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Journal of Medicine and Health

jmh
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Published by Universitas Kristen Maranatha

ISSN : 24425227 EISSN : - DOI : -

Core Subject : Health, Science,

Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Journal of Medicine and Health (JMH) is an open access journal (OAJ), a periodic scientific publication biannually online published on February and August; using review and screening system by peer group reviewer. JMH receives original research articles which related to medicine, health, new developing therapy from traditional medicine or herbs and developing clinical therapy. JMH also receives otiginal review articles, case report, continuing medicine and health study. Articles should be written in good English or Indonesian language.

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Articles 12 Documents

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Search results for , issue "Vol. 1 No. 3 (2016)" : 12 Documents clear

The Effect of Olive Oil Addition into Oatmeal in Lowering Total Blood Cholesterol and LDL (Low Density Lipoprotein) in Wistar Rat Sebastian Hadinata; Heddy Herdiman; Fenny Tanuwijaya
Journal of Medicine and Health Vol. 1 No. 3 (2016)
Publisher : Universitas Kristen Maranatha

Oat contains beta-glucan fiber and olive oil contains unsaturated fatty acids which havebeen proven to decrease blood cholesterol. This research compared the effect between acombination of oatmeal and olive oil and each food as single intake in decreasing total bloodcholesterol and LDL cholesterol. We used 25 rats (Rattus norvegicus L.), divided them into fivegroups; negative control (KN), positive control (KP), olive oil group (KMZ), oatmeal group(KBG), and combination group (KMZ+KBG). The total blood cholesterol and LDL cholesterollevels were measured after 14 days of induction and after 28 days of treatment. Data wereanalyzed using one way ANOVA, continued with LSD test with Î± = 0.05. The result showedthere were 10.85%, 8.85% and 6.60% lower in total blood cholesterol level using KMZ+KBG,KMZ and KBG respectively and 13.85%, 9.33% ,and 8.80% lower in LDL cholesterol levelusing KMZ+KBG, KMZ and KBG respectively. ANOVA test showed a significant decrease ineach treatment. LSD test showed that there was a significant difference between KMZ+KBGcompared to KBG in total blood cholesterol and LDL lowering, but did not showed significantdifference compared to KMZ.Keywords: oatmeal, olive oil, total blood cholesterol, LDL

The Potential of MiRNAs as Biomarkers and Therapy Targets for Cancer Teresa L. Wargasetia
Journal of Medicine and Health Vol. 1 No. 3 (2016)
Publisher : Universitas Kristen Maranatha

MicroRNAs (miRNAs) are involved in the signaling circuits regulation within a cell andtheir deregulation plays an important role in cancer development and progression. In thisreview, we discussed miRNA biogenesis, miRNA function and the effect of miRNA abnormalitiesin cellular pathways that led to transformation of normal cells into cancer cells, as well as theindication of miRNAs as diagnostic and prognostic biomarkers of various types of cancer, asbiomarkers to predict the response to cancer therapy and the potential for development ofmiRNAs as cancer targeted therapy.Keywords: miRNA, cancer, diagnostic biomarker, prognostic biomarker, cancer therapy

The Ethanol Extract of Neem Leaf (Azadirachta Indica A. Juss) Effect towards Wound Healing in Male Swiss Webster Mice Hillary L. Mustamu; Endang Evacuasiany; Laella K. Liana
Journal of Medicine and Health Vol. 1 No. 3 (2016)
Publisher : Universitas Kristen Maranatha

accelerates wound healing. We examined the effect of Ethanol Extract of Neem Leaf (EENL) inaccelerating wound healing and compared its potential with povidone iodine. This was ananalytic experimental study, using Complete Randomized Design (CRD) with a comparativemethod. We used 30 male Swiss Webster mice that were divided into five groups (n=6). Eachgroup was given the Ethanol Extract of Neem Leaf (EENL) with a concentration of 25%, 12.5%and 25%, aquades (negative control) and povidone iodine 10% (comparison). The averagewound healing time of EENL 25%, EENL 12.5% , EENL 6.25% , povidone iodine and aquadeswere 11.2; 12.2;13.2;13.2;and 1.3 days respectively. The data was analized with one wayANOVA and showed a highly significant difference of p=0.000. Tukey HSD test showed thatEENL 25% and 12.5% had better potential than povidone iodine 10% and EENL 6.25% had thesame potential with povidone iodine 10%. This study concludes that ethanol extract of neem leafhas an effect in accelerating the duration of wound healing, with EENL 25% as the bestconcentration in accelerating the duration of wound healing.Keywords: neem leaf, Azadirachta indica A. Juss, wound healing, Swiss Webster mice

Potency of Black Soybean (Glycine max L. Merr) and Jati Belanda Leaves (Guazuma ulmifolia Lamk) for Dyslipidemia Treatment In Vivo Prahastuti, Sijani; Hidayat, Meilinah; Kurniadi, Michael W.; Christiany, Selvina
Journal of Medicine and Health Vol. 1 No. 3 (2016)
Publisher : Universitas Kristen Maranatha

Soybean Detam 1 and Jati Belanda leaves are potential alternative medicines for treating dyslipidemia. The purpose of this study is to explore Â the potential of the combination of Ethanolic Extract Soybean Detam 1 (EEKD) and Jati Belanda (EEJB) in lowering LDL cholesterol and triglycerides compared to single extract and Simvastatin. Using a real laboratory experimental method with CRD, a total of 36 male Wistar rats were divided into 6 groups and administrated for treatment of 28 days. The results showed a significant decrease of LDL cholesterol as well as triglyceride in NCÂ as compared to P1, P2, P3 (p <0.05) and no significant difference with PC (p> 0.05). The highest suppression of LDL cholesterol between P1 with P2 and P3 is (p <0.05) while the triglyceride is between P1 and P2 (p <0.05). This study concludes that the combination of EEKD 10 mg, 20 mg EEJB, EEKD 30 mg and EEJB 30 mg is significantly lowering LDL cholesterol and triglyceride. The combination of EEKD 10 mg, 20 mg EEJB is the highest compression of LDL cholesterol and triglyceride, and has an equivalent effect with simvastatin in lowering LDL cholesterol and triglycerides in male Wistar rats induced with high fat diet.Â Keywords: LDL cholesterol, triglycerides

Generalized Lymphadenopathy due to Chronic Lymphocytic Leukemia (CLL) : 18F-FDG PET Imaging Basuki Hidayat; Febby Hutomo; Ryan Yudistiro; Ivana D. Mulyanto; Hendra Budiawan; Johan S. Masjhur
Journal of Medicine and Health Vol. 1 No. 3 (2016)
Publisher : Universitas Kristen Maranatha

Lymphadenopaty is a common clinical finding with a broad differential diagnosis, withCarcinoma of Unknown Primary (CUP) as one of itâ€™s most common causes. Flourine-18 fluoro-2 deoxy glucose (18F- FDG) positron emission tomography (PET) is a Nuclear Medicinescintigraphy procedure commonly used to localize suspected a primary lesion by depicting ametabolic status. However, in the expertise of 18F FDG PET study, clinical finding andepidemiologic data must be considered to get a better conclusion. We describe 18F-FDG PETstudy in the presence of generalized lymphadenopathy due to chronic lymphocytic leukemia(CLL), a rare disease which is initially suspected of having CUP.Keywords: 18F-FDG PET, lymphadenopathy, lymphoma, leukemia

Prevention and Treatment of Early Childhood Caries (ECC) Jeffrey .
Journal of Medicine and Health Vol. 1 No. 3 (2016)
Publisher : Universitas Kristen Maranatha

Early Childhood Caries (ECC) is a chronic disease that can be prevented. It commonlyaffects children involving in one or more decayed (with lesions or not) teeth, missing teeth (dueto caries), or teeth with fillings in children aged under 71 months. The disease is sometimesoverlooked, but this condition usually affects the general health of children. Early detection ofEarly Childhood Caries (ECC) can prevent problems which are harmful to children. Therefore,the ECC must be prevented and for teeth that have had dental caries they should be givenproper treatment so as not to worsen and affect the quality of life in children. Prevention of thisdisease is a significant component in any health program to prepare for the optimal basis forthe oral health of children. This condition will become a serious health problem if not handledproperly, and it is a major health problem for health providers throughout the world.Primarypreventive must be initiated since a woman getting pregnant.Keywords: Early Childhood Caries (ECC), prevention, treatment

Cytotoxic Activity of Red Fruit (Pandanus conoideus Lam.) Oil and Its Effect On Cyclooxygenase-2 Gene Expression in Raji Cells Fen Tih
Journal of Medicine and Health Vol. 1 No. 3 (2016)
Publisher : Universitas Kristen Maranatha

The number of cancer patient is increasing, while a really effective therapy has not yet been discovered. One concept of carcinogenesis is the relation between chronic inflammation and cancer. Cyclooxygenase-2 (COX-2) has a carcinogenic effect in inflamed and malignant tissues. Red Fruit contains carotenoid that can suppress COX-2 gene expression and tocopherol, which is a potent inhibitor ofÂ COX-2.Â The purpose of this study is to determine cytotoxic activity of Red Fruit oil and its effect on COX-2 gene expression. The experiment used 5 dosages of Red Fruit, 100, 200, 300, 400, and 500 Âµg/mL, exposed to Raji cells. However, unexposed Raji cells were used as control. Cytotoxic activities were evaluated by MTT Assay, while Lethal Concentration50 (LC50) was determined through regression-correlation analysis. Red Fruit oil effect on COX-2 gene expression was evaluated by Reversed Transcriptase Chain Reaction (RT-PCR) method and electrophoresis. Electrophoresis bands were analyzed by Scion Image for Windows. Optical Integrated Density (OID) of unexposed and exposed groups were statistically analyzed with one way Analysis of Variance (ANOVA), followed by Duncan test with Î±=0.05. The results showed that Red Fruit had a cytotoxic activity on Raji cells with LC50 of331.42 Âµg/mL. Red Fruit suppressed COX-2 gene expression with an effective dosage obtained at 500 Âµg/mL.Â Â Â Â Â Â Â Â Â Keywords: red fruit, cytotoxicity, cox-2 gene expression, raji cells

Progressive Neurological Deficit in Adult Idiopathic Syringomyelia (IS): Case Report and Literature Review Yudoyono, Farid; Widhiatmo, Anugrah O.; Wirjomartani, Beny A.
Journal of Medicine and Health Vol. 1 No. 3 (2016)
Publisher : Universitas Kristen Maranatha

A syringomyelia is a clinical entity of any tubular fluid-filled cavity within the spinalcord that causes slowly but relentlessly progressive symptoms as well as expansion of thecavity, which is most commonly associated with Chiari malformation Type I, which due toadvancement of imaging techniques has resulted in more incidental idiopathic syringes that arenot associated with tumor, trauma, or postinfectious causes. Idiopathic syringomyelia (IS) is apathological entity in which no overt etiology is evident for a syrinx. In this study, we describe acase in a 45 year-old woman presented with progressive difficulties in walking and also hadmyelopathic signs evidenced by hyperreflexia in the lower extremities and underwent foramenmagnum decompression and C1 lamiectomy. Idiopathic syringomyelia is a pathological entityin which no overt etiology is evident for a syrinx. It can be managed succesfully byconservative treatment but if there is a progression of neurological deficit, surgicaldecompression is a mandatory.Keywords: idiopathic syringomyelia, neurological deficit

Peer Reviewers of JMH Volume 1 Number 3 February 2016 Editorial Editorial Team
Journal of Medicine and Health Vol. 1 No. 3 (2016)
Publisher : Universitas Kristen Maranatha

We would like to thank our peer reviewers for the precious contributions in providing clinical,scientific, and methodological expertise for JMH Volume 1 Number 3. We appreciate everythoughtful review of submitted manuscripts and for making important contributions to improve thescientific quality of articles published in JMH. We listed the names in alphabetical order.Dr.dr.Agung Budi,Sp.BSdr. Amaylia Oehadian,Sp.PD-KHOMProf. Dr. Ambrosius Purba, dr.,MS.,AIFOdr.Cherry Azaria, M.Kesdr.Decky Gunawan,M.Kesdr. Djaja Rusmana, M.Si.dr Dono Pranoto, SpB., M.Kesdr. Frecillia Regina,Sp.A.,IBCLCDr. dr. Hana Ratnawati, M.Kes., PA(K)Ingrid S. Surono, PhDProf.dr. Jeanne A. Pawitan, MS, PhDdr. Justin Ginting, Sp.Raddr. Laella Kinghua Liana,Sp.PA,M.Kesdrg. Linda Sari Sembiring, Sp.KGADr. dr. Meilinah Hidayat, M.KesProf. Dr. dr. M. Nurhalim Shahibdrg. Ruslin,Sp.BM.,M.KesProf. Dr. dr. Susy Tjahjani, M.KesProf. dr. Wahyuni Lukita Atmadja, PhD.dr. Yenni Limyati, Sp.KFR.,M.Kes

Cytopathology Lymphadenopathy Feature in HIV Positve Patient: Diagnosis Tools Comorbidities Agustina, Hasrayati; Wisudarma, Yenni; Kristiana, Ris; Hernowo, Bethy S.
Journal of Medicine and Health Vol. 1 No. 3 (2016)
Publisher : Universitas Kristen Maranatha

Lymphadenopathy is enlarged lymph nodes caused by infection, inflammation or malignancy. On HIV positive patients, lymphadenopathy is one of the most common clinical manifestations and it is usually persistent. Fine-needle aspiration biopsy (FNAB) is an effective cytology technique in determining the diagnosis of lymphadenopathy. This study aimed to describe the cytopathology of lymphadenopathy in HIV positive patients. This is a descriptive study of 21 cases of lymphadenopathy in patients with HIV positive who underwent FNAB examination in Anatomical Pathology Department of Dr.Hasan Sadikin Hospital between 2013-2014. Medical data was taken from the patient medical records including age, sex, location, size and cytopathological diagnosis. Cytopathology overview of FNAB specimens were reassessed by 2 pathologists. In this study, lymphadenopathy in HIV positive patients were mainly found in men (n = 15.71%) with an average age between 20-30 years. The most frequent location was the neck (n = 20.95.2%). The lymph nodes size were found between 0.5-3 cm. Most diagnosis was tuberculous lymphadenitis (n = 15.71%) with the most common cytology feature was granulomatous lymphadenitis (n = 5.33.3%) and suppurative lymphadenitis (n = 5.33.3%). FNAB examination in lymphadenopathy is very helpful to identify the cause of infection in HIV positive patients. Keywords: FNAB, HIV, lymphadenopathy, cytopathology

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