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Universa Medicina
Published by Universitas Trisakti
ISSN : 19073062     EISSN : 24072230     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Universa Medicina (univ.med) is a four-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Universa Medicina Online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic
Arjuna Subject : -
Articles 13 Documents
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Search results for , issue "Vol. 43 No. 3 (2024)" : 13 Documents clear
Early radial band deflation after transradial access coronary catheterization reduces complications: a systematic review Nugroho, Rico Maulana; Waluyo, Agung; Herawati, Tuti
Universa Medicina Vol. 43 No. 3 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.363-377

Abstract

BACKGROUNDTransradial access (TRA) coronary catheterization is widely used for coronary artery disease (CAD) management. However, complications such as pain, hematoma, and radial artery occlusion (RAO) often occur due to prolonged use of radial compression bands. Early deflation protocols have been proposed to minimize these complications while maintaining effective hemostasis. This systematic review evaluates the impact of early radial band deflation protocols on reducing TRA-related complications. METHODSA systematic literature search was conducted in ProQuest, PubMed, ScienceDirect, Sage Journal, and Scopus databases, including studies published between 2018 and March 2024. Inclusion criteria focused on randomized controlled trials (RCTs), cohort studies, and quasi-experimental studies evaluating radial band deflation protocols in TRA coronary catheterization patients. Outcomes included pain, hematoma, and RAO. Twelve studies were critically appraised using the Joanna Briggs Institute (JBI) tools and synthesized using narrative and quantitative approaches. RESULTSThe review included eight RCTs, three cohort studies, and one quasi-experimental study involving a total of 4,477 patients. Findings revealed that early radial band deflation (1.5–2 hours) reduced pain and hematoma incidence compared to prolonged durations (>4 hours). RAO rates were significantly lower with gradual and early deflation protocols. However, shorter durations (<1.5 hours) slightly increased bleeding risk. Evidence supported the TR Band® Light Protocol as an effective and safe deflation strategy. CONCLUSIONEarly radial band deflation protocols effectively reduce TRA-related complications, enhancing patient comfort and safety. Standardized deflation protocols and further research, including innovative technologies, are recommended to optimize post-TRA care.
The effect of saffron serum on collagen density, inflammatory gene expression, and autophagy in UVB-exposed Wistar rats Octavia, Chitra; Gunadi, Julia Windi; Adhika, Oeij Anindita; Ishak, Lani; Jasaputra, Diana Krisanti; Rosali, Alexandrina Everdine; Sanjaya, Ardo
Universa Medicina Vol. 43 No. 3 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.329-339

Abstract

BackgroundSkin aging is a complex biological phenomenon influenced by intrinsic and extrinsic factors. Photoaging can be prevented by applying phytochemicals that have sun-protective properties. This study aimed to evaluate the effect of saffron serum to restore collagen density and autophagy processes and reduce inflammatory gene expression in UVB-exposed Wistar rats. MethodsAn experimental laboratory study was conducted involving 20 male Wistar rats that were divided into 4 groups: control, UVB, UVB + base serum, UVB + saffron serum exposed to UVB radiation for 5 weeks with a total dose of 3100 mJ/cm2. The skin was extracted then underwent Masson Trichrome staining and real-time PCR to obtain collagen density and gene expression. ResultsThe gene expression of MMP1, IL6, TNFá, LC3, and p62 was significantly increased in the UVB group compared to the control group. Topical administration of saffron serum significantly increased collagen density (p=0.001). Induction by UVB significantly increased LC3 (p=0.020) and p62 (p=0.030) gene expression, indicating an inhibition of autophagy. The saffron serum might modulate autophagy by increasing LC3, but not significant (p=0.495) and significantly decreasing p62 gene expression (p=0.001). As for MMP1, IL6, and TNFá, no significant decrease in gene expression was found in the UVB + saffron serum group compared to the UVB group. ConclusionSaffron serum increases collagen density and modulates autophagy in the skin of UVB-exposed Wistar rats. Inflammatory markers were increased after UVB induction, but no differences were found after saffron serum topical administration.
Evaluating sarcopenia prevalence and relationship with disease activity of primary Sjögren syndrome in females Başaran, Pınar Özge; Eker Büyükşireci, Dilek
Universa Medicina Vol. 43 No. 3 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.340-348

Abstract

BackgroundPrimary Sjögren’s syndrome (pSS) leads to impaired muscle function and mass as well as pain and fatigue. Sarcopenia is the pathological reduction of skeletal muscle mass and strength. We aimed to investigate the prevalence of sarcopenia and determine its relationship with disease activity levels in females with primary Sjögren syndrome. MethodsThis cross-sectional study was performed on 62 female patients diagnosed with pSS and 62 female age matched healthy controls. Disease activity was evaluated with the EULAR Sjögren’s syndrome patient reported index (ESSPRI) and EULAR Sjögren’s syndrome disease activity index (ESSDAI), fatigue severity scale (FSS), hospital anxiety and depression scale (HADS), and numerical rating scale (NRS). A simple questionnaire to rapidly diagnose sarcopenia (SARC-F) was used to screen for sarcopenia. Degree of sarcopenia was evaluated by handgrip strength, anterior thigh muscle thickness by USG, the 6-meter walk test (6MWT), and the five times sit-to-stand test (FTSST). ResultsThe prevalence of sarcopenia was found to be 36/62 (58.1%) in pSS and 6/62 (9.7%) in healthy controls (p<0.001). HADS anxiety and depression scores and SARC-F scores were significantly higher in pSS (p<0.001). There were significant differences in 6MWT, FTSST, and hand grip strength results in pSS (p<0.001). Anterior thigh muscle thickness was similar in both groups (p=0.298). A positive correlation was found between SARC-F on the one hand and ESSPRI and NRS on the other (r=0.595, p=0.009; r=0.569, p=0.014). ConclusionSarcopenia prevalence was increased in female patients with pSS and there was a relationship of SARC-F scores with pain and disease activity levels.

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