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Paediatrica Indonesiana

paediatrica-indonesiana
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Published by Ikatan Dokter Anak Indonesia

ISSN : 00309311 EISSN : 2338476X DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology

Paediatrica Indonesiana is a medical journal devoted to the health, in a broad sense, affecting fetuses, infants, children, and adolescents, belonged to the Indonesian Pediatric Society. Its publications are directed to pediatricians and other medical practitioners or researchers at all levels of health practice throughout the world.

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Articles 2,118 Documents

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Immunopathogenesis of cowâ€™s milk allergy Ariyanto Harsono
Paediatrica Indonesiana Vol 43 No 4 (2003): July 2003
Publisher : Indonesian Pediatric Society

Given the publicâ€™s increasing awareness of cowâ€™smilk allergy and their frequent misperception thatvarious illness is caused by cowâ€™s milk-induced aller-gic reactions, the physician must retain some skepti-cism throughout the evaluation and rely on objectivemeasures to arrive at the final diagnosis. Over diag-nosis of cowâ€™s milk allergy has led to malnutrition,eating disorders, and psychosocial problems, as wellas family disruption, whereas under diagnosis leavesthe patient suffering unnecessarily and may result ingrowth failure and permanent physical impairments.The following discussion provides an immunologicalbasis of cowâ€™s milk allergy in an attempt to improveour understanding in clinical manifestations, diagno-sis and management of the disease.

Splenectomy and its relation to non-transfusion-transmitted infection in thalassemic patients Mururul Aisyi; Alan Roland Tumbelaka; Bulan Ginting Munthe; Bambang Madiyono
Paediatrica Indonesiana Vol 46 No 3 (2006): May 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi46.3.2006.134-8

Background Splenectomy has been associated with an increasedsusceptibility to infection. Overwhelming postspelenectomy infec-tion (OPSI) can lead to high mortality. Decreased IgM and tuftsinconcentration on splenectomized patients seems to play a role ininfectionâ€™s susceptibility. Many studies have been performed todetermine the risk factors of infection in thalassemic patients.Objective To find out morbidity patterns and risk factors for pre-dicting the likelihood of infection in splenectomized thalassemicpatients.Methods A retrospective cross sectional study was conducted onconfirmed thalassemic children who came to Department of ChildHealth, Cipto Mangunkusumo Hospital within the period of 1973-2003. Splenectomized patients were categorized as cases groupand non-splenectomized patients as control group. Risk factors fordevelopment of common cold and diarrhea were analyzed usingchi-square test with level of significance <0.05.Results A total of 300 thalassemic patients, 100 of them were sple-nectomized, were enrolled in this study. The 15-year-age group orabove is the most common group underwent splenectomy (35%).Common cold is the most common mild infection in both splenec-tomized group (75%) and non-splenectomized (71%). A significantassociation was found between the risk of infection and splenec-tomy in thalassemic patients (OR=3.8;CI=2.2;6.62; P=0.000). As-sociation between time after splenectomy and frequency of com-mon cold in thalassemia was significant (OR=2.85;CI=1.16;7.14;P=0.011). Severe infection and acute diarrhea were considerednot significantly different between the two groups.Conclusion Splenectomy in thalassemia can increase the sus-ceptibility of non-transfusion-transmitted mild infection. Furtherstudy is needed to elaborate this finding

Pedigree analysis of glucose-6 phosphate dehydrogenase (G6PD) deficiency of a Javanese Chinese family in Indonesia IDG Ugrasena; Taku Shirakawa; Kaoru Nishiyama; Masafumi Matsuo
Paediatrica Indonesiana Vol 41 No 1-2 (2001): January 2001
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi41.1.2001.56-9

The molecular and pedigree analyses in a Javanese Chinese family were carried oul on glucose-6-phosphate dehydrogenase deficiencies. By method of Â MPTP scanning without the sequencing steps, those variants could be confirmed. Two out of three sons were clinically jaundiced at birth due to G6PD deficiency and identified to have a G to T nucleotide change al 1376th nucleotide 01 the G6PD gene (GI376T), corresponding to G6PD Canton. Another son was also identified to have a C to T nucleotide change at 1311st nucleotide 01 the G6PD gene (CI311T), corresponding to a Silent mutation. Their father was normal, but their mother obsorved to have the heleromutation 01 G1376T (G6PD Canton and C1311T (a Silent mutation).

Intravenous paracetamol and patent ductus arteriosus closure in preterm infants Rizky Adriansyah; Nikmah S. Idris; Mulyadi M. Djer; Sukman T. Putra; Rinawati Rohsiswatmo
Paediatrica Indonesiana Vol 57 No 4 (2017): July 2017
Publisher : Indonesian Pediatric Society

Background Indomethacin and ibuprofen are the drugs of choice for closure of patent ductus arteriosus (PDA) in preterm infants. However, intravenous preparations are of limited availability in Indonesia. Circumstantial evidence has shown that intravenous paracetamol may be an alternative therapy for PDA closure in premature infants.Objective To evaluate the effect of intravenous paracetamol on PDA closure in preterm infants.Methods A before-and-after study was conducted between May and August 2014 in Cipto Mangunkusumo General Hospital, Jakarta in preterm infants with hemodynamically significant PDAs, as established by echocardiography using the following criteria: duct diameter >1.4 mm/kg, left atrium to aorta ratio >1.4, and mean velocity in the left pulmonary artery >0.42 m/s or mean diastolic velocity in the left pulmonary artery >0.2 m/s. Subjects, aged 2 and 7 days, received intravenous paracetamol (15 mg/kg every six hours) for 3 days. Paired T-test was used to compare pre-intervention PDA diameter to those assessed at 24 hours after the intervention and at 14 days of life.Results Twenty-nine subjects had a mean gestational age of 30.8 weeks and mean birth weight of 1,347 grams. Nineteen (65.5%) patients had closed PDAs at the day 14 evaluation, 1 experienced PDA reopening, and 9 had failed PDA closure. No liver toxicity was identified. Mean duct diameters before, 24 hours after the intervention, and at 14 days of life were 3.0, 0.9, and 0.6 mm, respectively (P<0.0001).Conclusion Intravenous paracetamol seems to be reasonably effective for PDA closure in preterm infants.

Malignant osteopetrosis in a child Annie Kusumadewi; Moersintowati B. Narendra; Bambang Permono
Paediatrica Indonesiana Vol 47 No 5 (2007): September 2007
Publisher : Indonesian Pediatric Society

Cotinine and interferon-gamma levels in pre-school children exposed to household tobacco smoke Lina Kalalo; Diana Takumansang-Sondakh; Audrey Wahani
Paediatrica Indonesiana Vol 53 No 5 (2013): September 2013
Publisher : Indonesian Pediatric Society

Background Environmental tobacco smoke has been consistently linked to negative health outcomes, especially in children, including an increased susceptibility to infections. Cigarette smoking has a depressive effect on interferon-Î³ (IFN-Î³). Serum cotinine is a marker of exposure to smoke.Objective To determine the association between serum cotinine and interferon-Î³ (IFN-Î³) levels in children with household tobacco smoke exposure.Methods We conducted a cross-sectional study at the Tumumpa and Singkil Districts of Manado, Indonesia, from February to May 2012. Subjects were collected by consecutively sampling of healthy children aged 1-3 years who came to the integrated health posts. Seventy-four children were recruited and consisted of two groups of 37 subjects each, the tobacco smoke exposure group and the non-tobacco smoke exposure group. Blood specimens were collected from all subjects for laboratory blood tests of cotinine and IFN-Î³ levels. Results were analyzed by T-test and Pearsonâ€™s correlation analysis with a P<0.05 is considered as statistically significant.Results There was no significant correlation between serum cotinine and interferon-Î³ levels in the tobacco smoke exposure group. However, the interferon-Î³ level in the tobacco smoke exposure group was significantly lower than that of the non-tobacco smoke exposure group (P<0.0001).Conclusion Cotinine is not related to the interferon-Î³ level in children exposed to tobacco smoke, however, the interferon-Î³ level in children with tobacco smoke exposure is lower than in the non-tobacco smoke exposure group.

Clinical characteristics and electroencephalography features of intractable childhood epilepsy - A case series Irawan Mangunatmadja; Eva Devita Harmoniati
Paediatrica Indonesiana Vol 50 No 3 (2010): May 2010
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi50.3.2010.133-8

Background The majority of epilepsy patients have good prognosis,Â but lOAO% will develop intractable epilepsy. Early identificationÂ of patients v.ith risks of developing intractable epilepsy allowsÂ more intensive therapy to be performed.Objective To study clinical characteristics and electroencephalography (EEG) features of intractable childhood epilepsy.Methods We reviewed children \\lith intractable epilepsy attendingÂ the Pediatric Neurology and Growth and Development Clinic inÂ Child Health Department, Cipto Mangunkusumo Hospital fromÂ 2005ô€2008. EEG examination was perfonned in epilepsy patientsÂ who had consumed two or more antiepileptic drugs for at leastÂ 18 months but still experienced seizure at least once per month.Â Data of clinical characteristics were collected from the medicalÂ records and information provided by the parents.Results There were 41 subjects. Age of onset between oô€ 1 yearÂ old was found in 50% subjects, neurological impainnent in 80%,Â microcephaly in 50%, and abnonnalÂ neuroimaging in 14 of 24Â subjects. Seizure manifestations were mostly generalized tonicÂ clonic, tonic, my oclonic, and complex partial seizures. AbnonnalEEG features were found in 88% subjects and the majorityÂ showed generalized sloMng of the background activity. FocalÂ and multifocal epileptifonn activity was found in 31 % and 28%Â subjects, respectively. Epileptifonn activity was located mostly inÂ the frontal and temporal lobe.Conclusions Most patients Mth intractable epilepsy haveageÂ of onset before the age of 1 year. A substantialpoportionofÂ them have neurological impairment, microcephaly,abnonnalÂ neuroimaging, and abnormal EEG features. Seizure manifestationÂ ismostlygeneralized seizure. Epileptiform activity in intractableÂ childhood epilepsy is often found in the frontal and temporal lobe.Â

Associations of maternal body composition and nutritional intake with fat content of Indonesian mothersâ€™ breast milk Ardesy Melizah Kurniati; Diana Sunardi; Ali Sungkar; Saptawati Bardosono; Neng Tine Kartinah
Paediatrica Indonesiana Vol 56 No 5 (2016): September 2016
Publisher : Indonesian Pediatric Society

Background Breast milk is the best sole food for infants in their first six months of life. Breast milk fat content accounts for the largest part of infantsâ€™ energy and may be influenced by many factors, including maternal factors, which may vary in different settings. So far, there has been no published data about the breast milk fat content of Indonesian mothers, including whether it is affected by their body composition or nutritional intake.Objective To investigate breast milk fat content of Indonesian mothers and its associations with maternal body composition and nutritional intake. Method This cross-sectional study was conducted at Budi Kemuliaan Mothersâ€™ and Childrenâ€™s Hospital. Breast milk specimens were collected from 48 nursing mothers, centrifuged, and tested by creamatocrit for fat content. A 24-hour food recall was performed to evaluate maternal macronutrient intake. Maternal body composition was evaluated by bioelectric impedance analysis. Univariable correlations between breast milk fat content and either energy and macronutrient intake were assessed using the Spearman rho test.Results All nursing mothers had breast milk fat content within clinically normal range [mean 59.4 (SD 15.9) g/L]. There was no significant correlation between milk fat content and maternal body fat (r = -0.03, P=0.840), total body water (r = 0.09 P=0.509), or muscle mass (r = 0.08, P=0.577). Milk fat content seemed to weakly correlated with maternal fat intake, although it was not statistically significant (r = 0.27, P=0.065).Conclusion Breast milk fat content at one-month post delivery appears not associated with with maternal body composition. It seems to weakly correlate with maternal fat intake but findings need to be confirmed in larger studies with adjustment for confounding variables.Â

Broad Thumbs and Toes with Mental Retardation; Syndrome of Rubinstein and Taybi Purnomo Subagiyo; J. S. Bliek
Paediatrica Indonesiana Vol 14 No 3-4 (1974): March - April 1974
Publisher : Indonesian Pediatric Society

Seeing the unusual syndrome inan Indonesian baby we consideredpublication worthwhile.The Rubinstein and Taybi syndro-me consists of a large number ofcongenital anomalies. Some of theseare common to all cases, many areseen in some cases only.

Serological profile and hemolytic disease in term neonates with ABO incompatibility Desiana Dharmayani; Djajadiman Gatot; Rinawati Rohsiswatmo; Bambang Tridjaja
Paediatrica Indonesiana Vol 49 No 4 (2009): July 2009
Publisher : Indonesian Pediatric Society

Background Hemolytic disease of the newborn (HDN) due toABO blood type incompatibility is one of the most commoncause of neonatal hyperbilirubunemia that potentially leads tobilirubin encephalopathy. Data on ABO-hemolytic disease of thenewborn (ABO-HDN), especially regarding umbilical cord bloodserological profile, are limited.Objective To identify the serological profile and hemolytic disease in term neonates with ABO incompatibility.Methods This was a cross-sectional descriptive study, conductedat RSIA Budi Kemuliaan Jakarta.Results We found 68 healthy term neonates with ABOincompatibility, nine of them had positive direct antiglobulintest (OAT) result, and 38 subjects had a positive result onOAT with elution method. The highest titer of IgG was 1:8.Hyperbilirubinemia was found in 30 ( 44%) subjects, andABO-HDN was diagnosed in 28 (41 %) subjects. Within thepositive OAT group, eight out of nine subjects had sufferedfrom hyperbilirubinemia and ABO-HDN. Meanwhile, withinthe positive OAT with elution method group; 24 subjects hadsuffered from hyperbilirubinemia with 23 of them having ABOHDN. Based on the chi-square analysis; those with positive OAT with elution method had 3.2 times higher risk of suffering from ABO-HDN. Furthermore, there was a 3.6 times higher risk ofsufferring from hyperbilirubinemia.Conclusion In healthy term neonates with ABO incompatibility,the incidence of ABO-HDN is 41%. OAT serological examinationwith elution method is better than OAT in assessing riskfor hyperbilirubinemia and ABO-HDN.

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