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Pharmacy Study Program, Faculty of Mathematics and Natural Science, Sam Ratulangi University, Manado, North Sulawesi, Indonesia, 95115
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Kota manado,
Sulawesi utara
INDONESIA
PHARMACON
Published by Universitas Sam Ratulangi
ISSN : 23022493     EISSN : 27214923     DOI : 10.35799
Core Subject : Health,
Medicine & Pharmacology
Pharmacon is the journal published by Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Indonesia (P-ISSN: 2302-2493 E-ISSN: 2721-4923). Pharmacon was established in 2012 and published four times a year. Pharmacon is an open access journal and has been indexed by main indexing Google Scholar, GARUDA, Crossref.
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Articles 4 Documents
 1 
Search results for , issue "Vol. 15 No. 1 (2026): PHARMACON" : 4 Documents clear
Uji Aktivitas Antioksidan Ekstrak Etanol Karang Lunak Lobophytum sp. yang diperoleh dari Pantai Tongkaina, Kota Manado Sumare, Chika Wanda; Yudistira, Adithya; Hariyanto, Yuanita Amalia
PHARMACON Vol. 15 No. 1 (2026): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.15.2026.63998

Abstract

Soft coral contain bioactive compounds, such as alkaloids, alkaloids, flavonoids, and saponins, which have important antioxidant activity. This research aims to tested the antioxidant activity of ethanol extract of Lobophytum sp. using method DPPH (2,2-diphenyl-1-picrylhydrazyl). Phytochemical screening results show the presence of tannins, flavonoids, and saponins in the extract of Lobophytum sp. obtained from Tongkaina Beach, Manado City. Antioxidant activity test shows that the extract has high activity an IC50 value of 49,13 ppm which is categorized as very strong. Average value of percent inhibition increased along with increasing extract concetration, reaching 67,13% at concetration of 100 ppm. These findings indicate that Lobophytum sp. potential be a source of natural antioxidants that can be developed for prevention degenerative disease caused by free radicals. Further research necessary to explore more specific active compounds. Keywords: Antioxidant, IC50, Lobophytum sp., Percent inhibition, Phytochemical Screening
FORMULASI DAN KARAKTERISASI SEDIAAN SNEDDS (Self-Nano Emulsifying Drug Delivery System) EKSTRAK JAHE MERAH (Zingiber officinale var. Rubrum) Laloan, Dearizky; Jaya Edy, Hosea; Abdullah, Surya Sumantri
PHARMACON Vol. 15 No. 1 (2026): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.15.2026.64131

Abstract

Jahe merah (Zingiber officinale var. Rubrum) dikenal sebagai tanaman obat dengan banyak kegunaan. Namun, senyawa ini memiliki kelarutan air yang rendah sehingga membatasi bioavailabilitasnya. Untuk mengatasi keterbatasan tersebut, dilakukan formulasi ekstrak jahe merah ke dalam sistem penghantaran obat Self-Nano Emulsifying Drug Delivery System (SNEDDS). Penelitian ini bertujuan untuk memformulasikan dan mengkarakterisasi sediaan SNEDDS dari ekstrak jahe merah. Ekstraksi dilakukan dengan metode maserasi menggunakan etanol 96%. SNEDDS diformulasikan menggunakan Virgin Coconut Oil sebagai fase minyak, Tween 80 sebagai surfaktan, dan PEG 400 sebagai kosurfaktan. Evaluasi dilakukan terhadap delapan formula melalui uji organoleptik, sentrifugasi, Heating-cooling cycle, pengukuran pH, dan analisis ukuran partikel. Hasil menunjukkan bahwa formula F4 hingga F8 memiliki stabilitas yang baik, dengan formula F8 menunjukkan ukuran partikel nano rata-rata sebesar 14,37 ± 0,47 nm dan indeks polidispersitas sebesar 0,30 ± 0,043, yang mengindikasikan distribusi partikel yang homogen. Kesimpulannya, ekstrak jahe merah dapat diformulasikan ke dalam sistem SNEDDS yang stabil dan berpotensi meningkatkan bioavailabilitas senyawa aktifnya.
FORMULATION AND EVALUATION OF PEEL-OFF MASK PREPARATION OF ETHANOL EXTRACT OF RARU BARK (COTYLELOBIUM MELANOXYLON PIERRE) Remin Serawati Simanjorang
PHARMACON Vol. 15 No. 1 (2026): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.15.2026.66040

Abstract

Background: The use of natural as active compounds in cosmetic product has increased due to growing public awareness of product safety and quality. Raru bark (cotylelobium melanoxylon perre) contains various secondary metabolites with antioxidant potential, yes its application in cosmetic formulations remains limited this study aimed to formulate and evaluate a peel-off facial mask containing ethanol extract of raru bark. Methods: this experimental study included plant determination preparation of simplicia, extraction using 80% ethanol, phytochemical screening, formulations of peel-off mask with different eextract concentrations, and physical evaluation of the formulations. The evaluations comprised organoleptic properties, homogeneity, PH, viscosity, spreadability and drying time to assess the quality of the formulations. Results: phytocmical screening revealed the presence of flavonoid, tannins, saponins,alkaloids, glycosides, and steroid/triterpenoid compound in the ethanol extract. All peel-off mask formulations exhibited good organoleptic stability and homogeneity. The pH values were the physiological range of skin, while spreadability and drying time met the required standards. Variations in extract concentration influenced the viscosity of the formulations. Conclusion: ethanol extract of raru bark can be successfully formulated into a peel-off mask that meets physical quality requirements and shows potential as a natural-based cosmetic product.
Aktivitas Tonikum Ekstrak Etanol Kulit Nanas (Ananas comosus L. Merr.) terhadap Mencit dengan Metode Natatory Exhaustion dan Induksi Tidur Puspita, Rani Sintia
PHARMACON Vol. 15 No. 1 (2026): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.15.2026.66579

Abstract

Tonikum adalah obat yang digunakan untuk meningkatkan energi atau stamina tubuh. Kulit nanas (Ananas comosus L. Merr.) mengandung flavonoid yang bersifat antioksidan dan mampu meningkatkan daya tahan fisik. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak etanol kulit nanas terhadap efek tonikum pada mencit putih (Mus musculus) dan menentukan dosis optimalnya dengan metode natatory exhaustion dan induksi tidur. Penelitian dilakukan secara eksperimental dengan 25 ekor mencit jantan yang dibagi dalam lima kelompok, yaitu kontrol negatif (Na-CMC 0,5%), kontrol positif (Kafein 100 mg), dan ekstrak etanol kulit nanas dosis 125, 250, dan 500 mg/kgBB. Pengujian tonikum dilakukan menggunakan metode natatory exhaustion dan induksi tidur dengan parameter waktu ketahanan renang dan waktu latensi tidur. Hasil perhitungan persentase efek tonikum disajikan dalam bentuk tabel dan grafik serta dianalisis statistik. Hasil penelitian menunjukkan bahwa ekstrak etanol kulit nanas memiliki aktivitas tonikum pada kedua metode pengujian. Dosis 125, 250, 500 mg/kgBB dan kontrol positif dengan persentase sebesar (48,63 ± 9,80)%, (76,50 ± 5,19)%, (79,50 ± 4,35)% dan (85,77 ± 1,50)% pada metode natatory exhaustion serta pada metode induksi tidur sebesar (27,45 ± 6,74)%, (42,18 ± 6,47)%, (51,30 ± 5,78) dan (60,70 ± 2,63)%. Kesimpulan dari penelitian ini adalah ekstrak etanol kulit nanas memiliki aktivitas tonikum terhadap mencit dengan dosis optimal sebesar 250 mg/kgBB pada metode natatory exhaustion dan induksi tidur.

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