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Paediatrica Indonesiana

paediatrica-indonesiana
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Published by Ikatan Dokter Anak Indonesia

ISSN : 00309311 EISSN : 2338476X DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology

Paediatrica Indonesiana is a medical journal devoted to the health, in a broad sense, affecting fetuses, infants, children, and adolescents, belonged to the Indonesian Pediatric Society. Its publications are directed to pediatricians and other medical practitioners or researchers at all levels of health practice throughout the world.

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Articles 2,114 Documents

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Haemoglobinopathies and their occurrence in South East Asia J.H.P. Jonxis
Paediatrica Indonesiana Vol 15 No 3-4 (1975): March - April 1975
Publisher : Indonesian Pediatric Society

A great number of hereditary abnormalities in the rate of haemoglobin synthesis and in structure of haemoglobins are known at the moment. Most of these abnormalities occur only in a few families and are not very important for the health of a population. Some forms occur, however, rather frequently. In Eastern Asia both alfa and beta thalassaemia cases are rather common. The alfa thalassaemia gene seems to occur in a rather high frequency in people from Chinese extraction. The beta thalassaemia gene, too, is not rare in the population of many etnic groups in South- East Asia.The symptoms of homozygocity, heterozygocity and double-heterozygocity for the different thalassaemia genes are described. In most Asia countries genetic abnormalities, causing abnormal haemoglobins, are not as common as they are for instance in many African groups. Forms of Lepore haemoglobin, Hb E, Hb Thai, Hb O, Hb S, have been found in East Asian populations, Hb Thai being rather frequent in Thailand, Hb E in Ceylon.The different clinical pictures of heterozygocity, homozygocity and double-heterozygocity for these genetic abnormalities are described.

Clinical Edema and Chest X-Ray Findings in Acute Poststreptococcal Glomerulonephritis Husein Albar; Syarifuddin Rauf; Dasril Daud; Azis Tanra; M. Faried Kaspan
Paediatrica Indonesiana Vol 37 No 3-4 (1997): March - April 1997
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi37.3-4.1997.69-75

We report the results of a retrospective study evaluating clinical edema and chest X-ray findings in 17b patients with acute poststreptococcal glomeruÂ¬lonephritis (APSGN), hospitalized in the Pediatric Nephrology Unit of Ujung Pandang General Hospital, from January 1, 1980 through December 31, 1990. Of the total 194 patients, only 176 fulfilled the criteria and could be evaluated. There were 98 boys (55,7%) and 78 girls (44.3%) aged between 1 year 9 months and 14 years, mostly beÂ¬tween 6-12 years (72.8%). We found that edema of the palpebra was more frequently noted (98.9%) than that of the pretibia (71.6%), face (64.2%) and ascites (21.0%). This study showed evidence of cardiomegaly (84.1%), pulmonary vascular congestion (68.2%), pleural effusion (65.9%) and pulmonary' edema (48.9%). Our study results documented that roentgenographic abnormality of the chest of patients with APSGN, included each of the following findings, e.g., cardiomegaly, pleural effusion, pulmonary vascular congestion, and pulmonary edema, was significantly more frequent in patients with clinical evidence of severe edema than those with moderate and mild edema (p < 0.01).

Sleep patterns in 1 to 36 month-old children Catharina Sambo; Rini Sekartini; Partini Trihono
Paediatrica Indonesiana Vol 50 No 3 (2010): May 2010
Publisher : Indonesian Pediatric Society

Background Better understanding about sleep patterns inIndonesian children can contribute to basic knowledge foreducating parents and health providers about good sleephygiene.Objectives To find out sleep patterns in 1ô€Š36 monthô€Šoldchildren.Method A descriptive, crossô€Šsectional study was held in EastJakarta on May 2009. Subjects were 1 to 36 months old childrenwho came \\lith their parents or primary caregivers. Data collectionwas performed using modified Brief Infant Sleep Questionnaire(BISQ), consisted of subjects' characteristics, sleep patterns, sleepproblems, and associating factors.Results Among 147 children, sleep problems were identified in33.3% of them. Bedtime was mostly at 8 p.m., wake up time was5 a.m. Median time needed to fall asleep was 20 minutes. Averagefrequency of night waking was twice during one night. Mediannight waking duration was 15 minutes. Median sleep duration atnight was 9 hours 20 minutes, and median nap duration was 2hours 20 minutes. Median total sleep time was 12 hours. Pronesleeping position was significantly associated \\lith sleep problems(pô€‹0.036, RRô€‹1.67, 95%CIô€‹1.66-2.64).Conclusions Prevalence of sleep problem is 33.3%, \\lith awakeningat night was being the most occurring problem. Prone sleepingposition is associated \\lith sleep problems. [Paediatr Indones.2010;50:170-5].

Tumor necrosis factor-alpha and interleukin-6 in early-onset neonatal sepsis Prambudi Rukmono; Nani Dharmasetiawani; Warsono Warsono; Yan Wirasti; Eryati Darwin
Paediatrica Indonesiana Vol 56 No 1 (2016): January 2016
Publisher : Indonesian Pediatric Society

Background Neonatal sepsis remains a major cause of mortality and morbidity in newborns. Early-onset neonatal sepsis occurs in infants under the age of 72 hours, while late-onset neonatal sepsis occurs in infants over the age of 72 hours and may be due to nosocomial infection. Diagnosing neonatal sepsis is a challenge, as its clinical symptoms are not clear. Corroborating tests include routine blood, C-reactive protein (CRP), serology, tumor necrosis factor-alpha (TNF-Î±), and interleukin-6 (IL-6) examinations.Objective To compare the TNF-Î± and IL-6 levels in patients with proven and unproven early-onset neonatal sepsis (EONS)Methods This case-control study was done in the Perinatology Unit, Abdul Moeloek Hospital, Lampung. Subjects were under the age of 72 hours with risk factors and clinical symptoms of sepsis. They underwent routine blood tests and blood cultures. Infants with positive cultures were considered to have proven sepsis (26 subjects) and infants with negative blood cultures were considered to have unproven sepsis (26 subjects). All subjects underwent serological examinations of TNF-Î± and IL-6.Results There were no differences in the basic characteristics of subjects between the two groups. Levels of TNF-Î± in the sepsis group were significantly higher than in the unproven group [(28.30 vs. 10.96 pg/mL, respectively (P=0.001)]. Furthermore, Il-6 was significantly higher in the proven sepsis group than in the unproven sepsis group [(28.3 vs. 9.69 pg/mL, respectively) (P=0.006)].Conclusion Levels of TNF-alpha and IL-6 are significantly higher in infants with proven than unproven early-onset neonatal sepsis.

Thyroid hormone profile and PELOD score in children with sepsis Agung G. Tanurahardja; Antonius H. Pudjiadi; Pramita G. Dwipoerwantoro; Aman Pulungan
Paediatrica Indonesiana Vol 54 No 4 (2014): July 2014
Publisher : Indonesian Pediatric Society

Background Thyroid hormonal dysfunction, also known aseuthyroid sick syndrome or nonthyroidal illness, can be seenin sepsis. There have been few studies on thyroid hormonedysfunction in septic children, as well as on a relationshipbetween their thyroid hormone profiles and pediatric logisticorgan dysfunction (PELOD) scores. Procakitonin (PCT) is oneof the sepsis biomarker.Objective To evaluate the thyroid hormone profile in childrenwith sepsis as well as to assess for a correlation between the thyroidlevels and PELOD scores, PCT levels, and patient outcomes.Methods This cross-sectional study included children aged 1- 18years admitted to the pediatric intensive care unit (PICU) with aprimary diagnosis of sepsis. PELOD scores and thyroid hormonallevels were assessed once during the first 24 hours after PICUadmission.Results Thirty subjects were included in the study. The medianvalues ofT3, free T4, and TSH were 45 (range 17 -133) ng/dL,0.81 (range 0.3-1.57) ng/dL, and 1.36 (range 0.05-7.78) Î¼IU/L,respectively. The T3, free T4, and TSH levels were decreased in97%, 50% and 40% of the subjects. There were no significantdifferences between low and normal to high TSH with regards tothe PELOD score (P=0.218), PCT level (P=0.694), or patientoutcomes (P=0.55). The risk of death increased by 15 timesamong the subjects with PELOD score ~20 compared to thosewith PELOD score <20 (OR 15; 95%CI: 1.535 to 146.545;P=0.012).Conclusion Thyroid hormones are decreased in septic childrenwith the majority having low T3. A high PELOD score is stronglycorrelated with mortality and can be used as a prognostic parameterfor septic children in the PICU, but there is no correlation withdecreased TSH.

Risk factors of childhood leukemia Paulina K. Bangun; Bidasari Lubis; Sri Sofyani; Nelly Rosdiana; Olga R. Siregar
Paediatrica Indonesiana Vol 54 No 6 (2014): November 2014
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi54.6.2014.358-64

Background The incidence of childhood leukemia has increasedannually. Recent studies have shown that childhood leukemia isinitiated in utero, and have focused on prenatal risk factors suchas birth weight and parental age. Exposure to pesticides andradiation, as well as parental smoking, breastfeeding, and thenumber of older siblings have also been sugges ted as risk factorsfor childhood leukemia.Objective To evaluate possible risk factors for childhood leukemia,including birth weight, parental age, and other risk factors.Methods This case-con trol study was conducted from October2011 to February 2012 in Haji Adam Malik Hospital, Medan .Case subjects were children aged below 18 years and diagnosedwith leukemia. Control subjects were children aged below 18years who were diagnosed with any non-cancerous acute illnessesin this hospital, and individually matched for age and gen der tothe case subject group. Patients and parents were asked to fill astructured questionnaire. Data was analyzed using conditionallogistic regression .Results A total of 140 subjects were eligible, with 70 subjects ineach group. Birth weight 2: 4000 g and maternal age 2:35 yearswere significant risk factors with OR 10.13 (95%CI 1.124 to 91.2 7)and OR 4.98 (95%CI 1.276 to 19.445), respectively. Paternal ageof 2:35 years was not a significant risk factor. Exposure to pesticideswas also noted as another significant risk factor (OR= 6.66; 95%CI2.021 to 21.966) .Conclusion High birth weight, advan ced maternal age, andexposure to pesticides are risk factors of childhood leukemia.

Histopathological Features of Primary Nephrotic Syndrome in Children M P Damanik; N Yoshikawa
Paediatrica Indonesiana Vol 38 No 1-2 (1998): January - February 1998
Publisher : Indonesian Pediatric Society

Â Renal biopsy was performed on 28 out of 50 children with primary nephrotic syndrome encountered during the period January 1994 - December 1995. Light microscope (LM) and immunofluorescence microscope QM) examinations were performed on all biopsy specimens. LM examination indicated minimal changes (MC) in 13 cases (46.4%), focal segmental glomerulosclerosis (FSGS) in 10 (35.7%), membranous glomerulonephritis (MG) in 2 (7.1%), mesangial proliferative glomerulonephritis (MPG) in 7 (7.1 %), and membranoproliferative glomerulonephritis (MPGN) in 1 (3.6%). On IM examination, immunoglobulin deposit was not detected in any MC patients, whereas in FSGS, lgG, lgM, C3 and fibrinogen deposits were found. In the MG group, IgG deposition was detected in one case. In the MPG cases, depositions of lgA, IgG, lgM, C3 and fibrinogen were detected and in the case of MPGN, deposits of lgM and C3 were found. Regarding to response to steroid treatment in the MC group, there was a significant difference between the steroid sensitive and steroid insensitive (p<0.05). For the FSGS abnormality in the steroid treatment of U1e insensitive patients, there was found significant difference with the steroid sensitive abnormality (p<0.05). In conclusion, nephritic symptoms (hematuria, proteinuria, azothemia) are possibly the non minimal group and hence, it would be necessary to carry out renal biopsy to prove this.

Efficacy of synbiotic and probiotic treatments on acute watery diarrhea in children Ani Isti Rokhmawati; Wahyu Damayanti; Madarina Julia
Paediatrica Indonesiana Vol 52 No 4 (2012): July 2012
Publisher : Indonesian Pediatric Society

Background In developing countries, acute watery diarrhea isa common cause of morbidity and mortality in children. Givingsynbiotics or probiotics may decrease the severity of diarrhea.Objective To compare the efficacy of synbiotics and probioticsin decreasing the frequency of diarrhea, shortening the duration,and increasing patient body weight.Methods This was a doubleô€€·blind, randomized clinical trial tocompare the effects of synbiotic vs probiotic treatment in childrenaged 6ô€€·59 months v.ith acute watery diarrhea. This study wasperformed from October to December 2010 in two hospitals inCentral Java. Subjects received either synbiotics or probioticstv.ice daily for five days. The measured outcomes were durationof diarrhea, daily frequency of diarrhea, and increase in bodyweight.Results There was no significant difference in the mean durationof the diarrhea in the synbiotic and probiotic groups, 3.92 days(SD 0.79) vs 3.80 days (SD 0.82) ,(Pô€€¸0.35), respectively. Nor didwe observe a significant difference in the mean increase in bodyweight in the synbiotic and probiotic groups, 150 g (SD 49.7) vs160 g (SD 48.9), (Pô€€¸ 0.67), respectively.Conclusion We observed no significant differences in efficacy ofsynbiotic and probiotic treatment for management of acute waterydiarrhea. [Paediatr Indones. 2012;52:209,12].

Correlation between nosocomial pneumonia and ventilated patients in pediatric intensive care unit Cahya Dewi; Purnomo Suryantoro; Roni Naning
Paediatrica Indonesiana Vol 48 No 3 (2008): May 2008
Publisher : Indonesian Pediatric Society

Background NP (NP) especially YAP (ventilator-associated pneu-monia) is the most common infection in intensive care unit, whichcorrelates with the increasing of morbidity and mortality. Thereare some risk factors for development ofNP, the most importantone is duration of mechanical ventilator and reintubation.Objective To determine the correlation between NP and use ofmechanical ventilator in pediatric intensive care unit (PICU).Methods A matched case control study was conducted at Dr.Sardjito Hospital on all patients admitted to the PICU from2004 until 2006. Case group was defined as all patients who hadNP; age and sex matched control group included all patients notdiagnosed as NP. Statistical analysis was done by using chi-squareand t-tests as appropriate. Logistic regression analysis was doneto determine the role of risk factors.Results One-hundred and forty-one patients were included inthis study. The incidence of NP was 25. 7%. There was associa-tion between using mechanical ventilator (OR 1.08; 95%CI 1.07;8.20, P=0.036) and duration of using mechanical ventilator morethan four days (OR 1.75, 95%CI 1.87;18.02) with developmentof NP. There was a significant difference in event free survival ofNP between those using mechanical ventilator group and thosenot using mechanical ventilator group (P<O.OOl).Conclusion There is an association between the use of mechani-cal ventilator and duration of use of mechanical ventilator morethan four days with the development of NP

Early allergy symptoms in infants aged 0-6 months on breast milk substitutes Mulya Safri; Aulia Rahman Putra
Paediatrica Indonesiana Vol 55 No 1 (2015): January 2015
Publisher : Indonesian Pediatric Society

Background Atopic diseases are common in children and a serious health problem worldwide. Atopic dermatitis, food allergies, asthma and allergic rhinitis, have been described as the natural progression of allergic diseases, also known as the â€œallergic marchâ€. Cowâ€™s milk protein is known to be a common trigger of food allergies and hypersensitivity reactions during infancy. Objective To give an overview of the breast milk substitutes (BMS) and incidence of early allergy onset (allergic march) in atopic infants aged 0-6 months. Methods This cross-sectional study included a total of 40 atopic infants collected by consecutive sampling. A questionnaire was used for interview that inquired information on the type of BMS used, initial allergy complaints, the age of the emergence of early allergic symptoms, and the breakdown for BMS type. Univariate analysis was carried out to describe their characteristics as frequency distributions and percentages of each variables. Results Atopic dermatitis and wheezing were more common in boys (62.5%). Atopic dermatitis was the most common initial symptom to occur in atopic infants (52.5%). Atopic dermatitis and wheezing occurred together in 27.5% subjects. Early allergy symptoms that first occurred at the age of 1 month were seen in 42.9% for atopic dermatitis category, 37.5% for wheezing category, and 63.6% for both symptoms category, respectively. Cowâ€™s milk was the most common type of BMS given to atopic infants in the first 6 months of life (47.5%). Conclusion Early symptoms of allergies, such as atopic dermatitis and wheezing, are more common in boys than girls. Atopic dermatitis is the most common early symptom to arise, but both symptoms occur at an early age, often during the first month of life.Â

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