activity (P .05). One item from the SPICE questionnaire, which was the seventh item related to understanding the role of other professionals in the interdisciplinary team, had a significant increase (P .05).

IDENTIFICATION OF THE SPREAD OF BORAX USE IN MEATBALL SKEWERS IN BANTUL DISTRICT, SPECIAL REGION OF YOGYAKARTA Sabtanti Harimurti; Imelda Horirotul Bariroh; Asep Setiyawan; Ratna Indah Permatasari; Friccillia Dwi Putri; Leni Yasinta Fajriana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 2 (2020)
Publisher : Sanata Dharma University

Borax is an additive that is often added to some foods such as meatball skewers. The government has banned this ingredient from being added to food because it is harmful to health when consumed for a long time. This study aims to identify the use of borax in Bakso Tusuk or meatball skewers sold in Bantul area. Samples were drawn from 17 sub-districts in Bantul, Special Region of Yogyakarta. Two samples were taken from each sub-district, so the number of total samples was 34. The speed of decay test was carried out by observing the appearance of fungus, maggots, and consistency of the surface of meatball skewers. The presence of borax in the meatball skewers was done by turmeric paper and flame test, while the quantitative analysis utilized the acid-base titration method. Based on the results of the study, all samples tested positive for borax with concentrations between 0.06% - 5.15%, and the decay rate test showed that the speed of decay was independent of the level of borax.

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Contact Name
Florentinus Dika Octa Riswanto

Contact Email
editorial.jpsc@usd.ac.id

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editorial.jpsc@usd.ac.id

Editorial Address
Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA

Abstract

Abstract

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Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Florentinus Dika Octa Riswanto

Contact Email editorial.jpsc@usd.ac.id

Phone -

Journal Mail Official editorial.jpsc@usd.ac.id

Editorial Address Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location Kab. sleman, Daerah istimewa yogyakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Florentinus Dika Octa Riswanto

Contact Email
editorial.jpsc@usd.ac.id

Phone
-

Journal Mail Official
editorial.jpsc@usd.ac.id

Editorial Address
Faculty of Pharmacy, Universitas Sanata Dharma, Indonesia

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA