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Pharmacy Study Program, Faculty of Mathematics and Natural Science, Sam Ratulangi University, Manado, North Sulawesi, Indonesia, 95115
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INDONESIA
PHARMACON
Published by Universitas Sam Ratulangi
ISSN : 23022493     EISSN : 27214923     DOI : 10.35799
Core Subject : Health,
Medicine & Pharmacology
Pharmacon is the journal published by Pharmacy Study Program, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Indonesia (P-ISSN: 2302-2493 E-ISSN: 2721-4923). Pharmacon was established in 2012 and published four times a year. Pharmacon is an open access journal and has been indexed by main indexing Google Scholar, GARUDA, Crossref.
Arjuna Subject : -
Articles 1,131 Documents
 72   73   74   75   76 
UJI EFEK HEPATOPROTEKTOR EKSTRAK ETANOL DAUN BENALU LANGSAT (Dendrophthoe petandra (L.) Miq.) terhadap KADAR MALONDIALDEHID (MDA) pada HATI TIKUS PUTIH JANTAN GALUR WISTAR yang DIINDUKSI KARBON TETRAKLORIDA (CCl4) Tristanti, Irma; Fatimawali, Fatimawali; Bodhi, Widdhi
PHARMACON Vol 2, No 3 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.2383

Abstract

ABSTRACTLeaves of Langsat parasite (Dendrophthoe petandra (L.) Miq.) contains flavonoids. Theobjective of this research was to examine hepatoprotector effect of leave extract from langsatparasite on white male rats induced with CCl4. Treatment was conducted for 8 days to 13 rats,which group I (P1) were administered with EDBL 35mg/KgBB,group II (P2) wereadministered with EDBL 70mg/KgBB,group III (K+) were administered withCurcuma81mg/KgBB orally. Group IV (K-) and V (KP) were administered with aquadestad libitum.At 8th day, all groups except (KP) were induced with CCl4 1mL/KgBB intraperitoneally.Eighteen hours after inducing time, all rats in every group were sacrafied to take its liver.Rats liver were analyzed using TBARS (Thiobarbituric Acid Reactive Subtance) method tocalculate MDA (Malondialdehid) level that were the end product of lipid peroxidation in ratsliver.MDA content of P1 were 2,715μM, P2 were 2,080μM, K+ were 1,708μM, and K- were3,413μM. Data analysis using SPSS ver.20 by One-Way ANOVA and Duncan Multiple RangeTest.Keywords : leave of Langsat parasite, hepatoprotector effect,CCl4, MDA
ANALISIS PENERAPAN SISTEM MANAJEMEN KESEHATAN DAN KESELAMATAN KERJA (SMK3) DI RSIA KASIH IBU MANADO Toding, Ryane
PHARMACON Vol 5, No 1 (2016): Pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.5.2016.11317

Abstract

ANALISIS PENERAPAN SISTEM MANAJEMEN KESEHATAN DAN KESELAMATAN KERJA (SMK3) DI RSIA KASIH IBU MANADO Ryane Toding1),Jootje M.L. Umboh1),Johan Josephus1) 1)Fakultas Kesehatan Masyarakat Universitas Sam Ratulangi Manado   ABSTRACT Hospital as the service industry is an industry that has a variety of labor issues are complicated by a variety of risk of occupational disease occupational accident even according to type of work, so it is obliged to implement the Occupational Health and Safety efforts Hospital. Occupational health is a specialization in health sciences / medicine and its practice that aims to enable the worker / community health workers and obtain degrees as high, baikfsik, mental, and social, with the efforts of preventive and curative, against peyakit-disease or disruptions- health problems caused factors of work and working environment, as well as against common diseases. This study is a qualitative research approach to in-depth interviews (depth interview). Informants in this study amounted to 5 persons namely Hospital director, HRD Hospital, a nurse, in charge of the laboratory's Hospital, as well as the Occupational Health and Safety inspectors Labor department Manado city. The results of the study are commitment and policy management in the implementation SMK3, plans drawn up by the leadership of the RS orally, and the implementation of K3 is programmed but does not have a dedicated organization and experts K3 include the provision of PPE and K3 trainings for employees of the hospital as well as measurement and evaluation is not maximized implemented. Key words : management, occupational health and safety ABSTRAK Rumah sakit sebagai industri jasa merupakan sebuah industri yang mempunyai beragam persoalan tenaga kerja yang rumit dengan berbagai risiko terkena penyakit akibat kerja bahkan kecelakaan akibat kerja sesuai jenis pekerjaannya, sehingga berkewajiban menerapkan upaya Keselamatan dan Kesehatan Kerja Rumah Sakit. Kesehatan kerja adalah spesialisasi dalam ilmu kesehatan/kedokteran beserta prakteknya yang bertujuan, agar pekerja/masyarakat pekerja beserta memperoleh derajat kesehatan yang setinggi-tingginya, baikfsik, mental, maupun sosial, dengan usaha-usaha preventif dan kuratif, terhadap peyakit-penyakit atau gangguan-gangguan kesehatan yang diakibatkan faktor-faktor pekerjaan dan lingkungan kerja, serta terhadap penyakit-penyakit umum. Penelitian ini merupakan penelitian kualitatif dengan pendekatan in-depth interview (wawancara mendalam). Informan dalam penelitian ini berjumlah 5 orang yaitu direktur Rumah Sakit, HRD Rumah Sakit, perawat, penanggung jawab laboratorium Rumah Sakit, serta pengawas Kesehatan dan Keselamatan Kerja dinas Tenaga kerja kota manado. Hasil penelitian dari penelitian ini adalah adanya komitmen dan kebijakan manajemen dalam pelaksanaan SMK3, perencanaan disusun oleh pimpinan RS secara lisan, dan pelaksanaan kegiatan  K3 sudah terprogram tetapi belum mempunyai organisasi khusus dan ahli K3 antara lain penyediaan APD dan pelatihan K3 bagi pegawai RS serta pengukuran dan evaluasi belum maksimal dilaksanakan.   Kata kunci : Manajemen, kesehatan dan keselamatan kerja
UJI EFEKTIVITAS INFUSA DAUN NASI (Phyrnium capitatum Willd) TERHADAP PENURUNAN KADAR GULA DARAH TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus) Tintingon, Riska Christina
PHARMACON Vol 3, No 2 (2014)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.3.2014.4769

Abstract

This study aims to evaluate the effectiveness of daun nasi infusion (Phyrnium capitatum Willd ) in blood sugar level reduction of rats and determine the relationship between the dose of daun nasi infusion (Phyrnium capitatum Willd) and blood sugar level reduction of rats. This study was experimental study with randomized controlled group design, using male Wistar rats (Rattus norvegicus) that were made hyperglycemia by aloksan 130 mg/bw intravenously. Samples consist of 18 rats which were divided into 6 groups, normal control as a standard of comparison which is not induced by aloksan, positive control (glibenclamide suspension 0.63 mg/bw), negative control (CMC 0.5 %), and treatments group with dose 2.32 g/bw, 4.64 g/bw and 9.28 g/bw  daily for two weeks period. The study result of blood sugar level, was analyzed by one way ANOVA and LSD test to know the significant differences between groups. The result shows that daun nasi infusion have an effect to reduce blood sugar level, but the most effective dose of daun nasi infusion is 9.28 g/bw. Daun nasi infusion with doses 2.32 g/bw and 4.64 g/bw were not have a significant difference with positive control.   Key words : Phyrnium capitatum Willd, hyperglycemia, alloxan, Rattus norvegicus
PENGARUH SALIVA BUATAN DAN BELIMBING WULUH (Averrhoa bilimbi L.) TERHADAP KEKERASAN RESIN KOMPOSIT NANO HYBRID Langen, Elvira N.
PHARMACON Vol 6, No 1 (2017): Pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.6.2017.14999

Abstract

PENGARUH SALIVA BUATAN DAN BELIMBING WULUH (Averrhoa bilimbi L.) TERHADAP KEKERASAN RESIN KOMPOSIT NANO HYBRID Elvira N. Langen1), Jimmy F. Rumampuk1), Michael A. Leman1) 1)Program studi pendidikan dokter gigi Fakultas kedokteran UNSRAT Manado, 95115 ABSTRACT Bilimbi (Averrhoa bilimbi. L) had an acid agent which can affect the surface hardness of resin composite. The change of surface hardness of resins is caused by infiltration of water contains acid agent. This process affected to bonding of matrix and filler of composite, this is due to the degradation process of resin composite. However, there is artificial saliva that can neutralize this condition. The purpose of this study was to determine the effect of immersed bilimbi and artificial saliva on surface hardness of composite. This experimental study designed in post test only control group. The samples of resin composite had 5 mm diameters and 2 mm in thickness (n= 24). Sampels divided into four groups; three groups as interverence and the other one as a control group, samples were alternately immersed in 60, 90 and 120 minutes. Post immersion samples measured by Micro Vickers Hardness Tester. Statistical analysis was performed by one-way ANOVA and post-hoc LSD test (𝛼=0.05) showed a significant difference of surface hardness on resin composite (p<0,05). It was concluded that artificial saliva increases the surface hardness of resin immersed in bilimbi. Keywords: resin composite, artificial saliva, bilimbi, surface hardness ABSTRAK Belimbing wuluh (Averrhoa bilimbi. L) memiliki kandungan asam tinggi yang dapat mempengaruhi kekerasan dari permukaan resin komposit nano hybrid. Perubahan ini disebabkan oleh proses penyerapan air yang mengandung asam sehingga mempengaruhi ikatan matriks dan filler yang menyebabkan terjadinya degradasi. Akan tetapi, saliva buatan dapat menetralkan kondisi ini. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh perendaman saliva buatan dan belimbing wuluh terhadap perubahan kekerasan resin komposit nano hybrid. Jenis penelitian yang digunakan adalah eksperimental laboratorik dengan desain post test only control group. Jumlah sampel dalam penelitian sebanyak 24 sampel dengan diameter 5 mm dan tebal 2 mm, sampel dibagi menjadi empat kelompok dengan tiga durasi waktu perendaman yang berbeda yaitu 60, 90, dan 120 menit. Setelah perendaman, sampel diukur nilai kekerasannya menggunakan Micro Vickers Hardness Tester, kemudian diuji secara statistik dengan menggunakan uji one-way ANOVA dan post-hoc uji LSD (𝛼=0,05). Hasil menunjukkan adanya pengaruh signifikan dari perendaman saliva buatan dan belimbing wuluh terhadap perubahan kekerasan resin komposit (p<0.05). Kata kunci: resin komposit, saliva buatan, belimbing wuluh, kekerasan permukaan      
UJI DAYA HAMBAT PERASAN RIMPANG KUNYIT (Curcuma longa L.) TERHADAP PERTUMBUHAN Candida albican Harianto, I Kadek
PHARMACON Vol 6, No 2 (2017): Pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.6.2017.15831

Abstract

UJI DAYA HAMBAT PERASAN RIMPANG KUNYIT (Curcuma longa L.) TERHADAP PERTUMBUHANCandida albicans I Kadek Harianto1) , Pieter L. Suling1), Christy Mintjelungan1)1) Program Studi Pendidikan Dokter Gigi Fakultas Kedokteran UNSRAT Manado, 95115  ABSTRACT           Candida albicans are the microorganism who present in oral cavity. Candida has more than 200 different species, 75% of fungus infections in oral cavity are caused by Candida albicans. Candida albicans can become opportunistic pathogen in certain condition such as bad oral hygine, bad immune system, and systemic disease. Turmeric (Curcuma longa L.) is one kind of plant belonging to the family of Zingiberaceae. Turmeric (Curcuma longa L.) have properties as herbal and traditional medicine for various diseases. Compounds in turmeric such as curcumin and essential oil has a role as an antioxidant, anticancer, antitumor, antifungal, and antivenom. The purpose of this study was to determine the inhibition of turmeric (Curcuma longa L.) to the growth of Candida albicans.This study is a true experimental in vitro with post test only control group design. Testing method using Kirby-bauer method by  filterpaper. Turmeric sample were grated, squeezed then filtered and stored in a sterile sealed glass bottles. Candida albicans was taken from pure stock Pharmacy Laboratory Faculty of Math and Science, University of Sam Ratulangi.The results of this study obtained inhibition zone diameter turmeric (Curcuma longa L.) on the growth of Candida albicans in the amount of 11,1 mm which is strong inhibition category. As the conclution, turmeric (Curcuma longa L.) has an inhibitory effect on  Candida albicans fungus growth. Keywords:Turmeric(Curcuma longa L.), Candida albicans,Inhibibotory zone  ABSTRAK Candida albicans merupakan mikroorganisme yang terdapat di dalam rongga mulut. Candida memiliki sekitar 200 spesies yang berbeda, 75% infeksi jamur di rongga mulut pada manusia disebabkan oleh Candida albicans. Candida albicans dapat menjadi patogen oportunistik dalam keadaan tertentu seperti kebersihan rongga mulut yang buruk, penurunan sistem imun dan riwayat penyakit sistemik. Rimpang kunyit (Curcuma longa L.) merupakan salah satu jenis tanaman yang termasuk dalam keluarga Zingiberaceae. Rimpang kunyit (Curcuma longa L.) mempunyai khasiat sebagai jamu dan obat tradisional untuk berbagai jenis penyakit. Senyawa yang terkandung dalam rimpang kunyit (Curcuma longa L.) seperti curcumin dan minyak atsiri mempunyai peranan sebagai antioksidan, antitumor, antikanker, antijamur, antimikroba, dan antiracun.Tujuan penelitian ini yaitu untuk mengetahui daya hambat perasan rimpang kunyit (Curcuma longa L.) terhadap pertumbuhan jamur Candida albicans. Penelitian ini merupakan penelitian laboratorium eksperimental secara in vitro dengan rancangan penelitian Post test only control group design. Metode pengujian menggunakan metode Kirby-bauer berbahan kertas saring. Sampel rimpang kunyit (Curcuma longa L.) diparut, diperas dan disaring serta disimpan dalam botol kaca steril. Jamur Candida albicans diambil dari stok biakan jamur murni Laboratorium Farmasi FMIPA Universitas Sam Ratulangi Manado.Hasil penelitian ini didapat diameter zona hambat perasan rimpang kunyit (Curcuma longa L.) pada pertumbuhan Candida albicans yaitu sebesar 11,1 mm dan tergolong dalam kriteria zona hambat kuat. Kesimpulannya perasan rimpang kunyit (Curcuma longa L.) mempunyai daya hambat terhadap pertumbuhan jamur Candida albicans. Kata kunci: Rimpang kunyit (Curcuma longa L.), Candida albicans, Zona hambat
PENGUJIAN EFEK DIURETIK SARI WORTEL (Daucus carota L.) PADA TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus) Sinaga, Mery A R; Bodhi, Widdhi; Yamlean, Paulina V Y
PHARMACON Vol 1, No 2 (2012)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.1.2012.484

Abstract

Carrot (Daucus carota L.) is a plant which used as traditional medicine and one of its benefits isas diuretic. The research was aimed to find out diuretic effect of Carrot juice and relationship ofthe increases of Carrot juice (Daucus carota L.) concentration on white male mice strain Wistar(Rattus norvegicus). Fifteen mices were divided into five group of treatment, namely negativecontrol group (CMC 1% suspension), positive control group (furosemid suspension), 15%suspension of carrot juice group, 30% suspension of carrot juice group and 60% suspension ofCarrot juice group.The test of diuretic effect were conducted by calculate volume of excretedurine during 24 hours treatment. Data were analyzed using spss ver.19. The differences betweentreatments were analyzed using one way ANOVA.The result shows that suspension of Carrotjuice treatment increase urine volume. The increases of juice concentration shows better effect.Based on result, it can be concluded that Carrot juice possess diuretic effect (p<0,05), and thereare correlation between concentrations of Carrot juice to the increasing of urinevolume.Keywords : Carrot juice, diuretic effect, Rattus norvegicus
ANALISIS KANDUNGAN ZAT PENGAWET BORAKS PADA BAKSO YANG DISAJIKAN PADA KIOS BAKSO PERMANEN DI KECAMATAN MALALAYANG KOTA MANADO Monijung, Sixtian F.
PHARMACON Vol 5, No 2 (2016): Pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.5.2016.12180

Abstract

ANALISIS KANDUNGAN ZAT PENGAWET BORAKS PADA BAKSO YANG DISAJIKAN PADA KIOS BAKSO PERMANEN DI KECAMATAN MALALAYANG KOTA MANADO Sixtian F. Monijung1), Prof. dr. Jootje M. L. Umboh1), Ricky C. Sondakh1) 1)Fakultas Kesehatan Masyarakat Universitas Sam Ratulangi Manado   ABSTRACT Food is a basic daily needs, which are crucial for human survival (Law No. 18 of 2012). The food comes from food that is everything that comes from biological sources of agricultural products, agriculture, forestry, fisheries, animal husbandry, aquatic, whether treated or untreated designated as a food or beverage for human consumption, including additives for food, raw materials food, and other materials used in the preparation, processing, and manufacture of food or drink that everyone needs to be guaranteed to obtain quality and safe food. To determine whether there is the content of the preservative borax in meatballs meatballs served on a permanent stall in the district Malalayang city of Manado. This research is a descriptive survey with laboratory examination to portray how the content of the preservative borax in meatballs sold by merchants who have a permanent stall in the district Malalayang city of Manado. Based on the research that has been done, it can be concluded that There are kiosks that use borax meatballs in the meatball that is ready to be served. Keywords: Preservatives Borax ABSTRAK Makanan merupakan kebutuhan pokok sehari-hari yang berperan penting untuk kelangsungan hidup manusia (UU No. 18 Tahun 2012). Makanan berasal dari bahan pangan yang merupakan segala sesuatu yang berasal dari sumber hayati produk pertanian, perkebunan, kehutanan, perikanan, peternakan, perairan, baik yang diolah maupun tidak diolah yang diperuntukkan sebagai makanan atau minuman bagi konsumsi manusia, termasuk bahan tambahan Pangan, bahan baku Pangan, dan bahan lainnya yang digunakan dalam proses penyiapan, pengolahan, dan/atau pembuatan makanan atau minuman sehingga setiap orang perlu dijamin untuk memperoleh pangan yang bermutu dan aman. Untuk mengetahui ada tidaknya kandungan zat pengawet boraks pada bakso yang disajikan pada kios bakso permanen di kecamatan Malalayang kota Manado. Penelitian ini merupakan penelitian survey deskriptif dengan pemeriksaan laboratorium untuk mengambarkan bagaimana kandungan zat pengawet boraks pada bakso yang dijual oleh pedagang yang memiliki kios permanen di kecamatan Malalayang kota Manado. Berdasarkan hasil penelitian yang telah dilakukan, maka dapat disimpulkan bahwa Tidak Terdapat kios bakso yang menggunakan boraks dalam bakso yang siap disajikan. Kata kunci : Zat pengawet Boraks  
UJI EFEK EKSTRAK ETANOL DAUN LIDAH MERTUA (Sansevieria trifasciata Prain) TERHADAP PENURUNAN KADAR GULA DARAH TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus L.) YANG DIINDUKSI SUKROSA Laimeheriwa, Chornelia
PHARMACON Vol 3, No 3 (2014)
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.3.2014.5394

Abstract

ABSTRACT This study aimed to test the effect of ethanol extract Lidah Mertua leaves (Sansevieria trifasciata Prain) to decrease blood sugar levels of white male wistar (Rattus norvegicus L.) who induced sucrose. This type of research laboratory experiments using a Complete Randomized Design methods. Animal testing of this experiments is a white 15 rat males totaled are divided into 5 groups. The five groups which are a negative control group given a solution of CMC 0,5%, a positive control group was given 0,036 mg/kg body weight suspension of glibenklamid, then the treatment Group's was given ethanol ekstract 0,0083 g/kg body weight of Lidah Mertua leaves (Sansevieria trifasciata Prain) for the group treatment  first, group treatment second 0,041 g/kg body weight, and treatment group third 0,083 g/kg body weight. Data obtained from the examination of the fasting blood sugar levels, 30 minutes after induction with sucrose and at first hour, second hours, third hours and fourth hours after treatment was given. The data analysis statistics test using ANOVA and LSD to see the difference between the negative control group, positive control group and treatment group 1, 2 and 3. The statistical analysis showed a significant difference with negative control group.   Key words : Sansevieria trifasciata Prain, blood sugar levels, sucrose   ABSTRAK Penelitian ini bertujuan untuk menguji efek ekstrak etanol daun Lidah Mertua (Sansevieria trifasciata Prain) terhadap penurunan kadar gula darah tikus putih jantan galur wistar (Rattus norvegicus L.) yang diinduksi sukrosa. Jenis penelitian yaitu eksperimen laboratorium dengan menggunakan metode Rancangan Acak Lengkap (RAL). Hewan uji berupa tikus putih jantan berjumlah 15 ekor dibagi dalam 5 kelompok yaitu kelompok kontrol negatif diberikan larutan CMC 0,5%, kelompok kontrol positif diberikan suspensi glibenklamid dengan dosis 0,36 mg/kgBB, kemudian untuk kelompok perlakuan diberikan ekstrak etanol daun Lidah Mertua (Sansevieria trifasciata Prain) dengan dosis 0,0083 g/kgBB untuk kelompok perlakuan 1, kelompok perlakuan 2 dengan dosis 0,041 g/kgBB, kelompok perlakuan 3 dengan dosis 0,083 g/kgBB. Data diperoleh dari pemeriksaan kadar gula darah puasa (t0), 30 menit setelah diinduksi sukrosa (t1) dan pada jam ke 1(t2), jam ke 2(t3), jam ke 3(t4), dan jam ke 4(t5) setelah pemberian perlakuan. Data dianalisis statistik menggunakan uji ANOVA dan LSD untuk melihat perbedaan antara kelompok kontrol negatif, kelompok kontrol positif dan kelompok perlakuan 1, 2 dan 3. Hasil analisis statistik menunjukkan berbeda secara signifikan dengan kontrol negatif.   Kata kunci : Sansevieria trifasciata Prain, kadar gula darah, sukrosa
EVALUASI PENYIMPANAN DAN DISTRIBUSI OBAT PSIKOTROPIKA DI RUMAH SAKIT JIWA PROF. DR. V. L. RATUMBUYSANG MANADO Lumenta, Jimbrif T.
PHARMACON Vol 4, No 4 (2015): Pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.4.2015.10203

Abstract

EVALUASI PENYIMPANAN DAN DISTRIBUSI OBAT PSIKOTROPIKA      DI RUMAH SAKIT JIWA PROF. DR. V. L. RATUMBUYSANG          MANADO Jimbrif T. Lumenta1), Adeanne C. Wullur1), Paulina V. Y. Yamlean1) 1)Program Studi Farmasi, FMIPA UNSRAT Manado   ABSTRACT Psychotropic substances or drugs are either natural or synthetic non narcotic, efficacious psychoactive through selective effect on the central nervous system that causes the typical changes in mental activity and behavior. Problems that are often found in the storage and distribution systems among which does not use First In First Out (FIFO) or First expired first out (FEFO), system alphabetically, card stock, do not put the medicine in its proper place, the unavailability of storage equipment support and infrastructure inadequate storage. This study aimed to evaluate the storage and distribution of psychotropic drugs in Mental Hospital Prof. Dr. V.L Ratumbuysang using qualitative descriptive method with retrospective and prospective approach. The results showed that the psychotropic drugs storage system in Mental Hospital Prof. Dr. V.L Ratumbuysang overall not in accordance with standards based on the Pharmacy Hospital Supplies Storage Management Guidelines and Health Ministerial Regulation No. 3 Year (2015). While in the process of distribution of psychotropic drugs in accordance to the Hospital Pharmacy Service Standards by Minister of Health Regulation No. 58 Year (2014) and Drug Distribution Operating Procedure Standard in Mental Hospital Prof.Dr.V.L Ratumbuysang. Keywords : Storage, Distribution, Psychotropic Substances. Mental Hospital Prof Dr. V. L. Ratumbuysang. ABSTRAK Psikotropika adalah zat atau obat, baik alamiah maupun sintetis bukan narkotika, yang berkhasiat psikoaktif melalui pengaruh selektif pada susunan saraf pusat yang menyebabkan perubahan khas pada aktivitas mental dan perilaku. Permasalahan yang sering ditemukan pada sistem penyimpanan dan distribusi diantarannya yaitu tidak menggunakan sistem First In first Out (FIFO) atau First expired first out (FEFO), sistem alfabetis, kartu stok, tidak menempatkan obat pada tempat yang semestinya, tidak tersedianya peralatan penyimpanan pendukung dan sarana prasarana penyimpanan yang tidak memadai. Penelitian ini bertujuan untuk mengevaluasi penyimpanan dan distribusi obat psikotropika di RSJ Prof. Dr. V. L. Ratumbuysang menggunakan metode deskriptif kualitatif dengan pendekatan retrospektif dan prospektif. Hasil penelitian menunjukan bahwa sistem penyimpanan obat psikotropika di RSJ Prof. Dr. V. L. Ratumbuysang secara keseluruhan belum sesuai dengan Standar Penyimpanan berdasarkan Pedoman Pengelolaan Perbekalan Farmasi Rumah Sakit dan Peraturan Menteri Kesehatan RI Nomor 3 Tahun (2015).  Sedangkan pada proses distribusi obat psikotropika telah sesuai dengan Standar Pelayanan Farmasi Rumah Sakit berdasarkan Peraturan Menteri Kesehatan Nomor 58 Tahun (2014)   dan Standar Operasional Prosedur Distribusi Obat di RSJ Prof.Dr.V.L. Ratumbuysang.   Kata kunci :   Penyimpanan, Distribusi, Psikotropika. Rumah Sakit Jiwa Prof Dr. V. L. Ratumbuysang.
Analisis Kandungan Merkuri Pada Krim Pemutih Yang Beredar Di Kota Manado Parengkuan, Kissi; Fatimawali, Fatimawali; Citraningtyas, Gayatri
PHARMACON Vol 2, No 1 (2013): pharmacon
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.2.2013.886

Abstract

ABSTRACT Whitening cream is a mix of chemicals which whiten skin or bleach black fleck on the skin. The use of Mercury in whitening cream effects many things, such as skin color changes, and at the end cause black flecks, allergy, and irritation. The use of high dose cause permanent brain damage and cancer. The objectives of this research were to identify and determine Mercury (Hg) in some whitening creams marketed in Manado City.Sample of whitening cream were 10 samples.Identification of Mercury using color test, and Cold Vapour-Atomic Absorption Spectrophotometry (CVAAS). The results shows that five samples contains Mercury (Hg)0,0004 ppm, 0,0003 ppm, 0,0006 ppm, 0,0004 ppm, and 0,0005 ppmwithin ten samples analysis. Key words : Whitening cream, Mercury, CV-AAS (Cold Vapour Atomic AbsorbtionSpectrophotometry).

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