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Universa Medicina
Published by Universitas Trisakti
ISSN : 19073062     EISSN : 24072230     DOI : -
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Universa Medicina (univ.med) is a four-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Universa Medicina Online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic
Arjuna Subject : -
Articles 589 Documents
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Mucuna pruriens restores spermatogenesis in mice after exposure to 2-methoxyethanol Putu Oky Tania; Sri Winarni
Universa Medicina Vol. 32 No. 3 (2013)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2013.v32.137-145

Abstract

Background Increasing industrial activity is causing many problems in reproductive health, such as infertility. The factors causing infertility are hormones, infection, radiation, drugs and chemicals. One of these is 2-methoxyethanol (2-ME). The objective of this study was to evaluate the effect of Mucuna pruriens (MP) seed fraction on spermatogenesis, including number of spermatogenic cells and spermatozoal membrane protein profiles after exposure to 2-ME in mice. Methods This study was of experimental design. Thirty mice were randomized into 5 groups, i.e. 2 control groups and 3 treatment groups. All mice were injected subcutaneously with 2-ME doses of 100mg/kg body weight (BW)/day, for a period of 12 days. Positive (PC) and negative controls (NC) were treated with carboxy methyl cellulose (CMC). The three treatment groups were given MP seed fraction in doses of 14 (T1), 28 (T2) and 56 mg/kg BW (T3), respectively, from day 13 until day 64. Data on spermatogenic cells were collected from histological cross-sections and analyzed with one-way ANOVA. The spermatozoal membrane protein profile was identified by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) with silver staining and were analyzed descriptively. Results Administration of MP seed fractions resulted in significantly different numbers of spermatocytes I and round spermatids between PC and T1, T2, and T3. A protein with the molecular weight of 41.6 kDa was expressed in all groups except the positive controls, while a 24.5 kDa protein was expressed in the positive controls only. Conclusion MP seed fraction effectively recovers spermatogenesis loss in mice due to 2-ME exposure.
Pleiotropic effects of statins in stroke prevention Yenny, Yenny
Universa Medicina Vol 28, No 2 (2009)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2009.v28.117-126

Abstract

Cardiovascular disease is the leading cause of death and disability, and  contributes substantially to healthcare budgets. The lipid-lowering drugs, 3-hydroxy-3-methylgulutaryl-coenzyme A (HMG-CoA) reductase inhibitor or statins, reducing mortality and cardiovascular morbidity in patients with established cardiovascular disease. Statins therefore have a place in the secondary prevention of cardiovascular disease. Recent experimental and clinical studies suggest that statins may exert vascular protective effect beyond cholesterol reduction. The cholesterol-independet or “pleiotropic” effects of statin include the upregulation and activation of endothelial nitric acid synthase (eNOS) that can increase nitric oxide (NO) production. Augmentation of NO production increases cerebral blood flow, which can lead to neuroprotection during brain ischaemia. By inhibiting mevalonate synthesis, statins prevent the formation of several isoprenoids (including farnesylpyrophosphate and geranylgeranylpyrophosphate). Inhibiting geranylgeranylation of RhoA small G proteins increases the stability of eNOS mRNA through the remodeling of endothelial actin microfilamens. Moreover, statins directly increase eNOS activity within minutes by activating the pathway involving phosphoinositide 3-kinase and protein kinase B. In the secondary prevention of stroke, the use of statins reduces the incidence of either recurrent stroke or other major vascular events and treatment should be initiated soon after the event. The use of statins does not increase hemorrhagic stroke or cancer and may also favor atherosclerotic plaque regression.
Dietary fat and cardiovascular disease? Merijanti, Lie T.
Universa Medicina Vol 34, No 3 (2015)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.159-160

Abstract

Dietary saturated fat (SF) intake has been shown to increase low density lipoprotein (LDL) cholesterol and therefore has been associated with increased risk of cardiovascular disease (CVD). This evidence coupled with inferences from epidemiologic studies and clinical trials, had led to longstanding public health recommendations for limiting SF intake as a means of preventing CVD. However the relationship between SF and CVD risk remains controversial, due at least in part to the intrinsic limitations of clinical studies that have evaluated this relationship. A recent meta analysis showed that current evidence does not clearly support cardiovascular guidelines that encourage high consumption of polyunsaturated fatty acids (PUFA) and low consumption of total SF. They found weak positive associations between circulating palmitic and stearic acids (found largely in palm oil and animal fats, respectively) and CVD, whereas circulating margaric acid (a dairy fat) significantly reduced the risk of CVD.(2,3) Saturated fat are not associated with all cause mortality, CVD, CHD, ischemic stroke or type 2 diabetes, but the evidence is heterogenous with methodological limitations.
Amniocentesis increases level of anxiety in women with invasive prenatal diagnosis of Down syndrome Yanuarita Tursinawati; Serene Thain; Christina Choi; George Heong Yeo Seow
Universa Medicina Vol. 34 No. 2 (2015)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.112-120

Abstract

Backgound Invasive prenatal diagnosis (PND) through amniocentesis and chorionic villus sampling (CVS) can detect Down syndrome. Pregnant women usually experience a variety of psychological responses associated with invasive PND. This study is intended to assess depression, anxiety and stress levels and the factors related to their psychological responses in pregnant women with invasive prenatal diagnosis of Down syndrome.Methods A cross sectional study was conducted at Kandang Kerbau Women’s and Children’s Hospital, Singapore. The psychological responses of 70 women undergoing PND were assessed by Depression Anxiety Stress Scale 21 (DASS 21) questionnaire. A multiple linear regression analysis was used to analyze association between knowledge and perceived risk with psychological responses (CI 95% and significance value p<0.05).Results More than half of the participants had normal anxiety (55.7%), stress (72.8%), depression levels (65.8%). The results revealed significantly higher level of anxiety in women with gestational age >13 weeks who had pursued amniocentesis. Women with no previous children had higher levels of depression and stress. Women who pursued amniocentesis had significantly higher anxiety scores compared to women undergoing CVS (p=0.015).Conclusions Women’s psychological responses are associated with gestational age, type of procedure and parity. The level of anxiety increased in women who underwent amniocentesis for diagnosis of Down syndrome. Knowledge and perceived risk of having a baby with Down syndrome do not seem to have psychological effects to women.
Short-term aerobic exercise does not change kidney function in students of Nnamdi Azikiwe University, Nigeria Chinedu, Ihim Augustine; Obi, Patrick Chinedu; Udoka, Egbe Josephat; Osakue, Nosakhare; Ozuruoke, Donatus F.; Nwobodo, Emmanuel I.; Meludu, Samuel C.; Okechukwu, Okeke Chizoba
Universa Medicina Vol 36, No 3 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.166-172

Abstract

BackgroundExercise has been known to have beneficial effects on human health. The kidneys play an important role in regulating acid-base and water-electrolyte balance disturbances induced by exercise. The objective of this study was to investigate the effect of short term aerobic exercise (volleyball training) on the kidney function of apparently healthy individuals. MethodsAn experimental study of pre-post test design was conducted involving 41 amateur volleyball players, comprising 22 males and 19 females. They were randomly divided into seven different teams. Each team trained for at least 45 minutes for four consecutive days for two weeks. Both pre-and post-exercise blood pressure (BP) was measured using an automatic blood pressure measuring device OMRON 907 (OMRON, Hoofddorp, Netherlands). Likewise, both pre- and post-exercise blood samples were collected into lithium heparin tubes and centrifuged at 3000 rpm for 10 minutes and the plasma separated into plain tubes. Electrolytes were analysed using ion selective electrode machine (SFRI 4000, Germany), urea using modified Berthelot method, creatinine using Jaffe-Slot method and uric acid using the uricase method and estimated glomerular filtration state (eGFR) was calculated using the Modification of Diet in Renal Disease (MDRD) formula. ResultsThe mean levels of pre- and post-exercise systolic blood pressure, creatinine, urea, sodium, potassium, chloride, bicarbonate and eGFR did not differ significantly (p&gt;0.05). However, serum uric acid was significantly increased (p&lt;0.05), while diastolic BP significantly decreased after exercise (p&lt;0.05).ConclusionThe study showed that short-term moderate intensity aerobic exercise does not have any significant effect on the renal functions.
Maternal perception of sickness as a risk factor of stunting in children aged 2-5 years Dellu, Maria Fatima Dete; Mexitalia, Maria; Rosidi, Ali
Universa Medicina Vol 35, No 3 (2016)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2016.v35.156-164

Abstract

BackgroundStunting in children is caused by past nutritional problems, adversely affects the physical and mental characteristics of children and is a well-established child-health indicator of chronic malnutrition. Socio-cultural factors can affect parenting, thereby indirectly affecting child growth. The objective of this study was to determine socio-cultural factors and parental short stature as risk factors of stunting in children aged 2 to 5 years.MethodsThe study used a quantitative approach with case control design and a qualitative approach with in-depth interview. The study subjects were children aged 2-5 years, consisting of 45 cases of stunting and 45 controls (normal subjects). Socio-cultural data were obtained through interviews with the mothers, while height was measured with a stadiometer. Data were analyzed using chi square and logistic regression tests to calculate the odds ratio (OR).ResultsThe logistic regression test showed that maternal perception of sickness as a curse (OR=7.43; 95% CI: 2.37-23.21), stopping breastfeeding at &lt;24 months (OR=6.01;95% CI: 1.83-19.69) and low household expenditure for food (OR=5.78;95% CI: 1.28-26.01) were risk factors of stunting incidence with a probability of 73.8%. The most dominant risk factor of stunting was maternal perception of sickness (OR=7.43 95% CI: 2.37-23.21). ConclusionMaternal perception of sickness was the most dominant risk factor of stunting in children 2-5 years of age. A multidisciplinary approach is needed to address the range of raised issues and so combat stunting in children.
Validity and reliability of Preschool Language Scale 4 for measuring language development in children 48-59 months of age Sidarta, Nuryani; Tulaar, Angela BM; Nasution, Amendi; Suryanto, Suryanto
Universa Medicina Vol 27, No 4 (2008)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2008.v27.174-182

Abstract

Prevalence rates for speech and language delay have been reported across wide ranges. Speech and language delay affects 5% to 8% of preschool children, often persisting into the school years.  A cross-sectional study was conducted in 208 children aged 48-59 months to determine the validity and reliability of the Indonesian edition of the Preschool Language Scale version 4 (PLS4) as a screening tool for the identification of language development disorders. Construct validity was examined by using Pearson correlation coefficient. Internal consistency was tested and repeated measurements were taken to establish the stability coefficient and intraclass correlation coefficients (ICC) for test-retest reliability. For construct validity, the Pearson correlation coefficient ranged from 0.151-0.526, indicating that all questions in this instrument were valid for measuring auditory comprehension (AC) and expressive communication skills (EC). Cronbach’s alpha level ranged from 0.81-0.95 with standard error of measurement (SEM) ranging from 3.1-3.3. Stability coefficients ranged from 0.98-.0.99 with ICC coefficient ranging from 0.97-0.99 both of which showed an excellent reliability. This study found that PLS-4 is a valid and reliable instrument. It is easy to handle and can be recommended for assessing language development in children aged 48-59 months.
Screening for prostate cancer: what are the benefits ? Murad Lesmana
Universa Medicina Vol. 31 No. 1 (2012)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.1-3

Abstract

In men of advanced age, the epithelial cells of the prostate gland undergo substantial stress-associated changes that may result in DNA damage. The aging prostate gland acquires several cancer cell foci originating from special clonal transformation. Most of these foci never develop into clinically detectable cancer.
Centella asiatica increases B-cell lymphoma 2 expression in rat prefrontal cortex Kuswati Kuswati; Djoko Prakosa; Brian Wasita; Nanang Wiyono
Universa Medicina Vol. 34 No. 1 (2015)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.10-16

Abstract

BACKGROUNDStress is one of the factors that cause apoptosis in neuronal cells. Centellaasiatica has a neuroprotective effect that can inhibit apoptosis. This studyaimed to examine the effect of Centella asiatica ethanol extract on B-celllymphoma 2 (Bcl-2) protein expression in the prefrontal cortex of rats.METHODSAn experimental study was conducted on 34 brain tissue samples from maleSprague Dawley rats exposed to chronic restraint stress for 21 days. Thesamples were taken from following groups: non-stress group K, negativecontrol group P1 (stress + arabic gum powder), P2 (stress + C.asiatica at150 mg/kgBW), P3 (stress + C.asiatica at 300 mg/kg BW), P4 (stress +C.asiatica at 600 mg/kg body weight) and positive control group P5 (stress+ fluoxetine at 10 mg/kgBW). The samples were made into sections thatwere stained immunohistochemically using Bcl-2 antibody to determine thepercentage of cells expressing Bcl-2. Data were analyzed using one wayANOVA test followed by a post - hoc test.RESULTSThere were significant differences in mean Bcl-2 expression between thegroups receiving Centella asiatica compared with the non-stress group andstress-only group (negative control group) (p<0.05). The results werecomparable to those of the fluoxetine treatment group.CONCLUSIONThe Centella asiatica ethanol extract was able to increase Bcl-2 expressionin the prefrontal cortex of Sprague Dawley rats exposed to restraint stress.This study suggests that Centella asiatica may be useful in the treatment ofcerebral stress.
Membrane potential, serum calcium and serum selenium decrease in preeclampsia subjects in Owerri Nnodim, Johnkennedy; Emmanuel, Nwodo; Hope, Okorie; Nwadike, Constance; Ukamaka, Edward; Christian, Onah
Universa Medicina Vol 36, No 2 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.88-93

Abstract

Background Pre-eclampsia is a serious hypertensive condition of pregnancy associated with high maternal and fetal morbidity and mortality. Women who have had pre-eclampsia have a greater risk of developing hypertension, stroke and ischemic heart disease in later life. The etiology of pre-eclampsia remains unclear. Placental insufficiency plays a key role in the progression of this disease. The aim of this study was to determine membrane potential, serum calcium and serum selenium levels in preeclampsia subjects in Owerri. MethodsA case control study involving 200 primigravida (100 preeclamptic and 100 apparently healthy) between the ages of 20 and 32 years attending General Hospital Owerri. Fasting venous blood was collected for the determination of serum selenium and serum calcium while membrane potential was calculated using the Nernst equation. The serum calcium was estimated using Randox Kit and serum selenium by atomic absorption spectrophotometry. The Independent Student t test was used for statistical analysis. ResultsThe results revealed that membrane potential and serum selenium as well as serum calcium were significantly decreased in preeclampsia when compared with the controls, at p&lt;0.05. ConclusionOur study demonstrated that the decrease in membrane potential, serum calcium and serum selenium levels may play a critical role in the pathogenesis of pre-eclampsia. There may be a need for increasing the dietary intake of these essential trace metals during pregnancy to prevent pre-eclampsia in Owerri. 

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