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Journal of Medical Biomedical and Applied Sciences

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Published by Innovative Journal

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Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Articles 112 Documents

7 8 9 10 11

Left ventricular hypertrabeculation /noncompaction in 3-HMG coenzyme A lyase deficiency Finsterer, MD, PhD, Josef
Journal of Medical Biomedical and Applied Sciences Vol 6 No 8 (2018)
Publisher : Journal of Medical Biomedical and Applied Sciences

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Co-Existance of Dengue Fever And Malaria In Patients Presenting With Febrile Ilness Samsoor Zarak, Muhammad; Khan, Jaffar; Malik, Maham; Ul Haq, Noman; Nasim, Aqeel; Riaz, Sohail; Saood, Muhammad; kakar, Saliha; sana, Hamaiyal; Arshad, Zara; Ullah, Asad
Journal of Medical Biomedical and Applied Sciences Vol 6 No 8 (2018)
Publisher : Journal of Medical Biomedical and Applied Sciences

Objective: To determine the co-existence of dengue fever and malaria in patients presenting with febrile illness.Introduction: Malaria is worldâs most widespread infection. It occurs throughout most of the tropical regions ofthe world. Plasmodium falciparum predominates in Africa, plasmodium vivax is more common in Central America,plasmodium malariae is found in most endemic areas, especially throughout Africa, plasmodium ovale is unusualoutside of Africa and comprises <1% of isolates. The rationale of this study is to confirm d ual i nfections (malariaand dengue) in our setup in order to treat and prevent complications of co-existing disease. Secondly, both diseasesare associated with bleeding disorder hence by making proper diagnosis we can prevent risk of bleeding.Material And Methods: A cross sectional study was done at Department of Medicine, Shaikh Zayed MedicalComplex, Lahore. The time duration of the study was from 5-10-2016 to 5-4-2017. This study a total of 150patients were observed. By taking all aseptic measures 3ml blood was taken in three bottles (one CBC and twoserum bottles). One serum bottle was clearly marked with hospital number and patient name and sent to theoutside laboratory in order to check Anti Brucella antibodies, typhidot test and Paul Bunnel and Monospot test ofInfectious mononucleosis. 2nd serum bottle was clearly marked with hospital number and patient name and sent tothe laboratory in order to check dengue virus antigen, dengue serology, CBC bottle was sent to check malariaparasite by making thick and thin films. Results: In the present study mean age of study patients was 40.02 +14.4 years. The female and male gender proportions were 61% and 39% respectively. Our study concludes thatthe co-existence of dengue fever and malaria was 19% in patients presenting with febrile illness.Conclusion: Our study concludes that the co-existence of dengue fever and malaria was 19% in patients presentingwith febrile illness.

Frequency of Lumbar Spinal Stenosis in symptomatic patients of age â¥ 50 years diagnosed on Magnetic Resonance Imaging (MRI) Zarak, Muhammad Samsoor; kakar, Kaleemullah; Khan, Alamzeb; Tareen, Bisma; Khan, Rozi; Ullah, Asad
Journal of Medical Biomedical and Applied Sciences Vol 6 No 8 (2018)
Publisher : Journal of Medical Biomedical and Applied Sciences

Introduction: Lower Back pain with radiation to the lower extremities is a frequent complaint, especially in elderlypeople, and lumbar spinal stenosis (LSS) is one of the underlying conditions. Computed Tomography (CT) orMagnetic Resonance Imaging(MRI) can verify a stenosis in the lumbar spinal region. The incidence and prevalenceof symptomatic lumbar stenosis are rather speculative with no pertinent data. This study is designed to know the bestestimate of LSS in symptomatic patients to help in resource allocation and to make strategies to cut down the morbidity.Subject and Methods: A cross sectional study was done at Neurology and Medicine Department, Bolan MedicalCollege, Quetta. Total duration was from 01/01/2018 to 30/06/2018. A total of 169 symptomatic patients were includedin this study. A detailed history was taken for the duration of symptoms, and MRI was advised. Patients fulfilling thecriteria of lumbar spinal stenosis on MRI reported by the consultant radiologist and having symptoms for more than 3months, were marked as having lumbar spinal stenosis.Results: - The average age of the patients was 63.01 8.39 years Out of 169 cases, 102(60.03%) were male and67(39.64%) female. Frequency of spinal stenosis diagnosed on imaging in symptomatic patients was observed in37.27% (63/169) cases.Conclusion: The results of this study provide significant statistics for doctors that can help in promoting awarenessabout spinal stenosis. In future it might also help to reduce its incidence by designing local protocols and strategiesfor overcoming a problem of such a magnitude which may ultimately help in locating proper funds and proper timeallocation to deal with this disease entity.

Importance of Serum Adiponectin Levels in The Prediction And Ethiopathogenesis of Intrauterine Growth Restriction KarlÃ„Â±, Pervin; BaÃ…ÂŸbuÃ„ÂŸ, Alper; KÃ„Â±lÃ„Â±ÃƒÂ§, ÃƒÂ‡iÃ„ÂŸdem; Kutluer, GÃƒÂ¼lÃ…ÂŸen; Artar, Ã„Â°shak; GÃƒÂ¼lerman, Hacer Cavidan
Journal of Medical Biomedical and Applied Sciences Vol 6 No 6 (2018)
Publisher : Journal of Medical Biomedical and Applied Sciences

Objective: Our aim in this study is to determine the possibility that patients with IUGR (intrauterine growth retardation)will be able to look at the adenonetin levels in the early stages of pregnancy and to have IUGR. In this respect, earlydiagnosis, treatment and follow-up are aimed to reduce morbidity and mortality due to IUGRMaterial Method: The study was carried out between January and March 2010. Zekai Tahir Burak WomenÃ¢â¬â¢s HealthEducation and Research Hospital 28-40. with 89 patients aged 18-40 years. Groups 44 IUGR patients and 45 normalpregnant patients were divided into two groups. To examine the serum adiponectin level, an average of 3 cc was takenin the gel biochemistry tubes and then centrifuged at 4000 10 minutes. The resulting serum samples were collectedfor the ELISA kit and kept at -80 C until the day the patients were collected. In the study, adiponectin levels weremeasured by serum ELISA (enzyme linked immunosorbent assay) method.Results: In adiponectin evaluation, mean value was 105.90 19.02 pg / ml for the IUGR group, 65.96 16.5 pg / mlfor the control group and 1.6 times higher for the IUGR group( p < 0.001)Conclusion: In this study, the increased adiponectin levels of IUGR patients were significantly higher than those ofIUGR patients, suggesting that pregnancies of IUGR patients can be measured high in the first weeks and if IUGR ishigh in those weeks, IUGR can be predicted.

Bioinformatics Technology In Clinical And Public Health Microbiology Applying Computational Methods Kim, Hyunjo
Journal of Medical Biomedical and Applied Sciences Vol 6 No 9 (2018)
Publisher : Journal of Medical Biomedical and Applied Sciences

The role of clinical genomics in infectious disease diagnostics and public health microbiology is the topic of discussion during a recent decade. Although much of this work is aimed at describing the structure of outbreak communities, the methodology works equally well to identify pathogens in clinical samples. Clinical genomics is the exploitation of genome sequence data for diagnostic, therapeutic, and public health purposes. Central to this field is the high-throughput DNA sequencing of genomes and metagenomes. The key concept in using clinical genomics methodology is that detection of microbes is independent of culture and is not limited to targets used for in-depth PCR assays. Rather, it is a process of generating large-scale sequence data sets that adequately sample a specimen for microbial content and then of applying computational methods to resolve the sequences into individual species, genes, pathways, or other features.

Accuracy of 12 Lead ECG For Diagnosis of Posterior Myocardial Infarction Taking 15 Lead ECG As Gold Standard Panezai, Sikander Azeem; Azim, Waqar; Kakar, Kaleemullah; khan, Alamzeb; Tareen, Sehrish Ghani; Tareen, Zarghoona
Journal of Medical Biomedical and Applied Sciences Vol 6 No 9 (2018)
Publisher : Journal of Medical Biomedical and Applied Sciences

INTRODUCTIONThe acute management of ST-elevation myocardial infarction (STEMI) is based on interpretation of the ECG. Thisis typically undertaken by doctors in the emergency department (ED) and acute medical unit. Increasingly, the ECGdiagnosis is being made by paramedics, allowing them to pre-alert the ED or even initiate thrombolytic therapy inregions where primary angioplasty is unavailable. Identification of ST-segment elevation or presumed new left-bundlebranch block in combination with a history of cardiac chest pain results in prompt initiation of reperfusion therapy.SUBJECT AND METHODA cross sectional study was done at Cardiology Department, Bolan Medical College, Quetta. Total duration was from01/02/2018-30/07/2018. 196 patients were recruited from Out Patient Department and Emergency Department of BolanMedical Complex, Quetta on the basis of inclusion/exclusion criteria, that is all patient with chest pain and age >18 and< 70 with posterior MI as per operational definition presenting within 12 hours of symptoms were included and allpatients with underlying LBBB on ECG, PPM and paced rhythm on ECG and pericardial effusion were excluded asthey are effect modifiers and bring bias in study.RESULTSTotal 196 patients were included in the study according to the inclusion criteria of the study. Mean age (years) in thestudy was 40.28+14.38 whereas there were 123 (62.8) male and 73 (37.2) female patients in the study. The diagnosticaccuracy, sensitivity, specificity, PPV and NPV of 12 lead ECG for diagnosis of posterior myocardial infarction taking 15lead ECG as gold standard was 82.14%, 87.12%, 57.58%, 91.03% and 47.50% respectively.CONCLUSIONThe study concludes that diagnostic accuracy of 12 lead ECG for diagnoses of posterior wall myocardial infarction washigh. The high sensitivity identified more patients to be re vascularized early.

Mitochondrial neuropathy in pediatric patients carrying mtDNA, POLG1, SURF1, and PDHA1 mutations Finsterer, MD, PhD, Josef; Zarrouk-Mahjoub, PhD, Sinda
Journal of Medical Biomedical and Applied Sciences Vol 6 No 9 (2018)
Publisher : Journal of Medical Biomedical and Applied Sciences

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Postnatal Prognosis of Fetal Noncompaction Is Uncertain In Sibs Carrying a PKP2 Deletion Finsterer, MD, PhD, Josef; Zarrouk-Mahjoub, PhD, Sinda
Journal of Medical Biomedical and Applied Sciences Vol 6 No 9 (2018)
Publisher : Journal of Medical Biomedical and Applied Sciences

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Toxoplasma Gondii Stimulates The Behavioural Changes of Rodents: Updated Evidence Che Omar, Siti Shafiyyah; Mohd Moklas, Mohamad Aris; Mohtarrudin, Norhafizah; Osman, Malina
Journal of Medical Biomedical and Applied Sciences Vol 6 No 9 (2018)
Publisher : Journal of Medical Biomedical and Applied Sciences

In recent years, there have been an increased number of reports in the literatures on animal behavioural changeslinked with intracellular protozoan Toxoplasma gondii. Evidence for animal behavioural changes with Toxoplasmagondii infection comes from experimental tests on animal models such as mice and rats. These studies describethe important mechanisms of behavioural changes which involving neuromodulator and neurotransmitter level.Furthermore, behavioural changes also have been identified in human as well as animal models that may also playa role in development of schizophrenia in humans

Dressing Out Percent And Some Carcass Characteristic of EL Gash Sheep M. O. M, Omer; A.N, Ekhlas; O.M.A, Atif
Journal of Medical Biomedical and Applied Sciences Vol 6 No 9 (2018)
Publisher : Journal of Medical Biomedical and Applied Sciences

This study was conducted to evaluate dressing out percent and carcass characteristic potentials of EL Gash sheep,under their natural habitat in Kassala town abattoir, Thirty , sheep 15 males and 15 females , were purchased formthe different local market of El Gash Area. Each sex was comprised of five groups , according to the age studied .live animals body weights were be taken before and after slaughtering .The evaluation of dressing out percent carcassyield characteristic were be taken. The slaughter data results significant difference between the two sexes . The resultindicated that dressing out percentage were 49.4% and 47.3% for the male and the female respectively with overallaverage of 48% . Slaughter at different ages showed significant differences in some parts of internal organs betweenthe two sexes. Alive weight, muscle, bone, trims, head, skin, rumen full, intestine full intestine empty, liver, heart, lungsreproductive organs and spleen were heavier in male than the female it might be due to the sex male hormone, butmesenteric fat, omentum fat, kidney knob canal fat [k.k.c.f], and fat were heavier in female than the males while muscle,bone, fat, trims, head, mesenteric fat, omentum fat, spleen and knob canal fat (k.k.c.f)were significant.

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