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Paediatrica Indonesiana
ISSN : 00309311     EISSN : 2338476X     DOI : -
Core Subject : Health,
Paediatrica Indonesiana is a medical journal devoted to the health, in a broad sense, affecting fetuses, infants, children, and adolescents, belonged to the Indonesian Pediatric Society. Its publications are directed to pediatricians and other medical practitioners or researchers at all levels of health practice throughout the world.
Arjuna Subject : -
Articles 2,118 Documents
Effects of live versus heat-killed probiotics on acute diarrhea in young children Atik Indriyani; Mohammad Juffrie; Amalia Setyati
Paediatrica Indonesiana Vol 52 No 5 (2012): September 2012
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (111.025 KB) | DOI: 10.14238/pi52.5.2012.249-54

Abstract

Background Diarrhea remains one of the major causes ofmorbidity and mortality in children in developing countries.Probiotics have been shown to be beneficial for decreasing thefrequency and duration of diarrhea. However, the reported effectson reducing the duration of diarrhea have been varied.Objective To compare the effectiveness of live and heat􀁂killedprobiotics in 6􀁂60 month􀁂old children with acute diarrhea fordecreasing duration and frequency of diarrhea and improvingweight gain.Methods We conducted a randomized, single􀁂blind, controlledtrial in children aged 6􀁂60 months with acute diarrhea. Childrenwere randomized into two groups, receiving either live or heat􀁂killed probiotics. All children received standard treatment fordiarrhea and probiotics as adjuvant treatment. The primaryoutcomes were duration and frequency of diarrhea, as well asweight gain. T􀁂test was used for data analysis.Results There were 165 children with acute diarrhea enrolledin this study. They were divided into 2 groups, with 83 childrenreceiving live probiotics and 82 children receiving heat􀁂killedprobiotics. There were no significant differences in diarrhealduration in the two groups. The mean durations of diarrhea inthe live and heat􀁂killed probiotic groups were 3.64 (SD 0.85) daysand 3.74 (SD 0.73) days (P>0.05), respectively. Mean diarrhealfrequencies were also not significantly different, with 3.25 (SD1.44) times per day in the live probiotic group and 3.26 (SD 1.20)times per day in the heat􀁂killed probiotic group (P>0.05). Inaddition, mean weight gain was not significantly different, 'With241.57 (SD 75.84) g in the live prohiotic group and 221.95 (SD85.38) g in the heat-killed prohiotic group (P>0.05).Conclusion There were no significant differences between live andheat􀁂killed probiotics for reducing duration and frequency of diarrhea,as well as in weight gain in children aged 6􀁂60 months 'With acutediarrhea. [paediatr lndones. 2012;52:249-54].
Superoxide dismutase levels and peak expiratory flow in asthmatic children Arie Kurniasih; Madarina Julia; Amalia Setyati
Paediatrica Indonesiana Vol 55 No 6 (2015): November 2015
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (109.58 KB) | DOI: 10.14238/pi55.6.2015.309-14

Abstract

Background Asthma is a chronic inflammatory process which involve variety of cells such as inflammatory mediators, reactive oxygen species (ROS), and cytokines. The inflammatory process would be exacerbated in the presence of oxidative stress. Superoxide dismutase (SOD) is the first important enzyme to protect the respiratory tract against oxidative stress. The decreased of SOD has a correlation with increased of airway obstruction and bronchospasm. Objective To assess for a correlation between superoxide dismutase (SOD) levels and peak expiratory flow, as well as to determine the impact of SOD levels for predicting asthma attacks. Methods We conducted a prospective cohort study at Dr. Sardjito Hospital, Yogyakarta, between February and April 2011 involving asthmatic children aged 5-18 years. Subjects’ serum SOD levels and peak expiratory flow were measured at the same time point. We then performed a prospective study following up on the same subjects to find out if they had a recurrent asthma attack within one month of the tests. We also reassessed their peak expiratory flow one month after blood specimens were obtained. Results Thirty-nine patients were enrolled in this study. There was no significant correlation between SOD level and peak expiratory flow [r=0.289; 95%CI -0.025 to 0.47; P=0.074]. However, older age was significantly associated with higher peak expiratory flow (􀁂=0.5; 95%CI 3.10 to 11.57; P=0.01). Lower levels of SOD increased the risk of asthma attacks in a month following the initial measurements (RR=5.5; 95%CI 1.6 to 18.9; P=0.009). Conclusion Superoxide dismutase (SOD) level is not significantly associated with peak expiratory flow. However, we find a relationship between older age and higher peak expiratory flow and a relationship between lower SOD levels and risk of asthma attacks within one month following the tests.
Effect of intranasal mometasone furoate administered in children with coexisting allergic rhinitis and asthma towards asthma attacks and lung function Ellen P. Gandaputra; Zakiudin Munasir; Bambang Supriyatno; Jose R. L. Batubara
Paediatrica Indonesiana Vol 49 No 6 (2009): November 2009
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (114.377 KB) | DOI: 10.14238/pi49.6.2009.359-64

Abstract

Background Allergic rhinitis and asthma are allergic manifestations in respiratory tract, which related each other. Intranasal corticosteroid is effective in allergic rhinitis and has benefits in decreasing lower airway reactivity.Objectives To evaluate effectiveness of intranasal mometasonefuroate towards asthma in children aged 6-18 years with coexisting allergic rhinitis and asthma.Methods A one group pretest-posttest ("before and after") study was conducted in Cipto Mangunkusumo Hospital from May to December 2008. Subjects were children aged 6-18 years, with moderate-severe intermittent or persistent allergic rhinitis with coexisting frequent episodic asthma or persistent asthma, and visited outpatient clinic of allergy immunology division or respirology division. Subjects were administered intranasal mometasone furoate 100 J-ig daily only for 8 weeks, without long term administration of oral and inhaled corticosteroid. Improvements in allergic rhinitis and asthma were evaluated using questionnaires and lung function tests.Results There were 35 subjects and four of them dropped outduring the study. There was >50% improvement in allergic rhinitis symptoms after 4 weeks of treatment (P<0.001). This improvement was associated with decreasing in frequency of asthma attack >50% after 8 weeks of treatment (P< 0.001). There was an insignificant improvement in FEY 1 (P=0.51). However, the evaluation of sinusitis was not performed in all subjects, thus may influence the results. During study, there were no side effects observed.Conclusions Intranasal mometasone furoate improves allergicrhinitis and decrease >50% of asthma symptoms, however it is not followed with significant improvement in lung function. No side effects are reported during 8 weeks use of intranasal mometasone furoate.
Qualitative evaluation of antibiotic usage in pediatric patients Hindra Irawan Satari; Agus Firmansyah; Theresia Theresia
Paediatrica Indonesiana Vol 51 No 6 (2011): November 2011
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi51.6.2011.303-10

Abstract

Background Antibiotics are among the most commonly prescribed drug for pediatric patients. Inappropriate use of antibiotics can increase morbidity, mortality, patient cost and bacterial antibiotic resistence. Antibiotic uses can be evaluated quantitatively and qualitatively.Objective To qualitatively evaluate antibiotic use in patients using Gyssens algorithm.Methods We performed a descriptive, retrospective study of matient medical records of those admitted to the pediatric ward from January 1 – June 30, 2009. Records were screened for patient antibiotic use, followed by qualitative evaluation using Gyssens algorithm on data from patient who received antibiotic treatment.Results We found 49.2% of subject were prescribed antibiotics. The majority of patients given antibiotics were aged 1 month - 1 year (39.3%). Antibiotic use was categorized by therapy type : empirical, prophylactic, or definitive. We found empirical therapy in 73% of cases, prophylactic in 8%, and definitive in 15%. Cefotaxime was the most common antibiotic used (25.1%), followed by ceftazidime (14%) and cotrimoxazole (1%). 39.6% of subjects were given antibiotics appropriately, while 48.3% were given inappropriately. In 3.3% of patients, antibiotics were given without indication and in 8.8% there was insufficient data.Conclusions Of hospitalized patients receiving antibiotic treatment at the Departement of Child Health, Cipto Mangunkusumo Hospital, 39.6% were given antibiotic appropriately, while 48.3% were given antibiotics inappropriately. Cefotaxime was the most commonly used, as well as most inappropriately given antibiotic.
Chronic diarrhoea in protein-energy malnutrition Michael Gracey
Paediatrica Indonesiana Vol 21 No 11-12 (1981): November - December 1981
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi21.11-12.1981.235-9

Abstract

Infection and malnutrition exemplify synergistic role of these two major factors in the pathogenesis of diarrhoea in protein-energy malnutrition.
Using N-terminal pro-B-type natriuretic peptide to diagnose cardiac abnormalities in children with dyspneaen with dyspnea Zakaria Mukalla; Ria Nova; Legiran Legiran; Yangtjik Yangtjik
Paediatrica Indonesiana Vol 57 No 3 (2017): May 2017
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (226.356 KB) | DOI: 10.14238/pi57.3.2017.124-8

Abstract

Background. Dyspnea could be caused by various reason, one of which is the presence of cardiac abnormality. Physical examination sometimes difficult to distinguish breath caused by heart abnormalities, especially small children, so we need another way to find out.Objective. To evaluate whether the examination of NT-proBNP levels can be used as a screening tool to diagnose cardiac abnormality in children presenting with dyspnea.Methods. A Cross sectional study was conducted from August to October 2015 on pediatric patients aged 1 month to 18 years presenting with dyspnea in pediatric ward Mohammad Hoesin Hospital Palembang. All subjects performed blood sampling for NT-proBNP examination and echocardiography to assess the presence of cardiac abnormalities. The diagnostic value analyzed by ROC curve, and determined the optimal cut-off point, sensitivity and specificity. Result. We obtained 58 subjects with median age 9.5 (1-180) months, consisted of 39 subjects with cardiac abnormalities and 19 subjects without cardiac abnormality. There is a significant difference (p = 0.002) of NT-proBNP levels in both groups with a median  1,775 (189-9,000) pg/ml vs 759 (245-9,000) pg/ml. In ROC curve analysis, AUC value was 0.75, and at the optimal cut-off point 1,235 pg/ml, sensitivity was 74.4% and specificity was 73.7%.Conclusion. The level of NT-proBNP can be used to diagnose cardiac abnormalities in children presenting with dyspnea.
Validity of protein-creatinine and protein-osmolality ratios in the estimation of massive proteinuria in children with nephrotic syndrome M. Sukmawati; K. Suarta
Paediatrica Indonesiana Vol 47 No 4 (2007): July 2007
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (378.971 KB) | DOI: 10.14238/pi47.4.2007.139-43

Abstract

Background Children with nephrotic syndrome have massiveproteinuria, a rate of excretion equal to or greater than 40 mg/hour/m 2 body surface. The ability to quantitate massive urinaryprotein excretion is very important for both diagnostic andprognostic purposes. Quantification of proteinuria using 24-hoururine collection (Esbach) is difficult to do especially in children;moreover, many false-positive and false-negative results arereported for any semi-quantitative methods such as dipstick andsulfosalicylic acid measurement.Objective To determine the accuracy of protein-creatinine ratio(PCR) and protein-osmolality ratio (POR) in quantification ofmassive proteinuria in children with nephrotic syndrome.Methods Diagnostic tests were conducted on children withnephrotic syndrome aged 2-12 years with Esbach as a referencestandard. Sensitivity, specificity, positive predictive value (PPV),negative predictive value, (NPV), pre and posttest probabilitywere compared between PCR and POR.Results Study patients consisted of 47 children, 38 (81%) withmassive proteinuria. PCR has sensitivity of 92%, specificity of78%, PPV of 95%, NPV of 70% and posttest probability of 95%.POR has sensitivity of 76%, specificity of 78%, PPV of 94%, NPVof 44% and posttest probability of 94%.Conclusion Both PCR and POR are accurate to determine massiveproteinuria in children with nephrotic syndrome.
Antibiotics on incidence of infection in neonates with meconium-stained amniotic fluid M. Sholeh Kosim; N. P. Noerpramana; Asril Aminullah; Suharyo Hadisaputro
Paediatrica Indonesiana Vol 53 No 1 (2013): January 2013
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (118.004 KB) | DOI: 10.14238/pi53.1.2013.50-5

Abstract

Background The effectiveness of antibiotics for preventinginfection in neonates with meconium-stained amniotic fluid(MSAF) remains unclear. Not all neonates with MSAF developmeconium aspiration syndrome (MAS) or neonatal infection.Furthermore, neonatal infection diagnosis may be difficult dueto lack of symptoms. As such, clinical manifestations, laboratoryresults, and infection markers are important for diagnosis.Objective To evaluate antibiotic use on the incidence ofinfectionin neonates with MSAF.Methods This double-blind randomized controlled clinical trialwas performed at Dr. Kariadi Hospital, Semarang, Indonesia fromOctober 2009 to March 2010. Subjects were newborns with MSAFwho were diagnosed by two observers (Kappa test intraobserveragreement was 0.74) and with feces metabolites found in theiramniotic fluid. Sixty-nine newborns were divided into groups Iand II, comprised of 35 and 34 subjects, respectively. Group Isubjects (control group) were not given antibiotics, while groupII subjects (treatment group) were given combination antibioticsof ampicillin (50 mg;kg BW) and gentamicin (8 mg;kg BW), assingle doses. Neonatal infection diagnosis was based on clinicalmanifestations, laboratory results (leucocyte count, blood culture,and I: T ratio), and the following infection markers: procalcitonin(PCT), interleukin-6 (IL-6), tumor necrosis tumor-a (TNF-a),and C-reactive protein (CRP). Chi-square and Fischer's exacttests were used for statistical analyses.Results We found no significant differences in the incidence ofneonatal infection between those who received and those whodid not receive antibiotics, based on clinical manifestations, thefirst and second examination of laboratory marker (P=0.53),examinations of CRP, IL-6, TNF-a, and PCT either as singlemarkers or combinations of 2, 3, or 4 markers (P> 0.05) , as wellas mortality rate (P=0.30).Conclusion There is no significant difference in the incidenceof infection in neonates with MSAF who received prophylactic antibiotics compared to those who did not receive antibiotics.
Dermatoglyphic patterns of goitrous children in endemic iodine deficiency area Martira Maddeppungeng; R Satriono
Paediatrica Indonesiana Vol 44 No 3 (2004): May 2004
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (683.896 KB) | DOI: 10.14238/pi44.3.2004.117-20

Abstract

Background Goiter mapping on elementary school students in1998 showed that the prevalence of endemic goiter was still highat Enrekang regency, South Sulawesi despite various programs tomanage this problem. This raised questions if there were any otherfactors that contribute to the occurrence of goiter e.g. genetic fac-tor, which can be assessed indirectly by dermatoglyphic pattern.Objective To determine the dermatoglyphic pattern in goitrouschildren and compare it to normal children.Methods A cross sectional study was done to investigate the cor-relation between goiter and dermatoglyphic patterns on 115 el-ementary school students at Anggeraja and Baraka subdistricts,Enrekang regency. Dermatoglyphic patterns of finger tips of bothhands and right hallux were scanned using Prolink scanner withMaximum Resolution of 19200x19200dpi and interpreted usingphoto/image editing computer program.Results Seventy two (62.6%) of 115 children were goitrous, sev-enty (97%) were of stage1, and 2 (3%) of stage 2. No significantdifference was found in dermatoglyphic patterns between normaland goitrous children. Tibial loop pattern of the right hallux tendedto be more frequent in goitrous children than that of normal chil-dren, but it was not statistically different (in level of significancy of0.05) compared to normal children (p=0.085).Conclusions This study indicates that the possibility of the role of ge-netic factor in the development of goiter in endemic area is unlikely
Knowledge and behavior of mothers about the way of suckling their babies Titi S. Sularyo; Rini Sekartini; Soedjatmiko Soedjatmiko; Hartono Gunardi; Corrie Wawolumaya
Paediatrica Indonesiana Vol 42 No 9-10 (2002): September 2002
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi42.5.2002.201-5

Abstract

Background A good and proper knowledge and behavior of mothers as to how they breast-feed their young is supposed to enhance the health of the community.Objective To find out the knowledge and behavior of mothers of under-fives about the technique of nursing and its related factors.Methods The study was perionned from September 20 to October 15, 1999 at Kelurahan Pisangan Baru, East Jakarta. The respondents were 101 mothers owning under-fives, attained by the multi-stage cluster random sampling method. Questionnaires were used and observation was made only on mothers who were suckling their child during the interview.Results Mother's knowledge about the way of suckling was found unsatisfactory in 46.5% although 51.5% of mothers revealed a good behavior. Statistical analysis showed no significant relationships between factors such as age, educational level, occupation, family income and mother's activity with mother's knowledge and behaviorabout the way of nursing their child.Conclusions There was no significant relationship between mother's knowledge and behavior about breastfeeding. Other factors beyond this studied factors should be taken into account.

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