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Pharmacy Study Program, Faculty of Mathematics and Natural Science, Sam Ratulangi University, Manado, North Sulawesi, Indonesia, 95115
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Kota manado,
Sulawesi utara
INDONESIA
PHARMACON
Published by Universitas Sam Ratulangi
ISSN : 23022493     EISSN : 27214923     DOI : 10.35799
Core Subject : Health,
Medicine & Pharmacology
Pharmacon is the journal published by Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Indonesia (P-ISSN: 2302-2493 E-ISSN: 2721-4923). Pharmacon was established in 2012 and published four times a year. Pharmacon is an open access journal and has been indexed by main indexing Google Scholar, GARUDA, Crossref.
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Articles 17 Documents
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Search results for , issue "Vol. 12 No. 2 (2023): PHARMACON" : 17 Documents clear
A SPONGE (Stylissa sp.) ANTIOXIDANT TEST COLLECTED FROM MANADO BAY: UJI AKTIVITAS ANTIOKSIDAN (Stylissa sp.) YANG DIPEROLEH DARI TELUK MANADO Billy Arthur Porajow; Adithya Yudistira; Erladys Rumondor
PHARMACON Vol. 12 No. 2 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.38357

Abstract

The Stylissa sp. were under the sea, and these sponge contains active compound, wich are more active than the compounds produced by teresterial plants. The purpose of this study was intended to test the antioxidant activity of the stylissa sp. Sample of the stylissa sp sponge was from the territorial of manado bay. This research an experimental laboratory by testing the ethanol extract of Stylissa sp sponge using DPPH method (1.1-diphenil-2- pikrhydrazil) to analyze antioxidant activity using spectrophotometri uv-vis with variations in concentrations 2, 4, 6, 8, and 10mg/ L. Was extracted Stylissa sp, sponge by maceration using ethanol 95% as a solvent. The value results of % inhibisi (2mg/ L); 86.50% (4mg/ L); 90.5% (6mg/L); 90.53% (8mg/ L) and 90,83% (10mg/L). The highest antioxidant activity at 10mg/L concentration with mean precentage 90.83% inhibisi. The result for this study indicate that the extract from ethanol Stylissa sp sponge has highest antioxidant activity. Keywords: Antioxidant, DPPH, Stylissa sp., bay of Manado
POTENSI EKSTRAK DAN FRAKSI SPONS Theonella swinhoei YANG DIPEROLEH DARI PERAIRAN PULAU MANADO TUA TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus DAN Escherichia coli Diana Graselia Maniagasi; Defny S.Wewengkang; Deby A. Mpila
PHARMACON Vol. 12 No. 2 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.41078

Abstract

DIANA GRASELIA MANIAGASI. Potensi Ekstrak Dan Fraksi Spons Theonella swinhoei yang diperoleh dari Perairan Pulau Manado Tua Terhadap Pertumbuhan Bakteri Staphylococcus aureus dan Eschericia coli. Dibawah bimbingan DEFNY S. WEWENGKANG sebagai ketua dan DEBY A. MPILA sebagai anggota. Spons merupakan salah satu penyusun komponen kehidupan bawah laut, spons juga adalah salah satu biota laut penyusun terumbu karang yang mempunyai potensi bioaktif yang belum banyak dimanfaatkan. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri dari ekstrak spons Theonella swinhoei terhadap pertumbuhan bakteri Staphylococcus aureus dan Eschericia coli. Metode ekstraksi yang digunakan adalah maserasi dengan menggunakan pelarut etanol 95%. Pengujian aktivitas antibakteri menggunakan metode disc diffusion Kirby-bauer. Hasil yang ditunjukkan dari pengujian aktivitas antibakteri terhadap bakteri Staphylococcus aureus menghasilkan zona hambat pada semua ekstrak dan fraksi yaitu, ekstrak etanol dengan daya hambat 9,17 mm, fraksi n-heksan 8,89 mm, fraksi kloroform 9,35 mm, dan fraksi methanol 9,27 mm sedangkan pada bakteri Escherichia coli menghasilkan zona hambat pada semua ekstrak dan fraksi yaitu, ekstrak etanol dengan daya hambat 8,17 mm, fraksi n-heksan 7,46 mm, fraksi kloroform 8,86 mm, dan fraksi methanol 8,85 mm. Dengan demikian, ekstrak dan fraksi dari sampel Theonella swinhoei memiliki aktivitas pada bakteri Staphylococcus aureus dan Escherichia coli dengan daya hambat kategori yang sedang.  Kata Kunci: Spons Theonella swinhoei, Antibakteri, Staphylococcus aureus, Escherichia coli
Gambaran Penyimpanan obat di gudang farmasi RSUD Bolaang Mongondow Selatan Alfamega Pinasang; Gayatri Citraningtyas; Imam Jayanto; Mahendra Kusuma Nugraha
PHARMACON Vol. 12 No. 2 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42182

Abstract

The storage of medicines and good health supplies aims to maintain the quality of medicines, avoid irresponsible use, maintain the continuity of supplies and facilitate the search and control. The purpose of this study is to see the picture of drug storage and determine indicators of strengths, weaknesses, opportunities and threats that affect drug storage in the warehouse of the pharmaceutical installation of Bolaang Mongondow Selatan Hospital. This research is a qualitative research conducted with a Single Variable Analytical Descriptive Method. The results showed that the picture of drug storage at BolaangMongondow Selatan Hospital has not fully met the requirements according to drug storage standards in the Minister of Health Regulation no. 72 of 2016 with the value per Bolaang Mongondow Selatan Hospital not fully meeting the storage standards according to Permenkes no. 72 of 2016 because it shows a percentage of < 100%. Where the results of the analysis of the suitability of drug storage conditions (73.68%) and fulfillment of drug storage procedures (72.92%) while logistics management is fairly goodwith the percentage of drug suitability between the stock card and the system 100% and the discovery of expired drugs during the 2022 period. The results of the identification of internal factors include advantages, namely a good pharmaceutical supply structuring system, adequate information system facilities, warehouse heads coming from pharmaceutical personnel, good logistics management cycles, the weakness is that there are frequent power outages, warehouse locations that are not separated from pharmaceutical installations, facilities and infrastructure that are still lacking. The opportunities that have are the development of a good Management Information System while threats, distributor regulations, demand for goods or drugs at night, the location of warehouses that are not separated from pharmaceutical installations allow the risk of losing drugs to be even greater.  Keywords: Drug Storage, Pharmacy Warehouse
PENGETAHUAN, SIKAP, DAN PRAKTIK MENGENAI METODE KONTRASEPSI PADA WANITA HAMIL SERTA FAKTOR YANG MEMPENGARUHINYA Agustina Nila Yuliawati; Pande Made Desy Ratnasari; Heny Dwi Arini; Ni Ketut Taman
PHARMACON Vol. 12 No. 2 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.44301

Abstract

Wanita hamil dalam penggunaan metode kontrasepsi dirasa masih kurang memaksimalkan manfaatnya dikarenakan minimnya pengetahuan, sikap dan praktiknya serta dapat dipengaruhi oleh berbagai karakteristik yang melekat pada dirinya. Penelitian ini bertujuan untuk menganalisis ketiga domain perilaku tersebut tentang metode kontrasepsi serta faktor yang mempengaruhinya. Penelitian cross-sectional ini dilakukan pada 190 responden wanita hamil di salah satu apotek di Denpasar yang memenuhi kriteria inklusi-ekslusi penelitian. Data dikumpulkan dengan kuesioner untuk mengukur ketiga domain perilaku dan mencatat identitas responden. Gambaran perilaku dan karakteristik responden diolah dengan analisis univariat, kemudian hubungan domain perilaku dengan karakteristik responden dianalisis menggunakan uji statistika Spearman-rho, Eta, dan Kruskal Wallis. Hasil penelitian menunjukkan sebagian besar responden memiliki pengetahuan yang tergolong rendah terhadap metode kontrasepsi, namun sikap dan praktik yang tergolong tinggi. Selain itu, ditunjukkan adanya hubungan signifikan antara karakteristik responden yaitu agama, usia, jumlah kehamilan dan anak yang lahir terhadap pengetahuan, sikap, dan praktik responden terhadap metode kontrasepsi (p<0,05).
EVALUASI KETERSEDIAAN OBAT ESENSIAL DI PUSKESMAS TUMARATAS KECAMATAN LANGOWAN BARAT KABUPATEN MINAHASA GERALD EDWARD RUNDENGAN
PHARMACON Vol. 12 No. 2 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.47839

Abstract

Tujuan penelitian ini adalah untuk mengevaluasi ketersediaan obat esensial di Puskesmas Tumarata Kecamatan Langowan Barat Kabupaten Minahasa. Penelitian dilakukan pada bulan Juni hingga Agustus 2022, menggunakan metode observasional kuantitatif dengan desain cross sectional. Data diperoleh dari laporan penggunaan obat dan formulir permintaan obat (LPLPO) di puskesmas tahun 2021. Populasinya adalah semua dokumen LPLPO di puskesmas, dan sampelnya adalah 40 obat essensial yang harus tersedia di Tumaratas. Pusat kesehatan. Data dianalisis secara deskriptif menggunakan Microsoft Excel, dan ketersediaan obat dihitung dalam persentase dan dibandingkan dengan standar pemerintah. Hasil penelitian menunjukkan bahwa ketersediaan obat esensial masih di bawah standar yang ditetapkan pemerintah. Akibat dari kurangnya ketersediaan obat, tentunya hal ini dapat mempengaruhi kualitas pelayanan kefarmasian yang diberikan kepada masyarakat. Temuan penelitian menunjukkan perlunya Puskesmas meningkatkan ketersediaan obat esensial dan penambahan tenaga kefarmasian di puskesmas untuk menjamin efektivitas dan meningkatkan kualitas pelayanan kefarmasian di puskesmas. Kata Kunci : Puskesmas, Ketersediaan obat, esensial
FINGERPRINT ANALYSIS OF BETEL (Piper betle L.) AS RAW MATERIALS OF TRADITIONAL MEDICINE USING FTIR SPECTROSCOPE Vibrila Berliana Djanas; Fatimawali; Elly Suoth
PHARMACON Vol. 12 No. 2 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.40599

Abstract

Betel (Piper betle L.) is a plant that has long been used as a traditional medicine due to its nutritious chemical components in it. These components can be analyzed using the FTIR (Fourier Transform Infra-Red) spectroscopy method which can describe the chemical structure based on the fingerprint spectrum. The purpose of this study was to analyze the fingerprints of betel nut originating from Manado, North Minahasa, Minahasa, and Bitung using the FTIR spectroscopic method. Betel fruit samples were measured in the mid-IR region (4000-650 Cm-1) and obtained 4 FTIR spectra which were relatively the same, then the functional groups were determined for each main peak. The results showed that there were 10 functional groups in 17 absorbance bands for each betel fruit spectrum obtained. Fingerprint analysis of betel fruit with FTIR spectroscopic method can provide an overview of the chemical structure contained in 4 types of betel fruit based on geographically different growing areas.
Overview of Public Knowledge About Malaria Treatment in Matungkas Village of Dimembe District of North Minahasa Regency Tryastuti Paula Andini Abast
PHARMACON Vol. 12 No. 2 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.40680

Abstract

Malaria is a disease caused by protozoan parasite of the genus. Plasmodium that is naturally transmitted through the bite of a female Anopheles mosquito. Until now, malaria is still a major problem in world health glasses. This research ains to find out the public's knowledge about malaria, with preventive behavior and ways of treatment of malaria. This research uses observational study research design and with a Cross-sectional approach. The population obtained as many as 76 samples. Data collection in this study using questionnaires. Based on questionnaire data, from the characteristics of respondents obtained, the following results were obtained: The level of public understanding of malaria treatment is quite large, which is 75%, then the level of public understanding of the spread of moderate malaria is 51.3%, then the level of public understanding of malaria prevention is high level of 61.8%. Based on these three data, it can be said that public knowledge about Malaria is 50% high level and 50% low level.
Studi Penggunaan Antibiotik Non Resep di Kecamatan Malalayang Kota Manado Riskawati Ajid Buamona
PHARMACON Vol. 12 No. 2 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.41055

Abstract

ABSTRACT       The use of antibiotics requires proper clinical consideration to meet rationality so as to ensure maximum safety, accuracy and effectiveness. This study aims to find out the level of knowledge of the use of antibiotics without a prescription in Malalayang Subdistrict Bahu Village manado city which is reviewed from the level of awareness of antibiotic use and behavior that affects using antibiotics without a doctor's prescription. This research is descriptive with accidental sampling. The results of the study were obtained by respondents with a total of 380 respondents had used antibiotics without a prescription and the respondent's level of awareness was still low (61.84%). Behavior of respondents using antibiotics without a prescription: sources obtained antibiotics (79.74%) from pharmacies, recommended using antibiotics the majority of doctors (33.42%), willingness to use at any time (55.26%), the most commonly purchased antibiotic is amoxicillin (41.05%), a disease that is often treated, namely fever symptoms (21.84%), the advice obtained in buying antibiotics the majority buy all (52.63%). The high use of antibiotics without a prescription can also cause clinical and economic harm. Keywords: antibiotics without a prescription, level of awareness, behavior of respondents ABSTRAK       Penggunaan antibiotik memerlukan pertimbangan klinis yang tepat untuk memenuhi rasionalitas sehingga menjamin keamanan, ketepatan dan efektivitas yang maksimal. Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan penggunaan antibiotik tanpa resep di Kelurahan Bahu Kecamatan Malalayang Kota Manado yang ditinjau dari tingkat kesadaran terhadap penggunaan antibiotik dan perilaku yang mempengaruhi menggunakan antibiotik tanpa resep dokter. Penelitian ini bersifat deskriptif dengan pengambilan sampel secara accidental sampling. Hasil penelitian didapatkan responden dengan jumlah 380 responden pernah menggunakan antibiotik tanpa resep dan tingkat kesadaran responden masih rendah (61,84%). Perilaku responden menggunakan antibiotik tanpa resep: sumber memperoleh antibiotik sebanyak (79,74%) dari apotek, anjuran menggunakan antibiotik mayoritas dari dokter (33,42%), kesediaan untuk digunakan sewaktu-waktu (55,26%), antibiotik yang paling sering dibeli yaitu amoxicillin (41,05%), penyakit yang sering diobati yaitu gejala demam (21,84%), anjuran yang diperoleh dalam membeli antibiotik mayoritas membeli semua (52,63%). Tingginya penggunaan antibiotik tanpa resep juga dapat menimbulkan kerugian secara klinis maupun ekonomi.Kata Kunci: antibiotik tanpa resep, tingkat kesadaran, perilaku responden
DETERMINATION NON-SPESIFIK STANDARIZATION OF FOREST ONION BULBS EXTRACT (ELEUTHERINE AMERICANA MERR) Yusril Mokodompit
PHARMACON Vol. 12 No. 2 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42040

Abstract

This research aims to find out result from the test non-specific standardization extract forest onion (Eleutherine americana Merr). Extract forest onion (Eleutherine americana Merr.) obtained by maceration method, the extract obtained was observed by parameter non-specific which include drying shrink, water content, total dust content, and acid insoluble dust. Parameter non-specific compared with reference determation standart parameter. The result testing this parameter non-specific extract dayak onion from passi village obtain shrink drying 0,1137 %, water content 0,1545 %, total dust content 0,3931 %, and dust acid insoluble 9,8062 %. According the result of extract dayak onion standart shrink drying parameter, water content, and total dust content, meanwhile for acid insoluble dust parameter it is not accordance with because procces washing that is not clean so there a lot impurity
ORGANOLEPTIC TEST OF FRESH PINEAPPLE FRUIT JUICE (Ananas Comosus (L.) Merr.) FROM KOTAMOBAGU AND BITUNG CITY Frandi Mangindano
PHARMACON Vol. 12 No. 2 (2023): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.12.2023.42625

Abstract

Pineapple (Ananas comosus (L.) Merr.) is one of the most widely cultivated fruit plants in Indonesia. This plant has many benefits, especially the fruit itself. This study aims to compare the color, aroma, taste, and texture of pineapple juice from Kotamobagu City and Bitung City. The research method used is hedonic by testing the organoleptic test of each sample on 4 parameters. From the results of this study, it can be seen that fresh pineapple juice from Kotamobagu and Kota bitung, which is dissolved in distilled water, each has a distinctive value of four (4) parameters (Color, Taste, Aroma, and Texture). Excellent/preferred scores were found in sample A (fresh pineapple from Kotamobagu).

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